Diode Green Laser in the Lid Trichiasis Treatment

Purpose: To validate the standard values and evaluate the success rate in the treatment of minor and major trichiasis using thermoablation with a diode green laser. Methods: In this interventional prospective study, individuals with minor or major trichiasis who were treated with thermoablation using diode green laser were included. The patients’ mean age was 72.1 years; the majority were females (54.1%) and Caucasian (98%). The parameters of the diode laser were wavelength of 532 nm, application time of 200 ms, target size of 50 μm, interval between the shots 150 to 200 ms, and power of 600 to 750 mW. The number of shots was defined by the depth of ablation sufficient to reach the pilus hair bulb. The patients were evaluated by slit-lamp every 3 to 4 months, for up to 15 months. The treatment success rate and the association between variables were analyzed. Results: The study sample was comprised of 98 patients with 135 affected lids and 337 lashes with trichiasis. Minor trichiasis (91.8%), unilateral trichiasis (67.3%), trichiasis affecting the lower eyelid (85.9%), and trichiasis resulting from blepharitis (64.3%) were the most common presentation profiles. The overall cure rate at the end of the study was 85%, with 69% being cured with a single session and 82.8% with two treatment sessions. Conclusion: Thermoablation using a diode green laser applying the specified parameters to treat minor and major trichiasis is effective and results in high cure rate.

Analysis of the gastroprotective potential of the essential oil of Lippia gracilis Schauer (Verbenaceae) in experimental models of gastric ulcer: a brief review

Gastric ulcer is a disease that affects a large portion of the world population, with a prevalence of 2.4% in the Western population and annual incidence rates of 0.10% to 0.19%, with a high cure rate, but with a high recurrence rate. The aim of this research is to perform a literature review on the gastroprotective potential of the essential oil of Lippia gracilis Schauer. To this end, an integrative review study was carried out, which selected 26 scientific articles found in virtual platforms that approached the proposed theme. Based on the established criteria, the literature suggests that the essential oil of Lippia gracilis Schauer is a compound with several biological activities, including some already described in the literature, however, its gastroprotective potential is still lacking many evidences in the literature. The findings show that the EO of L. gracilis can delay and bring an improvement in the degree of involvement by the ulcerative disorder. However, new scientific approaches are necessary to better elucidate the effect of this oil, which can then become an additional therapeutic method for cases of gastric lesions.

Surgical Management of Primary Hyperparathyroidism—Clinicopathologic Study of 1019 Cases from a Single Institution

Background: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by hypercalcemia and caused by the presence of disordered parathyroid glands. Parathyroidectomy is the only curative therapy for pHPT, but despite its high cure rate of 95–98%, there are still cases where hypercalcemia persists after this surgical procedure. The aim of this study was to present the results of a surgical treatment of patients due to primary hyperparathyroidism and failures related to the thoracic location of the affected glands. Methods: We present a retrospective analysis of 1019 patients who underwent parathyroidectomy in our department in the period 1983–2018. Results: Among the group of 1019 operated-on patients, treatment failed in 19 cases (1.9%). In 16 (84.2%) of them, the repeated operation was successful. In total, 1016 patients returned to normocalcemia. Conclusions: Our results confirm that parathyreoidectomy is the treatment of choice for patients with primary hyperparathyroidism. The ectopic position of the parathyroid gland in the mediastinum is associated with an increased risk of surgical failure. Most parathyroid lesions in the mediastinum can be safely removed from the cervical access.

Application of Radiofrequency Ablation in Treatment of Tachyarrhythmia based on CartoUnivu and Carto3 Intelligent System (Preprint)

BACKGROUND Background: Radiofrequency ablation has obvious advantages in the treatment of arrhythmia, like few postoperative complications, high cure rate, low recurrence rate, and small trauma, which has become the first choice for patients to treat arrhythmia. OBJECTIVE Objective: To study the X-ray dose of radiofrequency ablation in patients with paroxysmal supraventricular tachycardia (PSVT), ventricular premature beat and ventricular tachycardia (PVC/VT) arrhythmia based on CartoUnivu and Carto3 intelligent system. METHODS Methods: Radiofrequency ablation based on CartoUnivu and Carto3 system was used to treat patients with PSVT, PVC/VT arrhythmia, and the X-ray dose of thyroid, perineum, left upper arm, intrathyroid, extrathyroid, intrathoracic, extrathoracic, intraperineum, extraperineum and other parts during the treatment was analyzed. RESULTS Results: In most PSVT patients, radiofrequency ablation guided by Carto-3 system had lower X-ray dose than that of CartoUnivu. Radiofrequency ablation under the guidance of CartoUnivu was better than that of Carto3 regarding the X-ray level of most PVC/VT patients. Radiofrequency ablation under the guidance of CartoUnivu system had lower X-ray radiation for PVC/VT patients. CONCLUSIONS Conclusions: CartoUnivu system and Carto3 system can guide the precise treatment of complex arrhythmia, have a high success rate and better safety, can significantly reduce the X-ray exposure time and dose received by patients and operators, and the risk of X-ray related damage is significantly reduced, which is worth promoting. CLINICALTRIAL

Standard Surgical Excision of Basal Cell Carcinomas in the Non-H Area of the Face: A Case Series Illustrating an Alternative to Mohs Micrographic Surgery

Introduction: Basal cell carcinoma (BCC) is the most common cutaneous malignancy among Caucasians. Most studies compare the efficacy of standard surgical excision versus Mohs micrographic surgery (MMS) for the treatment of non-melanoma skin cancers in the high-risk or H area of the face. This case series focuses on the lesser-studied non-H area and suggests the use of standard surgical excision as an alternative to MMS for these regions of the face. Methods: A total of 10 patients with BCCs of the non-H area of the face underwent standard surgical excision with repair at the James A. Lovell Federal Health Center between October 2014 to October 2018. The average age of this group was 77.3 years and all patients were males. Nine of the 10 patients had nodular type BCCs and 1 patient had micronodular type BCC with ulceration. BCCs were located on the forehead in 8 cases and the cheek in 2 cases. Diameters of the lesions ranged from 6mm-8mm. Excision margins were 3- to 5-mm. Defects were repaired using local flaps in 9 cases and linear closure in 1 case. Results: Histopathologic evaluation of the excision specimens revealed clear surgical margins in 9 out of 10 cases. There was one case in which positive deep margins were identified, although the patient had a BCC with a more aggressive histologic pattern. Of the 9 cases with clear surgical margins, none had clinical evidence of local recurrence at follow-up ranging from 2 to 38 months. Discussion: BCCs in the non-H area of the face can be successfully treated using standard surgical excision with a high cure rate and low postoperative complications. MMS should be reserved for BCCs at increased risk for recurrence on the basis of factors such as location in the H area on the face and an aggressive histologic growth pattern (e.g. micronodular, morpheaform, infiltrating, metatypical). Practice points: • Basal cell carcinomas in the non-H area of the face can be successfully treated using standard surgical excision with a high cure rate and low postoperative complications. • Mohs micrographic surgery should be reserved for BCCs at increased risk for recurrence on the basis of factors such as location in the H area on the face and an aggressive histologic growth pattern (e.g. micronodular, morpheaform, infiltrating, metatypical).

Significance of mammography in the diagnosis and treatment of Stana Arbud

The definition of arbuda when at any part of the body when vitiated doshas takes place by afflicting flesh it produce a swelling which is rounded, fixed, slightly painful, big in size, broad based, slowly growing and not suppurate. It is deep seated and takes place by mansa dushti and medodushti. Mammography is the only tool which has reduced death rates due to breast cancer. Early detection results in a high cure rate of breast cancer. Screening mammography can detect precancerous changes in breast. It is our job to educate patients, order appropriate imaging, provide consistent follow-up and communicate. Screening is the key to early diagnosis but only works if patients trust that it is safe and effective .Regarding these things, the topic presented here is on the concept of stanarbuda and significance of Mammography in diagnosis of Stanarbuda.