scholarly journals Synthesis, Characterization and Evaluation of Anti-tubercular Activity of Ofloxacin Chalcone Conjugates

2021 ◽  
pp. 22-30
Author(s):  
Ramakrishna Chintakunta ◽  
Venkata Subbareddy Gopireddy
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Melting Point ◽  
Antitubercular Activity ◽  
Deionized Water ◽  
Synthesis And Characterization ◽  
Spectroscopic Methods ◽  
Compound A ◽  
Chalcone Derivatives ◽  
Ft Ir

Synthesis and characterization of Ofloxacin Chalcone derivatives were carried out and evaluated for their antitubercular activity. Synthesized Ofloxacin Chalcone derivatives (Compound A to F). These molecules are characterized by analytical methods (TLC), melting point, and Spectroscopic methods (FT-IR, Mass, NMR). The evaluated antitubercular activity of molecules of synthesized compounds and Ciprofloxacin Pyrazinamide, and Streptomycin as standard drugs. concentrations of synthesized derivatives were prepared (0.8, 1.6, 3.12, 6.25, 12.5, 25, 50, 100 µg/ml) by using sterile deionized water as a solvent. Antitubercular Assay was Performed by Mycobacterium tuberculosis using the MABA method. Analyzed MIC values. Compound E showed the best results among 6 Compounds at a very low concentration at 3.12 µg/ml.

scholarly journals Synthesis and characterization of novel mono, bis and tris heteroaryl chalcone derivatives of 1,3,5-trimethoxybenzene

2021 ◽  
Vol 14 (1) ◽  
pp. 39-47
Author(s):  
M. Fatih Polat ◽  
Derya Aktaş Anı
Keyword(s):  
Elemental Analysis ◽  
High Purity ◽  
Synthesis And Characterization ◽  
Spectroscopic Techniques ◽  
Reaction Conditions ◽  
Chalcone Derivatives ◽  
Ft Ir ◽  
Derivatives Of

In this study, a new series consisting of 12 heteroaryl chalcone derivatives of 1,3,5-trimethoxybenzene were synthesised. Chalcones were synthesised in high purity and efficiency, via condensation of mono, bis and tris 2,4,6-trimethoxy acetophenones with hetero-2-carbaldehyde derivatives based on Claisen Schdmit condensation. The reactions feature a good scope for the all products, mild reaction conditions and good yields. The synthesized compounds were characterized by using FT-IR, NMR and elemental analysis spectroscopic techniques.

scholarly journals Synthesis and Characterization of 2,3-Diaminomaleonitrile Derivatives by One-Pot Schiff Base Reaction and Their Application in Dye Synthesized Solar Cells

2020 ◽  
Author(s):  
Saifaldeen Muwafag Abdalhadi ◽  
Asmaa Yahya Al-Baitai ◽  
Hazim Abdulrazzaq Al-Zubaidi
Keyword(s):  
Schiff Base ◽  
Solar Cells ◽  
Melting Point ◽  
Computational Study ◽  
Control Cell ◽  
Synthesis And Characterization ◽  
One Pot ◽  
Vis Spectroscopy ◽  
Ft Ir

In a one-pot reaction, three new 2,3-diaminomaleonitrile (DAMN) derivative dyes were prepared by simple Schiff base reaction. The compounds were designed as a sensitizer in dye synthesizes solar cells (DSSCs). Many conditions have been used to provide the methodology to get the best yield. The prepared dyes were characterized by melting point, elemental microanalysis, mass spectroscopy, FT-IR, 1H-NMR, and UV-Vis spectroscopy. A computational study was carried out to support our results. The DSSC data was shown the best performance for SA3 dye with 0.38% efficiency at AM 1.5 then SA2 with 0.22% and the last dye is SA1 with 0.09%, compared to control cell (N719) 5.4%.

Synthesis and Characterization of Biphenylnate Liquid Crystalline Polyurethanes

2010 ◽  
Vol 428-429 ◽  
pp. 158-161 ◽  
Author(s):  
Jian Feng Ban ◽  
Shao Rong Lu ◽  
Chen Xi Zhang
Keyword(s):  
Transition Temperature ◽  
Melting Point ◽  
Diethylene Glycol ◽  
Liquid Crystalline ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
Flexible Chain ◽  
Ft Ir ◽  
Thermotropic Properties

A series of novel biphenylnate liquid crystalline polyurethanes (BLCPs) were synthesized by polyaddition reaction of 4,4’-dihydroxybiphenyl with 2,4-TDI(2,4-toluenediisocyanate) and diethylene glycol through changing the molar ratio of diphenol and diol. The thermotropic properties, the melting point (Tm) and the isotropization temperature (Ti) of the synthesized polyurethanes were characterized by FT-IR, DSC, POM and WXRD. The results of experiments showed that all of the polyurethane polymers exhibited thermotropic liquid crystalline properties between 130°C and 230°C. The transition temperature (Tm and Ti) decreased with an increase in the length of the flexible chain.

scholarly journals Preparation and Characterization of Cu (II), Mn(II) and Zn(II)complexes with new sulfamethoxazole Compounds

2017 ◽  
Vol 14 (3) ◽  
pp. 575-581
Author(s):  
Baghdad Science Journal
Keyword(s):  
Magnetic Susceptibility ◽  
Melting Point ◽  
Metal Complexes ◽  
Atomic Absorption ◽  
Spectroscopic Methods ◽  
Aqueous Alcohol ◽  
Spectroscopic Techniques ◽  
Ft Ir ◽  
Ir Spectroscopic

Acetophenone sulfamethoxazole and 3-Nitrobenzophenone sulfamethoxazole were prepared from the reaction of sulfamethoxazole with two ketones. The prepared ligands were identified by (C.H.N) analysis and UV-VIS, FT-IR spectroscopic techniques. Metal complexes of the two ligands were prepared in an aqueous alcohol with Zn (II), Mn (II) and Cu (II) ions with a molar ratio1:1. The proposed general formula for the resulting complexes was [ML.CL2.H2O]H2O .The complexes were characterized by (C.H.N) technique , spectroscopic methods ,conductivity, atomic absorption ,magnetic susceptibility measurements and melting point. According to the results obtained, the suggested geometry is to be octahedral for all the complexes.

Synthesis and Characterization of Heterocyclic Compounds Derived from Schiff base Glycerol Triester

2021 ◽  
Vol 19 (9) ◽  
pp. 88-96
Author(s):  
Marwa Abdulameer Mseer ◽  
Khudheyer Jawad ◽  
Yahya Al-Khafaji
Keyword(s):  
Schiff Bases ◽  
Heterocyclic Compounds ◽  
Benzoyl Chloride ◽  
Synthesis And Characterization ◽  
Second Step ◽  
Compound A ◽  
The Third ◽  
Aminobenzoic Acids ◽  
Ft Ir

Heterocyclic compounds were prepared from Schiff bases triester derivatives, the first step was included, p- aminobenzoic acids convert to p-amino benzoyl chloride in the presence of thionyl chloride then glycerol was added to form triesters compound A. second step reaction of triester product with the 4-nitrobenzaldehyde, and 3-amino benzaldehyde to produce M1, and M2. The third step. Involve reacted Schiff bases triester derivatives to give heterocyclic compounds M1S, M1A, M2P, and M2K. The structure of all compounds is monitored by (TLC), and identified by many techniques 1HNMR, FT-IR, and melting point.

scholarly journals Synthesis and characterization of some biological active transition metal complexes of Schiff base derived from cefixime with mixed ligand 8-hydroxy quinoline

2015 ◽  
Vol 12 (4) ◽  
pp. 797-807
Author(s):  
Baghdad Science Journal
Keyword(s):  
Melting Point ◽  
Metal Ion ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Hydroxy Quinoline

The aim of the work is synthesis and characterization of bidentate ligand [dipotassium sodium7-((E)-2-(2-((Z)-1-carboxylatoethylideneamino)thiazol-4-yl)-2 (carboxylatemethoxyimino) acet amido)-8-oxo-3-vinyl-5- thia-1-azabicyclo[4.2.0] oct-2- ene-2- carboxylate] [Nak2L], from the reaction of cefixime with sodium pyruvet to produce the ligand [Nak2L], the reaction was carried out in methanol as a solvent under reflux. The prepared ligand [Nak2L] which was characterized by FT-IR, UV-Vis spectroscopy, 1H, 13C-NMR spectra, Mass spectra, (C.H.N) and melting point. The mixed ligand complexes were prepared from ligand [Nak2L] was used as a primary ligand while 8-hydroxy quinoline [Q] was used as a secondary ligand with metal ion M(?).Where M(?) = (Mn ,Co ,Ni ,Cu ,Zn and Cd) at reflux ,using methanol as a solvent, KOH as a base. Complexes of the composition [(M)2(Q)2(KL)(H2O)4] with (2:2:1) molar ratio were prepared. All the complexes were characterized by spectroscopic methods (FT-IR, UV-Vis spectroscopy) along with elemental analysis (A.A), chloride content and melting point measurements were carried out, together with conductivity and magnetic susceptibility. These measurements showed octahedral geometry around (Mn??, Co??, Ni??, Cu??, Zn?? and Cd??) ions. The biological activity of the ligands [NaK2L], [Q] and complexes [(M)2(Q)2(KL)(H2O)4] were studied by using inhibition method.

Chemical Synthesis and Characterization of Conducting Poly(2-Aminothiazole)

2016 ◽  
Vol 867 ◽  
pp. 111-115 ◽  
Author(s):  
Peng Fei Lv ◽  
Xia Wang ◽  
Hua Zou
Keyword(s):  
Copper Chloride ◽  
Chemical Oxidation ◽  
Deionized Water ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
Polymerization Temperature ◽  
Oxidation Method ◽  
Ft Ir ◽  
Scanning Electron

In this work, poly(2-aminothiazole) (P2AT) was synthesized by chemical oxidation method using 2-aminothiazole as the monomer. The polymerization was initiated using three different oxidants, CuCl2, FeCl3 and (NH4)2S2O8. The results suggested that the monomer was easily polymerized and higher yields were achieved when CuCl2 was used as the oxidant. The effects of reaction time and polymerization temperature on the yield of polymerization using CuCl2 were investigated. The polymerization yield of the P2ATs was 25.2 % at oxidant/monomer molar ratio of 0.1 for 24 h in the copper chloride /deionized water. The P2ATs were characterized by FT-IR, UV-vis, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM).

scholarly journals Synthesis and Characterization of New Polyimide Contain Heterocyclic

2013 ◽  
Vol 10 (4) ◽  
pp. 1203-1210
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nucleophilic Substitution ◽  
Hydrazine Hydrate ◽  
Carbon Disulfide ◽  
13C Nmr ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Spectroscopic Methods ◽  
Synthetic Route ◽  
Ft Ir

Novel heterocyclic polyimide 5(a,b) have been synthesized based on polyacrylic backbone. The synthetic route start with nucleophilic substitution of 2-amino, or 4-amino, pyridine 1(a,b) to the polyacryloyl chloride afforded poly substituted amide 2(a,b). Another nucleophilic substitution were carried with adipoyl chloride to form polyimide chloride 3(a,b). Treatment of 3(a,b) with hydrazine hydrate afforded acid hydrazide polyimide 4(a,b), which upon cyclocondensation with carbon disulfide gave the target heterocyclic polyimide. The synthesized compounds were identified by spectroscopic methods: FT-IR, 1H-NMR and 13C-NMR.

scholarly journals Synthesis and Characterization of Some New Tropylidene Derivatives and Studying their Biological Activities

2021 ◽  
pp. 3307-3322
Author(s):  
Muath Jabbar Tarfa Al-Abbasee ◽  
Ahmood khalaf Jebur ◽  
Afraa Sabir Shihab
Keyword(s):  
Melting Point ◽  
Biological Activities ◽  
Chemical Properties ◽  
Synthesis And Characterization ◽  
Antibacterial And Antifungal Activities ◽  
Ft Ir ◽  
Antibacterial And Antifungal ◽  
And Chemical Properties

    Some new tropylidene derivatives were prepared in this work and their in vitro antibacterial and antifungal activities were studied. All the prepared compounds were characterized by their physical properties, such as melting point and color, and chemical properties, using the techniques of FT-IR, 1H-NMR and 13C-NMR.

Electrospun PU/MgO/Ag Nanofibers for Antibacterial Activity and Flame Retardency

2021 ◽  
pp. 0887302X2110094
Author(s):  
V. Mamtha ◽  
H. N. Narasimha Murthy ◽  
V. Pujith Raj ◽  
Prashantha Tejas ◽  
C. S. Puneet ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Melting Point ◽  
Protective Clothing ◽  
Electrospun Nanofibers ◽  
Synthesis And Characterization ◽  
Zone Of Inhibition ◽  
Solution Combustion ◽  
E Coli ◽  
Afterglow Time

Antibacterial activity and fire retardation are equally desired for protective clothing. For achieving this, AgNP and MgO are independently researched as nanofillers in Polyurethane based electrospun nanofibers and their synergistic effect is scarcely addressed. This article reports synthesis and characterization of MgO of 70.01 nm and AgNP of 51 to 76 nm by solution combustion and hydrothermal routes respectively and their incorporation in electrospinning of Polyurethane. Flow rate 1 ml/hr, applied voltage 13 kV, tip to collector distance 15 cm were adopted for the electrospinning. Nanofibers of 65 nm were obtained for PU/MgO (3 wt. %) and 106 nm for PU/MgO (3 wt. %)/Ag (1 wt. %). Addition of MgO increased the melting point, after flame time and afterglow time. Incorporation of AgNP improved antibacterial activity. PU/MgO/Ag (2 wt. %) exhibited zone of inhibition of 2.1 cm and 3 cm against E. Coli and S. Aureus, respectively.

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