scholarly journals Rapid sex-specific adaptation to high temperature in Drosophila

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Sheng-Kai Hsu ◽  
Ana Marija Jakšić ◽  
Viola Nolte ◽  
Manolis Lirakis ◽  
Robert Kofler ◽  
...  
Keyword(s):  
Reproductive Strategies ◽  
Adaptive Strategies ◽  
Selection Response ◽  
Functional Requirements ◽  
Natural Habitats ◽  
Medical Treatments ◽  
Specific Adaptation ◽  
Males And Females ◽  
The Impact ◽  
New Mutations

The pervasive occurrence of sexual dimorphism demonstrates different adaptive strategies of males and females. While different reproductive strategies of the two sexes are well-characterized, very little is known about differential functional requirements of males and females in their natural habitats. Here, we study the impact environmental change on the selection response in both sexes. Exposing replicated Drosophila populations to a novel temperature regime, we demonstrate sex-specific changes in gene expression, metabolic and behavioral phenotypes in less than 100 generations. This indicates not only different functional requirements of both sexes in the new environment but also rapid sex-specific adaptation. Supported by computer simulations we propose that altered sex-biased gene regulation from standing genetic variation, rather than new mutations, is the driver of rapid sex-specific adaptation. Our discovery of environmentally driven divergent functional requirements of males and females has important implications-possibly even for gender aware medical treatments.

scholarly journals The Impact of Work Hours on Depressive Symptoms among Koreans Aged 45 and Over

2021 ◽  
Vol 18 (3) ◽  
pp. 853
Author(s):  
Juyeong Kim ◽  
Eun-Cheol Park
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Social Services ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Work Hours ◽  
Middle Aged ◽  
Health Studies ◽  
Males And Females ◽  
The Impact

Background: Given the documented importance of employment for middle-aged and older adults’ mental health, studies of the association between their number of work hours and depressive symptoms are needed. Objectives: To examine the association between the number of work hours and depressive symptoms in Korean aged 45 and over. Methods: We used data from the first wave to fourth wave of the Korea Longitudinal Study of Aging. Using the first wave at baseline, data included 9845 individuals. Depressive symptoms were measured using the 10-item Center for Epidemiological Studies Depression scale. We performed a longitudinal analysis to estimate the prevalence of depressive symptoms by work hours. Results: Both unemployed males and females aged 45–65 years were associated with higher depressive symptoms (β = 0.59, p < 0.001; β = 0.32, p < 0.001). Females working ≥ 69 h were associated with higher depressive symptoms compared to those working 41–68 h (β = 0.25, p = 0.013). Among those both middle-aged and older adults, both males and females unemployed were associated with higher depressive symptoms. Those middle-aged female working ≥69 h were associated with higher depressive symptoms. Conclusions: An increase in depressive symptoms was associated with unemployed males and females working ≥69 h compared to those working 41–68 h. Although this association was found among middle-aged individuals, a decrease in depressive symptoms in both sexes was associated with working 1–40 h. Depressive symptoms should decrease by implementing employment policies and social services to encourage employers to support middle-aged and older adults in the workforce considering their sex and age differences.

scholarly journals IoT-Based Patient Movement Monitoring: The Post-Operative Hip Fracture Rehabilitation Model

2021 ◽  
Vol 13 (8) ◽  
pp. 195
Author(s):  
Akash Gupta ◽  
Adnan Al-Anbuky
Keyword(s):  
Hip Fracture ◽  
Real Time ◽  
System Performance ◽  
Digital Health ◽  
Time Behavior ◽  
Functional Requirements ◽  
Rehabilitation Process ◽  
Rehabilitation Model ◽  
The Impact ◽  
Movement Monitoring

Hip fracture incidence is life-threatening and has an impact on the person’s physical functionality and their ability to live independently. Proper rehabilitation with a set program can play a significant role in recovering the person’s physical mobility, boosting their quality of life, reducing adverse clinical outcomes, and shortening hospital stays. The Internet of Things (IoT), with advancements in digital health, could be leveraged to enhance the backup intelligence used in the rehabilitation process and provide transparent coordination and information about movement during activities among relevant parties. This paper presents a post-operative hip fracture rehabilitation model that clarifies the involved rehabilitation process, its associated events, and the main physical movements of interest across all stages of care. To support this model, the paper proposes an IoT-enabled movement monitoring system architecture. The architecture reflects the key operational functionalities required to monitor patients in real time and throughout the rehabilitation process. The approach was tested incrementally on ten healthy subjects, particularly for factors relevant to the recognition and tracking of movements of interest. The analysis reflects the significance of personalization and the significance of a one-minute history of data in monitoring the real-time behavior. This paper also looks at the impact of edge computing at the gateway and a wearable sensor edge on system performance. The approach provides a solution for an architecture that balances system performance with remote monitoring functional requirements.

scholarly journals Assessing Habitat Vulnerability and Loss of Naturalness: Applying the GLOBIO3 Model in the Czech Republic

2021 ◽  
Vol 13 (10) ◽  
pp. 5355
Author(s):  
Vilém Pechanec ◽  
Ondřej Cudlín ◽  
Miloš Zapletal ◽  
Jan Purkyt ◽  
Lenka Štěrbová ◽  
...  
Keyword(s):  
Land Use ◽  
Czech Republic ◽  
Habitat Quality ◽  
Species Abundance ◽  
Biodiversity Loss ◽  
Infrastructure Development ◽  
Natural Habitats ◽  
The Czech Republic ◽  
New Equation ◽  
The Impact

Global and regional biodiversity loss is caused by several drivers including urban development, land use intensification, overexploitation of natural resources, environmental pollution, and climate change. The main aim of our study was to adapt the GLOBIO3 model to the conditions of the Czech Republic (CR) to assess loss of naturalness and biodiversity vulnerability at the habitat level on a detailed scale across the entire CR. An additional aim was to assess the main drivers affecting the biodiversity of habitat types. The GLOBIO3 model was adapted to CZ-GLOBIO by adapting global to local scales and using habitat quality and naturalness data instead of species occurrence data. The total mean species abundance (MSA) index of habitat quality, calculated from the spatial overlay of the four MSA indicators by our new equation, reached the value 0.62. The total value of MSA for natural and near-natural habitats was found to be affected mainly by infrastructure development and fragmentation. Simultaneously, intensity of land use change and atmospheric nitrogen deposition contributed primarily to the low total value of MSA for distant natural habitats. The CZ-GLOBIO model can be an important tool in political decision making to reduce the impact of the main drivers on habitat biodiversity in the CR.

scholarly journals Are Multi-Language Design Smells Fault-Prone? An Empirical Study

2021 ◽  
Vol 30 (3) ◽  
pp. 1-56
Author(s):  
Mouna Abidi ◽  
Md Saidur Rahman ◽  
Moses Openja ◽  
Foutse Khomh
Keyword(s):  
Programming Languages ◽  
Language Design ◽  
Functional Requirements ◽  
Code Smells ◽  
Design And Implementation ◽  
Design Smells ◽  
The Cost ◽  
The Impact ◽  
Fault Proneness

Nowadays, modern applications are developed using components written in different programming languages and technologies. The cost benefits of reuse and the advantages of each programming language are two main incentives behind the proliferation of such systems. However, as the number of languages increases, so do the challenges related to the development and maintenance of these systems. In such situations, developers may introduce design smells (i.e., anti-patterns and code smells) which are symptoms of poor design and implementation choices. Design smells are defined as poor design and coding choices that can negatively impact the quality of a software program despite satisfying functional requirements. Studies on mono-language systems suggest that the presence of design smells may indicate a higher risk of future bugs and affects code comprehension, thus making systems harder to maintain. However, the impact of multi-language design smells on software quality such as fault-proneness is yet to be investigated. In this article, we present an approach to detect multi-language design smells in the context of JNI systems. We then investigate the prevalence of those design smells and their impacts on fault-proneness. Specifically, we detect 15 design smells in 98 releases of 9 open-source JNI projects. Our results show that the design smells are prevalent in the selected projects and persist throughout the releases of the systems. We observe that, in the analyzed systems, 33.95% of the files involving communications between Java and C/C++ contain occurrences of multi-language design smells. Some kinds of smells are more prevalent than others, e.g., Unused Parameters , Too Much Scattering , and Unused Method Declaration . Our results suggest that files with multi-language design smells can often be more associated with bugs than files without these smells, and that specific smells are more correlated to fault-proneness than others. From analyzing fault-inducing commit messages, we also extracted activities that are more likely to introduce bugs in smelly files. We believe that our findings are important for practitioners as it can help them prioritize design smells during the maintenance of multi-language systems.

Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice

2021 ◽  
pp. 026988112199688
Author(s):  
Eduardo R Butelman ◽  
Caroline Baynard ◽  
Bryan D McElroy ◽  
Thomas E Prisinzano ◽  
Mary Jeanne Kreek
Keyword(s):  
Locomotor Activity ◽  
Forced Swim Test ◽  
Male And Female ◽  
Short Acting ◽  
Swim Test ◽  
Central Nervous System Dysfunction ◽  
Forced Swim ◽  
Males And Females ◽  
The Impact ◽  
Κ Receptor

Background: Novel short-acting κ(kappa)-opioid receptor selective antagonists are translational tools to examine the impact of the κ-receptor/dynorphin system in assays related to central nervous system dysfunction (e.g., substance use disorders, anhedonia and depression). The effects of such compounds have been compared in males and females under very limited conditions. Aims: The goal of this study was to examine potential sex differences in the effects of a κ-agonist and a short-acting κ-antagonist in an ethologically relevant test of anhedonia, the “splash test” of self-grooming, and also in the forced swim test and in locomotor activity. Methods: We examined the dose-dependence of grooming deficits caused by the κ-agonist U50,488 (0.1–3.2 mg/kg intraperitoneal (i.p.)) in gonadally intact adult male and female C57BL/6J mice. We then compared the effects of the short-acting κ-antagonist LY2795050 ((3-chloro-4-(4-(((2S)-2-pyridin-3-ylpyrrolidin-1-yl)methyl) phenoxy)benzamide)); 0.032–0.1 mg/kg i.p.) in blocking grooming deficits caused by U50,488 (3.2 mg/kg). The effects of LY2795050 were also studied in the forced swim test (FST). The effects of LY2795050 in blocking the locomotor depressant effects of U50,488 (10 mg/kg) were also studied. Results: U50,488 produced dose-dependent grooming deficits in male and female mice, and LY2795050 prevented these effects. In contrast, LY2795050 decreased immobility in the FST in males at a dose of 0.1 mg/kg, but not in females, up to a dose of 0.32 mg/kg. Also, LY2795050 (0.32 mg/kg) prevented and also reversed the locomotor-depressant effects of U50,488 (10 mg/kg), in males and females. Conclusions: This study further implicates the κ-receptor system in ethologically relevant aspects of anhedonia, and confirms sexual dimorphism in some behavioral effects of novel κ-antagonists.

scholarly journals 129 Effects of a multi-strain Bacillus subtilis-based direct-fed microbial on growth performance, nutrient digestibility, and colonic pH in diets fed to weanling pigs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 101-102
Author(s):  
Jaron R Lewton ◽  
Adrienne Woodward ◽  
Ronny Moser ◽  
Kyan M Thelen ◽  
Adam J Moeser ◽  
...  
Keyword(s):  
Amino Acids ◽  
Bacillus Subtilis ◽  
Growth Performance ◽  
Distal Colon ◽  
Nutrient Digestibility ◽  
Nursery Pigs ◽  
Fiber Digestion ◽  
Males And Females ◽  
Dietary Treatments ◽  
The Impact

Abstract A study was conducted to evaluate the effects of a multi-strain Bacillus subtilis-based direct-fed microbial (DFM) on apparent digestibility and colonic pH of nursery pigs. Eighty pigs, of equal number of barrows and gilts (initial BW: 6.99 ± 1.67 kg), were weaned at 21 ± 1 d and randomly allotted to sixteen pens, with five pigs per pen. Two dietary treatments were implemented, a basal control (CON) and a control plus DFM (DFM). Both diets were corn, soybean meal, and distillers dried grains based, formulated to meet all or exceed all nutritional requirements, and manufactured on site. Diets were fed for 42 days. Performance measures were recorded weekly. On d 21 and 42 of the experiment, one pig per pen was randomly selected and euthanized, with equal number of males and females represented. Digestibility of specific nutrients was evaluated within the duodenum, jejunum, ileum, ascending and distal colon. There were no overall differences in growth performance. Overall means ± SD were 0.51 ± 0.05 kg/d, 0.79 ± 0.05 kg/d and 0.66 ± 0.05 for ADG, ADFI, and G:F, respectively. Digestibility of tryptophan within the jejunum tended (P = 0.06) to increase with addition of DFM, as did cysteine (P = 0.12) and methionine (P = 0.10). The analysis also suggested that the impact of the DFM on the digestibility of amino acids may be early in the nursery phase. The pH of contents in ascending colon, a possible indicator of varied fiber digestion, did not differ. Likewise, no differences were observed between treatment in apparent total tract nitrogen and energy digestibility (analysis of distal colon contents). The addition of a multi-strain Bacillus subtilis-based DFM appears to impact digestibility of select amino acids depending upon location in the gastrointestinal tract.

scholarly journals Summer Movements and Impact of Individual Striped Skunks, Mephitis mephitis, on Duck Nests in Saskatchewan

2006 ◽  
Vol 120 (3) ◽  
pp. 342
Author(s):  
Serge Larivière ◽  
Lyle R. Walton ◽  
François Messier
Keyword(s):  
Mephitis Mephitis ◽  
Direct Function ◽  
Canadian Prairies ◽  
Striped Skunk ◽  
Intensive Observations ◽  
Males And Females ◽  
Foraging Movements ◽  
The Impact ◽  
Striped Skunks ◽  
Nesting Season

Striped Skunks (Mephitis mephitis) are important predators of duck eggs in the Canadian prairies. We estimated the impact of individual Striped Skunks on duck nests by intensive observations of foraging movements and depredation of duck nests in southern Saskatchewan, 1993-1994. Nightly, skunk movements were variable (range 0-20 km per night), and did not differ among seasons for females, or between males and females during the parturition/rearing season. Overall, nightly movement of Striped Skunks averaged 7.4 km for females (SD = 5.9 km, n = 20 females) and 6.7 km for males (SD = 3.2 km, n = 5 males). During 1,873 h of radio-tracking, we observed depredation of 10 duck nests by 8 skunks (7 F, 1 M). Using our observed estimate of one depredation for every 187 h, and averaged nightly activity of 8-10 h per night, we estimated that individual skunks find one duck nest every 19-23 nights. Thus, during the 60-day nesting season for ducks (mid-May to mid-July), individual skunks probably find 2-3 duck nests. These observations reinforce the growing evidence that, at normal duck nest densities (<2.5 nests/ha), depredation of eggs by Striped Skunks is opportunistic, and the impact of Striped Skunks on duck nests is a direct function of Striped Skunk abundance.

Sex Differences in Interpreting Male-Female Dyad Interactions: Males' Predominance in Perceiving Sexual Intent

2002 ◽  
Vol 9 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Aldert Vrij ◽  
Emma Kirby
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Social Environment ◽  
Rape Myths ◽  
Rape Myth ◽  
Sexual Intent ◽  
Female Dyad ◽  
Acceptance Scale ◽  
Males And Females ◽  
The Impact

Astudy is reported investigating gender differences in judging the behaviour of males and females during mixed-dyad conversations and the impact of the endorsement of rape myths in explaining these gender differences. A total of 51 males and 40 females watched a videotape of a male actor and female actor verbally interacting in a social environment and were asked to give their impression about this interaction. They were also requested to fill in the Rape Myths Acceptance Scale (1980). Results revealed that compared to females, males had a stronger tendency to see the interaction in sexual terms. Also, male participants endorsed rape myths more strongly. Finally, gender differences in rape myth endorsements accounted for gender differences in perceiving male-female mixed-dyad interactions to alimited extent. Implications of the findings are discussed.

The COVID-19 Lockdown and Changes in Routine-Oriented Lifestyle Behaviors and Symptoms of Depression, Anxiety, and Insomnia in South Africa

2021 ◽  
pp. 1-12
Author(s):  
Jonathan P. Davy ◽  
Karine Scheuermaier ◽  
Laura C. Roden ◽  
Candice J. Christie ◽  
Alison Bentley ◽  
...  
Keyword(s):  
Online Survey ◽  
Lifestyle Behaviors ◽  
Exercise Time ◽  
South Africans ◽  
Symptoms Of Depression ◽  
Sleep Timing ◽  
Sleep Debt ◽  
Males And Females ◽  
The Impact ◽  
Habitual Routines

Background: The authors assessed the impact of lockdown in response to the COVID-19 pandemic on routine-oriented lifestyle behaviors and symptoms of depression, anxiety, and insomnia in South Africans. Methods: In this observational study, 1048 adults (median age = 27 y; n = 767 females; n = 473 students) responded to an online survey on work, exercise, screen, alcohol, caffeine and sleep behaviors, depression, anxiety, and insomnia before and during lockdown. Comparisons were made between males and females, and students and nonstudents. Results: During lockdown, males reported larger reductions in higher intensity exercise and alcohol use than females, while depressive symptoms increased more among females, more of whom also reported poorer sleep quality. Students demonstrated larger delays in work and sleep timing, greater increases in sitting, screen, sleep duration, napping, depression and insomnia and larger decreases in work hours, exercise time, and sleep regularity compared with nonstudents. Conclusions: Students experienced more changes in their routine-oriented behaviors than nonstudents, coupled with larger increases in depression and insomnia. The dramatic change in their work and sleep timing suggests habitual routines that are at odds with their chronotype, with their sleep changes during lockdown likely reflecting “catch-up” sleep in response to accumulated sleep debt under usual routines.

CHANGING PATTERNS IN THE RESPONSE TO HUMOROUS SEXUAL STIMULI: SEX ROLES AND EXPRESSION OF SEXUALITY

1983 ◽  
Vol 11 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Frank J. Prerost
Keyword(s):  
Life Experiences ◽  
Sex Role ◽  
Sexual Experience ◽  
Sexual Expression ◽  
Adult Males ◽  
Sexual Stimuli ◽  
Changing Patterns ◽  
Males And Females ◽  
The Impact ◽  
Sex Attitudes

Considering the relaxation of sex role restraints and the convergence of male/female reactions to erotica, this study examined the impact of humorous sexual stimuli on adult males and females. Results showed the importance of personal sexual experience and enjoyment with sexual expression on the reactions to sexual humor. Sexist ideas within sexual humor was a significant factor in influencing female appreciation of sexual jokes. Yet some females, depending on life experiences, evidenced cross-sex attitudes in humor preferences.

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