scholarly journals The Pathogenesis and Immune-Response in Dengue Haemorrhagic Fever

2019 ◽  
pp. 1-12
Author(s):  
A. M. Meer Ahmad ◽  
S. Arumugam ◽  
Chee Loon Leong
Keyword(s):  
Immune Response ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Case Fatality ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
Robust Immune Response ◽  
Different Strains ◽  
Original Antigenic Sin ◽  
Near Future

Introduction: Dengue fever has spread to be endemic in addition of 100 countries to a total estimate incidence of 50 – 100 million cases annually globally. About 0.7% of these cases become the complication that is dengue hemorrhagic fever which is severe and leads to about 22,000 deaths annually. The pathogenesis of benign dengue fever becoming dengue hemorrhagic fever, and aspects of the immune-response behind it, have remained relatively unknown. Methods: Existing literature on the Topic was retrieved through Google Scholar and PubMed searches, and the literature reviewed. Results: Dengue hemorrhagic fever appears commoner in females and those with co-morbids such as diabetes-mellitus and obesity. Also, the case-fatality rate in severe dengue appears much bigger in females. The reasons for this are largely unknown but the additionally robust immune response in females, resulting in females to be additionally prone to develop bigger inflammatory response or enhanced susceptibility to capillary permeability could be the reason. It has been shown that viremic-load, including the initial viremic-load at the bite of the Aedes-mosquito may be a factor leading to dengue hemorrhagic fever. Yet different factors felt to be causative in the pathogenesis of dengue hemorrhagic fever include the role of the viral-protein, and then that which is termed the original antigenic-sin, the antibody-directed enhancement, autoimmunity, inhibition of interferon-alpha and cytokine-storm within the memory-cells. Regionally, certain different strains of the DENV also seem to be associated with dengue hemorrhagic fever. Newer-vaccines, based on the immunology of the disease, offer much hope in the near future. Conclusion: Much knowledge has been forthcoming in realizing the pathogenesis of dengue hemorrhagic fever. But, additional studies need to be done.

scholarly journals Clinico-epidemiological study of dengue fever in Ajmer region

2019 ◽  
Vol 6 (5) ◽  
pp. 2046
Author(s):  
Dharmendra Rawat ◽  
Kanwar Singh ◽  
Pukhraj Garg
Keyword(s):  
Dengue Fever ◽  
Case Fatality Rate ◽  
Wide Spectrum ◽  
Dengue Infection ◽  
Case Fatality ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
Common Disease ◽  
Hemorrhagic Disease ◽  
Fatality Rate

Background: Dengue infection is a major challenge to public health, especially in South-East Asia. It present with a diverse clinical spectrum. Estimates suggest that annually over 50 million cases of dengue hemorrhagic fever (DHF) occur in Asian countries with a case fatality rate of less than 5%. Of those with DHF, at least 90% are children younger than 15 years old. In humans, dengue infection causes a spectrum of illness ranging from relatively mild, non-specific viral syndrome known as Dengue fever (DF) to severe hemorrhagic disease and death. Definitive early Dengue diagnosis requires laboratory tests and those suitable for use at this stage of illness are either costly, such as RT-PCR for Dengue; not sufficiently rapid, such as virus isolation. Currently test available are NS1 antigen detection and ELISA for dengue, IgM and IgG antibodies. Objective of this study is to study clinico-epidemiological and haematological features of Dengue infection.Methods: Prospective observational study involving initial 100 registered cases who were serologically confirmed dengue infection for a period of one year.Results: DF, DHF and DSS were found in 41%, 53% and 6% patients respectively. Most common presenting complaint and bleeding manifestation were fever and petechiae. Uncommonly altered sensorium and icterus were found in severe dengue infection. 6% patients had coagulopathy, 37 patients had hepatic involvement and 2 patients had deranged renal function who had DSS. Fever was present in (100%) cases of DF, DHF and DSS. 26% patients had their platelet count <50000/mm3.Conclusions: Dengue is a common disease in the India with wide spectrum of clinical presentations, affecting 5-15 years age group children commonly. It is one of the dreaded fevers but early diagnosis and management according to recent WHO guidelines can decrease case fatality rate significantly.

scholarly journals Selection for Virulent Dengue Viruses Occurs in Humans and Mosquitoes

2005 ◽  
Vol 79 (2) ◽  
pp. 853-859 ◽  
Author(s):  
Raymond Cologna ◽  
Philip M. Armstrong ◽  
Rebeca Rico-Hesse
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Virus Transmission ◽  
Indirect Evidence ◽  
Hemorrhagic Fever ◽  
Viral Disease ◽  
Southeast Asian ◽  
Severe Dengue ◽  
Dengue Viruses ◽  
Dengue Disease

ABSTRACT Dengue is the most common mosquito-borne viral disease in humans. The spread of both mosquito vectors and viruses has led to the resurgence of epidemic dengue fever (a self-limited flu-like syndrome) and the emergence of dengue hemorrhagic fever (severe dengue with bleeding abnormalities) in urban centers of the tropics. There are no animal or laboratory models of dengue disease; indirect evidence suggests that dengue viruses differ in virulence, including their pathogenicities for humans and epidemic potential. We developed two assay systems (using human dendritic cells and Aedes aegypti mosquitoes) for measuring differences in virus replication that correlate with the potential to cause hemorrhagic dengue and increased virus transmission. Infection and growth experiments showed that dengue serotype 2 viruses causing dengue hemorrhagic fever epidemics (Southeast Asian genotype) can outcompete viruses that cause dengue fever only (American genotype). This fact implies that Southeast Asian genotype viruses will continue to displace other viruses, causing more hemorrhagic dengue epidemics.

scholarly journals Platelet count and AST can reliably predict the onset of plasma leakage in dengue, a low-cost triage tool during epidemics

2019 ◽  
Author(s):  
Arjuna Medagama ◽  
Chamara Dalugama ◽  
Darshani Lakmali ◽  
Gukes Meiyalakan
Keyword(s):  
Regression Analysis ◽  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Low Cost ◽  
Clinical Signs ◽  
Hemorrhagic Fever ◽  
Severe Dengue ◽  
Upper Limit ◽  
Plasma Leakage

Abstract Background: Dengue is one of the most important mosquito-borne viral infections to affect humans. It is most often a self-limiting febrile illness but in some instances can progress to plasma leakage and in extreme cases culminate in death. The objective of this study was to identify reliable, low-cost, easily-accessible and objective predictors of Dengue hemorrhagic fever (DHF) that can be used as a triage tool in epidemic situations. Methods A cohort of dengue fever patients were selected and data on symptoms, clinical signs, routine lab tests, ultrasonography and packed cell volume measurements collected. The demographics and clinical characteristics of severe and non-severe dengue cases were described Bivariate and regression analysis were used to identify variables significantly correlated with plasma leak. Results Serologically confirmed 350 serial adult dengue patients were included in the study. 257 (73.4%) were classified as dengue fever (DF, non leakers) and 93 (26.5%) as DHF with plasma leakage. Bivariate and regression analysis showed platelet count (Pearson r 0.59), and AST (r 0.27) to be significantly correlated with plasma leakage and platelet count to have a moderate predictive association ( R 2 0.35) with plasma leakage. Platelet count <50,000/mm 3 (OR 23.7; 95% CI 12.2-45.9), AST> twice, upper limit of normal (OR 7.5; 95% CI 3.9-14.3) and ALT> twice, upper limit of normal (OR 2.4; 95%CI 1.4-3.6) increased the likelihood of DHF.In the final analysis, logistic regression identified platelet count <50,000/mm 3 (OR 17.2; 95% CI 8.6-34.1) and AST>2ULN (OR 5.1, 95% CI 2.1-12.1) at time of plasma leakage as significant independent predictors of DHF.ROC curve performed for Platelet count had an AUC of .89 and at a platelet count of 50,000/mm 3 predicted DHF with a sensitivity of 87% and specificity of 79%. AUC for AST was 0.72 and at 93Iu/L predicted DHF with a sensitivity of 85% and specificity of 60%. Conclusion: We have identified 2 laboratory parameters that could be used to identify plasma leakage and might be useful to stratify dengue-infected patients at risk for developing dengue hemorrhagic fever

scholarly journals A spatiotemporal analysis of dengue hemorrhagic fever in Banyumas, Indonesia

2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Dwi Sarwani Sri Rejeki ◽  
Nunung Nurhayati ◽  
Budi Aji
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Urban Areas ◽  
Case Fatality ◽  
Public Health Problem ◽  
Hemorrhagic Fever ◽  
Local Variation ◽  
Spatiotemporal Analysis ◽  
Cross Sectional ◽  
Central Java

Dengue hemorrhagic fever (DHF) is a public health problem in the world and also in Indonesia. One of the districts in Central Java that is still having problems with this disease is Banyumas, Indonesia. The incidence rate (IR) data in 2018 was 2.75 per 100,000 populations and the case fatality rate (CFR) was 3.64%. Spatiotemporal analysis was used to determine local variation, geographic determination of risk zones, and measurement of disease control interventions. Therefore, this study aimed to determine the distribution and grouping of dengue cases based on the spatiotemporal analysis. The design was observational with a cross-sectional spatial analysis. This study was conducted in Banyumas, Indonesia with the analysis unit for dengue fever patients in 2018 using as many as 57 cases. Furthermore, the data analysis used includes overlay, buffering, and clustering with SaTScan and ArcGis software. The results showed that there was a clustering of dengue cases in Banyumas, with one primary and three secondary clusters detected. The primary cluster occurred in March-April 2018, involving four sub-districts in urban areas. It was then concluded that the significantly identified clusters indicate a transmission of dengue fever in the Banyumas area with a radius of three kilometers.

PENGARUH PELATIHAN PENGENDALIAN VEKTOR DEMAM BERDARAH TERHADAP MAYA INDEX PADA SISWA SEKOLAH DASAR DI MAJALENGKA

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wawan Kurniawan
Keyword(s):  
Vector Control ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Intervention Group ◽  
Hemorrhagic Fever ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Quasi Experimental ◽  
Dengue Vector Control

ABSTRAK  Latar belakang: Demam Berdarah Dengue (DBD) disebabkan oleh virus Dengue dapat menyebabkan kematian. Pencegahan DBD yang dianggap paling tepat adalah Pemberantasan Sarang Nyamuk (PSN). Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan pengendalian vektor Demam Berdarah pada siswa sekolah dasar terhadap Maya Index di Majalengka. Metode: Penelitian ini menggunakan desain quasi experiment (pretest-posttest control group design). Sebanyak 4 sekolah terpilih sebagai kelompok intervensi dan 4 sekolah lainnya sebagai kontrol. Subyek penelitian adalah siswa kelas IV-VI yang terdiri dari 171 siswa pada kelompok intervensi dan 163 pada kelompok kontrol. Instrumen yang digunakan adalah formulir pemantauan jentik berkala. Hasil: Jumlah rumah dengan kategori Maya Index tinggi berkurang dari 27,5% menjadi 9,4%. Terjadi penurunan angka BRI kategori tinggi pada kelompok intervensi dari 20,5% menjadi 1,8%. Pada kelompok kontrol tidak terjadi penurunan angka BRI kategori tinggi (22,1%), sebaliknya terjadi penurunan kategori rendah dari 34,4% menjadi 3,7%. Tidak terjadi penurunan angka HRI pada kelompok intervensi maupun kontrol. Kesimpulan: Pelatihan pengendalian vektor Demam Berdarah dapat menurunkan nilai BRI dan Maya Index, tetapi tidak berpengaruh terhadap nilai HRI. Tidak adanya perubahan nilai HRI menunjukkan bahwa kebersihan dan sanitasi lingkungan merupakan faktor yang berpengaruh terhadap probabilitas kejadian demam berdarah. Kata Kunci : Demam Berdarah, Maya Index, pelatihan, pengendalian vektor   ABSTRACT Background: Dengue Hemorrhagic Fever (DHF) caused by Dengue virus could cause death. The most appropriate prevention of Dengue is eradication of mosquito nests (PSN). This study aims to determine the effect of Dengue vector control training on elementary students towards Maya Index in Majalengka. Method: This study used quasi-experimental design (pretest-posttest control group design). A total of 4 schools were selected as intervention groups and 4 other schools as controls. The subjects were students in grades IV-VI consisting of 171 students in the intervention group and 163 in the control group. The instrument used was periodic larva monitoring form. Results: The number of houses with a high Maya Index category in the intervention group decreased from 27.5% to 9.4%. There was a decrease in the high BRI category in the intervention group from 20.5% to 1.8%. In the control group, there was no decrease in the high BRI category (22.1%), on the contrary, there was a decrease in the low category from 34.4% to 3.7%. There was no decrease in HRI rates both of intervention or control groups. Conclusion: Dengue Fever vector control training could decrease the value of BRI and Maya Index, but does not affect the value of HRI. The absence of changes in HRI  indicate that environmental hygiene and sanitation are factors that influence the probability of dengue fever occurrence. Keywords: Dengue Hemorrhagic Fever, Maya Index, training, vector control

COMMUNITY KNOWLEDGE OF DENGUE FEVER IN ALLAMA IQBAL TOWN, LAHORE

2020 ◽  
pp. 52-58
Author(s):  
OJS Admin
Keyword(s):  
Public Health ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Health Problem ◽  
Public Health Problem ◽  
Hemorrhagic Fever ◽  
Community Knowledge

Globally, dengue is an emerging serious public health problem with a million infections occurring annually including significant number of dengue hemorrhagic fever cases.

scholarly journals Business Intelligence Development in Distributed Information Systems to Visualized Predicting and Give Recommendation for Handling Dengue Hemorrhagic Fever

2020 ◽  
Vol 6 (1) ◽  
pp. 55
Author(s):  
Radityo Prasetianto Wibowo ◽  
Wiwik Anggraeni ◽  
Tresnaning Arifiyah ◽  
Edwin Riksakomara ◽  
Febriliyan Samopa ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Business Intelligence ◽  
Success Factors ◽  
Hemorrhagic Fever ◽  
Distributed Information ◽  
Development Method ◽  
Fever Patient ◽  
Number Of Patients ◽  
Using Data

 Background: Indonesia has 150 dengue cases every month, and more than one person dies every day from 2017 to 2020. One of the factors of Dengue Hemorrhagic Fever (DHF) patients dying is due to the late handling of patients in hospitals or clinics. Health Office of Malang Regency recorded 1,114 cases of DHF that occurred during 2016, and the number of patients room available is limited. Therefore, Malang Regency is used as a case study in this research.Objective: This study aims to make a dashboard to display the predictions, visualize the distribution of DHF patients, and give mitigation recommendations for handling DHF patients in Malang Health Office.Methods: This study used the Business Intelligence (BI) Development method, which consists of two main phases, namely the making of Business Intelligence and the use of Business Intelligence. This research used the making of the BI phase, which consists of four stages, which are BI development strategies, identification and preparation of data sources, selecting BI tools, and designing and implementing BI. In the Extract, Load, and Transform process, this study used essential transformation and forecast.Results: BI method has succeeded in building the dashboard. The dashboard displays the visualization of Dengue Hemorrhagic Fever predicted results, detail of Dengue Fever Patient number, Dengue Fever patient trends per year and predictions 2 Monthly patient, and mitigation recommendation for each Community Health Office.Conclusion: We have built the BI Dashboard using the BI development method. It needs some treatment to get better performance. These are improving ETL performance using data virtualization technology, considering the use of cloud computing technology, conducting further evaluations by understanding the critical success factors to determine the level of success and weaknesses.

scholarly journals Cytokine Expression in Dengue Fever and Dengue Hemorrhagic Fever Patients with Bleeding and Severe Hepatitis

2020 ◽  
Vol 102 (5) ◽  
pp. 943-950 ◽  
Author(s):  
Hisham Ahmed Imad ◽  
Weerapong Phumratanaprapin ◽  
Benjaluck Phonrat ◽  
Kesinee Chotivanich ◽  
Prakaykaew Charunwatthana ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Cytokine Expression ◽  
Severe Hepatitis

scholarly journals A study on the outbreak of dengue fever in a tertiary care children’s hospital in southern Tamil Nadu, India

2019 ◽  
Vol 6 (3) ◽  
pp. 1194
Author(s):  
Belgin Premkumar ◽  
Baburaj S. ◽  
Margaret Hepzibah N. ◽  
Misha K. P. ◽  
Binu Abraham
Keyword(s):  
Dengue Fever ◽  
Tamil Nadu ◽  
Tertiary Care ◽  
Case Fatality ◽  
Dengue Shock Syndrome ◽  
Viral Disease ◽  
Severe Dengue ◽  
Care Hospital ◽  
Clinical Criteria ◽  
Public Health Challenge

Background: Dengue fever is the most rapidly spreading mosquito-borne viral disease in the world.Incidence has increased 230-fold with increasing geographic expansion with potential for further spread. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden. This study’s objective is to assess the outbreak of epidemic of dengue fever in a tertiary care children hospital and to describe their socio-demographic, clinical outcome and serological profile.Methods: It is an observational descriptive study conducted for a period of 1 year in less than 12 years old children in a tertiary care hospital at Southern Tamil Nadu.Results: Among the 360 children admitted with dengue fever, there were 198 boys (55%) and 162 (45%) were girls. Maximum incidence of dengue incidence was seen in infants less than 1 year (25%). The highest number of cases were admitted during September and October. The most common affected age group was less than 3 years with 179 (49%). Among the cases, 297 (82%) were of severe dengue which constitute dengue haemorrhagic fever-183(38%) and Dengue shock syndrome 114 (62%). Serological analysis showed NS1 Ag was positive in 144 children (40%), Dengue IgM was positive in 54 children (15%), both IgM and IgG positive in 126 children (35%) and IgG was positive in 36 children (10%). Out of the total children admitted with dengue fever, the case fatality was 0.5% (2 children).Conclusions: This study highlights the importance of WHO clinical criteria for early diagnosis of severe dengue. Moreover, the early and intensive management reduces the mortality significantly.

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