scholarly journals Annona muricata L. Suppresses Stannous Chloride Effects through Changing Hematological Parameters in Male New Zealand White Rabbits

2021 ◽  
pp. 251-262
Author(s):  
Marfoua. S. Ali ◽  
Fayrouz A. Khaled ◽  
Hajir Sh Saloumah
Keyword(s):  
Body Weight ◽  
New Zealand ◽  
Blood Cell ◽  
Cell Volume ◽  
Stannous Chloride ◽  
Hematological Parameters ◽  
Annona Muricata ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
New Zealand White Rabbits

Background: Annona muricata. L has a wide range of therapeutic characteristics and is frequently used in traditional medicine to treat a variety of ailments. Stannous chloride (SnCl2) are widely used in daily life and distributed in many tissues and nutrients. Although over-ingestion of SnCl2, can cause health problems, relatively little attention has been given to the toxic effects of this compound in livestock health and hematological parameters. This study was designed to study protective roles of A. muricata L. against SnCl2 effects through alleviating hematological disturbances in adult male New-Zealand white rabbits. Materials and Methods: Four rabbits per group were assigned to 1 of 4 treatment groups: 0 mg A. muricata and 0 mg SnCl2/kg BW (control); 100 mg of A. muricata /kg BW; 20 mg SnCl2/kg BW; 20 mg SnCl2 plus 100 mg of A. muricata /kg BW. Rabbits were orally administered the respective doses every other day for 10 weeks. Results: The obtained results showed that A. muricata alone caused increase in body weight, relative weight of liver, lung, heart and kidney. It also caused increase hemoglobin (Hb), packed cell volume (PCV) level and number of platelets (PLT) compared to control. However, treatment with A. muricata was caused significant decrease in white blood cell counts (WBCs) and non-significant decrease in red blood cell counts (RBCs), mean cell volume (MCV). Meanwhile, treatment with SnCl2 was lead to adverse effect on the body weight and relative organs weight practically spleen. It was caused significant increase in WBCs, MCV compared to control. The rest of hematological parameters (RBCs, PCV, PLT, Hb and MCHC) were significantly decreased, which indicated to cause anemia. Previous parameters were returned to normal values in group that treatment with A. muricata plus SnCl2. In term of bone marrow smear, all smears are similar in terms of numbers and types of cells. Conclusion: Results of the present study convincingly demonstrated that SnCl2 exposure resulted in varying degree of hematological parameters of rabbits. A. muricata has been promise as nutritional supplements to help prevent disorders involving SnCl2 induced these effects. Thus A. muricata may be helpful to combat SnCl2 associated sufferings in human as well as animal.

scholarly journals Evaluation of Angiopoietins 1 and 2 in Malaria-Infested Children

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
A. O. Oluboyo ◽  
S. I. Chukwu ◽  
B. O. Oluboyo ◽  
O. O. Odewusi
Keyword(s):  
Blood Cell ◽  
Severe Malaria ◽  
Uncomplicated Malaria ◽  
Malaria Infection ◽  
Hematological Parameters ◽  
Endothelial Activation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Control Serum

Background. Malaria could affect people of all ages, most especially young children. The study evaluated the levels of serum angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) which are critical regulators of endothelial activation and integrity with some hematological parameters (total white blood cell counts (WBC), total red blood cell counts (RBC), platelet counts, and malaria parasite density) in malaria-infected children. Method. A total of 92 blood samples from children between the ages of 6 months to 15 years were analyzed. The samples consisted of 30 cases of severe malaria, 40 cases of uncomplicated malaria, and 22 apparently healthy subjects served as control. Serum Ang-1 and -2 levels were determined using the enzyme-linked immunosorbent assay technique. The hematological parameters were determined using the WHO standard. Results. There was significant decrease (p<0.05) in serum Ang-1 of uncomplicated malaria and severe malaria compared with the control, while significant increase (p<0.05) was observed in Ang-2 and Ang-2/Ang-1 ratio in uncomplicated malaria and severe malaria compared with the control. RBC and platelet showed significant decrease, while WBC showed significant increase in severe malaria compared with uncomplicated malaria and control. Conclusion. This study showed that subjects with malaria infection had a significant increase of Ang-2 and Ang-2 : Ang-1 ratio but presented with a significant decrease of Ang-1. Ang-1 and Ang-2 may be used to determine the severity of malaria infection since their levels differ significantly in malaria subjects compared with the control.

scholarly journals Lymphocyte subsets as a predictor of severity and prognosis in COVID-19 patients

2021 ◽  
Vol 35 ◽  
pp. 205873842110485
Author(s):  
Peng Zhang ◽  
Wei Du ◽  
Ting Yang ◽  
Lei Zhao ◽  
Richeng Xiong ◽  
...  
Keyword(s):  
T Cells ◽  
Blood Cell ◽  
Lymphocyte Subsets ◽  
Cox Regression ◽  
Hematological Parameters ◽  
Characteristic Curve ◽  
Hospital Death ◽  
Cox Regression Analysis ◽  
Cell Counts ◽  
Blood Cell Counts

Background Coronavirus disease 2019 (COVID-19) had become a worldwide health threat. Early prediction of the severity of COVID-19 patients was important for reducing death rate and controlling this disease. Methods and materials A total of 301 patients confirmed with COVID-19 in Wuhan from 8 February to 10 April 2020 were included. Clinical data were collected and analyzed. Diagnostic and prognostic utility of blood cell counts and lymphocyte subsets in COVID-19 patients were investigated. The receiver operator characteristic curve (ROC) was used in discriminating the mild and severe/critical cases. Results There were difference in blood cell counts and lymphocyte subsets among mild, severe and critical patients, which were also influenced by comorbidities and duration of disease. The area under the ROC of lymphocyte, CD3+ T cells, CD4+ T cells, and CD8+ T cells were 0.718, 0.721, 0.718, and 0.670, which were higher than that of other hematological parameters. The optimal threshold was 1205, 691, 402, and 177 per μl, respectively. Patients with higher counts of lymphocyte, CD3+ T cells, CD4+ T cells, or CD8+ T cells were correlated with shorter length of stay in hospital ( p < 0.05). Multivariable Cox regression analysis showed disease severity, CD3+ T cells counts and time when the nucleic acid turned negative were independent risk factors for in-hospital death of COVID-19 patients ( p < 0.05). Conclusion Blood cell counts and lymphocyte subsets correlated with severity of COVID-19.

scholarly journals Effect of bioactive compounds extracted from euphorbious plants on hematological and biochemical parameters of Channa punctatus

2011 ◽  
Vol 53 (5) ◽  
pp. 259-263 ◽  
Author(s):  
Jaya Shahi ◽  
Ajay Singh
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Hematological Parameters ◽  
Channa Punctatus ◽  
Mean Corpuscular Hemoglobin ◽  
Hematological Indices ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Sublethal Concentrations

Channa punctatus was exposed to four different concentrations of Rutin, Taraxerol and Apigenin. Changes in some hematological parameters of Channa punctatus were assessed to determine the influence of these compounds on test fish. Fish were exposed to sublethal concentrations (80% of LC50 of 24h) of these compounds for one week. Control fish were also administered for one week. Thereafter, blood samples were obtained from the control and experimental fish. Blood was assayed for selected hematological parameters (hematocrit, hemoglobin, red blood cell count, white blood cell count total plasma protein and plasma glucose concentration). The derived hematological indices of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) were calculated. Sublethal concentrations of these compounds caused a dose dependent decrease in hemoglobin values coupled with a decrease in hematocrit values and red blood cell counts are an obvious indication of anemia. The total white blood cell counts and the differential white blood cell counts were decreased except for the lymphocytes, where there was a slight increase. Plasma protein and glucose were also lower in exposed fish when compared with control. The hematological indices MCH, MCHC, MCV were also lowered. The result from this study reveals high mortality rate and deleterious consequences on the health of fish subjected to acute exposure of Rutin, Taraxerol and Apigenin and therefore, should not be used directly in aquaculture without having the proper knowledge.

scholarly journals Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

2014 ◽  
Vol 83 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Sheng Jiang ◽  
Hong-Gang Fan ◽  
De-Zhang Lu ◽  
Jin-Long Hou ◽  
Xu-Dong Song ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Blood Cell ◽  
Cell Volume ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Packed Cell Volume ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Baseline Values

Oxidative stress in the body occurs when the production of free radicals overwhelms the antioxidant defence systems. The aim of this study was to examine the effects of a tiletamine/zolazepam-xylazine-tramadol combination on the antioxidant status, lipoperoxidase and blood cell indicators in eight miniature pigs. Baseline measures were recorded prior to anaesthesia, then the animals were anaesthetized with the combination of tiletamine/zolazepam (3.5 mg/kg), xylazine (1.32 mg/kg), and tramadol (1.8 mg/kg). Blood samples were collected from the anterior vena cava at 15, 30, 60, 90, 120 min, 24 h, and 72 h after anaesthesia. Plasma malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase concentrations were measured by colorimetry, and red blood cell counts, white blood cell counts, haemoglobin and packed cell volume were determined using an automated cell counter. The results showed that the concentration of malondialdehyde increased significantly at 30 and 60 min after the injection (P< 0.05), whereas glutathione peroxidase and catalase activity increased slightly (P> 0.05) then returned to baseline values after 90 min (P> 0.05). Superoxide dismutase activity increased significantly (P< 0.05) at 30 and 60 min, and then gradually decreased to baseline values after 90 min. Changes in red blood cell counts, haemoglobin and packed cell volume were not significant, while white blood cell count decreased significantly (P< 0.05) at 30 and 60 min. Our study is the first to demonstrate that tiletamine/zolazepam-xylazine-tramadol provide antioxidant effects, which may be proposed for alleviating the stress of examination and research at veterinary clinics or long-distance transportation.

PSII-16 Effects of Oligosaccharide-based Polymer on Blood Profiles in Weanling Pigs Experimentally Infected with a Pathogenic E. coli

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 167-168
Author(s):  
Kwangwook Kim ◽  
Yijie He ◽  
Cynthia Jinno ◽  
Seijoo Yang ◽  
Xunde Li ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Blood Cell Count ◽  
E Coli ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Blood Profiles

Abstract The objective of this experiment was to investigate dietary supplementation of oligosaccharide-based polymer on blood profiles of weaned pigs experimentally infected with a pathogenic F18 Escherichia coli (E. coli). Forty-eight pigs (7.23 ± 1.11 kg BW) were individually housed in disease containment rooms and randomly allotted to one of four treatments with 12 replicate pigs per treatment. The four dietary treatments were a nursery basal diet (control), and 3 additional diets supplemented with 50 mg/kg Mecadox (AGP), 10 or 20 mg/kg of oligosaccharide-based polymer. The experiment lasted 18 d [7 d before and 11 d after the first inoculation (d 0)]. The doses of F18 E. coli inoculum were 1010 cfu/3 mL oral dose daily for 3 days. Blood samples were collected before E. coli inoculation (d 0), and on d 2, 5, 8, and 11 post-inoculation (PI). Total and differential blood cell count were analyzed by CBC test. All data were analyzed by ANOVA using the PROC MIXED of SAS with pig as the experimental unit. Supplementation of oligosaccharide-based polymer linearly (P &lt; 0.05) reduced white blood cell counts, neutrophils, eosinophils, and basophils on d 2 PI, and neutrophils on d 5 PI, compared with the control. No differences were observed in total and differential white blood cell counts among AGP and two oligosaccharide-based polymer treatments except that pigs fed with AGP had greater (P &lt; 0.05) lymphocytes on d 2 PI compared with pigs fed with oligosaccharide-based polymer diets. Supplementation of low dose oligosaccharide-based polymer or AGP reduced (P &lt; 0.05) red blood cell count and packed cell volume on d 2 PI, whereas inclusion of high dose oligosaccharide-based polymer or AGP reduced (P &lt; 0.05) packed cell volume on d 5 PI, compared with the control. In conclusion, supplementation of oligosaccharide-based polymer may alleviate the systemic inflammation caused by F18 E. coli infection.

scholarly journals Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank

2019 ◽  
Vol 110 (2) ◽  
pp. 461-472 ◽  
Author(s):  
Tammy Y N Tong ◽  
Timothy J Key ◽  
Kezia Gaitskell ◽  
Timothy J Green ◽  
Wenji Guo ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Hematological Parameters ◽  
Diet Group ◽  
Uk Biobank ◽  
Platelet Counts ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
The Uk

ABSTRACTBackgroundThere may be differences in hematological parameters between meat-eaters and vegetarians.ObjectiveThe aim of this study was to perform cross-sectional analyses of hematological parameters by diet group in a large cohort in the United Kingdom.MethodsA complete blood count was carried out in all UK Biobank participants at recruitment (2006–2010). We examined hemoglobin, red and white blood cell counts, and platelet counts and volume in regular meat eaters (>3 times/wk of red/processed meat consumption, n = 212,831), low meat eaters (n = 213,092), poultry eaters (n = 4815), fish eaters (n = 10,042), vegetarians (n = 6548), and vegans (n = 398) of white ethnicity and meat eaters (n = 3875) and vegetarians (n = 1362) of British Indian ethnicity.ResultsIn both white and British Indian populations, compared with regular meat eaters (or meat eaters in Indians), the other diet groups had up to 3.7% lower age-adjusted hemoglobin concentrations (difference not significant in white vegan women) and were generally more likely to have anemia (e.g., 8.7% of regular meat eaters compared with 12.8% of vegetarians in white premenopausal women; P < 0.05 after Bonferroni correction). In the white population, compared with regular meat eaters, all other diet groups had lower age- and sex-adjusted total white cells, neutrophils, lymphocytes, monocytes, and eosinophils (P-heterogeneity < 0.001 for all), but basophil counts were similar across diet groups; in British Indians, there was no significant difference in any of the white blood cell counts by diet group. Compared with white regular meat eaters, the low meat eaters, poultry eaters, fish eaters, and vegans had significantly lower platelet counts and higher platelet volume, whereas vegetarians had higher counts and lower volume. Compared with British Indian meat eaters, vegetarians had higher platelet count and lower volume.ConclusionsIn the UK Biobank, people with low or no red meat intake generally had lower hemoglobin concentrations and were slightly more likely to be anemic. The lower white blood cell counts observed in low and non-meat eaters, and differences in mean platelet counts and volume between diet groups, warrant further investigation. This observational study was registered at http://www.isrctn.com/ as ISRCTN10125697.

scholarly journals Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Leonardo M. Bella ◽  
Isis Fieri ◽  
Fernando H. G. Tessaro ◽  
Eduardo L. Nolasco ◽  
Fernanda P. B. Nunes ◽  
...  
Keyword(s):  
Blood Cell ◽  
Hematological Parameters ◽  
Serum Levels ◽  
Diabetic Mice ◽  
Blood Cell Count ◽  
Hydroxyvitamin D ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
25 Hydroxyvitamin D ◽  
Cholecalciferol Supplementation

Background/Aims. The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood. Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice.Methods. Male diabetic (alloxan, 60 mg/kg i.v., 10 days) and nondiabetic mice were supplemented with cholecalciferol for seven days. The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues.Results. Relative to controls, cholecalciferol supplementation increased serum levels of 25-hydroxyvitamin D, calcium, hemoglobin, hematocrit, and red blood cell counts and decreased leukocyte cell counts of PeL and BAL fluids in diabetic mice. Diabetic mice that were not treated with cholecalciferol had lower serum calcium and albumin levels and hemoglobin, WBC, and mononuclear blood cell counts and higher serum creatinine and urea levels than controls.Conclusion. Our results suggest that cholecalciferol supplementation improves the hematological parameters and reduces leukocyte migration into the PeL and BAL lavage of diabetic mice.

scholarly journals HEMATOLOGICAL PARAMETERS AND TUMOR SIZE IN RECTAL CANCER

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
O. Andronic ◽  
Alexandra Bolocan ◽  
Georgiana Radu ◽  
D.N. Păduraru ◽  
D. Ion ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Biological Parameters ◽  
Mortality And Morbidity ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
High Incidence ◽  
The World ◽  
White Blood Cell Counts

Rectal cancer is a pathology that still has a high incidence, mortality and morbidity all around the world. As with other types of neoplasm, researchers all around the world are attempting to find statistically significant linkages between easy and inexpensive hematological parameters and the progression of this disease which is affecting approximately 1.8 million individuals. The present study aims to investigate whether biological parameters measured in rectal cancer patients change significantly with tumor growth. The results show a significant change in WBC (white blood cell counts) (p = 0.002).

Effect of coadministration of clozapine and fluvoxamine versus clozapine monotherapy on blood cell counts, plasma levels of cytokines and body weight

2000 ◽  
Vol 149 (2) ◽  
pp. 163-169 ◽  
Author(s):  
D. Hinze-Selch ◽  
M. Deuschle ◽  
B. Weber ◽  
I. Heuser ◽  
T. Pollmächer
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Plasma Levels ◽  
Cell Counts ◽  
Blood Cell Counts
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