scholarly journals Static and dynamic alterations in the amplitude of low-frequency fluctuation in patients with amyotrophic lateral sclerosis

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10052
Author(s):  
Xujing Ma ◽  
Fengmei Lu ◽  
Heng Chen ◽  
Caihong Hu ◽  
Jiao Wang ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Brain Activity ◽  
Low Frequency ◽  
Total Power ◽  
Support Vector ◽  
Precentral Gyrus ◽  
Lingual Gyrus ◽  
The Right ◽  
Local Brain ◽  
Lateral Sclerosis

Background Static changes in local brain activity in patients suffering from amyotrophic lateral sclerosis (ALS) have been studied. However, the dynamic characteristics of local brain activity are poorly understood. Whether dynamic alterations could differentiate patients with ALS from healthy controls (HCs) remains unclear. Methods A total of 54 patients with ALS (mean age = 48.71 years, male/female = 36/18) and 54 (mean age = 48.30 years, male/female = 36/18) HCs underwent magnetic resonance imaging scans. To depict static alterations in cortical activity, amplitude of low-frequency fluctuations (ALFF) which measures the total power of regional activity was computed. Dynamic ALFF (d-ALFF) from all subjects was calculated using a sliding-window approach. Statistical differences in ALFF and d-ALFF between both groups were used as features to explore whether they could differentiate ALS from HC through support vector machine method. Results In contrast with HCs, patients with ALS displayed increased ALFF in the right inferior temporal gyrus and bilateral frontal gyrus and decreased ALFF in the left middle occipital gyrus and left precentral gyrus. Furthermore, patients with ALS demonstrated lower d-ALFF in widespread regions, including the right lingual gyrus, left superior temporal gyrus, bilateral precentral gyrus, and left paracentral lobule by comparison with HCs. In addition, the ALFF in the left superior orbitofrontal gyrus had a tendency of correlation with ALSFRS-R score and disease progression rate. The classification performance in distinguishing ALS was higher with both features of ALFF and d-ALFF than that with a single approach. Conclusions Decreased dynamic brain activity in the precentral gyrus, paracentral gyrus, lingual gyrus, and temporal regions was found in the ALS group. The combined ALFF and d-ALFF could distinguish ALS from HCs with a higher accuracy than ALFF and d-ALFF alone. These findings may provide important evidence for understanding the neuropathology underlying ALS.

scholarly journals Altered Amplitude of Low-Frequency Fluctuations in Inactive Patients with Nonneuropsychiatric Systemic Lupus Erythematosus

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yang Yu ◽  
Liheng Chen ◽  
Qiaohong Wang ◽  
Lingzhen Hu ◽  
Qiuping Ding ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Brain Activity ◽  
Low Frequency ◽  
Brain Regions ◽  
Precentral Gyrus ◽  
Spontaneous Brain Activity ◽  
Low Frequency Oscillations ◽  
Postcentral Gyrus ◽  
Frequency Fluctuations ◽  
The Right

Objective.This study is aimed at investigating the characteristics of the spontaneous brain activity in inactive patients with nonneuropsychiatric systemic lupus erythematosus (non-NPSLE). Methods. Thirty-one female inactive patients with non-NPSLE and twenty healthy controls were examined by resting-state functional magnetic resonance imaging (RS-fMRI). Three amplitude methods including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and percent amplitude of fluctuation (PerAF) (with and without standardization) were applied to evaluate the spontaneous brain activity. The correlation was performed between low-frequency oscillations and clinical and neuropsychological factors in inactive patients with non-NPSLE. Results. Compared to healthy controls, patients with non-NPSLE showed increased standardized ALFF (mALFF) in the left inferior temporal gyrus and left putamen, decreased PerAF in the right postcentral gyrus and bilateral precentral gyrus, and increased standardized PerAF (mPerAF) in the left putamen and decreased mPerAF in the right postcentral gyrus and bilateral precentral gyrus. By standardized fALFF (mfALFF), no significant brain regions were found between the two groups. Correlation analysis revealed significantly positive correlations between glucocorticoid dose and PerAF in the right precentral gyrus and mPerAF in the left putamen, and Complement 3 (C3) and mPerAF in the right postcentral gyrus. There was a significant negative correlation between C3 and mALFF in the left putamen. Conclusion. Abnormal low-frequency oscillations in multiple brain regions were found in inactive patients with non-NPSLE, indicating that the alteration of mALFF, PerAF, and mPerAF in specific brain regions might be an imaging biomarker of brain dysfunction in inactive patients with non-NPSLE.

Effects of the SNAP25 on Integration Ability of Brain Functions in Children With ADHD

2020 ◽  
pp. 108705472096456
Author(s):  
Yue Yang ◽  
Gang Peng ◽  
Hongwu Zeng ◽  
Diangang Fang ◽  
Linlin Zhang ◽  
...  
Keyword(s):  
Time Window ◽  
Precentral Gyrus ◽  
Children With Adhd ◽  
Brain Functions ◽  
Lingual Gyrus ◽  
Window Method ◽  
Central Gyrus ◽  
The Right ◽  
The Brain ◽  
Insight Into

Objective: The present study aimed to examine the effects of SNAP25 on the integration ability of intrinsic brain functions in children with ADHD, and whether the integration ability was associated with working memory (WM). Methods: A sliding time window method was used to calculate the spatial and temporal concordance among five rs-fMRI regional indices in 55 children with ADHD and 20 healthy controls. Results: The SNAP25 exhibited significant interaction effects with ADHD diagnosis on the voxel-wise concordance in the right posterior central gyrus, fusiform gyrus and lingual gyrus. Specifically, for children with ADHD, G-carriers showed increased voxel-wise concordance in comparison to TT homozygotes in the right precentral gyrus, superior frontal gyrus, postcentral gyrus, and middle frontal gyrus. The voxel-wise concordance was also found to be related to WM. Conclusion: Our findings provided a new insight into the neural mechanisms of the brain function of ADHD children.

scholarly journals Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Ruiping Zheng ◽  
Yuan Chen ◽  
Yu Jiang ◽  
Mengmeng Wen ◽  
Bingqian Zhou ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Neural Activity ◽  
Temporal Variability ◽  
Brain Activity ◽  
Low Frequency ◽  
First Episode ◽  
Posterior Lobe ◽  
Major Depressive ◽  
Drug Naïve ◽  
The Right

Background: Major depressive disorder (MDD) has demonstrated abnormalities of static intrinsic brain activity measured by amplitude of low-frequency fluctuation (ALFF). Recent studies regarding the resting-state functional magnetic resonance imaging (rs-fMRI) have found the brain activity is inherently dynamic over time. Little is known, however, regarding the temporal dynamics of local neural activity in MDD. Here, we investigated whether temporal dynamic changes in spontaneous neural activity are influenced by MDD.Methods: We recruited 81 first-episode, drug-naive MDD patients and 64 age-, gender-, and education-matched healthy controls who underwent rs-fMRI. A sliding-window approach was then adopted for the estimation of dynamic ALFF (dALFF), which was used to measure time-varying brain activity and then compared between the two groups. The relationship between altered dALFF variability and clinical variables in MDD patients was also analyzed.Results: MDD patients showed increased temporal variability (dALFF) mainly focused on the bilateral thalamus, the bilateral superior frontal gyrus, the right middle frontal gyrus, the bilateral cerebellum posterior lobe, and the vermis. Furthermore, increased dALFF variability values in the right thalamus and right cerebellum posterior lobe were positively correlated with MDD symptom severity.Conclusions: The overall results suggest that altered temporal variability in corticocerebellar–thalamic–cortical circuit (CCTCC), involved in emotional, executive, and cognitive, is associated with drug-naive, first-episode MDD patients. Moreover, our study highlights the vital role of abnormal dynamic brain activity in the cerebellar hemisphere associated with CCTCC in MDD patients. These findings may provide novel insights into the pathophysiological mechanisms of MDD.

scholarly journals The Cumulative Therapeutic Effect of Acupuncture Treatment in Patients With Migraine Without Aura: Evidence From Dynamic Alterations of Intrinsic Brain Activity and Effective Connectivity Analysis

2021 ◽  
Author(s):  
Yilei Chen ◽  
Yingjie Kang ◽  
Shilei Luo ◽  
Shanshan Liu ◽  
Bo Wang ◽  
...  
Keyword(s):  
Migraine Attack ◽  
Therapeutic Effect ◽  
Migraine Without Aura ◽  
Acupuncture Treatment ◽  
Brain Activity ◽  
Effective Connectivity ◽  
Life Questionnaire ◽  
Precentral Gyrus ◽  
The Right ◽  
Intrinsic Brain Activity

Abstract Background: The underlying neurological mechanism of acupuncture treatment in migraine without aura (MwoA) remains unclear. Therefore, we explored the dynamic alterations of intrinsic brain activity and effective connectivity in patients with MwoA after acupuncture treatment.Methods:The fMRI scans were separately obtained at baseline, after the first and after the 12th acupuncture sessions in 40 patients with MwoA. The acupuncture treatments were finished within 6 weeks as twice a week. 36 matched healthy controls (HCs) were recruited and performed once fMRI scan. The dynamic amplitude of low-frequency fluctuation (dALFF) and dynamic granger causality analysis(GCA) were used to analyze the difference of different time points in patients with MwoA. The correlation analyses were performed in dALFF variability, dynamic effective connectivity (DEC) variability with clinical variables in patients with MwoA.Results:Compared with HCs, Patients with MwoA at baseline showed decreased dALFF variability in regions within rostral ventromedial medulla (RVM), the superior lobe of left cerebellum (Cerebelum_Crus1_L), the right inferior frontal gyrus, triangular part (IFGtriang.R), the right median cingulate and paracingulate gyri (DCG.R), the right precuneus (PCUN.R), and the left inferior parietal, supramarginal and angular gyri (IPL.L), increased dALFF variability only in the left inferior occipital gyrus (IOG.L). After acupuncture treatment, the decreased dALFF variability of the RVM, Cerebelum_Crus1_L , and PCUN.R progressively recovered, the RVM revealed gradually increased DEC variability to the right middle frontal gyrus (MFG.R), the left insula (INS.L), the right precentral gyrus (PreCG.R), and the right supramarginal gyrus (SMG.R). And enhanced DEC variability from the right fusiform gyrus (FFG.R) to RVM. Furthermore, the increased DEC variability were found from Cerebelum_Crus1_L to the left middle occipital gyrus (MOG.L) and the left precentral gyrus (PreCG.L), from PCUN.R to the right thalamus (THA.R). These dALFF variabilities were significantly positive correlated with frequency of migraine attack and negative correlated with disease duration at baseline, dynamic GCA coefficients were significantly positive correlated with Migraine-Specific Quality of Life Questionnaire (MSQ) score, negative correlated with frequency of migraine attack and visual analog scale (VAS) score postacupuncture treatment.Conclusions:Our results provide insight into dynamic alterations from the perspective of dynamic local brain activity and effective connectivity for the understanding mechanisms of cumulative therapeutic effect of acupuncture in patients with MwoA.Trial registration: ChiCTR, ChiCTR1900023105. Registered 11 May 2019, http://www.chictr.org.cn/showproj.aspx?proj=36959.

scholarly journals Automatic amyotrophic lateral sclerosis detection using tunable Q-factor wavelet transform

2020 ◽  
Vol 9 (4) ◽  
pp. 744
Author(s):  
Abdelouahad Achmamad ◽  
Abdelali Belkhou ◽  
Atman Jbari
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Wavelet Transform ◽  
Nearest Neighbor ◽  
Neuromuscular Disorders ◽  
Computation Time ◽  
Support Vector ◽  
Q Factor ◽  
K Nearest Neighbor ◽  
Emg Signal ◽  
Lateral Sclerosis

Early diagnosis of amyotrophic lateral sclerosis (ALS) based on electromyography (EMG) is crucial. The processing of a non-stationary EMG signal requires powerful multi-resolution methods. Our study analyzes and classifies the EMG signals. In the present work, we introduce a novel flexible method for classification of EMG signals using tunable Q-factor wavelet transform (TQWT). Different sub-bands generated by the TQWT technique were served to extract useful information related to energy and then the calculated features were selected using a filter selection (FS) method. The effectiveness of the feature selection step resulted not only in the improvement of classification performance but also in reducing the computation time of the classification algorithm. The selected feature subsets were used as inputs to multiple classifier algorithms, namely, k-nearest neighbor (k-NN), least squares support vector machine (LS-SVM) and random forest (RF) for automated diagnosis. The experimental results show better classification measures with k-NN classifier compared with LS-SVM and RF. The robustness of the classification task was tested using a ten-fold cross-validation method. The outcomes of our proposed approach can be exploited to aid clinicians in neuromuscular disorders detection.

scholarly journals Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julio Plata-Bello ◽  
Ana Plata-Bello ◽  
Yaiza Pérez-Martín ◽  
David López-Curtis ◽  
Silvia Acosta-López ◽  
...  
Keyword(s):  
Androgen Deprivation Therapy ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Region Of Interest ◽  
Androgen Deprivation ◽  
Receptor Expression ◽  
Control Group ◽  
Precentral Gyrus ◽  
The Right

AbstractThe aim of the present work is to describe the differences in rs-fMRI measures (Amplitude of low frequency fluctuations [ALFF], Regional Homogeneity [ReHo] and Functional Connectivity [FC]) between patients exposed to Androgen deprivation therapy (ADT) and a control group. Forty-nine ADT patients and fifteen PC-non-ADT patients (Controls) were included in the study. A neuropsychological evaluation and a resting-state fMRI was performed to evaluate differences in ALFF and ReHo. Region of interest (ROI) analysis was also performed. ROIs were selected among those whose androgen receptor expression (at RNA-level) was the highest. FC analysis was performed using the same ROIs. Higher ALFF in frontal regions and temporal regions was identified in Controls than in ADT patients. In the ROI analysis, higher activity for Controls than ADT patients was shown in the left inferior frontal gyrus and in the left precentral gyrus. Lower ALFF in the right hippocampus and the lateral geniculate nucleus of the right thalamus was identified for Controls than ADT patients. Higher ReHo was observed in Controls in the left parietal-occipital area. Finally, ADT patients presented an increase of FC in more regions than Controls. These differences may reflect an impairment in brain functioning in ADT users.

scholarly journals The Cumulative Therapeutic Effect of Acupuncture Treatment in Patients with Migraine without Aura: Evidence from Dynamic Alterations of Intrinsic Brain Activity and Effective Connectivity Analysis

2022 ◽  
Author(s):  
Yilei Chen ◽  
Yingjie Kang ◽  
Shilei Luo ◽  
Shanshan Liu ◽  
Bo Wang ◽  
...  
Keyword(s):  
Migraine Attack ◽  
Therapeutic Effect ◽  
Migraine Without Aura ◽  
Acupuncture Treatment ◽  
Brain Activity ◽  
Effective Connectivity ◽  
Life Questionnaire ◽  
Precentral Gyrus ◽  
The Right ◽  
Intrinsic Brain Activity

Abstract We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate the underlying neurological mechanism of acupuncture treatment in patients with migraine without aura (MwoA). The fMRI scans were separately obtained at baseline, after the first and after the 12th acupuncture sessions in 40 patients with MwoA. Compared with HCs, patients with MwoA showed mostly decreased dynamic amplitude of low-frequency fluctuation (dALFF) variability in regions with differences. After acupuncture treatment, the decreased dALFF variability of the rostral ventromedial medulla (RVM), the superior lobe of left cerebellum (Cerebelum_Crus1_L), and the right precuneus (PCUN.R) progressively recovered. The RVM revealed gradually increased dynamic effective connectivity (DEC) variability outflow to the right middle frontal gyrus, the left insula, the right precentral gyrus, and the right supramarginal gyrus, and enhanced DEC variability from the right fusiform gyrus inflow to RVM. Furthermore, the increased DEC variability were found from Cerebelum_Crus1_L outflow to the left middle occipital gyrus and the left precentral gyrus, from PCUN.R outflow to the right thalamus. These dALFF variabilities were positive correlated with frequency of migraine attack and negative correlated with disease duration, dynamic GCA coefficients were positive correlated with Migraine-Specific Quality of Life Questionnaire score, negative correlated with frequency of migraine attack and visual analog scale score postacupuncture treatment. Our results provide insight into dynamic alterations from the perspective of dynamic local brain activity and effective connectivity for the understanding mechanisms of cumulative therapeutic effect of acupuncture in patients with MwoA.

scholarly journals Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xenia Kobeleva ◽  
Judith Machts ◽  
Maria Veit ◽  
Stefan Vielhaber ◽  
Susanne Petri ◽  
...  
Keyword(s):  
Working Memory ◽  
Amyotrophic Lateral Sclerosis ◽  
Functional Neuroimaging ◽  
Current Knowledge ◽  
Brain Activity ◽  
Reaction Times ◽  
Verbal Working Memory ◽  
Research Field ◽  
Fmri Study ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that causes progressive degeneration of neurons in motor and non-motor regions, affecting multiple cognitive domains. In order to contribute to the growing research field that employs structural and functional neuroimaging to investigate the effect of ALS on different working memory components, we conducted a functional magnetic resonance imaging (fMRI) study exploring the localization and intensity of alterations in neural activity. Being the first study to specifically address verbal working memory via fMRI in the context of ALS, we employed the verbal n-back task with 0-back and 2-back conditions. Despite ALS patients showing unimpaired accuracies and reaction times, there was significantly increased brain activity of frontotemporal and parietal regions in the 2-back minus 0-back contrast in patients compared to controls. This increased brain activity was largely associated with a better neuropsychological performance within the ALS group, suggesting a compensatory effect. This study therefore adds to the current knowledge on neural correlates of working memory in ALS and contributes to a more nuanced understanding of hyperactivity during cognitive processes in fMRI studies of ALS.

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