scholarly journals Kadar Kortisol Plasma pada Dispepsia Fungsional dengan Gangguan Psikosomatik

2020 ◽  
Vol 7 (1) ◽  
pp. 15
Author(s):  
Arina Widya Murni
Keyword(s):  
Functional Dyspepsia ◽  
Cortisol Level ◽  
Plasma Cortisol ◽  
Mean Value ◽  
Adenyl Cyclase ◽  
Normal Group ◽  
Prostaglandin E ◽  
Psychosomatic Disorder ◽  
Cross Sectional ◽  
Consecutive Sampling

Pendahuluan. Peningkatan kortisol akan merangsang produksi asam lambung dan dapat menghambat prostaglandin E yang merupakan inhibitor enzim adenyl cyclase dalam sel parietal yang melindungi mukosa lambung. Nilai kortisol plasma yang tinggi dikaitkan dengan stres psikologis yang dapat memicu keluhan dispepsia. Penelitian ini dilakukan untuk mengetahui kadar kortisol plasma pada penderita dispepsia fungsional dengan gangguan psikosomatik.Metode. Studi deskriptif analitik dengan desain cross sectional dilakukan pada pasien dispepsia yang dipilih menggunakan teknik non random consecutive sampling. Setelah diagnosis dispepsia, depresi, kecemasan, dan keduanya (depresi – kecemasan), semua subjek diperiksa gastroskopi dan kortisol plasma pada pagi dan sore hari.Hasil. Selama periode penelitian, didapatkan sampel sebanyak 40 pasien dengan dispepsia dan gangguan psikosomatik dan 10 pasien dengan dispepsia tanpa gejala psikosomatis sebagai kelompok kontrol dengan rentang usia 20 - 40 tahun. Rerata kadar kortisol di pagi hari pada pasien dengan gangguan psikosomatik adalah 322,33 nmol/L (simpang baku [SB] 166,92 nmol/L) sedangkan pada kelompok normal 188,82 nmol/L (SB 103,14 nmol/L). Sementara itu, median kortisol sore hari kelompok dengan psikosomatisk adalah 136,25 nmol/L (rentang 17,8-494,1 nmol/L) dan pada kelompok normal 91,40 nmol/L (rentang 10,6-291,6 nmol/L). Berdasarkan hasil uji statistik didapatkan bahwa terdapat peningkatan kortisol pagi hari yang signifikan antara kelompok depresi (rerata 338,82 nmol/L (SB 166,82 nmol/L) dengan kelompok normal, dengan nilai p=0,013. Sedangkan, nilai kortisol sore hari antara kelompok dengan gangguan psikosomatik tidak memiliki perbedaan yang signifikan secara statistik (p>0,05).Simpulan. Nilai kortisol plasma pagi hari pada dispepsia fungsional dengan gangguan psikosomatik (depresi) secara signifikan lebih tinggi daripada kelompok tanpa gangguan psikosomatik. Kata Kunci: Dispepsia fungsional, gangguan psikosomatik, kortisol plasmaLevel of Plasma Cortisol in Functional Dyspepsia with Psychosomatic DisorderIntroduction. Increasing of cortisol will stimulate the production of gastric acid and can inhibit prostaglandin E which is an inhibitor of the enzyme adenyl cyclase in parietal cells that is protective of gastric mucosa. High value of plasma cortisol is associated with psychological stress which can trigger the complaints of dyspepsia. This study aims to find out the level of plasma cortisol in dyspepsia functionalMethods. An analytic descriptive - cross sectional study with nonrandom consecutive sampling was conducted among dyspepsia patients. After diagnosis of functional dyspepsia, depression, anxiety and both of depression – anxiety, all subjects were examined for gastroscopy and plasma cortisol in the morning and evening.Results. There were 40 patients with dyspepsia and psychosomatic disorders and 10 patients with dyspepsia without psychosomatic symptom as control group with an age range of 20 – 40 years old. The mean value of cortisol level in the morning among subjects with psychosomatic disorder was 322.33 nmol/L (SD 166.92 nmol/L) whereas in the normal group was 188.82 nmol/L (SD 103.14 nmol/L). The median value of cortisol level in the evening among subjects with psychosomatic disorder was 136.25 nmol/L (range 17.8-494.1 nmol/L) whereas in the normal group was 91.40 nmol/L (range 10.6-291.6 nmol / L). Statistical analysis showed that there was a significant increased in the morning cortisol between sujects with depression (mean value = 338.82 nmol/L (SD 166.82 nmol/L) compared to normal group (p value=0.013). Meanwhile, there difference in afternoon cortisol between subjects with psychosomatic disorder and the normal group was not statistically significant (p>0.05).Conclusion. The level of morning plasma cortisol in functional dyspepsia with psychosomatic patients (depression) was significantly higher than patients without psychosomatic disorder.

scholarly journals Hubungan Derajat Keasaman Cairan Lambung dengan Derajat Dispepsia pada Pasien Dispepsia Fungsional

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Emil Prasetyo Muhammad ◽  
Arina Widya Murni ◽  
Delmi Sulastri ◽  
Saptino Miro
Keyword(s):  
Gastric Juice ◽  
Functional Dyspepsia ◽  
Sampling Technique ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Chi Square ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Chi Square Test ◽  
Acid Hypersecretion

AbstrakHipersekresi asam lambung dianggap penting sebagai salah satu mekanisme patologis dispepsia fungsional. Hipersekresi asam lambung dapat meningkatkan sekresi pepsin yang dapat menimbulkan kerusakan mukosa lambung pada dispepsia fungsional. Tujuan penelitian ini adalah menentukan hubungan derajat keasaman cairan lambung dengan derajat dispepsia yang dialami pasien dispepsia fungsional. Penelitian ini merupakan studi analitik dengan disain cross sectional yang dilakukan pada 35 sampel pasien dispepsia fungsional dengan teknik consecutive sampling di RSUP DR. M.Djamil Padang mulai Juli sampai Oktober 2014. Analisis data dilakukan secara komputerisasi menggunakan uji chi-square. Hasil penelitian didapatkan 51.4% pasien dispepsia fungsional memiliki derajat keasaman cairan lambung hyperacidity, 57.1% menderita dispepsia derajat sedang-berat, dan menunjukkan hubungan yang cukup kuat dengan tarif signifikansi (p) 0.029 (p < 0.05). Terdapat hubungan bermakna antara derajat keasaman cairan lambung dengan derajat dispepsia pada pasien dispepsia fungsional. Peningkatan derajat keasaman cairan lambung berbanding lurus dengan derajat dispepsia pada pasien dispepsia fungsional.Kata kunci: keasaman cairan lambung, derajat dispepsia, dispepsia fungsional AbstractGastric acid hypersecretion is considered important as one of the pathological mechanisms of functional dyspepsia. Gastric acid hypersecretion can increase the secretion of pepsin which can cause gastric mucosal damage in functional dyspepsia. The objective of this study was to determine the correlation of gastric juice acidity with dyspepsia level experienced by functional dyspepsia patients.This study was a analytic study with cross sectional design applied on 35 samples of functional dyspepsia patients with non-probability consecutive sampling technique at RSUP DR. M. Djamil Padang from July to October 2014. The data were computerized analyzed using chi-square test. The results showed 51.4% of patients with functional dyspepsia had hyperacidity gastric juice, 57.1% had moderate-to-severe dyspepsia level, and show a strong enough correlation with the rate of significance  0.029 (p < 0.05).There was a significant correlation between the gastric juice acidity with dyspepsia level of functional dyspepsia patients. Increase of gastric juice acidity is proportional to the dyspepsia level in functional dyspepsia patients.Keywords::gastric juice acidity, dyspepsia level, functional dyspepsia

scholarly journals HUBUNGAN OBESITAS DENGAN FAAL PARU PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Satriyani . ◽  
Karel Pandelaki ◽  
M. C. P. Wongkar
Keyword(s):  
Vital Capacity ◽  
Pearson Correlation ◽  
Sampling Technique ◽  
Mean Value ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Pearson Correlation Test ◽  
Grade Ii ◽  
Excessive Accumulation

Abstract: Obesity is a multifactor disease as the result of excessive accumulation of fat tissues that affect the reduction of respiratory compliance. Change of respiratory function by obesity affect lungs function, i.e. Forced Vital Capacity (FVC) and Forced Expiratory Volume in First Second (FEV1). The purpose of this research is to find out the correlation between Body Mass Index (BMI) and FVC and FEV1. This is a descriptive-analytic research with cross sectional method. Objects of the research were chosen with consecutive sampling technique. Subjects were 32 of Faculty of Medicine students, Sam Ratulangi University. FVC and FEV1 were measured using spirometry. The correlation between BMI and FVC and FEV1 were tested using Pearson correlation test. FVC mean value at grade I obesity is 116,92% pred. FVC mean value at grade II obesity is 98,47% pred. FVC mean value at grade II obesity is lower than grade I obesity. FEV1 mean value at grade I obesity is 118,23% pred. FEV1 mean value at grade II obesity is 107,16% pred. FEV1 mean value at grade II obesity is lower than grade I obesity. There is an insignificant negative correlation between FVC (r = -0,343; p = 0,054) and FEV1 (r = -0,297; p= 0,099). Conclusion: Increase in BMI can lower the lungs function, i.e. FVC and FEV1.Keywords: FVC, FEV1, obesityAbstrak: Obesitas merupakan suatu penyakit multifaktorial, yang terjadi akibat akumulasi jaringan lemak berlebihan, sehingga menurunkan compliance sistem pernafasan. Perubahan fungsi pernafasan akibat obesitas mempengaruhi nilai fungsi paru diantaranya Kapasitas Vitas Paksa(KVP) dan Volume Ekspirasi Paksa Detik Pertama(VEP1). Penelitian ini bertujuan untuk mengetahui hubungan Indeks Massa Tubuh dengan KVP dan VEP1. Penelitian ini bersifat deskriptif analitik dengan pendekatan cross sectional. Teknik pengambilan sampel yang digunakan yaitu consecutive sampling. Subyek penelitian adalah mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi dengan jumlah 32 subyek. KVP dan VEP1 diukur dengan menggunakan spirometer. Nilai mean KVP pada obese I ialah 116,92% pred, KVP obese II ialah 98,47% pred. Nilai mean KVP obese II 18,45% lebih rendah daripada obese I. Nilai mean VEP1 pada obese I ialah 118,23% pred, VEP1 obese II ialah 107,16% pred. Nilai mean VEP1 obese II 11,07% lebih rendah daripada obese I. Hubungan IMT dengan KVP dan VEP1 diuji dengan menggunakan uji korelasi pearson. Terdapat hubungan negatif non signifikan antara IMT dengan KVP (r = -0,343; p = 0,054) dan VEP1 (r = -0,297; p= 0,099). Simpulan: Peningkatan Indeks Massa Tubuh dapat menurunkan nilai fungsi paru diantaranya KVP dan VEP1.Kata Kunci: KVP, VEP1, obesitas

scholarly journals THE DIFFERENCES OF PATIENT’S FAMILIES PERCEPTIONS WITH BPJS INSURANCE AND GENERAL ABOUT RESPONSE TIME NURSE’S BASED ON TRIAGE IN THE EMERGENCY ROOM

2020 ◽  
Vol 4 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Yeny Martasari ◽  
Windu Santoso ◽  
Ana Zakiyah
Keyword(s):  
Response Time ◽  
Emergency Room ◽  
Mean Value ◽  
Comparative Approach ◽  
Positive Perception ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Family Perceptions ◽  
Quantitative Descriptive ◽  
The Right

Many families of BPJS or general patients assume that the nurse's response time is slow. The purpose of this study was to determine differences in family perceptions of BPJS and general patients about nurse response time based on triage in emergency room. The method in this study is quantitative descriptive with a comparative approach. The design used was cross-sectional with taking consecutive sampling techniques. The variables studied were differences in family perceptions of BPJS patients and the general about the response time of nurses based on triage in the emergency room. The results showed that the majority of patients including BPJS participants had a negative perception of 27 respondents (67.5%). And in General patients, most respondents had a positive perception of 17 respondents (42.5%). The results of the T-test obtained data p = 0.649> a = 0.05, H1 was rejected and H0 was accepted, meaning that there was no difference in family perceptions of BPJS patients and General about the response time of nurses based on triage in the emergency room. this is because the results of observations about the response time of the nurse show that the new patient is treated with the right time <5 minutes more than the slow one. This is because in the results of the questionnaire researchers have spread out, the results are more dominant with a mean value of 21.90 on the experience indicator.

PLASMA CORTISOL, CORTICOSTERONE AND NON-PROTEIN-BOUND CORTISOL IN EXTRACORPOREAL CIRCULATION

1972 ◽  
Vol 69 (3) ◽  
pp. 517-525 ◽  
Author(s):  
T. Uozumi ◽  
H. Manabe ◽  
Y. Kawashima ◽  
Y. Hamanaka ◽  
Y. Monden ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Extracorporeal Circulation ◽  
Plasma Cortisol ◽  
Elevated Level ◽  
Marked Decrease ◽  
Binding Capacity ◽  
Biologically Active ◽  
Major Surgery ◽  
Plasma Samples ◽  
Effective Factor

ABSTRACT The response of plasma cortisol, corticosterone and non-protein-bound cortisol in the extracorporeal circulation was investigated in 14 patients. The pre-perfusion levels of plasma cortisol, corticosterone and non-protein-bound cortisol were significantly elevated. During and immediately after perfusion, the levels of cortisol and corticosterone were found to decrease significantly from the pre-perfusion levels, while the percentage of non-protein-bound cortisol was shown to increase significantly. This indicates a marked decrease in cortisol binding capacity of plasma during extracorporeal circulation. Moreover in 200 plasma samples, it was demonstrated that the cortisol level increased markedly and the cortisol binding capacity decreased slightly during and shortly after major surgery without perfusion. It is concluded that stressful situations in major surgery with or without perfusion are associated with markedly increased levels of biologically active non-protein-bound cortisol. The elevated level of non-protein-bound cortisol in surgery seems to be dependent on the increase in the level of plasma cortisol as well as on the decrease in the cortisol binding capacity of plasma. Although the increased plasma cortisol plays the most important role in surgery with no perfusion, the decreased cortisol binding capacity may be the more effective factor involved during perfusion.

Analisis Faktor Determinan yang berhubungan dengan Kepatuhan Rekomendasi Modifikasi Gaya Hidup Pasien Hipertensi

2020 ◽  
Vol 7 (2) ◽  
pp. 256-263
Author(s):  
Abdul Qodir
Keyword(s):  
Blood Pressure ◽  
Lifestyle Modification ◽  
Multivariate Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Lifestyle Modifications ◽  
Chi Square ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Consecutive Sampling ◽  
Knowledge Practice

Penatalaksanaan farmakologis dan non farmakologis dipercaya dapat mengontrol tekanan darah dan mencegah komplikasi, tetapi banyak pasien hipertensi tekanan darahnya tidak terkontrol. Hal tersebut dikarenakan kepatuhan yang buruk dalam melaksanakan rekomendasi gaya hidup. Penelitian ini bertujuan untuk menganalisis determinan faktor yang berhungan dengan kepatuhan melaksanakan rekomendasi modifikasi gaya hidup. Penelitian ini menggunakan metode cross-sectional di pukesmas dinoyo Kota Malang tahun 2019. Teknik pengambilan sampel menggunakan Consecutive Sampling. Kuesioner yang digunakan meliputi : karakteristik demografi, pengetahuan dan rekomendasi mofifikasi gaya hidup pasien hipertensi. Hubungan antara rekomendasi modifikasi gaya hidup dengan variabel independen dianalisis menggunakan uji chi square dan analisis regresi logistik. 140 pasien hipertensi berpartisipasi dalam penelitian ini (60 laki-laki, 80 wanita). Prevalensi kepatuhan adalah 28,6 %. Tingkat pengetahuan berhubungan signifikan  dengan kepatuhan melaksanakan rekomendasi gaya hidup (p=0,00). Jenis kelamin, usia, dan tingkat pendidikan tidak mempunyai hubungan signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup (p= 0,06; p=0,21; p=0,87). Pengetahuan mempunyai hubungan yang signifikan dengan kepatuhan rekomendasi modifikasi gaya hidup. Management of pharmacological and non-pharmacological is believed to control blood pressure and prevent complications,  but many hypertensive patients have uncontrolled blood pressure. This is due to poor adherence to recommended lifestyle modifications. This study was aimed to determine the factors associated with adherence to recommended lifestyle modifications of hypertensive patients. A cross-sectional study was conducted in Pukesmas Dinoyo Malang in 2019. Consecutive Sampling was used to select study subjects. The questionnaire included information about demographic characteristics, knowledge, practice of lifestyle-modification measures. Associations between adherence to lifestyle modification and independent variables were analyzed using chi square and multivariate logistic regression analysis. 140 hypertensive patients participated in the study (60 men, 80 women). The prevalence of adherence was 28.6%. The level of knowledge was significant associated with adherence to recommended lifestyle modifications (p = 0.00). Genders , age, and educational level were no significant associated with to recommended lifestyle modifications (p= 0.06; p=0.21; p=0.87). Knowledge was significant associated with adherence to recommended lifestyle modifications of hypertensive patients.

Self Management Menentukan Kualitas Hidup Pasien Diabetes Mellitus

2019 ◽  
Vol 4 (2) ◽  
pp. 402
Author(s):  
Iskim Luthfa ◽  
Nurul Fadhilah
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Correlation Study ◽  
Self Management ◽  
Rank Test ◽  
P Value ◽  
Cross Sectional ◽  
Spearman Rank ◽  
Consecutive Sampling

<p><em>People with diabetes mellitus are at risk of developing complications, so that it affects the quality of life. These complications can be minimized through self-care management. This study aims to determine the relationship between self management with the quality of life for people with diabetes mellitus. This research is a kind of quantitative research with correlation study. This research used cross sectional design. The sampling technique uses non probability with estimation consecutive sampling. The number of respondents in this research are 118 respondents. Instrument for measuring self management used diabetes self management questionnaire (DSMQ), and instruments to measure quality of life used quality of life WHOQOL-BREEF. The data obtained were processed statistically by using spearman rank test formula and p value of 0,000 There is a significant relationship of self management with the quality of life of people with diabetes mellitus.</em></p><p> </p><p><em>Penderita </em><em>Diabetes mellitus </em><em>beresiko mengalami komplikasi yang dapat mempengaruhi kualitas hidupnya. Komplikasi tersebut dapat diminimalkan melalui manajemen perawatan diri (self management). Penelitian ini bert</em><em>ujuan </em><em>untuk</em><em> menganalisis hubungan self management dengan kualitas hidup pasien diabetes melitus. </em><em>Jenis p</em><em>enelitian ini </em><em>adalah</em><em> deskriptif korelasi</em><em> dengan desain cross sectional</em><em>. Teknik pengambilan sampel menggunakan non probability </em><em>sampling </em><em>dengan pendeka</em><em>t</em><em>an consecutive sampling</em><em>.</em><em> </em><em>J</em><em>umlah </em><em>sampel sebanyak</em><em> </em><em>118 responden.</em><em> </em><em>Instrumen </em><em>penelitian </em><em>untuk mengukur self management </em><em>menggunakan</em><em> </em><em>diabetes self management questionnaire</em><em> (DSMQ), </em><em>dan instrumen untuk mengukur kualitas hidup menggunakan </em><em>quality of life </em><em>WHOQOL-BREEF.</em><em> Analisis data menggunakan spearman rank dan didapatkan hasil nilai </em><em>p value 0,000</em><em> dan r 0,394.Terdapat </em><em>hubungan </em><em>antara </em><em>self management</em><em> dengan kualitas hidup pasien diabetes mellitus</em><em> dengan arah korelasi positif.</em></p>

Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi

2018 ◽  
Vol 3 (3) ◽  
pp. 568
Author(s):  
Ainal Mardiah ◽  
Arni Amir ◽  
Andi Friadi ◽  
Ellyza Nasrul
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Community Health ◽  
Health Center ◽  
Iron Deficiency Anemia ◽  
Community Health Center ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Neurotropic Factor

<p><em>Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates </em><em>and it also influences on </em><em>Brain Derived Neurotropic Factor (BDNF) </em><em> which affects cognitive function.</em><em> </em><em>The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. </em><em>The design of this research was Cross Sectional</em><em> </em><em>design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p &lt;0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. </em><em>The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.</em></p><p> </p><p>Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p&lt;0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi. <em></em></p>

scholarly journals Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Alexandra Gaál Kovalčíková ◽  
Ľubica Tichá ◽  
Katarína Šebeková ◽  
Peter Celec ◽  
Alžbeta Čagalová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anorexia Nervosa ◽  
Redox Homeostasis ◽  
Oxidative Status ◽  
Carbonyl Stress ◽  
Healthy Controls ◽  
Psychosomatic Disorder ◽  
Cross Sectional ◽  
Wide Range ◽  
Markers Of Oxidative Stress

Abstract Background Anorexia nervosa (AN) is a serious psychosomatic disorder with unclear pathomechanisms. Metabolic dysregulation is associated with disruption of redox homeostasis that might play a pivotal role in the development of AN. The aim of our study was to assess oxidative status and carbonyl stress in plasma, urine and saliva of patients with AN and healthy controls. Methods Plasma, spot urine, and saliva were collected from 111 girls with AN (aged from 10 to 18 years) and from 29 age-matched controls. Markers of oxidative stress and antioxidant status were measured using spectrophotometric and fluorometric methods. Results Plasma advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) were significantly higher in patients with AN than in healthy controls (by 96, and 82%, respectively). Accordingly, urinary concentrations of AOPP and fructosamines and salivary concentrations of AGEs were higher in girls with AN compared with controls (by 250, and 41% in urine; by 92% in saliva, respectively). Concentrations of thiobarbituric acid reactive substances (TBARS) in saliva were 3-times higher in the patients with AN than in the controls. Overall antioxidants were lower in plasma of girls with AN compared to the controls, as shown by total antioxidant capacity and ratio of reduced and oxidized glutathione (by 43, and 31%, respectively). Conclusions This is the first study assessing wide range of markers of oxidative status in plasma, urine and saliva of the patients with AN. We showed that both, higher levels of markers of oxidative stress and lower antioxidants play a role in redox disruption. Restoration of redox homeostasis might be of the clinical relevance

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