scholarly journals Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy

Theranostics ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1247-1266
Author(s):  
Thuy Giang Nguyen Cao ◽  
Ji Hee Kang ◽  
Wangyu Kim ◽  
Junha Lim ◽  
Su Jin Kang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Photoacoustic Imaging ◽  
Extracellular Vesicle ◽  
Stimuli Sensitive

A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo–sonodynamic cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 5587-5600 ◽  
Author(s):  
Caihong Dong ◽  
Qvzi Jiang ◽  
Xiaoqin Qian ◽  
Wencheng Wu ◽  
Wenping Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Photoacoustic Imaging ◽  
Sonodynamic Therapy ◽  
Carrier Free ◽  
Self Assembled

Nanosonosensitizer, Ce6-PTX@IR783, successfully realized the photoacoustic imaging-guided synergistic chemo–sonodynamic therapy with ultrasound-trigged controllable drug release and acquired high therapeutic efficacy for cancer.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

Tumor acidic microenvironment-induced drug release of RGD peptide nanoparticles for cellular uptake and cancer therapy

2021 ◽  
pp. 111673
Author(s):  
Zhongying Gong ◽  
Xiaoying Liu ◽  
Baolong Zhou ◽  
Guohui Wang ◽  
Xiuwen Guan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cellular Uptake ◽  
Rgd Peptide ◽  
Acidic Microenvironment ◽  
Peptide Nanoparticles

scholarly journals A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy

2021 ◽  
Author(s):  
Bin Zhang ◽  
Zichen Xu ◽  
Wen Zhou ◽  
Zhikun Liu ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Therapy ◽  
Drug Release ◽  
Distant Metastasis ◽  
Tumor Hypoxia ◽  
Treatment Resistance ◽  
Major Obstacle

Hypoxia is a major obstacle for cancer therapy due to its association with cell proliferation, tumor distant metastasis, and treatment resistance. In this study, a hypoxia-activated bifunctional prodrug (CC5) was...

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

2015 ◽  
Vol 128 (3) ◽  
pp. 1062-1067 ◽  
Author(s):  
Tianjiao Ji ◽  
Ying Zhao ◽  
Yanping Ding ◽  
Jing Wang ◽  
Ruifang Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Fibroblast Activation ◽  
Cancer Associated Fibroblast ◽  
Effective Cancer Therapy

MnO2-Coated Porous Pt@CeO2 Core-Shell Nanostructures for Photoacoustic Imaging-Guided Tri-modal Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Qing Xu ◽  
Danyang Li ◽  
Haijun Zhou ◽  
Biaoqi Chen ◽  
Junlei Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Conversion Efficiency ◽  
Photoacoustic Imaging ◽  
Core Shell ◽  
Photothermal Conversion ◽  
The Core ◽  
Shell Nanostructures

We describe the synthesis of MnO2-coated porous Pt@CeO2 core–shell nanostructures (Pt@CeO2@MnO2) as a new theranostic nano-platform. The porous Pt cores endow the core–shell nanostructures with high photothermal conversion efficiency (80%)...

scholarly journals Ultrasound‐controlled drug release and drug activation for cancer therapy

Exploration ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 20210023
Author(s):  
Li Tu ◽  
Zhihuan Liao ◽  
Zheng Luo ◽  
Yun‐Long Wu ◽  
Andreas Herrmann ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Drug Activation
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