A Systematic Review of the Relationship between Risk of Varicoceles and Obesity

Objectives: The systematic review was conducted to assess the relationship between varicoceles, risk of varicoceles or body mass index and obesity. Review Methods: The present systematic review scrutinized all the research articles published in English from 1971 to 12 July 2021 pertaining to the relationship between varicoceles, risk of varicoceles or body mass index and obesity. The systematic review was piloted under the PRISMA directives. Data Sources: Research articles were retrieved from the National Strength and Conditioning Association, Google Scholar, Web of Science, MEDLINE, Journal of Strength and Conditioning, and PubMed database using the vital search terms: risk of varicoceles or varicoceles in combination with obesity, body mass index. Results: There was a total of 370 studies found, with 29 publications included in this systematic review. There were 16 (55.1%) studies on the risk of varicoceles or varicoceles in combination with body mass index, 7 (24.1%) on the risk of varicoceles or varicoceles in combination with obesity, and 6 (20.7%) on the risk of varicoceles or varicoceles. Conclusions: Most cases in our systematic review included body mass index and risk of varicoceles or varicoceles, a few involved obesity and risk of varicoceles or varicoceles, while some included varicoceles relevant cases.

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Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Annals of the Rheumatic Diseases ◽

10.1136/ard.2009.125260 ◽

2010 ◽

Vol 69 (11) ◽

pp. 1976-1982 ◽

Cited By ~ 46

Author(s):

Hanneke J M Kerkhof ◽

Sita M A Bierma-Zeinstra ◽

Martha C Castano-Betancourt ◽

Moniek P de Maat ◽

Albert Hofman ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

Analysis Of Covariance ◽

C Reactive Protein ◽

Knee Oa ◽

Reactive Protein ◽

Serum Crp ◽

The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

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Investigating the Relationship between Body Mass Index and Pain in the Spine in Children or Adolescents: A Systematic Review

Childhood Obesity ◽

10.1089/chi.2020.0266 ◽

2021 ◽

Author(s):

Dilara Onan ◽

Ozlem Ulger

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

The Relationship

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The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: A systematic review and meta-analysis

Critical Reviews in Oncology/Hematology ◽

10.1016/j.critrevonc.2017.12.004 ◽

2018 ◽

Vol 121 ◽

pp. 68-73 ◽

Cited By ~ 8

Author(s):

Arwa S. Almasaudi ◽

Stephen T. McSorley ◽

Christine A. Edwards ◽

Donald C. McMillan

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Meta Analysis ◽

Postoperative Outcomes ◽

Short Term ◽

Curative Surgery ◽

The Relationship

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Body mass index and outcomes of patients with laparoscopic adrenalectomy: a systematic review and meta-analysis protocol

BMJ Open ◽

10.1136/bmjopen-2018-028579 ◽

2019 ◽

Vol 9 (6) ◽

pp. e028579

Author(s):

Celestin Danwang ◽

Valirie Ndip Agbor ◽

Jean Joel Bigna

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Laparoscopic Adrenalectomy ◽

Web Of Science ◽

Citation Index ◽

Meta Analysis ◽

Russian Science Citation Index ◽

Statistical Heterogeneity ◽

The Impact

IntroductionRecent advances in the field of medical imaging and minimal invasive surgery have improved the diagnosis and treatment of adrenal incidentalomas. Recent studies suggest increased morbidity and mortality among patients with obesity following laparoscopic adrenalectomy compared with patients without obesity. However, this claim remains to be ascertained. This review seeks to assess the outcome of patients with and without obesity after adrenalectomy.Methods and designWe will include cohort studies, case-control studies, cross-sectional studies and case series with more than 30 participants. EMBASE, Medline and Web of Science (Web of Science Core Collection, Current Contents Connect, KCI-Korean Journal Database, SciELO Citation Index, Russian Science Citation Index) will be searched for relevant abstracts of studies published between 1 January 2000 and 31 May 2019, without language restriction. The review will be reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. After screening of abstracts, study selection, data extraction and methodological quality assessment, we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Harbord’s test and visual inspection of funnel plots will be used to assess publication bias. Results will be presented by country and region.Ethics and disseminationSince primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data on the impact of body mass index on the outcome of laparoscopic adrenalectomy. The final report will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018117070.Review statusPreliminary searches.

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Parental Correlates of Outdoor Play in Boys and Girls Aged 0 to 12—A Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16020190 ◽

2019 ◽

Vol 16 (2) ◽

pp. 190 ◽

Cited By ~ 11

Author(s):

Karolina Boxberger ◽

Anne Reimers

Keyword(s):

Systematic Review ◽

Employment Status ◽

Web Of Science ◽

Outdoor Play ◽

Intervention Programs ◽

Eligibility Criteria ◽

Search Terms ◽

Health Relevance ◽

Relationship Of ◽

The Relationship

Outdoor play is one major source of physical activity (PA) in children. In particular, parents act as gatekeepers, because they can enable their children’s outdoor play. This systematic review aims to provide an overview of parental correlates of outdoor play. A systematic literature research of six electronic databases (ERIC, PsycARTICLES, PsycINFO, PubMed/Medline, SCOPUS, and Web of Science Core Collection) was conducted with previously defined search terms, focusing on children 0–12 years old. In total, 1719 potentially publications were screened based on eligibility criteria. Included studies were scored for overall study quality. Findings were summarized using a semi-quantitative method. Twenty-one peer-reviewed publications which examined the relationship of parental correlates and outdoor play were included. Overall, five parental correlates were associated with children’s amount of outdoor play: mothers’ ethnicity, mothers’ employment status, parents’ education level, the importance parents assign to outdoor play, and perceived social cohesion in the neighborhood. Merely four studies reported sex/gender-stratified results. In summary, only parents’ encouragement/support provided evidence for girls’ amount of outdoor play. The findings are considered to be of public health relevance for developing intervention programs to increase outdoor play and for improving child’s health. More research, especially considering sex/gender of the child, is required.

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The relationship between famine exposure during early life and body mass index in adulthood: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0192212 ◽

2018 ◽

Vol 13 (2) ◽

pp. e0192212 ◽

Cited By ~ 9

Author(s):

Jielin Zhou ◽

Liangjian Zhang ◽

Peng Xuan ◽

Yong Fan ◽

Linsheng Yang ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Early Life ◽

Meta Analysis ◽

Famine Exposure ◽

The Relationship

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The relationship between body mass index and hip osteoarthritis: A systematic review and meta-analysis

Joint Bone Spine ◽

10.1016/j.jbspin.2010.04.011 ◽

2011 ◽

Vol 78 (2) ◽

pp. 150-155 ◽

Cited By ~ 105

Author(s):

Liying Jiang ◽

Jiesheng Rong ◽

Yingchen Wang ◽

Fulan Hu ◽

Chundan Bao ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Meta Analysis ◽

Hip Osteoarthritis ◽

The Relationship

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The J-Shaped Relationship Between Body Mass Index and Mortality in Patients With Covid-19: A Systematic Review and Dose-Response Meta-Analysis

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.055 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A28-A29

Author(s):

Khulood Bukhari ◽

Huei-Kai Huang ◽

Duan-Pei Hung ◽

Carol Chiung-Hui Peng ◽

Ming-Chieh Shih ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Dose Response ◽

Meta Analysis ◽

Normal Weight ◽

Cochrane Library ◽

Severe Illness ◽

Underweight Patients ◽

The Relationship

Abstract Introduction: Several studies have linked obesity to more severe illness and higher mortality in COVID-19 patients. However, the relationship between being underweight and COVID-19 mortality remains inconclusive. Previous dose-response meta-analyses did not enroll or specifically analyze the underweight population. Herein, we conducted a systematic review and dose-response meta-analysis to investigate the relationship between body mass index (BMI) and mortality in both obese and underweight patients with COVID-19. Methods: We searched PubMed, Embase, Cochrane Library, Scopus, and Web of Science databases from inception until August 12, 2020 using the keywords “COVID-19,” “body mass index,” “obesity,” “overweight”, and “underweight.” Three reviewers independently assessed the relevant articles, including the title, abstract, and full text, to identify eligible studies. We performed a two-stage random-effects dose-response meta-analysis, including only studies with at least three quantitative classifications for BMI. The nonlinear trend was evaluated using a restricted cubic splines model with three-knots at the 10th, 50th, and 90th percentiles. A sensitivity analysis was conducted by pooling only those studies which specifically evaluated underweight patients (BMI<18.5 kg/m2). Results: Thirteen studies comprising 25,828 patients were included in the analysis. In the linear model, the mortality of patients with COVID-19 increased by 1.5% for each 1-kg/m2 increase in BMI (pooled relative risk [RR] =1.015, 95% confidence interval [CI] =1.004−1.027). However, a significant non-linear relationship between BMI and mortality was observed (Wald test: Pnon-linearity<0.001). We demonstrated a J-shaped curve, indicating that both underweight and obese patients had a higher mortality than those with normal weight. Interestingly, overweight patients (BMI, 25−30 kg/m2) seemed to have the lowest mortality risk. Using a BMI of 15 kg/m2 as the reference, the RRs of mortality decreased with BMI, and this trend continued until BMI of approximately 28 kg/m2 (RR=0.743, 95% CI=0.576−0.959). The relationship between BMI and mortality was then reversed, and an upward trend was observed when BMI exceeded 30 kg/m2; the RRs (95% CI) at BMIs 30, 35, 40, and 45 kg/m2 were 0.745 (0.570−0.974), 0.841 (0.643−1.100), 1.082 (0.850−1.377), and 1.457 (1.129−1.879), respectively. Conclusion: This study is the first dose-response meta-analysis that showed both underweight and obese COVID-19 patients are at higher risk of increased mortality. A J-curve relationship was demonstrated between BMI and COVID-19 mortality.

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