This chapter will explore best practices among school counselors for advocacy, prevention, and intervention related to addressing self-injury. In this chapter, the functions and purpose of Self-Injury (SI) will be explored, along with the relationship between SI and suicidality, and potential complications of SI. Ethical and legal issues associated with SI, including special considerations from the American School Counselor Association (ASCA), will also be addressed. Next, warning signs and risk factors for SI will be presented, and common myths will be discussed. Finally, the importance of collaborating with school personnel is highlighted, and best practices for school counselors working with students who engage in SI are provided.