Based on classic media theories and typical case studies, this paper analyzed the main media types and information sources in COVID-19 infections and the impacts on media trust and social trust, as well as the effects on public health prevention and national epidemic control. It found that news media, social media, aggregated media, medical media, and government media were the five main media types people used in this pandemic. News media performed well on professionalism, timeliness, closeness to public, and social support. Aggregated media and medical media also deserved public trust on error recovery, closeness to public, unselfishness, etc. The fake news on social media, inconsistent data, and information disclosure lag impaired public trust on media. Medical media promoted the health preventive behavior of the public. News media greatly influenced the agenda setting, public opinion, and national epidemic control in the COVID-19 pandemic.