Neuroimaging Assessment of Aggressive Pituitary Adenomas

Aggressive pituitary adenomas (APA) are adenomas that show rapid growth, invasiveness, frequent or multiple relapses, or are resistant to conventional therapies. Clinical-imaging assessment of aggressive pituitary adenomas with the aid of magnetic resonance imaging (MRI) plays an important role in early prediction, further disease outcomes and aggressive behavior of adenomas. Purpose of the Study: was to assess the correlation of neuroimaging data with the hormonal activity of APA. Materials and Methods: The study included 74 patients with aggressive pituitary adenomas. The average age of the patients was from 12 to 69. The patients underwent a basal assessment of the level of pituitary hormones: prolactin (PRL), GH (growth hormone), insulin-like growth factor-1 (IGF-1) and blood cortisol by the RIA method, as well as an MRI study. Knop's classification was used to assess the invasion. Results: The hormonal workup showed prevalence of inactive pituitary adenomas among aggressive adenomas. No correlation was found between the hormonal activity of aggressive adenomas and the volume of pituitary adenomas. Moreover, MRI data indicated that invasion into the cavernous sinus of the III degree and heterogeneity of the adenoma may be considered equivalents of aggressiveness. Conclusion: The established patterns support the need for visualization assessment of aggressive pituitary adenomas and strongly suggest the evaluation of the degree of aggression based on tumor heterogenecity, chiasm compression, hypo- and iso-intensity in T1 mode and hyperintensity in T2 modes.

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T1672 The Effects of Endogenous GLP-1 On Antro-Duodenal Contractility in the Fasted and Fed State: A Magnetic Resonance Imaging (MRI) Study

Gastroenterology ◽

10.1016/s0016-5085(09)62552-x ◽

2009 ◽

Vol 136 (5) ◽

pp. A-555

Author(s):

Elad Kaufman ◽

Mark Fox ◽

Michael Wyss ◽

Zsofia Forras-Kaufman ◽

Reto Treier ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Fed State ◽

Magnetic Resonance Imaging Mri ◽

Mri Study

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Carcinomatous encephalitis as clinical presentation of occult lung adenocarcinoma: case report

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2007000500022 ◽

2007 ◽

Vol 65 (3b) ◽

pp. 841-844 ◽

Cited By ~ 5

Author(s):

Henrique Barbosa Ribeiro ◽

Tadeu Ferreira de Paiva Jr ◽

Gustavo Pignatari Rosas Mamprin ◽

Milton Luiz Gorzoni ◽

Antônio José da Rocha ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Clinical Presentation ◽

Clinical Manifestations ◽

Mass Effect ◽

Pulmonary Adenocarcinoma ◽

Rare Entity ◽

Resonance Imaging ◽

Clinical Imaging ◽

Magnetic Resonance Imaging Mri

Carcinomatous encephalitis is a rare entity, originally described by Madow and Alpers in 1951, which is characterized by tumoral spreading perivascular, without mass effect. Clinical manifestations such as hemiparesis, seizures, ataxia, speech difficulties, cerebrospinal fluid findings as well as computed tomography are nonspecific. This leads the physician to pursue more frequent diseases that could explain those manifestations - toxic, metabolic, and/or infectious encephalopathy. A magnetic resonance imaging (MRI) with gadolinium, the method of choice, presumes the diagnosis. Previous reports of this unusual form of metastatic disease have described patients with prior diagnosis of pulmonary adenocarcinoma. We present the case of carcinomatous encephalitis in a 76-years-old woman as the primary manifestation of occult pulmonary adenocarcinoma with its clinical, imaging, and anatomopathological findings.

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Clinical and Magnetic Resonance Imaging Predictors of Disability in Primary and Secondary Progressive Multiple Sclerosis

Multiple Sclerosis Journal ◽

10.1177/135245859600100406 ◽

1996 ◽

Vol 1 (4) ◽

pp. 218-222 ◽

Cited By ~ 43

Author(s):

NA Losseff ◽

DPE Kingsley ◽

WI McDonald ◽

DH Miller ◽

AJ Thompson

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Sclerosis ◽

Magnetic Resonance ◽

Initial Study ◽

Progressive Multiple Sclerosis ◽

Resonance Imaging ◽

Secondary Progressive ◽

Short Period ◽

Magnetic Resonance Imaging Mri ◽

Mri Study

The role of magnetic resonance imaging (MRI) in predicting disability in multiple sclerosis (MS) remains unclear. In this study 21 patients with primary and secondary progressive MS were reviewed 5 years following a serial MRI study of 6 months duration. In the secondary progressive group (n=11) there was a significant relationship between the occurrence of enhancing lesions and clinical relapses during the initial 6 months and increase in diability 5 years later. For both groups change in disability over the initial study period was predictive of outcome. These results suggest that the presence and frequency of gadolinium enhancement (a marker of inflammation) and changes in disability over a short period are predictive of future deterioration in progressive patients.

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Incidental Findings in Paranasal Sinuses and Mastoid Cells: A Cross-Sectional Magnetic Resonance Imaging (MRI) Study in a Pediatric Radiology Department

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren ◽

10.1055/s-0032-1312861 ◽

2012 ◽

Vol 184 (07) ◽

pp. 629-634 ◽

Cited By ~ 11

Author(s):

T. von Kalle ◽

C. Fabig-Moritz ◽

H. Heumann ◽

P. Winkler

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Paranasal Sinuses ◽

Pediatric Radiology ◽

Incidental Findings ◽

Radiology Department ◽

Resonance Imaging ◽

Cross Sectional ◽

Magnetic Resonance Imaging Mri ◽

Mri Study

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GH-Producing Pituitary Adenoma and Concomitant Rathke’s Cleft Cyst: A Case Report and Short Review

Case Reports in Neurological Medicine ◽

10.1155/2015/948025 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Ryota Tamura ◽

Satoshi Takahashi ◽

Katsura Emoto ◽

Hideaki Nagashima ◽

Masahiro Toda ◽

...

Keyword(s):

Pituitary Adenoma ◽

Sella Turcica ◽

Short Review ◽

Pituitary Hormones ◽

Rathke’S Cleft Cyst ◽

Resonance Imaging ◽

Mr Images ◽

Rathke's Cleft Cyst ◽

Magnetic Resonance Imaging Mri ◽

Rathke's Cleft

Concomitant pituitary adenoma (PA) and Rathke’s cleft cyst (RCC) are rare. In some cases, such PA is known to produce pituitary hormones. A 53-year-old man was admitted to our hospital with a diagnosis of lacunar infarction in the left basal ganglia. Magnetic resonance imaging (MRI) incidentally showed a suprasellar mass with radiographic features of RCC. When he consulted with a neurosurgical outpatient clinic, acromegaly was suspected based on his appearance. A diagnosis of growth hormone- (GH-) producing PA was confirmed from hormonal examinations and additional MRI. Retrospectively, initial MR images also showed intrasellar mass that is compatible with the diagnosis of PA other than suprasellar RCC. The patient underwent endonasal-endoscopic removal of the PA. Since we judged that the RCC of the patient was asymptomatic, only the PA was completely removed. The postoperative course of the patient was uneventful and GH levels gradually normalized. Only 40 cases of PA with concomitant RCC have been reported to date, including 13 cases of GH-producing PA. In those 13 cases, RCC tended to be located in the sella turcica, and suprasellar RCC like this case appears rare. In a few cases, concomitant RCCs were fenestrated, but GH levels normalized postoperatively as in the cases without RCC fenestration. If radiographic imaging shows typical RCC, and PA is not obvious at first glance, the possibility of concomitant PA still needs to be considered. In terms of treatment, removal of the RCC is not needed to achieve hormone normalization.

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Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility

Molecules ◽

10.3390/molecules25204660 ◽

2020 ◽

Vol 25 (20) ◽

pp. 4660

Author(s):

Grace K. Fletcher ◽

Landon D. Nash ◽

Lance M. Graul ◽

Lindy K. Jang ◽

Scott M. Herting ◽

...

Keyword(s):

Shape Memory ◽

Medical Devices ◽

Shape Memory Polymer ◽

Shape Memory Polymers ◽

Tissue Scaffolds ◽

Resonance Imaging ◽

Clinical Imaging ◽

X Ray ◽

Device Development ◽

Magnetic Resonance Imaging Mri

The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue scaffolds with clinical imaging capabilities. Dual modality visibility was achieved by chemically incorporating monomers with X-ray visible iodine-motifs and MRI visible monomers with gadolinium content. Physical and thermomechanical characterization showed the effect of increased gadopentetic acid (GPA) on shape memory behavior. Multiple compositions showed brightening effects in pilot, T1-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices.

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Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia

Annals of General Psychiatry ◽

10.1186/1744-859x-7-25 ◽

2008 ◽

Vol 7 (1) ◽

pp. 25 ◽

Cited By ~ 36

Author(s):

Yujiro Yoshihara ◽

Genichi Sugihara ◽

Hideo Matsumoto ◽

John Suckling ◽

Katsuhiko Nishimura ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Early Onset ◽

Resonance Imaging ◽

Structural Magnetic Resonance Imaging ◽

Early Onset Schizophrenia ◽

Magnetic Resonance Imaging Mri ◽

Mri Study

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Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

Psychological Medicine ◽

10.1017/s0033291700028403 ◽

1993 ◽

Vol 23 (2) ◽

pp. 319-322 ◽

Cited By ~ 43

Author(s):

George J. Jurjus ◽

Henry A. Nasrallah ◽

Stephen C. Olson ◽

Steven B. Schwarzkopf

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Imaging Study ◽

Septum Pellucidum ◽

Healthy Controls ◽

Resonance Imaging ◽

Cavum Septum Pellucidum ◽

Clinical Difference ◽

Magnetic Resonance Imaging Mri ◽

Mri Study

SynopsisMany structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18·9 %, and of all psychotic subjects 18·1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9·7%, P = 0·01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0·02). No clinical difference was found between schizophrenics with or without CSP.

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