scholarly journals A Rare Case Report on Therapeutic Management of Wilm’s Tumour

2021 ◽  
pp. 115-118
Author(s):  
Priya Rewatkar ◽  
Manoj Patil
Keyword(s):  
Physical Examination ◽  
Wilms Tumor ◽  
Signs And Symptoms ◽  
Female Child ◽  
The United States ◽  
The Body ◽  
Therapeutic Interventions ◽  
Timely Initiation ◽  
Wilm's Tumor ◽  
Wilm’S Tumor

Introduction: Wilms's tumour was named after Carl Max Wilhelm Wilms, a 19th century German surgeon. Wilm’s tumor is derived from primitive metanephric blastema and is a form of childhood carcinoma that begins in the kidneys (also called nephroblastoma). In infants, it is the most common form of kidney carcinoma. 9 out of 10 kidney cancers in kids is Wilms Tumor. Carcinoma can spread to other parts of the body. The incidence is around seven new cases per million children in the United States, with a peak incidence between the ages of 2 and 3 years. Main symptoms and important clinical findings: A 11 yrs. old female child was admitted in Acharya Vinoba Bhave Rural Hospital, Wardha on 08/02/2021 with chief complaint of breathing difficulty, shortness of breath, blood in the urine, nausea and vomiting. After physical examination and investigations, doctors diagnosed it as a case of Wilm’s tumor. The main diagnoses, therapeutic interventions and outcomes: After physical examination and investigations like MRI, doctor diagnosed it as a case Wilm’s tumour. Tab. Actinomycin D (Dactinomycin), tab. Vincristine (chemotherapy) were started and calcium and multivitamin supplements were given for 7 days to enhance immune function. Tab. Septran 160 mg OD and tab. Acenet 400 mg OD, tab. Bactrim 5mg OD was also prescribed. Patient took all treatment and outcome was good. Her signs and symptoms improved. Conclusion: Accurate diagnosis and timely initiation of treatment speeded up recovery.

scholarly journals 1067 Neoplasia in Association with a Congenital Anomaly: Wilms Tumor in a Horseshoe Kidney

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
M Mubarak ◽  
O Alhamdan ◽  
H Alaradi ◽  
S Alhindi
Keyword(s):  
Ct Scan ◽  
Congenital Anomalies ◽  
Wilms Tumor ◽  
Horseshoe Kidney ◽  
Histopathological Analysis ◽  
Multiple Congenital Anomalies ◽  
Wagr Syndrome ◽  
Wilm's Tumor ◽  
Wilm’S Tumor

Abstract Introduction Horseshoe malformation is the most common form of fusion defects involving the kidney, whereas Wilm's tumor is the most common primary malignant renal tumor in children. The co-incidence of these two pathologies gives off an incidence rate of 0.48%. Case Report This is a case of a two-year-old female who presented early in life with multiple congenital anomalies including congenital heart disease, bilateral aniridia, persistent thrombocytopenia, and sickle cell trait in association with a painless abdominal mass. A CT scan showed a horseshoe kidney. The patient was lost for follow up until the age of two years, in which another CT scan revealed a left lower pole focal cystic mass measuring 5.1x5.3x6.3cm. WAGR syndrome was suspected and confirmed through genetic testing. A multidisciplinary approach was necessary to manage her efficiently due to the numerous co-existing congenital pathologies. The patient underwent six cycles of chemotherapy leading to a 35% reduction in tumor size and a left nephrectomy. She was admitted to the pediatric ICU post-operatively for observation. Histopathological analysis revealed features of stage two stromal type nephroblastoma. Her renal function and urine output were satisfactory throughout the duration of her admission as well as on follow up. Conclusions Keeping a high index of suspicion is imperative; individuals with renal anomalies, namely horseshoe kidney in the context of WAGR syndrome, mandate a comprehensive assessment through clinical examination, laboratory workup, and imaging. Though different approaches to standard Wilm's tumor cases have been explored thoroughly, it is crucial to keep in mind the need for multidisciplinary involvement in patients with multiple congenital anomalies.

scholarly journals Clinical Feature, Cause and Outcome in Female Paediatric Child with Osseomuscular Type of Wilson’s Disease

2021 ◽  
pp. 254-258
Author(s):  
Mayuri Yelekar ◽  
Lina Pahune ◽  
Indu Alwadkar ◽  
Aparna Kawale
Keyword(s):  
Physical Examination ◽  
Wilson’S Disease ◽  
Signs And Symptoms ◽  
Female Child ◽  
Wilson's Disease ◽  
Clinical Feature ◽  
Main Diagnosis ◽  
Chief Complaints ◽  
Abnormal Metabolism ◽  
All Treatment

Introduction: Genetically inherited diseases have grown in the last few decades. Wilson’s disease is one of those, named after the U.S.-born British neurologist Dr. Samuel Alexander Kinnier Wilson. Case Presentation: A 12 years old female child was admitted in A.V.B.R. hospital with the chief complaints of altered behaviour, speech disturbances, no physical coordination, uncontrolled movement since 2 to 3 months and fever since 2-3 days. Golden brown eye discoloration was present. After physical examination and investigation doctor diagnosed it as a case of Wilson’s disease. The Main Diagnosis, Therapeutic Intervention and Outcomes: After physical examination and investigation doctor diagnosed this as a case of Wilson’s disease.  Zinc and vitamin supplements were given for 7 days to enhance immunity.  Beta-blocker was given For 7days twice a day, Tab. Trietinine 250 mg was given once a day for 7 days to remove the heavy metal i.e. copper. She took all treatment and outcome was good. Her signs and symptoms got reduced and she was able to do her routine activities. Conclusion: The diagnosis of Wilson's disease relies largely on clinical examination and laboratory confirmation of abnormal metabolism of copper. This case responded well to all treatment and her recovery was good.

An Overview of Acute Flaccid Myelitis

2021 ◽  
Vol 20 ◽  
Author(s):  
Aseem Setia ◽  
Jasween Bhatia ◽  
Sankha Bhattacharya
Keyword(s):  
United States ◽  
Signs And Symptoms ◽  
The United States ◽  
Sudden Onset ◽  
Clinical Findings ◽  
The Body ◽  
Difficult Situation ◽  
Acute Flaccid Myelitis ◽  
Control And Prevention ◽  
Diagnostic Approaches

: Acute Flaccid Myelitis is defined by the presence of Acute Flaccid Paralysis (AFP) and a spinal cord lesion on magnetic resonance imaging that is primarily limited to the grey matter. AFM is a difficult situation to deal with when you have a neurologic illness. According to the Centers for Disease Control and Prevention (CDC), a large number of cases were discovered in the United States in 2014, with 90% of cases occurring in children. Although the exact cause of AFM is unknown, mounting evidence suggests a link between AFM and enterovirus D68 (EV-D68). In 2014, an outbreak of AFM was discovered in the United States. The condition was initially linked to polioviruses; however, it was later found that the viruses were caused by non-polioviruses Enteroviruses D-68 (EV-D68). The number of cases has increased since 2014, and the disease has been declared pandemic in the United States. The sudden onset of muscle weakness, usually in an arm or leg, as well as pain throughout the body, the patient's facial expression changing to one of weakness, and shortness of breath, ingesting, and speaking are all common symptoms in patients suffering from neurologic disease. This article includes graphic and histograms representations of reported AFM incidents and criteria for causality, epidemiology, various diagnostic approaches, signs and symptoms, and various investigational guidelines. It also includes key statements about recent AFM disease clinical findings.

scholarly journals Introductory remarks to the fourth session

1984 ◽  
Vol 304 (1118) ◽  
pp. 151-152
Keyword(s):  
Great Britain ◽  
United States Of America ◽  
Experimental Studies ◽  
Signs And Symptoms ◽  
The United States ◽  
The Body ◽  
Compressed Air ◽  
Dissolved Gas ◽  
Considerable Body ◽  
Fourth Session

The subjects of this session range from physics through neurophysiology to epidemiology but can, without using too high a level of abstraction, be related by the underlying presumption that the separation of dissolved gas from solution upon decompression leads to the formation of bubbles in the body and that they, in turn, produce pathological effects. An increasingly large workforce was exposed to raised pressures during the second half of the nineteenth century particularly in building the foundations of a bridge by the method of Triger (1841), a method that used compressed air to exclude water from the workings. The disturbances caused by the application of pressure and, more seriously, following the reduction in pressure were described by many authors from France, Italy, Germany, Great Britain and the United States of America. So there was a considerable body of observational data and hypothesis available by 1900 and the first experimental studies of decompression had been done by Bert (1878). He established that gas was indeed produced on decompression; that, after exposure to compressed air, the main constituent of bubbles was nitrogen and he thought it probable that such bubbles caused the signs and symptoms previously recognized as being associated with decompression.

Women and coronary disease: relationship between descriptors of signs and symptoms and diagnostic and treatment course

1998 ◽  
Vol 7 (3) ◽  
pp. 175-182 ◽  
Author(s):  
S Penque ◽  
M Halm ◽  
M Smith ◽  
J Deutsch ◽  
M Van Roekel ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chest Pain ◽  
Signs And Symptoms ◽  
The United States ◽  
Therapeutic Interventions ◽  
Initial Symptom ◽  
Men And Women ◽  
To Receive

BACKGROUND: Heart disease is the No. 1 killer among women in the United States. Differences in the clinical features of coronary heart disease among men and women have been reported, along with various approaches to the diagnostic workup and therapeutic interventions. PURPOSE: To explore the relationship between descriptors of signs and symptoms of coronary heart disease and follow-up care and to investigate any differences between male and female patients. METHODS: Structured interviews with patients and chart audits were used to assess initial signs and symptoms, associated cardiac-related signs and symptoms, and the diagnostic tests and interventions used for treatment. The sample consisted of 98 patients (51 women and 47 men) who were admitted with a medical diagnosis of myocardial infarction. RESULTS: Chest pain was the most common sign or symptom reported by both men and women. The 4 most common associated signs and symptoms were identical in men and women: fatigue, rest pain, shortness of breath, and weakness. However, significantly more women than men reported loss of appetite, paroxysmal nocturnal dyspnea, and back pain. Women were also less likely than men to have angiography and to receive i.v. nitroglycerin, heparin, and thrombolytic agents as part of acute management of myocardial infarction. CONCLUSION: Chest pain remains the initial symptom of acute myocardial infarction in both men and women. However, women may experience some different associated signs and symptoms than do men. Despite these similarities, men still are more likely than women to have angiography and to receive a number of therapies.

scholarly journals Case Report on Cellulitis with Diabetes

2021 ◽  
pp. 600-603
Author(s):  
Nidhi Ganeshpure ◽  
Darshana Kumari Wankhede ◽  
Shalini Lokhande
Keyword(s):  
The United States ◽  
Skin Condition ◽  
Clinical Findings ◽  
The Body ◽  
Therapeutic Interventions ◽  
Diabetic Foot Infections ◽  
Common Causes ◽  
Skin Redness ◽  
Wbc Count

Introduction: Cellulitis is a bacterial skin condition that is very frequent. In reality, cellulitis affects about 14 million people in the United States each year. If left untreated, the infection can spread to any part of the body and cause serious problems. Obesity and an inactive lifestyle are two of the most common causes of type 2 diabetes. Clinical Findings: Pain or tenderness in the leg, Skin redness or inflammation that gets bigger as the infection spreads, Skin sore or rash that starts suddenly, and grows quickly , Warm skin. Diagnostic Evaluation: Hb%- 10.7, MCHC- 33.4, MCV- 88.8, MCH- 29.8, Total RBC count- 3.6, Total WBC count- 7200, Total platelets count - 1.63, HCT- 37, Monocytes- 01, Granulocytes- 75, Lymphocytes - 20, RDW - 17.2, Eosinophils - 01. Therapeutic Interventions: Inj. Ceftriaxone 1mg x BD (IV), Inj. Pan 40 mg x OD (IV), Tab. Limcee 500 mg x OD, Tab. Pan 40 mg x OD, Protein powder 2 tsp x TDS, Inj. Insulin. Outcomes: A Male Patient of 88 year old was admitted in AVBRH with a chief Complaint of Cellulitis after getting treatment his condition is improving. Conclusion: Diabetic foot infections that aren't treated well or aren't treated at all result in lower-extremity amputation in about 10% of patients. Amputations of the lower extremities can be debilitating and have a significant impact on the patient's quality of life.

Consultation with the Specialist

1996 ◽  
Vol 17 (10) ◽  
pp. 371-372
Author(s):  
Brad W. Warner
Keyword(s):  
Physical Examination ◽  
Primary Care Physicians ◽  
Wilms Tumor ◽  
Abdominal Mass ◽  
The United States ◽  
Acute Hemorrhage ◽  
Tumor Progress ◽  
Routine Physical Examination ◽  
Male Patients ◽  
Symptoms And Signs

Wilms tumor is an important solid neoplasm in children that occurs with a frequency of 400 to 500 cases annually in the United States. It is important, therefore, for primary care physicians to be aware of the clinical presentation and associated symptoms and signs of Wilms tumor. Progress in management of this neoplasm has been outstanding, primarily because of cooperative efforts of the National Wilms Tumor Study Group. The significantly improved survival that has resulted from the Group's cooperative efforts serves as a paradigm for the management of all tumors. Presentation Wilms tumor most commonly presents as an asymptomatic abdominal mass. The average age of presentation is 3 to 4 years. This mass, which usually is located in the region of the flank, may be detected during a well-child routine physical examination. It also is not unusual for the mass to expand acutely due to hemorrhage within the tumor. This may account for discovery of the mass by the parents shortly after a recent thorough physical examination. The child also may present with abdominal pain associated with the mass due either to acute hemorrhage or to rupture of the tumor into the peritoneal cavity. Up to one third of children who have Wilms tumor may have microscopic hematuria, and in male patients, obstruction of the left spermatic vein can produce a left-sided varicocele.

Wilm’s Tumor: Syndrome-Based and Molecular Diagnostics

2017 ◽  
Vol 4 (4) ◽  
pp. 283-289 ◽  
Author(s):  
S. A. Kulyova ◽  
E. N. Imyanitov
Keyword(s):  
Molecular Diagnostics ◽  
Wilm's Tumor ◽  
Wilm’S Tumor

Odontoid cervical gout causing atlantoaxial instability: case report

2019 ◽  
Vol 30 (4) ◽  
pp. 541-544
Author(s):  
Justin Slavin ◽  
Marcello DiStasio ◽  
Paul F. Dellaripa ◽  
Michael Groff
Keyword(s):  
Rheumatoid Arthritis ◽  
Spinal Cord ◽  
Case Report ◽  
Physical Examination ◽  
Odontoid Process ◽  
Signs And Symptoms ◽  
Cord Compression ◽  
Atlantoaxial Instability ◽  
Posterior Stabilization ◽  
Rotatory Subluxation

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1–2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1–2 instability. However, despite the presence of a large retroodontoid pannus, she had no evidence of spinal cord compression on physical examination or imaging and did not require an anterior procedure to decompress the pannus. To confirm the diagnosis but avoid additional procedures and morbidity, the authors proceeded with the fusion as well as a posterior biopsy to the retroodontoid pannus and confirmed a diagnosis of gout.

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