scholarly journals Phytochemical Screening and Hepatoprotective Potential of Aqueous Fruit Pulp Extract of Adansonia digitata against CCL4 Induced Liver Damage in Rats

2020 ◽  
pp. 12-21
Author(s):  
A. M. Sa’id ◽  
A. H. Musa ◽  
J. A. Mashi ◽  
F. U. Maigari ◽  
M. N. Nuhu
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
Serum Levels ◽  
Health Science ◽  
Fruit Pulp ◽  
Medical Sciences ◽  
Adansonia Digitata ◽  
Hepatoprotective Effects ◽  
Dose Dependent ◽  
Basic Medical

Aim: The current study was carried out to evaluate the hepatoprotective effects of aqueous extract of Adansonia digitata fruit pulp on carbon tetrachloride (CCl4) induced liver damage in  rats. Place and Duration of Study: Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Science, between November 2017 and January 2018. Methodology: A. digitata fruit pulp was extracted by maceration using water; and a concentration of 100 mg/ml was used. Two doses of the aqueous extract (200 mg/kg and 300 mg/kg) and Livoline (25 mg/kg) were used to investigate their hepatoprotective effects on CCl4-induced hepatotoxicity in rats. Results: The two doses of the plant extract showed dose-dependent hepatoprotective effect on CCl4-induced hepatotoxicity, as evident by the significant reduction (P<0.05) in serum levels of AST, ALT, ALP and bilirubin along with the improved histopathological liver sections compared to CCl4-treated animals. Conclusion: Due to its hepatoprotective potentials, A. digitata extract may be used to develop standard treatment drugs against some liver disorders when it is further evaluated through extensive researches.

scholarly journals Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury

2015 ◽  
Vol 10 (2) ◽  
pp. 393 ◽  
Author(s):  
Liaqat Hussain ◽  
Muhammad Sajid Hamid Akash ◽  
Madeha Tahir ◽  
Kanwal Rehman
Keyword(s):  
Liver Injury ◽  
Serum Levels ◽  
Therapeutic Effects ◽  
Sapium Sebiferum ◽  
Dependent Manner ◽  
Protective Effects ◽  
Drug Induced ◽  
Standard Drug ◽  
Hepatoprotective Effects ◽  
Dose Dependent

<span><em>Sapium sebiferum</em> leaves were used to determine its hepatoprotective effects against paracetamol-induced hepatotoxicity in mice. A dose dependent study was conducted using two different doses (200 mg/kg and 400 mg/kg) of the extract of </span><em>S. sebiferum</em><span> against toxic effects of paracetamol (500 mg/kg) in experimental animal model. Silymarin (50 mg/kg) was used as standard drug to compare therapeutic effects of </span><em>S. sebiferum</em><span> with control and paracetamol-treated groups. Paracetamol significantly increased the serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract showed protective effects by normalizing the liver enzymes markers in a dose dependent manner. Histopathological results confirmed the hepatoprotective effects of leaves of </span><em>S. sebiferum</em><span>. We conclude that leaves of </span><em>S. sebiferum</em><span> have strong hepatoprotective effects against paracetamol-induced liver injury and can be used in liver injuries caused by drug-induced toxicity.</span>

scholarly journals Aqueous Extract Of Fruit Pulp Of Adansonia digitata (Linn): Phytochemical Screening And In Vitro Antitrypanosomal Effect

2019 ◽  
Vol 40 (1) ◽  
pp. 35
Author(s):  
O.O. Ogunleye ◽  
I.D. Jatau ◽  
A.J. Natala ◽  
O.O Obaloto ◽  
A.E. Adetutu ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Fruit Pulp ◽  
Phytochemical Screening ◽  
Adansonia Digitata

scholarly journals Hepatoprotective activity of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against CCl4-induced liver injury in rats

2019 ◽  
Vol 8 (8) ◽  
pp. 1758
Author(s):  
Naveen Kumar Bathula ◽  
Bimalendu Choudhary
Keyword(s):  
Alkaline Phosphatase ◽  
Superoxide Dismutase ◽  
Aqueous Extract ◽  
Liver Damage ◽  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Hepatoprotective Agent ◽  
Histopathological Studies ◽  
The Impact ◽  
Dose Dependent

Background: The botanical Latin name of the plant, Turnera aphrodisiaca, describes its ancient use as an aphrodisiac.Methods: The aim of the present study is to evaluate the protective effect of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against carbon tetrachloride (CCl4)-induced liver damage in male Wistar rats.Results: Administration with ethanolic and aqueous extract of Turnera aphrodisiaca leaves (200 and 400 mg/kg) for 7 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase in a dose dependent matter. In addition, treatment of both the extracts resulted in markedly increased the levels of superoxide dismutase and catalase enzymes in rats. The histopathological studies in the liver of rats also supported that both extracts markedly reduced the toxicity of CCL4 and preserved the histoarchitecture of the liver tissue to near normal.Conclusion: Thus, the results suggest that ethanolic and aqueous extract of  Turnera aphrodisiaca leaves acts as a potent hepatoprotective agent against CCl4 induced hepatotoxicity in rats.

scholarly journals In vivo effect of the aqueous extract of Adansonia digitata (Linn) fruit pulp on Trypanosoma brucei brucei infection in Wistar rats

2020 ◽  
Vol 17 (4) ◽  
pp. 1-8
Author(s):  
O.O. Ogunleye ◽  
I.D. Jatau ◽  
A.J. Natala ◽  
CO Idehen ◽  
O. Salami ◽  
...  
Keyword(s):  
Body Weight ◽  
Trypanosoma Brucei ◽  
Aqueous Extract ◽  
Albino Rats ◽  
Fruit Pulp ◽  
Adansonia Digitata ◽  
Trypanosoma Brucei Brucei ◽  
Significant Difference ◽  
Group A

This study investigated the effects of aqueous extract of fruit pulp of Adansonia digitata on albino rats infected with Trypanosoma brucei brucei. Acute toxicity test was conducted on the extract and then analysed for some phytoconstituents. Thirty-five adult rats were divided into seven groups of five rats each. Group A were the non-infected control group while groups B, C, D, E, F and G were inoculated with 1x 106 trypanosomes per 100 g body weight (BW). At day 6 post infection (6 PI), groups C and D were treated with diminazene aceturate and vitamin C at dose rates of 3.5 mg/kg BW intra peritonealy once and 200 mg/kg BW orally for 3 days respectively, while groups E, F, G were orally treated for 3 days with 40, 80, and 160 mg/kg BW of the extract respectively. The rats were monitored for parasitaemia, PCV and body weight. The LD50 of the extract was greater than 9000 mg/kg. The phytochemical analysis revealed 3.51% flavonoid, 0.07% alkaloid, 0.10% saponin and 0.03.0% oxalate in the extract. While there was progressive increase in parasitaemia from day 6 PI in groups E and F throughout the study, parasitaemia decreases and was completely cleared by day 8 and 11 PI in groups C and G respectively. PCV of group A was not significantly different (p>0.05) from that of F and G. There was significant difference (p<0.05) in the PCV of Group A and that of groups B and C and highly significantly different (p<0.01) with that of D and E. Significant (p<0.05) body weight increase of rats in groups D, E, F and G at day 10 PI was observed. Thus, fruit pulp of A. digitata at a dose of 9000 mg/kg was not toxic to rats, and contains active compounds with potential In vivo anti-trypanosoma activity. Keywords: Adansonia digitata, Albino rats, Animal trypanosomosis, Phytochemicals, Trypanosoma brucei brucei

Hepatoprotective Effects ofArctium Lappaon Carbon Tetrachloride- and Acetaminophen-Induced Liver Damage

2000 ◽  
Vol 28 (02) ◽  
pp. 163-173 ◽  
Author(s):  
Song-chow Lin ◽  
Tsao-chuen Chung ◽  
Chun-ching Lin ◽  
Tzuu-Huei Ueng ◽  
Yun-ho Lin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Perennial Herb ◽  
Dependent Manner ◽  
Arctium Lappa ◽  
Long Time ◽  
Mda Content ◽  
Hepatoprotective Effects ◽  
Dose Dependent ◽  
Cytochrome P 450

The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride ( CCl4, 32 μl/kg, i.p.) or acetaminophen (600 mg/kg. i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4or acetaminophen.

Interactive Computer-Video Modules for Health Sciences Education

1989 ◽  
Vol 28 (04) ◽  
pp. 360-363 ◽  
Author(s):  
J. McArthur ◽  
J. Bolles ◽  
J. Fine ◽  
P. Kidd ◽  
M. Bessis
Keyword(s):  
Medical Informatics ◽  
Computer Control ◽  
Health Science ◽  
Knowledge Structures ◽  
Image Recording ◽  
Central Computer ◽  
Key Word ◽  
The University ◽  
Development Group ◽  
Basic Medical

Abstract:Advances in electronic image recording and computer technologyhave resulted in a remarkable increase in the power and flexibility of interactive computer-video teaching systems. The University of Washington Health Science Videodisc Development Group first demonstrated a laser videodisc controlled by a remote central computer in 1980. Even this rudimentary unit highlighted basic medical informatics principles including: rapid accessibility; a “generic” or multi-purposed format; ease of computer control; and large collections of valid, rigorously reviewed images. Advances in medical informatics have led to the development of the following previously undescribed series of teaching units:1. The hypertext programs Hypercard, Linkway, and Guide have been used with videodiscs to develop easy-to-use instructional and reference materials. These materials demonstrate the ease with which a computer-naive instructor may develop new programs and the advantage that the intuitive nature of these programs brings to student users.2. Patient simulations using single and double screens plus pre-defined knowledge structures;3. Interactive single topic tutorials using preset knowledge structures;4. A key-word-based disc searching system;5. Electronic video microscopy;6. A series of programs developed independently by health science faculty who have purchased multi-purpose videodiscs that demonstrate the flexibility of the multi-purpose or “generic”: collection concept.

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