scholarly journals Phytochemistry and Toxicity Studies of Telfairia Occidentalis Aqueous Leaves Extract on Liver Biochemical Indices in Wistar Rats

2012 ◽  
Vol 2 (5) ◽  
pp. 103-110 ◽  
Author(s):  
Ekpenyong C. E ◽  
Akpan E. E ◽  
Udoh N. S
Keyword(s):  
Wistar Rats ◽  
Toxicity Studies ◽  
Telfairia Occidentalis ◽  
Biochemical Indices

acute and sub-acute toxicity studies of aqueous leaf extract of launaea taraxacifolia (willd.) in wistar rats

2021 ◽  
Vol 12 (1) ◽  
pp. 95
Author(s):  
Millicent Umaru ◽  
Kabiru Abubakar ◽  
Gabriel Uyaiabasi ◽  
Giaze Tijjani ◽  
Yusuf Alkali ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Toxicity Studies ◽  
Aqueous Leaf Extract

scholarly journals Safety evaluation of syringic acid: subacute oral toxicity studies in Wistar rats

Heliyon ◽  
2019 ◽  
Vol 5 (8) ◽  
pp. e02129 ◽  
Author(s):  
Anwarbaig C. Mirza ◽  
Shital S. Panchal
Keyword(s):  
Wistar Rats ◽  
Safety Evaluation ◽  
Syringic Acid ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals Effect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei brucei

2020 ◽  
pp. 10-19
Author(s):  
M. A. Kugama ◽  
T. Tese ◽  
H. Sabo ◽  
T. Andrew ◽  
Y. A. Onaolapo ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Potassium Concentration ◽  
Sodium Concentration ◽  
Chloroform Extract ◽  
Trypanosoma Brucei Brucei ◽  
Infection Treatment ◽  
Biochemical Indices ◽  
Senna Alata

This study was aimed at determining the effect of leaves of Senna alata extract on biochemical indices of Wistar rats infected with Trypanosoma brucei brucei. Phytochemical screening revealed the absence of steroids in all extracts, absence of saponins in chloroform extracts and the presence of free anthraquinones only in chloroform extract. Post-infection treatment of animals stirred the emergence of parasitaemia by Day 3. Only animals receiving 200 mg/kg b.wt. of chloroform extract survived by day 16. A significant (P<0.05) decrease in ALT for groups receiving methanol (400 mg/kg b.wt.), chloroform and aqueous extracts and significant (P<0.05) increase in unconjugated bilirubin in the group receiving methanol extract (200 mg/kg b.wt.) compared to infected not treated rats. Significant (P<0.05) decrease in potassium concentration in groups receiving methanol and chloroform, and a significant (P<0.05) increase in sodium concentration in the group receiving 400 mg/kg b.wt. of aqueous extract compared to the infected not treated rats. These results thereby demonstrate the ameliorative potential of Senna alata leaves against T. brucei brucei.

Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats

2019 ◽  
Vol 108 ◽  
pp. 104443 ◽  
Author(s):  
M. Clemente ◽  
M.D. Miguel ◽  
K.B. Felipe ◽  
C. Gribner ◽  
P.F. Moura ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Nasturtium Officinale ◽  
Toxicity Studies

Modulatory role of betulinic acid in N-nitrosodimethylamine-induced hepatorenal toxicity in male Wistar rats

2016 ◽  
Vol 36 (7) ◽  
pp. 734-743 ◽  
Author(s):  
GE Adeleke ◽  
OA Adaramoye
Keyword(s):  
Dna Fragmentation ◽  
Betulinic Acid ◽  
Wistar Rats ◽  
Saline Control ◽  
Gamma Glutamyl Transferase ◽  
Toxic Agent ◽  
Polychromatic Erythrocytes ◽  
Male Wistar Rats ◽  
Glutamyl Transferase ◽  
Biochemical Indices

N-nitrosodimethylamine (NDMA) is a toxicant found in foods and drinking water. Several synthetic agents used in alleviation of NDMA toxicity have been associated with serious side effects. Therefore, a safe and less toxic agent is desirable. In this study, betulinic acid (BA), a triterpenoid antioxidant, is proposed as a better and alternative agent to modulate NDMA-induced toxicity. Twenty-four Wistar rats were assigned into four groups of six rats each and treated with normal saline (control), BA (25 mg/kg), NDMA (5 mg/kg) and (BA + NDMA). BA was given by oral gavage for 14 consecutive days, while NDMA was administered intraperitoneally on days 7 and 12. Results showed that administration of NDMA significantly ( p < 0.05) elevated the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase and gamma-glutamyl transferase by 51%, 48% and 81%, respectively. Also, NDMA intoxication significantly ( p < 0.05) increased the levels of serum urea and creatinine by 64% and 82%, respectively, and decreased urinary creatinine by 67%. In addition, administration of NDMA significantly ( p < 0.05) increased the levels of hepatic and renal DNA fragmentation by 44% and 61%, respectively, relative to control. The number of micronucleated polychromatic erythrocytes (mnPCEs) in NDMA-treated rats (11.1 ± 2.6 mnPCE/1000PCE) was significantly higher than control (4.3 ± 1.1 mnPCE/1000 PCE). Immunohistochemistry revealed strong expressions of Bcl-2 and nuclear p53 in NDMA-intoxicated rats. Interestingly, pretreatment with BA significantly ( p < 0.05) ameliorated NDMA-induced changes in serum biochemical indices, mnPCEs, DNA fragmentation and expressions of Bcl-2 and p53 proteins. These findings suggest that BA protects against NDMA-induced toxicity via anti-oxidative and anti-apoptotic activities.

scholarly journals Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
C. P. Ekanayake ◽  
M. G. Thammitiyagodage ◽  
S. Padumadasa ◽  
B. Seneviratne ◽  
C. Padumadasa ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Ethyl Acetate ◽  
Wistar Rats ◽  
Cocos Nucifera ◽  
Toxicity Study ◽  
Immature Inflorescence ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Female Wistar Rats

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.

Subchronic toxicity studies of aqueous leaf and stem bark extract of Irvingia gabonensis in male albino wistar rats

2017 ◽  
Vol 26 (3) ◽  
pp. 553-559 ◽  
Author(s):  
Chukwunonso K. Ezeasor ◽  
Chigozie Chukwuma ◽  
Samuel O. Ekere ◽  
Patrick Abah
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Bark Extract ◽  
Subchronic Toxicity ◽  
Toxicity Studies ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

Safety assessment of the aqueous extract of the flowers of Nymphaea lotus Linn (Nymphaeaceae): Acute, neuro- and subchronic oral toxicity studies in albinos Wistar rats

2017 ◽  
Vol 14 (2) ◽  
Author(s):  
Mireille Kameni Poumeni ◽  
Danielle Claude Bilanda ◽  
Paul Désiré Dzeufiet Djomeni ◽  
Yolande Sandrine Mengue Ngadena ◽  
Marguerite Francine Mballa ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Safety Assessment ◽  
Wistar Rats ◽  
Behavioral Changes ◽  
Oral Toxicity ◽  
Supplementary Food ◽  
Toxicity Studies ◽  
Dose Dependent

AbstractBackgroundLinn (MethodsAqueous extract ofResultsOur findings indicate dose-dependent elevation of nitrites contents in the flowers aqueous extract ofConclusionsdo not possesses neurotoxicity but is able to induce behavioral changes in rats. Therefore, the application of this plant as either drug or supplementary food should be carefully considered.

scholarly journals Safety assessment of the methanol extract of the stem bark of Amphimas pterocarpoides Harms: Acute and subchronic oral toxicity studies in Wistar rats

2014 ◽  
Vol 1 ◽  
pp. 877-884 ◽  
Author(s):  
Job Tchoumtchoua ◽  
Oumarou Riepouo Mouchili ◽  
Sylvin Benjamin Ateba ◽  
Stéphane Zingue ◽  
Maria Halabalaki ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Stem Bark ◽  
Oral Toxicity ◽  
Toxicity Studies
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