scholarly journals Estimation of Alanine Transaminase (ALT), Alkaline Phosphate (ALP) and Aspartate (AST) Irrespective of Dietary Supplementation, Body Mass Index and Nature of Exercise

2021 ◽  
pp. 33-44
Author(s):  
Alamgir Khan ◽  
Muhammad Zafar Iqbal Butt ◽  
Abdul Manan ◽  
Ejaz Asghar ◽  
Muhammad Jamil ◽  
...  
Keyword(s):  
High Intensity ◽  
Liver Enzymes ◽  
Dietary Supplementation ◽  
Exercise Group ◽  
Alanine Transaminase ◽  
High Intensity Exercise ◽  
P Value ◽  
Low Intensity ◽  
Alkaline Phosphate ◽  
Low Intensity Exercise

Purpose: This research study was conducted for the assessment of liver enzymes i.e. Alanine Transaminase (ALT), Alkaline Phosphate (ALP) and Aspartate (AST) irrespective of dietary supplementation, body mass index and nature of the exercise. Methods: A randomized control trails were taken and thus Sixty (60) subjects ageing 20 to 30 years, (Twenty (20) from low-intensity exercise (EXG-II), Twenty (20) from high-intensity exercise (EXG-III) and Twenty (20) subjects as a control group (CG-III) were included in the study by using International Physical Activity Scale (IPAQ).5ml blood samples were collected from the subjects for the determination of liver functions and blood redox status. Each blood sample was marked with a separate identification mark. After the collection of blood samples, three particular liver enzymes tests i.e. ALT, ALP and AST were performed. The results of the samples test proceeded through the Statistical Package for Social Science (SPSS) Version 23. Results: The P-Value of the low-intensity exercise group (EXG-II) in term of ALT was less than the high-intensity exercise group ( EXG-III) ( p >.05), The P-Value of the low-intensity exercise group (EXG-II) in term of ALP was less than the high-intensity exercise group ( EXG-III) ( p >.05). The P-Value of low-intensity exercise group (EXG-II) in term of AST was less than high-intensity exercise group (EXG-III) (p >.05). Conclusion: Based on findings, it was concluded that low-intensity exercise with dietary supplementation positively affects the functions of the liver i.e. Alanine Transaminase (ALT), Alkaline Phosphate (ALP) and Aspartate (AST) as compared to high-intensity exercise. Similarly high-intensity exercise with dietary supplementation also positively influence as compared to performers of high-intensity exercise without dietary supplementation.

Phenylephrine decreases frontal lobe oxygenation at rest but not during moderately intense exercise

2010 ◽  
Vol 108 (6) ◽  
pp. 1472-1478 ◽  
Author(s):  
Patrice Brassard ◽  
Thomas Seifert ◽  
Mads Wissenberg ◽  
Peter M. Jensen ◽  
Christian K. Hansen ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
High Intensity ◽  
Sympathetic Activity ◽  
Near Infrared ◽  
Cerebral Metabolism ◽  
High Intensity Exercise ◽  
Mean Flow ◽  
Intense Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise

Whether sympathetic activity influences cerebral blood flow (CBF) and oxygenation remains controversial. The influence of sympathetic activity on CBF and oxygenation was evaluated by the effect of phenylephrine on middle cerebral artery (MCA) mean flow velocity ( Vmean) and the near-infrared spectroscopy-derived frontal lobe oxygenation (ScO2) at rest and during exercise. At rest, nine healthy male subjects received bolus injections of phenylephrine (0.1, 0.25, and 0.4 mg), and changes in mean arterial pressure (MAP), MCA Vmean, internal jugular venous O2 saturation (SjvO2), ScO2, and arterial Pco2 (PaCO2) were measured and the cerebral metabolic rate for O2 (CMRO2) was calculated. In randomized order, a bolus of saline or 0.3 mg of phenylephrine was then injected during semisupine cycling, eliciting a low (∼110 beats/min) or a high (∼150 beats/min) heart rate. At rest, MAP and MCA Vmean increased ∼20% ( P < 0.001) and ∼10% ( P < 0.001 for 0.25 mg of phenylephrine and P < 0.05 for 0.4 mg of phenylephrine), respectively. ScO2 then decreased ∼7% ( P < 0.001). Phenylephrine had no effect on SjvO2, PaCO2, or CMRO2. MAP increased after the administration of phenylephrine during low-intensity exercise (∼15%), but this was attenuated (∼10%) during high-intensity exercise ( P < 0.001). The reduction in ScO2 after administration of phenylephrine was attenuated during low-intensity exercise (−5%, P < 0.001) and abolished during high-intensity exercise (−3%, P = not significant), where PaCO2 decreased 7% ( P < 0.05) and CMRO2 increased 17% ( P < 0.05). These results suggest that the administration of phenylephrine reduced ScO2 but that the increased cerebral metabolism needed for moderately intense exercise eliminated that effect.

scholarly journals Psychological distress and its associated risk factors among university students

2020 ◽  
Vol 66 (4) ◽  
pp. 414-418
Author(s):  
Tingting Li ◽  
Xu Zhang ◽  
Mingming Chen ◽  
Rui Wang ◽  
Lianping He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psychological Distress ◽  
University Students ◽  
High Intensity ◽  
Education Level ◽  
High Intensity Exercise ◽  
Low Intensity ◽  
Significant Difference ◽  
Associated Risk Factors ◽  
Low Intensity Exercise

SUMMARY OBJECTIVE Psychological distress is an important mental health problem among university students. The goal of this study was to determine psychological distress and its associated risk factors among students in the Anhui province. METHODS A cross-sectional study was conducted in a sample of 1304 students. In this study, a self-administered questionnaire consisting of the general demography and General Health Questionnaire (GHQ-12) was completed. Psychological distress was assessed using the GHQ-12-item questionnaire. A dichotomous category split was imposed on the GHQ-12 for the purpose of analysis. A GHQ-12 score of 4 or higher indicated psychological distress. The data were analyzed by SPSS 20.0 system. RESULTS A total of 1304 samples were analyzed in this study. The results indicated that the education level of the father and mother was associated with the students’ psychological distress (P<0.001). A significant association was found between high-intensity exercise and low-intensity exercise and psychological distress. However, no significant difference was identified between gender and psychological distress (P=0.173). CONCLUSION The education level of parents, high-intensity exercise, and low-intensity exercise were associated with psychological distress. Our results suggest that it is indispensable to raise awareness of psychological disorders and its associated risk factors among university students. Further studies are required to develop appropriate interventions for high-risk groups.

scholarly journals Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

2018 ◽  
Vol 315 (5) ◽  
pp. E1034-E1045 ◽  
Author(s):  
Kristoffer Svensson ◽  
Jessica R. Dent ◽  
Shahriar Tahvilian ◽  
Vitor F. Martins ◽  
Abha Sathe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Exercise Performance ◽  
Pyruvate Dehydrogenase ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise ◽  
Muscle Contractile

The pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA and is an important control point for carbohydrate (CHO) oxidation. However, the importance of the PDC and CHO oxidation to muscle metabolism and exercise performance, particularly during prolonged or high-intensity exercise, has not been fully defined especially in mature skeletal muscle. To this end, we determined whether skeletal muscle-specific loss of pyruvate dehydrogenase alpha 1 ( Pdha1), which is a critical subunit of the PDC, impacts resting energy metabolism, exercise performance, or metabolic adaptation to high-fat diet (HFD) feeding. For this, we generated a tamoxifen (TMX)-inducible Pdha1 knockout (PDHmKO) mouse, in which PDC activity is temporally and specifically ablated in adult skeletal muscle. We assessed energy expenditure, ex vivo muscle contractile performance, and endurance exercise capacity in PDHmKO mice and wild-type (WT) littermates. Additionally, we studied glucose homeostasis and insulin sensitivity in muscle after 12 wk of HFD feeding. TMX administration largely ablated PDHα in skeletal muscle of adult PDHmKO mice but did not impact energy expenditure, muscle contractile function, or low-intensity exercise performance. Additionally, there were no differences in muscle insulin sensitivity or body composition in PDHmKO mice fed a control or HFD, as compared with WT mice. However, exercise capacity during high-intensity exercise was severely impaired in PDHmKO mice, in parallel with a large increase in plasma lactate concentration. In conclusion, although skeletal muscle PDC is not a major contributor to resting energy expenditure or long-duration, low-intensity exercise performance, it is necessary for optimal performance during high-intensity exercise.

scholarly journals High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

2014 ◽  
Vol 233 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Yoshifumi Tsuchiya ◽  
Daisuke Ando ◽  
Kazushige Goto ◽  
Masataka Kiuchi ◽  
Mitsuya Yamakita ◽  
...  
Keyword(s):  
Energy Consumption ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise

Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats

1997 ◽  
Vol 273 (6) ◽  
pp. H2627-H2631 ◽  
Author(s):  
Acácio Salvador Véras-Silva ◽  
Katt Coelho Mattos ◽  
Nilo Sérgio Gava ◽  
Patricia Chakur Brum ◽  
Carlos Eduardo Negrão ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiac Output ◽  
Exercise Training ◽  
High Intensity ◽  
Peripheral Resistance ◽  
High Intensity Exercise ◽  
Spontaneously Hypertensive ◽  
Low Intensity ◽  
Low Intensity Exercise

The decrease in cardiac sympathetic tone and heart rate after low-intensity exercise training may have hemodynamic consequences in spontaneously hypertensive rats (SHR). The effects of exercise training of low and high intensity on resting blood pressure, cardiac output, and total peripheral resistance were studied in sedentary ( n = 17), low- ( n = 17), and high-intensity exercise-trained ( n = 17) SHR. Exercise training was performed on a treadmill for 60 min, 5 times per week for 18 weeks, at 55% or 85% maximum oxygen uptake. Blood pressure was evaluated by a cannula inserted into the carotid artery, and cardiac output was evaluated by a microprobe placed around the ascending aorta. Low-intensity exercise-trained rats had a significantly lower mean blood pressure than sedentary and high-intensity exercise-trained rats (160 ± 4 vs. 175 ± 3 and 173 ± 2 mmHg, respectively). Cardiac index (20 ± 1 vs. 24 ± 1 and 24 ± 1 ml ⋅ min−1 ⋅ 100 g−1, respectively) and heart rate (332 ± 6 vs. 372 ± 14 and 345 ± 9 beats/min, respectively) were significantly lower in low-intensity exercise-trained rats than in sedentary and high-intensity exercise-trained rats. No significant difference was observed in stroke volume index and total peripheral resistance index in all groups studied. In conclusion, low-intensity, but not high-intensity, exercise training decreases heart rate and cardiac output and, consequently, attenuates hypertension in SHR.

scholarly journals The effect of exercise intensity and excess postexercise oxygen consumption on postprandial blood lipids in physically inactive men

2017 ◽  
Vol 42 (9) ◽  
pp. 986-993 ◽  
Author(s):  
Laurel A. Littlefield ◽  
Zacharias Papadakis ◽  
Katie M. Rogers ◽  
José Moncada-Jiménez ◽  
J. Kyle Taylor ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Energy Expenditure ◽  
Oxygen Uptake ◽  
Test Meal ◽  
High Intensity ◽  
Postprandial Lipemia ◽  
High Intensity Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise ◽  
Excess Postexercise Oxygen Consumption

Reductions in postprandial lipemia have been observed following aerobic exercise of sufficient energy expenditure. Increased excess postexercise oxygen consumption (EPOC) has been documented when comparing high- versus low-intensity exercise. The contribution of EPOC energy expenditure to alterations in postprandial lipemia has not been determined. The purpose of this study was to evaluate the effects of low- and high-intensity exercise on postprandial lipemia in healthy, sedentary, overweight and obese men (age, 43 ± 10 years; peak oxygen consumption, 31.1 ± 7.5 mL·kg−1·min−1; body mass index, 31.8 ± 4.5 kg/m2) and to determine the contribution of EPOC to reductions in postprandial lipemia. Participants completed 4 conditions: nonexercise control, low-intensity exercise at 40%–50% oxygen uptake reserve (LI), high-intensity exercise at 70%–80% oxygen uptake reserve (HI), and HI plus EPOC re-feeding (HI+EERM), where the difference in EPOC energy expenditure between LI and HI was re-fed in the form of a sports nutrition bar (Premier Nutrition Corp., Emeryville, Calif., USA). Two hours following exercise participants ingested a high-fat (1010 kcals, 99 g sat fat) test meal. Blood samples were obtained before exercise, before the test meal, and at 2, 4, and 6 h postprandially. Triglyceride incremental area under the curve was significantly reduced following LI, HI, and HI+EERM when compared with nonexercise control (p < 0.05) with no differences between the exercise conditions (p > 0.05). In conclusions, prior LI and HI exercise equally attenuated postprandial triglyceride responses to the test meal. The extra energy expended during EPOC does not contribute significantly to exercise energy expenditure or to reductions in postprandial lipemia in overweight men.

scholarly journals Exercise Intensities as Factors of Metabolic Outcomes in Type 2 Diabetes: A Systematic Review

2018 ◽  
Vol 31 (3) ◽  
pp. 193-203
Author(s):  
Elizabeth Moxley ◽  
Tory Bugaieski
Keyword(s):  
Type 2 Diabetes ◽  
High Intensity ◽  
Fasting Glucose ◽  
High Intensity Exercise ◽  
Systemic Review ◽  
Moderate Intensity ◽  
Low Intensity ◽  
Metabolic Outcomes ◽  
Low Intensity Exercise

Exercise is effective to prevent and treat type 2 diabetes, although currently underutilized. This review analyzes the metabolic response to exercise performance at various intensities in individuals with type 2 diabetes. These findings provide insight into the development of safe and efficacious exercise prescriptions and education. We conducted a systemic review of the literature to examine the association of various exercise protocols with metabolic outcomes in type 2 diabetes. Between 1984 and 2018, 29 studies were categorized per exercise mode and intensity levels according to the American College of Sports Medicine standards. The most consistent improvement was found in HbA1c following moderate- to high-intensity exercise—post-exercise fasting glucose improved to a lesser extent. Low-intensity exercise improved HOMA-IR (homeostasis model assessment for insulin resistance) levels. Glucose and HbA1c improved most following interval compared with continuous exercise, irrespective of intensity. A comparison of high-intensity exercise with moderate-intensity exercise demonstrated few differences in HbA1c, fasting glucose, fasting insulin, and HOMA-IR. Irrespective of exercise intensity, HbA1c improvements were observed, suggesting a delayed progression to diabetes-related complications. Initial low-intensity exercise, with increased quantities when feasible, will contribute to metabolic improvements. The variability in methodology and measurement contributed to inconsistent outcomes; additional research with larger samples sizes is warranted.

scholarly journals Acute effects of exercise on energy intake and feeding behaviour

1997 ◽  
Vol 77 (4) ◽  
pp. 511-521 ◽  
Author(s):  
Pascal Imbeault ◽  
Sylvie Saint-Pierre ◽  
Natalie AlméRas ◽  
Angelo Tremblay
Keyword(s):  
Total Energy ◽  
Energy Intake ◽  
High Intensity ◽  
Negative Energy ◽  
High Intensity Exercise ◽  
Acute Effects ◽  
Short Term ◽  
Post Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise

The main objective of the present study was to evaluate the short-term effects of exercise of different intensities on energy intake. Eleven young men were submitted to three randomly assigned sessions (one control and two exercise sessions) in which they ate, ad libitum, foods from a buffet-type meal. The energy cost of exercise was the same in the two exercise sessions. Results showed that there was no significant change in post-exercise subjective levels of hunger and fullness as well as total energy and macronutrient intakes in comparison with the control session. However, when energy intake relative to expenditure was considered by subtracting the surplus of energy expended during exercise from total energy intake, high-intensity exercise exerted a greater reducing effect on this variable compared with the control and low-intensity exercise sessions. These results suggest that for a given level of energy expenditure, high-intensity exercise favours negative energy balance to a greater extent than low-intensity exercise.

Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.

1997 ◽  
Vol 273 (3) ◽  
pp. E536 ◽  
Author(s):  
O M Buxton ◽  
S A Frank ◽  
M L'Hermite-Balériaux ◽  
R Leproult ◽  
F W Turek ◽  
...  
Keyword(s):  
Physical Activity ◽  
Circadian Rhythms ◽  
High Intensity ◽  
Real Life ◽  
Phase Shifts ◽  
High Intensity Exercise ◽  
Moderate Intensity ◽  
Low Intensity ◽  
Human Circadian Rhythms ◽  
Low Intensity Exercise

To determine the roles of intensity and duration of nocturnal physical activity in causing rapid phase shifts of human circadian rhythms, eight healthy men were studied three times under constant conditions with no exercise, a 3-h bout of moderate-intensity exercise, or a 1-h bout of high-intensity exercise. Exercise stimulus was centered at 0100. Circadian phase was estimated from the onsets of the nocturnal elevation of plasma thyrotropin (TSH) and melatonin. Mean phase shifts of TSH onsets were -18 +/- 8 (baseline), -78 +/- 10 (low-intensity exercise, P < 0.01), and -95 +/- 19 min (high-intensity exercise, P < 0.01). Mean phase delays of melatonin onsets were -23 +/- 10 (baseline), -63 +/- 8 (low-intensity exercise, P < 0.04), and -55 +/- 15 min (high-intensity exercise, P < 0.12). Taken together with our previous findings, this study indicates that nocturnal physical activity may phase delay human circadian rhythms and demonstrates that phase-shifting effects may be determined with exercise durations and intensities compatible with the demands of a real-life setting.

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