scholarly journals Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer

2021 ◽  
Vol 12 (8) ◽  
pp. 2385-2394
Author(s):  
Liting Lv ◽  
Xiao Liang ◽  
Dan Wu ◽  
Feng Wang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cardia Cancer ◽  
Differential Analysis

scholarly journals Evaluating Gastric Cancer Misclassification: a Potential Explanation for the Rise in Cardia Cancer Incidence

1999 ◽  
Vol 91 (9) ◽  
pp. 786-790 ◽  
Author(s):  
A. M. Ekstrom ◽  
L. B. Signorello ◽  
L.-E. Hansson ◽  
R. Bergstrom ◽  
A. Lindgren ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Incidence ◽  
Cardia Cancer ◽  
Potential Explanation

scholarly journals Clinicopathological characteristics of Barrett's carcinoma, cardia carcinoma type II and distal gastric carcinoma: Influence of observed parameters on the five-year postoperative survival of patients

2009 ◽  
Vol 137 (5-6) ◽  
pp. 249-254
Author(s):  
Ivan Jovanovic ◽  
Tamara Alempijevic ◽  
Tomica Milosavljevic ◽  
Dragan Popovic ◽  
Milos Bjelovic ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Gastric Adenocarcinoma ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Parameters ◽  
Cancer Type ◽  
Cardia Cancer ◽  
Tumour Invasion ◽  
Barrett’S Cancer ◽  
Distal Gastric Cancer

Introduction. In the past two decades, the increased frequency of distal esophageal adenocarcinoma, esophagogastric junction and proximal gastric adenocarcinoma has been observed. The vast majority of these tumours are diagnosed in advanced stages, when the prognosis is poorer than in other gastric cancers. Objective. The aim of our study was to analyze the demographic and clinicopathological characteristics of patients operated on for Barrett's, cardia and distal gastric adenocarcinomas, as well as to study the influence of manifestations of each cancerogenetic indication on the studied clinicopathological parameters and to analyze the 5-year survival rate of patients surgically treated for cardia adenocarcinoma in relation to the patients operated on for distal gastric adenocarcinoma. Methods. We analyzed gender and age, tumour type, depth of tumour invasion, involvement of blood and lymph vessels in 66 patients surgically treated at the Centre for Oesophageal Surgery of the Institute for Digestive Diseases of the Belgrade Clinical Centre. Results. Except for significant differences in the depth of tumour invasion during surgery, there were no other statistically significant differences between the studied groups of patients. In the patients operated on for Barrett's and cardia cancers, the tumours invaded more deeply the wall layers, i.e. they were significantly more invasive than the distal gastric tumour. The lymph node involvement was present in 87.5% of patients with Barrett's cancer, in 80% with cardia cancer and in 87% with distal gastric cancer. The 3-year survival rate of patients operated on for cardia cancer was 47.4% and the 5-year survival rate was 31.6%, while the 3-year survival rate of patients operated on for distal gastric cancer was 46.2% and the 5-year survival rate was 34.6%. These differences were not statistically significant (Wilcoxon 0,036; p=0,85). Singly, the patients' gender, cancer type and the degree of tumour differentiation had no influence on the length of patients' postsurgical survival rate. Conclusion. At the time of diagnosis cardia cancer and cancers developed at the location of the Barrett's oesophagus, developed significant deeper per continuitatem than gastric cancer. There were no other differences in regard to the analyzed clinicopathological parameters among the tumours of these three locations, and there was no difference between the 3-year and 5-year survival rate between the patients operated on for gastric cancer and cardia cancer. Each studied clinicopathological parameter had no influence on the illness course.

scholarly journals Sex difference in the incidence of cardia and non-cardia gastric cancer in the United States, 1992-2014

2020 ◽  
Author(s):  
Qiang Yao ◽  
Xiaona Qi ◽  
Shao-Hua Xie
Keyword(s):  
United States ◽  
Gastric Cancer ◽  
Sex Difference ◽  
The United States ◽  
Pacific Islanders ◽  
Cardia Cancer ◽  
Asian And Pacific Islanders ◽  
The Absolute ◽  
Male To Female ◽  
Over Time

Abstract Background Gastric cancer is more common in men than in women, but underlying reasons have not been completely understood. This study aimed to assess patterns of the sex difference in the incidence of gastric cancer in the United States.Methods Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results Program, we analyzed the age-specific sex difference in the incidence of gastric cancer by ethnicity, anatomic site and histological type in the United States during 1992-2014. We assessed the temporal trends in the sex differences in the incidence of gastric cancer during the study period.Results The male-to-female incidence ratio of cardia cancer increased with age until peaking at ages 55-69 years and decreased thereafter, while the ratio for non-cardia gastric cancer increased with age before ages <60 years and remained stable onwards. The age-specific patterns in the sex difference of gastric cancer incidence varied between intestinal and diffuse histological types. The sex difference in the incidence of cardia cancer remained relatively stable except for that the absolute difference between the sexes in whites decreased on average by 0.8% per year from 1992 to 2014. The absolute incidence difference between the sexes in non-cardia gastric cancer decreased over time in whites, blacks, and Asian and Pacific islanders by approximately 4% per year. The male-to-female incidence ratio of non-cardia gastric cancer decreased over time in whites and blacks, but remained relatively stable in Asian and Pacific islanders.Conclusions Both extrinsic and intrinsic factors may have contributed to the sex difference in gastric cancer. Sex hormones may play a role in the development of cardia cancer and intestinal type of gastric cancer.

Correlation of CHAF1A with adjuvant chemotherapy outcome and microsatellite instability in gastric cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15511-e15511
Author(s):  
Deqiang Wang ◽  
Deyu Chen ◽  
Bo Shen ◽  
Xiaofeng Chen ◽  
Martin Qi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cox Model ◽  
Survival Curve ◽  
Critical Role ◽  
Disease Free Survival ◽  
Immunohistochemical Method ◽  
Cardia Cancer

e15511 Background: Clinical outcomes of adjuvant chemotherapy in gastric cancer (GC) have considerable stage-independent variability, which underscores the need for predictive molecular markers. Previous studies indicated that CHAF1A played a critical role in tumor growth, but whether it was associated with adjuvant chemotherapy in GC was still unknown. This retrospective study investigated the prognostic value of CHAF1A in adjuvant chemotherapy of GC. Methods: A total of 325 stage IB-III patients with fluoropyrimidines (FU)-based adjuvant chemotherapy after curative D2 gastrectomy meeting eligibility criteria were selected. CHAF1A protein expression was determined by immunohistochemical method. The primary outcomes were Overall survival (OS) and Disease-free survival (DFS). Kaplan-Meier method was used to estimate survival curve and Cox model for multifactor analysis. Results: CHAF1A mRNA was overexpressed in GC tissues and positive CHAF1A protein expression was not associated with OS and DFS in overall patients treated by FU-based chemotherapy ( P = 0.391 and 0.511, respectively). However, as stratified by tumor sites, positive CHAF1A expression was associated with poor OS and DFS in non-cardia cancer ( P = 0.009 and 0.007, respectively) but not in cardia cancer ( P = 0.229 and 0.112, respectively). Multivariate analysis indicated that CHAF1A expression level was still an independent predictor for both OS (HR = 2.42; 95% CI: 1.12-5.20; P = 0.024) and DFS (HR = 1.91; 95% CI: 1.03-3.54; P = 0.039) in non-cardia GC. Furthermore, CHAF1A was correlated with the status of microsatellite instability ( P = 0.025). Conclusions: CHAF1A might be a predictor for outcomes of FU-based adjuvant chemotherapy in patients with non-cardia GC, but needed further prospective studies to confirm.

Identification of potential serum biomarkers for gastric cancer by a novel computational method, multiple normal tissues corrected differential analysis

2012 ◽  
Vol 413 (3-4) ◽  
pp. 428-433 ◽  
Author(s):  
Mirang Kim ◽  
Hyun Ja Kim ◽  
Bo Youl Choi ◽  
Jeong-Hwan Kim ◽  
Kyu-Sang Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Serum Biomarkers ◽  
Computational Method ◽  
Differential Analysis ◽  
Normal Tissues

Gastric mucosal atrophy is a strong predictor of non-cardia gastric cancer but not of cardia cancer

1998 ◽  
Vol 114 ◽  
pp. A606
Author(s):  
S. Hansen ◽  
S.E. Vollset ◽  
K. Melby ◽  
S. Aase ◽  
E. Jellun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Strong Predictor ◽  
Cardia Cancer ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy

scholarly journals Incidence and Survival for Gastric and Esophageal Cancer Diagnosed in British Columbia, 1990 to 1999

2008 ◽  
Vol 22 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Morteza Bashash ◽  
Amil Shah ◽  
Greg Hislop ◽  
Angela Brooks-Wilson ◽  
Nhu Le ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
British Columbia ◽  
Esophageal Cancer ◽  
Temporal Trends ◽  
Survival Rates ◽  
Gastric Cardia ◽  
Cardia Cancer ◽  
Gastric Cancers ◽  
Gastric Cardia Cancer ◽  
Over Time

BACKGROUND: Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described.METHODS: Incidence data for the period 1990 to 1999 were obtained from the BC Cancer Registry. Age-adjusted incidence and survival rates were computed by anatomical subsite, histological type and sex. All rates were standardized to the 1996 Canadian population. The estimated annual percentage change (EAPC) was used to measure incidence changes over time. Kaplan-Meier curves were used to show survival rates, and log-rank tests were used to test for differences in the curves among various groups.RESULTS: Between 1990 and 1999, 1741 esophageal cancer cases and 3431 gastric cancer cases were registered in BC. There was an increase in the incidence of adenocarcinoma of the esophagus over time (EAPC=9.6%) among men, and of gastric cardia cancer among both women (EAPC=9.2%) and men (EAPC=3.8%). Patients with proximal gastric (cardia) cancer had significantly better survival rates than patients with cancer in the lower one-third of the esophagus. Among gastric cancers, patients with distal tumours had a significantly better survival rate than patients with proximal tumours.DISCUSSION: The incidences of proximal gastric cancer and esophageal adenocarcinoma are increasing, and their survival patterns are different. Examining these cancers together may elucidate new etiological and prognostic factors.

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