scholarly journals Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma

2012 ◽  
Vol 13 (7) ◽  
pp. 3025-3029 ◽  
Author(s):  
Salih Emri ◽  
Saadettin Kilickap ◽  
Cem Kadilar ◽  
Meltem Gulhan Halil ◽  
Hadi Akay ◽  
...  
Keyword(s):  
Vitamin C ◽  
Malignant Pleural Mesothelioma ◽  
Beta Carotene ◽  
Serum Levels ◽  
Alpha Tocopherol ◽  
Pleural Mesothelioma

P-510 Serum vitamin E, vitamin C, beta carotene, and retinol levels and the risk of malignant pleural mesothelioma in Turkey

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S219 ◽  
Author(s):  
Salih Emri ◽  
Saadettin Kilickap ◽  
Cem Kadilar ◽  
Meltem Khalil ◽  
Hadi Akay ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Malignant Pleural Mesothelioma ◽  
Serum Vitamin ◽  
Beta Carotene ◽  
Pleural Mesothelioma

Changes in Thiamin, Riboflavin, Niacin, beta-carotene, Vitamins C, A, D and E Status of French Elderly Subjects during the First Year of Institutionalization

2000 ◽  
Vol 70 (2) ◽  
pp. 54-64 ◽  
Author(s):  
Jeanne Chantal Essama-Tjani ◽  
Jean-Claude Guilland ◽  
Françoise Fuchs ◽  
Marie Lombard ◽  
Dominique Richard
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Activity Coefficient ◽  
Reductase Activity ◽  
Population Sample ◽  
Serum Vitamin ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Elderly Subjects ◽  
Serum Retinol

Vitamin status was assessed in 26 recently institutionalized elderly subjects by combining dietary and biochemical measurements of thiamin, riboflavin, niacin, beta-carotene, vitamins C, A, D and E at admission (P1), and 1.5 (P2), 3.0 (P3), 4.5 (P4), 6.0 (P5), 12 (P6) months later. At admission, except for vitamin A, mean vitamin intakes were lower than the 1992 French Recommended Dietary Allowance. Thiamin, vitamins C, A and E status seemed nearly satisfactory as less than one-fourth of the population sample had blood values lower than the cut-off point for thiamin (erythrocyte thiamin pyrophosphate < 0.17 mumol/l), vitamin A (serum retinol < 1.05 mumol/l), vitamin C (serum vitamin C < 11.3 mumol/l) and vitamin E (serum alpha-tocopherol < 9.3 mumol/l) or higher than the cut-off point for thiamin (erythrocyte transketolase activity coefficient > 1.19). Almost half of the subjects for riboflavin, and almost all non supplemented subjects for vitamin D were in risk of vitamin deficiency (46% had an erythrocyte glutathione reductase activity coefficient > 1.19 and 72% had a plasma 25(OH)D3 < 25 nmol/l). During the study, vitamins status remained unchanged for riboflavin, niacin, vitamins A, D and E, improved for vitamin C (P = 0.004) or impaired for thiamin (P = 0.008). Thus, institutionalization seemed to have no effect on riboflavin, niacin, vitamins A, D and E status and a slight effect on thiamin and vitamin C status.

Numbers of Natural Teeth, Diet, and Nutritional Status in US Adults

2007 ◽  
Vol 86 (12) ◽  
pp. 1171-1175 ◽  
Author(s):  
R.E. Nowjack-Raymer ◽  
A. Sheiham
Keyword(s):  
Vitamin C ◽  
Nutritional Status ◽  
High Performance ◽  
Beta Carotene ◽  
Serum Levels ◽  
Dental Status ◽  
Multilinear Regression ◽  
Dietary Recall ◽  
Natural Teeth ◽  
The Relationship

Evidence that dental status affects diet is equivocal. The hypothesis of this study was that diet was affected by dental status. The objective was to assess the relationship between numbers of teeth and diet and nutritional status in US adult civilians without prostheses. We examined 6985 NHANES (1988–1994) participants. Data included socio-economics, demographics, dental status, and diet and nutritional status. Dietary data were obtained from food frequency questionnaires and 24-hour dietary recall. Serum levels of beta carotene, folate, and vitamin C were measured with isocratic high-performance liquid chromatography. The population was classified by numbers of teeth. Covariance and Satterthwaite F-adjusted statistical comparisons were made between tooth groupings and the fully dentate population. Multilinear regression models adjusted for covariates. People with fewer than 28 teeth had significantly lower intakes of carrots, tossed salads, and dietary fiber than did fully dentate people, and lower serum levels for beta carotene, folate, and vitamin C. Dental status significantly affects diet and nutrition.

scholarly journals Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

2019 ◽  
Author(s):  
Takumi Kishimoto ◽  
Nobukazu Fujimoto ◽  
Takeshi Ebara ◽  
Toyonori Omori ◽  
Tetsuya Oguri ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Damage ◽  
Serum Levels ◽  
Pleural Mesothelioma ◽  
Asbestos Fibers ◽  
Chemokine Ligand ◽  
History Of ◽  
Tumor Types ◽  
Study Participants

Abstract Background: Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients. Methods: The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA. Results: Levels of CCL2 were significantly elevated in the serum of patients with advanced MPM patients. Conclusions: Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

Antioxidant Vitamin Status (A, E, C, and Beta-Carotene) in European Adolescents - The HELENA Study

2011 ◽  
Vol 81 (4) ◽  
pp. 245-255 ◽  
Author(s):  
Christina Breidenassel ◽  
Jara Valtueña ◽  
Marcela González-Gross ◽  
Jasmin Benser ◽  
Andre Spinneker ◽  
...  
Keyword(s):  
Vitamin C ◽  
Reference Values ◽  
Representative Sample ◽  
Beta Carotene ◽  
Cross Sectional Study ◽  
Antioxidant Vitamins ◽  
Alpha Tocopherol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Apparently Healthy

Background: An adequate nutritional status of antioxidant vitamins (vitamins A, C, E) and b-carotene is essential especially during childhood and adolescence, because of their important roles in cell growth and development. Currently, there are no physiological reference values for blood concentration of these vitamins and b-carotene in apparently healthy European adolescents. The aim of the current study was to obtain reliable and comparable data of antioxidant vitamins and b-carotene in a cross-sectional study, within HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence), which was conducted in a representative sample of adolescents from ten European cities. Material and Methods: From a subsample of 1,054 adolescents (males= 501) of the HELENA Cross Sectional Study with an age range of 12.5 to 17.49 years, fasting blood samples were taken and analyzed for vitamins A, E, C, and b-carotene status. As specific reference values for adolescents are missing, percentile distribution by age and sex is given. Results: Mean concentrations were the following: Retinol: 356.4 ± 107.9 cm/mL; alpha-tocopherol: 9.9 ± 2.1 microg/mL; vitamin C: 10.3 ± 3.3 mg/L; and b-carotene: 245.6 ± 169.6 cm/mL. Females showed higher alpha-tocopherol and vitamin C values compared with males and 17-year-old boys had higher retinol levels than the same-aged girls (p = 0.018). Retinol serum concentrations increased significantly according to age in both gender, but girls had also significantly increasing b-carotene levels by age. Conclusions: For the first time, concentrations of antioxidant vitamins and pro-vitamin beta-carotene have been obtained in a representative sample of apparently healthy European adolescents. These data can contribute to the establishment of reference ranges in adolescents.

SERUM LEVELS OF RETINOL, BETA-CAROTENE, AND ALPHA-TOCOPHEROL IN OLDER ADULTS

1988 ◽  
Vol 127 (1) ◽  
pp. 114-123 ◽  
Author(s):  
GEORGE W. COMSTOCK ◽  
MARILYN S. MENKES ◽  
SUSAN E. SCHOBER ◽  
J-P. VUILLEUMIER ◽  
KNUD J. HELSING
Keyword(s):  
Older Adults ◽  
Beta Carotene ◽  
Serum Levels ◽  
Alpha Tocopherol

scholarly journals Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake – comments by Hernández-Garduño

2008 ◽  
Vol 101 (1) ◽  
pp. 145-145 ◽  
Author(s):  
Eduardo Hernández-Garduño
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Cancer Prevention ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Dietary Vitamin ◽  
Prevention Study ◽  
Tuberculosis Risk ◽  
Heavy Smokers ◽  
Vitamin E Supplementation

Hemilä & Kaprio(1) found a 72 % increase in the risk of tuberculosis (TB) in males taking vitamin E supplements and having high dietary vitamin C intake; the effect was restricted to heavy smokers as part of the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study.

scholarly journals Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

2019 ◽  
Author(s):  
Takumi Kishimoto ◽  
Nobukazu Fujimoto ◽  
Takeshi Ebara ◽  
Toyonori Omori ◽  
Tetsuya Oguri ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Damage ◽  
Elevated Serum ◽  
Serum Levels ◽  
Pleural Mesothelioma ◽  
Asbestos Fibers ◽  
Chemokine Ligand ◽  
History Of ◽  
Tumor Types

Abstract Background Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients.Methods The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA.Results Levels of CCL2 were significantly elevated in the serum of the MPM patients, and the increase was dependent on the stage of the disease.Conclusions Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Several, but not all, studies of serum CCL2 levels in patients with other types of cancer also report elevated serum CCL2, and many of these studies report that the increased levels of serum CCL2 are associated with the stage of the disease. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

Serum Antioxidants and Subsequent Mortality Rates of All Causes or Cancer among Rural Japanese Inhabitants

2002 ◽  
Vol 72 (4) ◽  
pp. 237-250 ◽  
Author(s):  
Yoshinori Ito ◽  
Koji Suzuki ◽  
Sadao Suzuki ◽  
Ryuichiro Sasaki ◽  
Motohiko Otani ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Beta Carotene ◽  
Serum Levels ◽  
Mortality Rates ◽  
High Serum ◽  
Alpha Tocopherol ◽  
Serum Samples ◽  
Total Carotenoids ◽  
Hazard Ratios

The purpose of this study was to investigate whether a relationship exists between mortality rates and serum antioxidant levels among Japanese inhabitants. The follow-up subjects, who participated in comprehensive health examinations, consisted of 2444 inhabitants (949 males and 1495 females) of a rural area in Hokkaido, Japan. Between 1991 and December 2000, 146 subjects (94 males and 52 females) died, with cancer accounting for 76 of these deaths (48 males and 28 females). Serum samples at fasting were collected at entry into the study, and serum levels of beta- and alpha-carotenes, lycopene, beta-cryptoxanthin, canthaxanthin, zeaxanthin/lutein, tocopherols, and retinol were measured separately by high-performance liquid chromatography (HPLC). The statistical analyses were conducted using the Cox proportional hazard model. Age- and gender-adjusted hazard ratios of the groups with high serum levels of lycopene, beta-carotene, zeaxanthin/lutein, and total carotenoids compared to those with low serum levels were 0.36 (95% C.I: 0.19–0.69), 0.53 (0.29–0.95), 0.73 (0.43–1.25), and 0.52 (0.30–0.92) for cancers of all sites, and 0.44 (95% C.I: 0.28–0.69), 0.59 (0.39–0.90), 0.61 (0.40–0.93), and 0.50 (0.33–0.76) for all causes, respectively. Similar results were found after adjusting for gender, age, smoking habits, alcohol consumption, and serum levels of total cholesterol and glutamic pyruvic transaminase (GPT) activity. Moreover, after excluding mortality within the first three years of follow-up, the hazard ratios of subjects with high serum levels of lycopene, total carotenes, and total carotenoids were significantly and inversely associated with subsequent mortality from all causes and cancers of all sites after adjusting for gender, age, and serum levels of total cholesterol, alpha-tocopherol, and retinol. These results suggest that high serum levels of antioxidants, such as lycopene, beta-carotene and zeaxanthin/lutein, play roles in preventing death from cancer and from all causes. However, high serum levels of tocopherols and retinol did not demonstrate clear associations with either low mortality rates from all causes or cancer of all sites.

Effects of 6-Month Multivitamin Supplementation on Serum Concentrations of alpha-Tocopherol, beta-Carotene, and Vitamin C in Healthy Elderly Women

2004 ◽  
Vol 74 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Wolters ◽  
Hermann ◽  
Hahn
Keyword(s):  
Placebo Group ◽  
Vitamin E ◽  
Vitamin C ◽  
Elderly Women ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Serum Concentrations ◽  
Double Blind ◽  
Multivitamin Supplementation ◽  
Healthy Elderly

Objective: The aim of this study was to evaluate the effect of supplementation with nutritional doses of antioxidant nutrients on the serum concentrations of ascorbic acid, alpha-tocopherol, and beta-carotene in healthy elderly women. Methods: The study was performed as a randomized placebo-controlled, double-blind trial. Two hundred forty-one free-living, healthy women aged 60 years and older were recruited by newspaper advertisement in Hanover, Germany and its environs. As 21 women dropped out, data of 220 women (aged 60–91 years, median 63 years) were included in this evaluation. Subjects were randomly assigned to receive either a multivitamin/mineral or placebo capsule with identical appearance for six months containing 36 mg vitamin E, 150 mg vitamin C, and 9 mg beta-carotene. Serum concentrations of vitamin C, alpha-tocopherol, and beta-carotene were measured initially and after six months of supplementation. Data were analyzed with the SPSS 10.0 program. Results: Median serum concentrations of alpha-carotene and vitamin E increased significantly in the supplemented group (p = 0.000), whereas no significant modifications were observed in the placebo group. Median vitamin C concentration of the supplemented group did not differ from baseline after intervention, but that of the placebo group was significantly decreased after six months (p = 0.000). In comparison to estimated desirable serum concentrations of > 30 mumol/L vitamin E, 50 mumol/L vitamin C, and > 0.4 mumol/l beta-carotene at baseline, lower concentrations were found in 21.1%, 6.9%, and 1.0% of all subjects, respectively. After supplementation none of the members of the supplemented group had tocopherol concentrations below 30 mumol/L and only one woman of the supplemented group had a serum beta-carotene concentration below 0.4 mumol/L. The change in serum concentrations of vitamin C and E in the supplemented group depended on the status at baseline. Conclusion: A six-month supplementation with physiological doses of antioxidant vitamins improves the blood concentration of these nutrients even in relatively well-nourished elderly women or, as seen for vitamin C, prevents reduction of serum concentrations. Prevalence of suboptimal serum concentrations can be reduced.

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