Blood in the Time of the Civic

Hematologies ◽  
2019 ◽  
pp. 178-201
Author(s):  
Jacob Copeman ◽  
Dwaipayan Banerjee
Keyword(s):  
Family Member ◽  
Blood Cells ◽  
Blood Donation ◽  
Civic Life ◽  
Transfusion Medicine ◽  
Biological Time ◽  
Commercial Transaction ◽  
Time Map ◽  
Time Regime ◽  
The One

This chapter focuses on blood in the time of the civic—that is, blood that is donated voluntarily as a dutiful contribution to civic life, that in turn ensures the continued efficacy and productivity of transfusion medicine. These voluntary donations take place according to a seemingly simple biological time map: the biological time of cellular production determines the biomedically mandated three-month gap between donations. The time regime of the repeated voluntary donation emerges from and is mapped upon the lifetime of blood cells. This is in contrast to apparently less civic-minded blood donation modes: the potentially dangerous commercial transaction of paid blood donation and the one-time mode of “replacement” donation, performed in order to release blood for the benefit of one's immediate family member in need of transfusion. As this chapter shows, these modes of donation are characterized by different temporalities. A routine of dutiful repetitive bloodshed structures voluntary blood donation's time of the civic.

F.VIII R:Ag in Hepatitis

1979 ◽  
Author(s):  
R. Kotitschke ◽  
J. Scharrer
Keyword(s):  
Chronic Hepatitis ◽  
Blood Donors ◽  
Blood Donation ◽  
Normal Population ◽  
Rabbit Antiserum ◽  
Two Dimensional ◽  
Plastic Plate ◽  
Significant Difference ◽  
Acute Hepatitis B ◽  
The One

F.VIII R:Ag was determined by quantitative immunelectrophoresis (I.E.) with a prefabricated system. The prefabricated system consists of a monospecific f.VIII rabbit antiserum in agarose on a plastic plate for the one and two dimensional immunelectrophoresis. The lognormal distribution of the f.VIII R:Ag concentration in the normal population was confirmed (for n=70 the f.VIII R:Ag in % of normal is = 95.4 ± 31.9). Among the normal population there was no significant difference between blood donors (one blood donation in 8 weeks; for n=43 the f.VIII R:Ag in % of normal is = 95.9 ± 34.0) and non blood donors (n=27;f.VIII R:Ag = 94.6 ± 28.4 %). The f.VIII R:Ag concentration in acute hepatitis B ranged from normal to raised values (for n=10, a factor of 1.8 times of normal was found) and was normal again after health recovery (n=10, the factor was 1.0). in chronic hepatitis the f.VIII R:Ag concentration was raised in the majority of the cases (for n=10, the factor was 3.8). Out of 22 carrier sera 20 showed reduced, 2 elevated levels of the f.VIII R:Ag concentration. in 5 sera no f.VIII R:Ag could be demonstrated. The f.VIII R:Ag concentration was normal for n=10, reduced for n=20 and elevated for n=6 in non A-non B hepatitis (n=36). Contrary to results found in the literature no difference in the electrophoretic mobility of the f.VIII R:Ag was found between hepatitis patients sera and normal sera.

scholarly journals Blood Donation across the Life Course: The Influence of Life Events on Donor Lapse

2019 ◽  
Vol 60 (2) ◽  
pp. 257-272 ◽  
Author(s):  
Tjeerd W. Piersma ◽  
René Bekkers ◽  
Wim de Kort ◽  
Eva-Maria Merz
Keyword(s):  
Life Course ◽  
Family Member ◽  
Life Events ◽  
Blood Donation ◽  
Longitudinal Survey ◽  
Blood Collection ◽  
Longitudinal Survey Data ◽  
Health Related ◽  
Human And Social Capital ◽  
The Life Course

This article examines how blood donation loyalty changes across the life course as a result of life events. Previous studies have shown that life events affect involvement in prosocial behavior, possibly as a result of loss of human and social capital. Using registry data from the blood collection agency in the Netherlands, linked to longitudinal survey data from the Donor InSight study (N = 20,560), we examined whether life events are related to blood donor lapse. Childbirth, losing a job, and starting a job increase the likelihood of donor lapse, while health-related events (i.e., blood transfusion in a family member, death of a family member) decrease the likelihood of donor lapse. Moreover, results showed how social and practical concerns explain donors’ decisions to donate blood after the occurrence of life events. We discuss theoretical implications for further studies on prosocial and health-related behavior.

A case study of a patient with anti-Yta alloantibodies against the high-prevalence antigen of red blood cells qualified for heart transplantation

2021 ◽  
Vol 56 (3) ◽  
pp. 1-7
Author(s):  
Monika Witoszek ◽  
Małgorzata Kalaga
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donation ◽  
Heart Diseases ◽  
Blood Group System ◽  
Transfusion Reaction ◽  
Indirect Antiglobulin Test ◽  
High Prevalence ◽  
Compatible Blood

The Yta antigen from the Cartwright blood group system is a high-prevalence antigen found in 99.8% of the population. The literature data shows that antibodies anti-Yta demonstrate the variable clinical significance and are rarely the cause of a hemolytic post-transfusion reaction. The study aims to present the difficulties related to the selection and sustainable supply of blood for transfusion for the patient of the Silesian Centre for Heart Diseases with anti-Yta alloantibodies, qualified for a heart transplant. If Yt(a-) blood is not available Institute of Hematology and Transfusion Medicine in Warsaw, referring to reports in the publications, allowed transfusion of the least incompatible red blood cells in indirect antiglobulin test. One hour after transfusion of leucocyte-depleted concentrate of red blood cells (RBCs), issued in accordance with the above recommendations by Regional Blood Donation Center in Katowice as the least incompatible, the patient was observed to experience symptoms of an adverse post-transfusion reaction. For subsequent transfusions, RBCs from Yt(a-) donors were selected, of which only eight were registered in Poland at that time. Medical decisions on RBCs transfusion in patients for whom no compatible blood can be selected is very difficult, and the benefits of incompatible transfusion should be weighed against the risk of possible complications. To avoid this, it should be remembered that the early identification of antibodies increases the chance of finding serologically compatible blood and in many cases allows to supply blood for a patient with autologous donations.

Blood Utilization at Regional Hospitals

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S151-S151
Author(s):  
Ryan Demkowicz ◽  
Josephine Dermawan ◽  
Sindu Shetty ◽  
Richard Scarborough ◽  
Haiyan Lu ◽  
...  
Keyword(s):  
Decision Process ◽  
Blood Cells ◽  
Chart Review ◽  
Blood Product ◽  
Transfusion Medicine ◽  
Screening Criteria ◽  
Packed Red Blood Cells ◽  
Blood Utilization ◽  
Regional Hospitals ◽  
Multiple Units

Abstract Introduction Transfusion medicine is unique to lab medicine. While it still involves testing and reporting of results, it is one of the few areas where the laboratory is providing treatment. The risk of providing a blood product must be weighed against the benefit before the decision is made to transfuse a patient. Our study looked at blood utilization at our regional hospitals to assess if there were areas where we need to improve this decision process. Methods Chart reviews were performed for patients who received packed red blood cells (RBCs) in the regional hospitals over a 2-month period. Using the AABB and Choosing Wisely recommendations, we created two screening criteria: hemoglobin (Hb) >8 g/dL or greater than 1 unit RBC ordered when Hb is >6 g/dL to screen for outliers among RBC orders. A more in-depth chart review including information on clinical diagnosis, indications, bleeding status, and blood loss during surgery was performed on cases that met these criteria. Using this information, a decision was made on the appropriateness of the transfusion. Results In total, 1,592 RBC units were screened at eight regional hospitals. Sixty-eight (4%) were flagged as inappropriate, 57 (83.8%) due to multiple units, and 11 (16.2%) for an Hb >8 g/dL. The percentage of inappropriate transfusions at a hospital ranged from 5.2% to 13.6%. However, all hospitals except one were under 5.5%. Discussion In general, regional physicians are transfusing RBCs appropriately. When a unit is ordered inappropriately, it is most likely due to ordering multiple units upfront. To further improve blood utilization, these data were presented to hospital administration and a new alert in the EMR was created. A repeat study will be performed to see if the alerts and awareness of these data has had an effect on blood utilization.

scholarly journals Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells

2020 ◽  
Vol 18 (7) ◽  
pp. 1535-1547
Author(s):  
Melissa M. Lee‐Sundlov ◽  
Sean R. Stowell ◽  
Karin M. Hoffmeister
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Transfusion Medicine

Erythroplateletapheresis: A New Strategy in the Global Apheresis Program

1998 ◽  
Vol 21 (6_suppl) ◽  
pp. 17-19
Author(s):  
G. Menichella ◽  
M. Ciarli ◽  
R. Serafini ◽  
L. Pierelli ◽  
M. Vittori ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Plasma Volume ◽  
Blood Cells ◽  
Storage Time ◽  
Blood Donation ◽  
Mean Values ◽  
Packed Red Blood Cells ◽  
New Strategy ◽  
The Mean

Blood donation allowed by cell separators can offer higher performance and higher yield to guarantee better quality and pureness of collected products. New systems for the collection of platelet concentrate (PC) and packed red blood cells (PRBC) are currently available. The aim of our work was to test the possibility of preparing PC routinely from normal apheresis donors in a minimum amount of time while providing a second product. Over a 3-month period we performed 40 procedures using the Hemonetics MCS3P blood cell separator and the Dideco Excel. The mean values of platelet yield were 2.8 x 1011 (range 1.4-4.1) with the MCS3P and 3.49 x 1011 (range 2.9-3.9) with the Excel, in a plasma volume of 240 ml and 215 ml respectively; the PRBC units were added with SAG-Mannitol allowing a storage time of 42 days. Collection times were 71’ and 48’ respectively. Donor tolerance was analogous to phateletapheresis or plasmapheresis.

Short Time Dynamics of an Irreversible Probabilistic Cellular Automaton

1998 ◽  
Vol 12 (21) ◽  
pp. 873-879 ◽  
Author(s):  
T. Tomé ◽  
J. R. Drugowich de Fel Icio
Keyword(s):  
Ising Model ◽  
Cellular Automaton ◽  
Early Time ◽  
Universality Class ◽  
Kinetic Ising Model ◽  
Time Dynamics ◽  
Probabilistic Cellular Automaton ◽  
Time Regime ◽  
The One ◽  
Short Time

We study the short-time dynamics of a three-state probabilistic cellular automaton. This automaton, termed TD model, possess "up-down" symmetry similar to Ising models, and displays continuous kinetic phase transitions belonging to the Ising model universality class. We perform Monte Carlo simulations on the early time regime of the two-dimensional TD model at criticality and obtain the dynamic exponent θ associated to this regime, and the exponents β/ν and z. Our results indicate that, although the model do not possess microscopic reversibility, it presents short-time universality which is consistent with the one of the kinetic Ising model.

scholarly journals Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages.

1995 ◽  
Vol 182 (2) ◽  
pp. 409-418 ◽  
Author(s):  
H Bouharoun-Tayoun ◽  
C Oeuvray ◽  
F Lunel ◽  
P Druilhe
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cells ◽  
Passive Transfer ◽  
Interleukin 4 ◽  
Polymorphonuclear Cells ◽  
Clinical Protection ◽  
The One ◽  
Necrosis Factor ◽  
Stage D

The relevance of the antibody-dependent cellular inhibition (ADCI) of Plasmodium falciparum to clinical protection has been previously established by in vitro studies of material obtained during passive transfer of protection by immunoglobulin G in humans. We here report further in vitro investigations aimed at elucidating the mechanisms underlying this ADCI effect. Results obtained so far suggest that (a) merozoite uptake by monocytes (MN) as well as by polymorphonuclear cells has little influence on the course of parasitemia; (b) the ADCI effect is mediated by a soluble factor released by MN; (c) this or these factors are able to block the division of surrounding intraerythrocytic parasites at the one nucleus stage; (d) the critical triggering antigen(s) targeted by effective Abs would appear to be associated with the surface of merozoites, as opposed to that of infected red blood cells; (e) the MN receptor for Abs effective in ADCI is apparently Fc gamma RII, and not RI; (f) MN function is up- and down-regulated by interferon-gamma and interleukin 4, respectively; and (g) of several potential mediators released by MN, only tumor necrosis factor (TNF) proved of relevance. The involvement of TNF in defense may explain the recently described increased frequency of the TNF-2 high-expression promoter in individuals living in endemic regions despite its compromising role in severe malaria.

Temporal distance and blood donation intention

2011 ◽  
Vol 17 (4) ◽  
pp. 590-599 ◽  
Author(s):  
Soe Yoon Choi ◽  
Hee Sun Park ◽  
Ju Yeon Oh
Keyword(s):  
Social Desirability ◽  
Blood Donation ◽  
Time Frame ◽  
Factors Affecting ◽  
One Year ◽  
The One ◽  
Donation Intention ◽  
Time Frames ◽  
Near Future ◽  
The Relationship

This study tested Construal Level Theory and examined social desirability and cultural differences as factors affecting blood donation intention across different time frames. Findings showed that individuals indicated stronger intentions for the distant future (one-year and no-time indication frames) than for the near future (one-week and three-month frames). The relationship between social desirability rating of blood donation and intention was positive and significant for the no-time indication frame, but it was not significant for the one-week time frame and the three-month time frame. Koreans and Americans did not differ in the relationship between social desirability and intentions across different time frames.

Sign in / Sign up

Export Citation Format

Share Document