scholarly journals Hepatoprotective activity of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against CCl4-induced liver injury in rats

2019 ◽  
Vol 8 (8) ◽  
pp. 1758
Author(s):  
Naveen Kumar Bathula ◽  
Bimalendu Choudhary
Keyword(s):  
Alkaline Phosphatase ◽  
Superoxide Dismutase ◽  
Aqueous Extract ◽  
Liver Damage ◽  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Hepatoprotective Agent ◽  
Histopathological Studies ◽  
The Impact ◽  
Dose Dependent

Background: The botanical Latin name of the plant, Turnera aphrodisiaca, describes its ancient use as an aphrodisiac.Methods: The aim of the present study is to evaluate the protective effect of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against carbon tetrachloride (CCl4)-induced liver damage in male Wistar rats.Results: Administration with ethanolic and aqueous extract of Turnera aphrodisiaca leaves (200 and 400 mg/kg) for 7 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase in a dose dependent matter. In addition, treatment of both the extracts resulted in markedly increased the levels of superoxide dismutase and catalase enzymes in rats. The histopathological studies in the liver of rats also supported that both extracts markedly reduced the toxicity of CCL4 and preserved the histoarchitecture of the liver tissue to near normal.Conclusion: Thus, the results suggest that ethanolic and aqueous extract of  Turnera aphrodisiaca leaves acts as a potent hepatoprotective agent against CCl4 induced hepatotoxicity in rats.

scholarly journals HEPATOPROTECTIVE EVALUATION OF EPALTES DIVARICATA (L.) CASS. WHOLE PLANT EXTRACTS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN RATS

2016 ◽  
Vol 8 (12) ◽  
pp. 231 ◽  
Author(s):  
K. Amala ◽  
R. Ilavarasan ◽  
R. Arunadevi ◽  
S. Amerjothy
Keyword(s):  
Aqueous Extract ◽  
Histopathological Examination ◽  
Hepatoprotective Activity ◽  
Hepatoprotective Effect ◽  
Dependent Manner ◽  
Traditional Use ◽  
Whole Plant ◽  
Medicinal Use ◽  
Histopathological Studies ◽  
Dose Dependent

<p><strong>Objective: </strong>The plant of <strong><em>Epaltes</em></strong><strong> <em>divaricata </em>(L.) </strong>Cass.<strong> Traditionally used for jaundice. </strong>The present work aimed to investigate the hepatoprotective activity of alcohol and aqueous extract of the whole plant against paracetamol-induced hepatotoxicity in rats to substantiate its traditional use.</p><p><strong>Methods: </strong>The alcohol and aqueous (200 and 400 mg/kg) extract of <em>Epaltes divaricata</em> prepared by cold maceration were administered orally to the animals with hepatotoxicity induced by paracetamol (1000 mg/kg). Silymarine (40 mg/k) was given as reference standard. Hepatoprotective activity was assessed by estimating marker enzymes and by histopathological studies.</p><p><strong>Results: </strong>Both alcohol and aqueous (200 and 400 mg/kg) extract treatment significantly restored the paracetamol-induced elevations in levels of serum enzymes aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphate (ALP) and total bilirubin in a dose-dependent manner. Histopathological examination revealed that the treatment attenuated the paracetamol-induced damage to the liver. The hepatoprotective effect of both extracts was comparable to that of the standard hepatoprotective agent, silymarin.</p><p><strong>Conclusion: </strong>The alcohol and aqueous extract of <em>E. divaricata</em> exhibited hepatoprotective effect against paracetamol-induced liver damage in rats. This study also validated their traditional medicinal use in jaundice.</p>

scholarly journals Hepatoprotective activity of Adina cordifolia against ethanol induce hepatotoxicity in rats

2012 ◽  
Vol 1 (9) ◽  
pp. 279-284 ◽  
Author(s):  
A Sharma ◽  
B Sangameswaran ◽  
V Jain ◽  
M S Saluja
Keyword(s):  
Pharmaceutical Journal ◽  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Hepatocellular Injury ◽  
Standard Drug ◽  
Blood Samples ◽  
Hepatic Cells ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Histopathological Studies ◽  
Serum Glutamate

The acetone (AEAC) and aqueous extracts (AQEAC) of Adina cordifolia, belonging to the family Rubiaceae, were studied for hepatoprotective activity against Wister rats with liver damage induced by ethanol. It was found that AEAC and AQEAC, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent and also significantly increased the levels of total protein. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AEAC and AQEAC showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11619 International Current Pharmaceutical Journal 2012, 1(9): 279-284 

EVALUATION OF HEPATOPROTECTIVE EFFECTS OF SELECTED FRUIT PEEL EXTRACTS AND THEIR POLY HERBAL MIXTURE ON CCL4 INDUCED HEPATOTOXICITY: AN IN VIVO STUDY

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (09) ◽  
pp. 67-74
Author(s):  
Gana Manjusha Kondepudi ◽  
Battu Ganga Rao ◽  
P Balakrishnaiah
Keyword(s):  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Albino Rats ◽  
Dependent Manner ◽  
Fruit Peel ◽  
Herbal Mixture ◽  
Wistar Albino Rats ◽  
Dose Dependent ◽  
Peel Extract

The main aim of this study was to screen the selected fruit peel extracts and their polyherbal mixture (PHM) for hepatoprotective activity. Male wistar albino rats (180-200 g), divided into 12 groups after induction of hepatotoxicity, were treated with selected fruit peel extracts and PHM and at the end of 14th day blood and liver samples were collected and analysed. The aqueous peel extract of Malus pumila was a better hepatoprotective among the selected peel extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM were shown to revert back the liver enzymes to the normal values in diseased rats in a dose dependent manner. In conclusion, the selected fruit peel extracts and poly herbal mixture can be a potent hepatoprotective agent due to their antioxidant and anti-inflammatory actions.

scholarly journals HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF OXALIS DEBILIS KUNTH AGAINST CCL4 - INDUCED LIVER DAMAGE

2017 ◽  
Vol 10 (9) ◽  
pp. 231
Author(s):  
Rojini Athokpam ◽  
Meenakshi Bawari ◽  
Manabendra Dutta Choudhury
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
Elevated Serum ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Post Treatment ◽  
Histopathological Study ◽  
Phytochemical Analysis ◽  
Ccl4 Intoxication ◽  
Pre Treatment

  Objective: To evaluate the hepatoprotective activity of aqueous extract of Oxalis debilis Kunth in carbon tetrachloride (CCl4)-induced hepatotoxicity in Swiss albino mice.Methods: Hepatotoxicity was induced by CCl4 30% in olive oil (1 ml/kg intraperitoneally). Mice were treated with aqueous extract of O. debilis at doses of 250 and 500 mg/kg body weight orally for 14 days. There were two groups, pre-treatment (once daily for 14 days before CCl4 intoxication) and post-treatment (2, 6, 24, and 48 hrs after CCl4 intoxication). The observed effects were compared with a known hepatoprotective agent, silymarin.Results: Pre-treatment and post-treatment groups of aqueous extract of O. debilis significantly reduced elevated serum levels of serum transaminases, alkaline phosphatase, and bilirubin and increased the level of total protein as compared to CCl4-treated group. The histopathological study also confirms the hepatoprotection. Preliminary qualitative phytochemical analysis of the plant revealed the presence of phenolic compounds, tannins, flavonoids, and saponins.Conclusion: The results of this study suggest that O. debilis can be used as safe, cheap, and alternative preventive and protective drugs against liver injury. The protective effect observed could be attributed to the presence of various phytochemicals which are responsible for the restoration of liver damage.

scholarly journals Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats

2018 ◽  
Vol 64 (3) ◽  
pp. 241-246 ◽  
Author(s):  
P.A. Kakorin ◽  
I.V. Babenkova ◽  
Y.O. Teselkin ◽  
G.V. Ramenskaya ◽  
T.A. Demura ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Alkaline Phosphatase ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Total Bilirubin ◽  
Histological Study ◽  
Blood Parameters ◽  
Hepatoprotective Activity ◽  
Reference Preparation ◽  
Liver Homogenates

The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation “Carcil”. This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2¢-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata.

scholarly journals Phytochemical Screening and Hepatoprotective Potential of Aqueous Fruit Pulp Extract of Adansonia digitata against CCL4 Induced Liver Damage in Rats

2020 ◽  
pp. 12-21
Author(s):  
A. M. Sa’id ◽  
A. H. Musa ◽  
J. A. Mashi ◽  
F. U. Maigari ◽  
M. N. Nuhu
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
Serum Levels ◽  
Health Science ◽  
Fruit Pulp ◽  
Medical Sciences ◽  
Adansonia Digitata ◽  
Hepatoprotective Effects ◽  
Dose Dependent ◽  
Basic Medical

Aim: The current study was carried out to evaluate the hepatoprotective effects of aqueous extract of Adansonia digitata fruit pulp on carbon tetrachloride (CCl4) induced liver damage in  rats. Place and Duration of Study: Department of Biochemistry, Faculty of Basic Medical Sciences, College of Health Science, between November 2017 and January 2018. Methodology: A. digitata fruit pulp was extracted by maceration using water; and a concentration of 100 mg/ml was used. Two doses of the aqueous extract (200 mg/kg and 300 mg/kg) and Livoline (25 mg/kg) were used to investigate their hepatoprotective effects on CCl4-induced hepatotoxicity in rats. Results: The two doses of the plant extract showed dose-dependent hepatoprotective effect on CCl4-induced hepatotoxicity, as evident by the significant reduction (P<0.05) in serum levels of AST, ALT, ALP and bilirubin along with the improved histopathological liver sections compared to CCl4-treated animals. Conclusion: Due to its hepatoprotective potentials, A. digitata extract may be used to develop standard treatment drugs against some liver disorders when it is further evaluated through extensive researches.

Protective Effect of Chichorium Intybus (Kasni) Roots on Hepatotoxocity Induced By Pyrazinamide in Male Mice

2021 ◽  
Vol 15 (11) ◽  
pp. 2942-2944
Author(s):  
Attiya Munir ◽  
Amanat Ali ◽  
Sameer Ahmed ◽  
Amtul Hafeez ◽  
Nauman Naseer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Aqueous Extract ◽  
Alanine Aminotransferase ◽  
Serum Markers ◽  
Control Group ◽  
Trial Methodology ◽  
Drug Induced ◽  
Group A ◽  
High Doses ◽  
Group B

Background: Tuberculosis (TB) is major health issue across the world. Yearly 2 million deaths are reported from this disease. Pakistan has been ranked in the top six countries that are bearing the major brunt of TB. Aim: To observe hepatoprotective role of aqueous extract of kasni (Chichorium intybus) roots on hepatotoxicity caused by Pyrazinamide in male BALB/c mice. Study Design: Randomized control Trial. Methodology: Healthy male albino Balb/C mice, fifty six in number were selected randomly and further grouped into four groups (n=14 mice). Group A labelled as control group and maintained on rodent diet with no medication. Group B was labelled as disease control group and only pyrazinamide was administered to mice in this group in dose (500mg/kg BW). Groups C and D designated as exploratory groups. Both group C & D were administered a combination of Anti TB drug, pyrazinamide along with aqueous extract preparations of Kasni roots in low (200mg/kg) & high doses (400mg/kg) respectively. Baseline blood samples were drawn at day zero. Results: Serum alanine aminotransferase (ALT) and alkaline Phosphatase (ALP) were improved in group C & D given aqueous extract of Chicorium intybus roots. Conclusion: It was concluded that high doses of aqueous extract preparations of kasni (Chichorium intybus) roots showed more improvements of serum markers in drug induced hepatotoxicity than low doses of aqueous preparations. Keywords: Chichorium intybus, Hepatoprotective, Alanine aminotransferase (ALT), Alkaline Phosphatase (ALP),

scholarly journals Cardioprotective Activity ofN′′,N′′′-Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Salma Tabassum ◽  
Kiran Gangarapu ◽  
Gouthami Thumma ◽  
Sarangapani Manda ◽  
Rama Narsimha Reddy Anreddy
Keyword(s):  
Superoxide Dismutase ◽  
Creatine Kinase ◽  
Histopathological Examination ◽  
Heart Tissue ◽  
Tissue Homogenate ◽  
Tissue Homogenates ◽  
Dose Dependent Decrease ◽  
Histopathological Studies ◽  
Dose Dependent Increase ◽  
Dose Dependent

The present study was aimed at evaluating the cardioprotective effect of novel syntheticN′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and triglycerides (TG) in plasma and antioxidants like catalase, superoxide dismutase in heart tissue homogenate, and histopathological examination of heart tissues. The results showed the significant (P<0.05) dose dependent decrease in elevated cardiotoxic biomarkers CK-MB, LDH, AST, and TG levels. The histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes. The results showed the significant (P<0.05) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. These observations enable us to conclude thatN′′,N′′′-bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity.

scholarly journals AMELIORATION OF ACETAMINOPHEN-INDUCED HEPATOTOXICITY USING SOLANUM TORVUM SW. FRUIT EXTRACT IN WISTAR RATS

2019 ◽  
pp. 238-242
Author(s):  
UMERA BEGAM AK ◽  
SENTHILKUMAR R ◽  
SIRAJUDEEN J
Keyword(s):  
Aqueous Extract ◽  
Tca Cycle ◽  
Hepatoprotective Activity ◽  
Marker Enzymes ◽  
Fruit Extract ◽  
Solanum Torvum ◽  
Medicinal Uses ◽  
Membrane Bound ◽  
Histopathological Studies

Objective: Ayurveda and Chinese pharmacopeia have highlighted the traditional medicinal uses of Solanum torvum Sw. The fruits are ethnomedical used in the treatment of liver and spleen enlargement, cough, and also used as a hematopoietic, antimicrobial, and analgesic agent. In the present study, the amelioration of acetaminophen (APAP)-induced hepatotoxicity of the aqueous extract of S. torvum Sw. fruits is evaluated. Methods: The hepatoprotective activity of the fruit extract against APAP insult was evaluated by assessing it is in vivo antioxidants status, membrane-bound adenosine triphosphatases (ATPases), and tricarboxylic acid (TCA) cycle marker enzymes and also through histopathological studies of the liver. Results: Administration of the aqueous fruit extract of the plant caused a significant increase in the in vivo antioxidant status as evident from the reduction in lipid peroxidation caused by APAP and improvement in the mitochondrial membrane stability which is proved from the activity of membrane-bound ATPases and TCA cycle marker enzymes. Histological studies also supported the fact that the plant extract proved to revive the architecture of the toxin damaged liver tissues in par with silymarin. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the aqueous extract of S. torvum. Conclusion: The results showed that the extract of S. torvum Sw. fruits has hepatoprotective potential which may be due to the antioxidant activity of its phytoconstituents, especially flavonoids, alkaloids, phenolics, etc.

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