Clinical factors associated with unfavorable outcomes in HIV-positive tuberculosis patients

The objective: to identify clinical factors with the highest sensitivity and specificity associated with an unfavorable outcome in the patient with tuberculosis and HIV infection.Subjects. 363 patients with TB/HIV co-infection. Group 1 – 59 (16.3%) patients with the unfavorable outcome, Group 2 – 304 (83.7%) patients with a favorable outcome.Methods: analysis of paired contingency tables by Pearson criterion, quantitative signs by Mann – Whitney test, simple and multiple logistic regression.Results. The following factors promoting unfavorable outcomes in the patient with TB/HIV co-infection with the highest sensitivity and specificity were identified: hemoglobin level (sensitivity – 78.0%; specificity – 73.7%), gastrointestinal candidiasis (72.9% and 84.5%), loose stool (40.7% and 97.4%), no lymphadenopathy (89.8% and 57.2%), and headache (49.2% and 88.5%). The combination of these clinical manifestations provides sensitivity of 78.0% and specificity of 94.4%.A formula is proposed for calculating the probability of an unfavorable outcome in the patient TB/HIV co-infection.

Deriving electrophysiological phenotypes of paroxysmal atrial fibrillation based on the characteristics of heart rate variability

Aim. To analyze heart rate variability of patients with paroxysmal atrial fibrillation and identify electrophysiological phenotypes of the disease by using methods of exploratory analysis of twenty-four-hour electrocardiographic (Holter) recordings. Methods. 64 electrocardiogram recordings of patients with paroxysmal atrial fibrillation were selected from the open Long-Term Atrial Fibrillation Database (repository PhysioNet). 52 indices of heart rhythm variability were calculated for each recording, including new heart rate fragmentation and asymmetry indices proposed in the last 5 years. Data analysis was carried out with machine learning methods: dimensionality reduction with principal component analysis, hierarchical clustering and outlier detection. Feature correlation was checked by the Pearson criterion, the selected patients subgroups were confirmed by using MannWhitney and Student's tests. Results. For the vast majority of patients with paroxysmal atrial fibrillation, heart rate variability can be described by five parameters. Each of these parameters captures a distinct approach in heart rate variability classification: dispersion characteristics of interbeat intervals, frequency characteristics of interbeat intervals, measurements of heart rate fragmentation, indices based on heart rate asymmetry, mean and median of interbeat intervals. Two large phenotypes of the disease were derived based on these parameters: the first phenotype is a vagotonic profile with a significant increase of linear parasympathetic indices and paroxysmal atrial fibrillation lasting longer than 4.5 hours; the second phenotype with increased sympathetic indices, low parasympathetic indices and paroxysms lasting up to 4.5 hours. Conclusion. Our findings indicate the potential of nonlinear analysis in the study of heart rate variability and demonstrate the feasibility of further integration of nonlinear indices for arrhythmia phenotyping.

Interrelation of venous and osteoarticular pathology in patients with Giacomini's vein

Objective: To establish a possible relationship between the Giacomini vein and osteoarticular pathology of the lower extremities in chronic venous diseases (CVD).Materials and methods. In 115 examined patients (out of 321), we identified the Giacomini vein (92 women, 23 men). The average age of men was 44.82 ± 1.62 years; women – 45.36 ± 3.31 years. All patients were divided into 3 groups by anatomical randomization. The first group was without pathology, the second group of patients had only CVD, and the third group included patients with CVD and osteoarticular pathology. The criteria for inclusion in the groups were: the presence of Giacomini vein in patients, chronic venous disease and osteoarticular pathology on one or both lower extremities. Exclusion criteria: age of patients less than 18 years, the presence of CVD C5-C6 according to the CEAP classification, post-traumatic changes in the osteoarticular system, post-thrombotic transformation of the veins of the lower extremities. Using triplex angioscanning, the anatomical features of the structure of the venous system of the lower extremities were assessed. The study of the condition of the foot was carried out using the Friedland method.Results. Group I with an absolute norm of the venous and osteoarticular systems included 30 people (26 %). The second group consisted of 45 patients (39.22 %) with CVD C0-C4 according to CEAP, and the third group consisted of 40 patients (34.78 %) who, in addition to venous, osteoarticular pathology. Chronic venous diseases in patients of groups II and III were distributed as follows: C0 – 25.6 %; C1 – 16.4 %; C2 – 49.4 %; C3 – 4.3 %; C4 – 4.3 % on the CEAP scale. Among the osteoarticular pathology, the most numerous group consisted of changes in the configuration of the foot, non-traumatic deformities – 32 (27.81 %) cases. To confirm the relationship between venous and osteoarticular pathology, we used the Pearson criterion. We found a significant correlation in the presence of nontraumatic deformities of the foot in the group of patients with CVD (Pearson's criterion 0.749642; p < 0.22). A strong correlation was established between the age of patients and changes in the venous and osteoarticular systems of the lower extremities (Pearson's criterion 0.7677696; p < 0.22), which confirms the relationship between the development of nontraumatic changes in the foot and CVD in patients with Giacomini vein with age.Conclusion. It was found that the presence of an altered Giacomini vein leads to an aggravation of venous stasis in the lower extremities, which in turn increases the likelihood of developing venous pathology. Chronic diseases of the veins of the lower extremities contribute to dystrophic changes in soft tissues, most pronounced in the distal part of the extremity and, as a consequence, predispose to the development of osteoarticular pathology.

Study of the value attitude towards the Homeland in primary school children

Introduction. The formation of a value attitude in the younger generation towards their Homeland, a sense of patriotism, as well as pride in their Homeland is the basis of the statehood of any country. This problem is especially acute in modern conditions, characterized by a large-scale rethinking of traditional values, the formation of new ideals, and spiritual and moral guidelines. Objective: to study the value attitude towards the Homeland in children aged 8-9 years. Materials and methods. The study was conducted on the basis of secondary schools in Nizhny Novgorod and the Nizhny Novgorod region (Russian Federation), the sample consisted of 316 students aged 8-9 years. The χ2-Pearson criterion was used to statistically evaluate the effectiveness of formative influences. Research results. Based on the theoretical analysis of current research and their own experience, the authors determined the criteria for developing the value attitude of children to the Homeland: awareness of the concept of "Homeland", moral categories, as well as inclusion in social activities. The data of the ascertaining stage showed that only 22.2% of the respondents have a high level of formation of the value attitude towards the Homeland. A significant number of students' answers (77.8%) testifies to the lack of the necessary knowledge regarding the Homeland. This necessitated the organization of purposeful activities aimed at forming a value attitude towards the Homeland among primary school students. As part of the formative stage, the following content lines were implemented: "Russia is my Homeland", "Native land", "I am a patriot of my country", "Father's house", "Culture and traditions of my people". Discussion and conclusion. For the first time, the value attitude towards the Homeland has been purposefully diagnosed among schoolchildren of 8-9 years old. Empirically, the results were obtained, reflecting the peculiarities of awareness of the concepts of "Homeland", "small homeland" by younger schoolchildren. The dynamics are most pronounced in terms of the indicators "Awareness of the concept of "Homeland" and "Involvement in active social activity" (χ2= 91.77; p<0.001).

Improving the Geodynamic Safety of the Developed Hydrocarbon Fields in the Oil and Gas Bearing Basin

The predominant area of application of the developed methodology is the construction of the distribution of the geodynamic state of the developed hydrocarbon fields in oil and gas basin, and the identification of the corresponding distribution law. A number of the hydrocarbon deposits in terms of geological conditions of occurrence, structure and other parameters are geodynamically hazardous during their development. The Federal Law «On Subsurface Resources» (Article 24) requires conducting a complex of geological, surveying, and other observations sufficient for ensuring a normal technological cycle of work, and the prediction of hazardous situations. The developed methodology based on the construction of aggregated additive models for each reservoir and field is presented. It includes four sequential stages (24 operations): first — prepare geodynamic data; second — determine the geodynamic state of productive strata; third — find the geodynamic state of the developed deposits subsoil; fourth — build the distribution of the bowels geodynamic state of these fields for the entire oil and gas basin and identify the relevant distribution law. Oil and gas basin in the west of the Orenburg Region (Volga — Ural and Caspian oil and gas provinces) is considered as an example of implementation. Unique data of twenty geodynamic parameters of 320 productive strata (56 fields) were used. It is revealed that in accordance with the Pearson criterion, the theoretical data with a high confidence probability (95 %) correspond to the law of normal distribution. Developed methodology has significant technical and economic advantages, since it allows to identify the geodynamic state of productive strata and subsoil of the fields being developed, to identify hazardous geodynamic processes and to choose rational modes for the development of hydrocarbon deposits.

Individualization in the upbringing of an anti-victim personality through physical education and sports

This article deals with the issue of the individualization of education in the context of the concept of anti-victim personality. The most undeveloped aspect of the individualization of education is the question of the use of physical education and sports as tools in the education of an anti-victim personality. The study used structured interviews in conjunction with victimological analysis. Statistical processing of the material was carried out using the nonparametric Pearson criterion χ2. Four groups of study participants were identified according to their level of awareness of the importance of physical development. Only the “active” athletes had anti-victim attitudes toward difficulties and failures in physical education and sporting activities. This proves that one of the ways to form an anti-victim personality in sports is to consciously overcome difficulties and increase levels of self-esteem.

Characteristics of the ultimate meanings and students’ life-purpose orientations depending on the gender

The relevance of the study is conditioned by rapid transition to digital forms of education, which is associated with the pandemic. Students have changed the way they interact with teachers and with each other, which constantly leads to transformation of personal meanings, values, rethinking of their purpose and role in the educational process. The purpose of the study, presented in the article, is to investigate unusual characteristics of the semantic sphere regarding male and female students’ academic activity. Hypothesis: semantic content of academic activity differs in male and female students. Participants are first-year full-time students, studying at the Faculty of Psychology, Faculty of Engineering and Economics and Faculty of Human Resources Management (N = 102, aged from 18 to 22 years, 52 participants are female students and 50 participants are male students). The participants were tested using Life-Purpose Orientations Test (D. A. Leontiev) and the Ultimate Meanings Technique (D. A. Leontiev). Based on the latter methodology, the entire sample was divided into five groups depending on the presence of a certain meaning. The conjugation of ultimate meanings and gender was determined using φ-Pearson criterion, while MANOVA criterion helped to investigate differences in life-purpose orientations depending on gender and ultimate meanings. We established differentiation within ultimate meanings in education depending on gender of a student: men are focused on respect and safety, while women are focused on getting pleasure and gaining confidence. We found that women connect getting pleasure and gaining confidence while learning with monitoring their lives, whereas male students connect it with the ultimate meanings of security and respect, satisfaction with their own lives and the feeling of being able to influence their life. The obtained results can help to draw the following conclusion: development of the individual system of life-purpose orientations and its functioning in the educational situation are interconnected with gender as one of the most essential biosocial characteristics of an individual.

Data Processing in the Pilot Training Process on the Integrated Aircraft Simulator

Flight safety is an integral part of air transportation. Flight accidents are highly unlikely to appear but most of them are caused by the human factor. The aircrew training system for abnormal operations relies on integrated aircraft simulator-based exercises. Crew needs to be trained not to degrade piloting technique quality when facing increased psychophysiological tension. Therefore, methods evaluating the characteristics of ergatic aircraft control systems, warning systems for deterioration due to failures in avionics systems, piloting technique quality, and abnormal operation algorithms are necessary. An analysis of the bank angle has revealed that there are hidden increased tension manifestations in the human operator expressed in the transition of the flight parameter variation from a stationary random process to deterministic fluctuations in the form of a sinusoid. The goal of the research is to increase the efficiency of pilots’ training using integrated aircraft simulators based on the design and implementation of statistical data processing algorithms. To achieve the goal of the research, two algorithms for detecting deterministic fluctuations based on the Neyman-Pearson criterion and the optimal Bayesian criterion are developed. The presented algorithms can be used in the integrated simulator software to automate the decision-making process on piloting quality.