THE STUDY OF SUBLINGUAL, ORALAND VAGINALADMINISTRATION OF MISOPROSTOL IN REGRESSION OF SYMPTOMS OF MISSED ABORTION

Background: Misoprostol is a widely popularly used drug in treatment of missed abortions. It is very simple to use, easily available and has an average efciency greater than 90%. Adrug this popular and versatile needs better study to improve its efciency and minimize all possible adverse unwanted effects. Hence the idea to make a comparative study between the different modes of administration of Misoprostol was arrived upon so as to understand it in a much better way. Aim: A comparison of the efcacy of Misoprostol used in sublingual, oral and vaginal routes for missed abortion. Material and methods: The study was conducted at the Department of Obstetrics and Gynaecology in Nilratan Sircar Medical College and Hospital, Kolkata after approval by the ethical committee. The sample size was 100 women being treated for missed abortions where prospective sampling was carried out to determine the candidates to be selected for the study. Single centred, institution based, randomized controlled trial. Cases included in this study were divided into 3 groups: Sublingual Group, Oral Group and Vaginal Group. Result: It was found that in oral, 4(11.8%) patients had fever. In sublingual, 6(17.6%) patients had fever. In vaginal, 2(5.9%) patients had fever. Association of fever vs. group was not statistically signicant (p=0.3220). Conclusion: The study demonstrates that both vaginal and sublingual misoprostol have similar and higher success rates in inducing abortion compared to oral route

A COMPARATIVE STUDY OF SUBLINGUAL, ORALAND VAGINAL ADMINISTRATION OF MISOPROSTOL IN THE MANAGEMENT OF MISSED ABORTION

Aim: A comparison of the efcacy of Misoprostol used in sublingual, oral and vaginal routes for missed abortion. A comparison of dose and time interval of drug administration to onset of action of three different routes. Material and methods: The study was conducted at the Department of Obstetrics and Gynaecology in Nilratan Sircar Medical College and Hospital, Kolkata after approval by the ethical committee. The sample size was 100 women being treated for missed abortions where prospective sampling was carried out to determine the candidates to be selected for the study. Single centred, institution based, randomized controlled trial. Cases included in this study were divided into 3 groups: Sublingual Group, Oral Group and Vaginal Group. Result: The mean Duration of induction to delivery time in hrs (mean±s.d.) of the patients was 14.0206 ± 1.4587 hr. In sublingual, the mean Duration of induction to delivery time in hrs (mean±s.d.) of patients was 9.3353 ± .8388 hr. In vaginal, the mean Duration of induction to delivery time in hrs (mean±s.d.) of patients was 10.4412 ± 1.2502 hr. Difference of mean Duration of induction to delivery time in hrs vs. group was statistically signicant (p<0.001). Conclusion: Incomplete abortion was higher in oral, followed by Vaginal and Sublingual misoprostol. Success rate was higher in Sublingual compared to Vaginal and Oral.

A study to evaluate the magnitude of understanding on harm’s way associated with heart disease among clients attending NCD clinic at nemam PHC

Non-communicable Disease (NCD), almost completely heart diseases, malignancy, diabetes and chronic obstructive pulmonary diseases are the main source of demise worldwide killing additional human beings further wise entire further sources merge. In 2008 nearly two-thirds of the demises were due to NCD, a 36 million out of 57. Out of this almost completely 80% of demise happens in little and medium earnings nation with over 50% of them happening amid human beings completely amount 70 years old and 29% under 60 years of age. At current heart diseases (CVD) are the numeral single sources of demise worldwide with little and medium earning nations existence pretentious uneven. So the current research is ready to evaluate the magnitude of understanding on harm’s way associated with heart disease among clients attending NCD clinic at nemam PHC. A descriptive research design was chosen to evaluate the magnitude of understanding on harm’s way associated with heart disease among clients attending NCD clinic at nemam PHC 100 samples are included within our study. Prospective sampling techniques method was utilized in selecting the samples. A self-arranged questionnaire was utilized to gather statistics. The evaluate the magnitude of understanding on harm’s way associated with heart disease among clients attending NCD clinic at nemam PHC are Inadequate knowledge: 23%Moderate knowledge: 56% Adequate knowledge: 21%. The study concludes that there is moderation risk factors associated with heart disease among clients attending NCD clinic at Nemam PHC.

Improving Intrusion Detection Model Prediction by Threshold Adaptation

Network traffic exhibits a high level of variability over short periods of time. This variability impacts negatively on the accuracy of anomaly-based network intrusion detection systems (IDS) that are built using predictive models in a batch learning setup. This work investigates how adapting the discriminating threshold of model predictions, specifically to the evaluated traffic, improves the detection rates of these intrusion detection models. Specifically, this research studied the adaptability features of three well known machine learning algorithms: C5.0, Random Forest and Support Vector Machine. Each algorithm’s ability to adapt their prediction thresholds was assessed and analysed under different scenarios that simulated real world settings using the prospective sampling approach. Multiple IDS datasets were used for the analysis, including a newly generated dataset (STA2018). This research demonstrated empirically the importance of threshold adaptation in improving the accuracy of detection models when training and evaluation traffic have different statistical properties. Tests were undertaken to analyse the effects of feature selection and data balancing on model accuracy when different significant features in traffic were used. The effects of threshold adaptation on improving accuracy were statistically analysed. Of the three compared algorithms, Random Forest was the most adaptable and had the highest detection rates.

Benign neck swellings: a clinico-radio-pathological study

<p class="abstract"><strong>Background:</strong> The present study aimed to know the common pathologies presenting as neck swellings in our region and their clinical, radiological, and cytopathological correlation in order to understand the nature of the lesion and accuracy of the diagnostic tools in finding a definitive diagnosis.</p><p class="abstract"><strong>Methods:</strong> Patients presenting with neck swelling to the ENT department of a tertiary care centre in Mangalore between June 2013 to July 2018 were included in the study based on retrospective and prospective sampling. Appropriate cytolopathological and radiological investigations were done and analyzed. </p><p class="abstract"><strong>Results:</strong> Out of 160 cases analyzed histopathology diagnosed 86.9% as benign and 13.1% as malignant. Radiologically 94.9% were diagnosed to be benign and 5.6% malignant whereas in cytological investigation 89.4% were diagnosed as benign and 6.9% as malignant while the remaining 3.8% cases were cytologically inconclusive. Intra operatively 6.9% cases had features of malignancy and rest 93% were benign. Thyroid was the most common benign neck swelling (73.2%) followed by cervical lymphadenopathy (6.9%) and thyroglossal cyst (5.6%).</p><p class="abstract"><strong>Conclusions:</strong> Discrepancy in clinico-radio-cytopathological correlation was highest in cases of thyroid swelling (more so in case of solitary thyroid nodule). None of the pre-operative investigations for neck swellings is 100% specific or definitive in diagnosing a benign from a malignant lesion in the neck.</p>

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEIKUTSERTAAN SENAM HAMIL PADA IBU HAMIL DI BPS NINA SURABAYA

Analysis of factors Affecting The Participant Pregnant Women Gymnactics in BPS Nina Surabaya. Pregnant women should get treatment during pregnancy. Treatment during pregnancy or antenatal care can be done via examination of pregnancy, pregnancy exercise, nutrition and other compliance requirements. Pregnancy exercise is an exercise undertaken to prepare and train the muscles so that it can be used to function optimally in a normal delivery.This study uses an analytical method with cross sectional design prospective. Sampling using total sampling technique. The independent variable is education, parity and maternal knowledge, while the dependent variable is exclusive breastfeeding. Data were analyzed using chi square test.The results showed a correlation between age and support of husband / family with the participation of pregnant women during pregnancy exercise with a p-value of <0.05, whereas for education and parity are not related to the participation of pregnant women against pregnancy exercise with a value of p>0.05.The conclusions of this study are the factors that influence the participation of pregnant women during pregnancy exercise is aged and the support of husband / family.

Diagnosis and Management Pattern of Lateral Epicondylitis in a Tertiary Care Center

Introduction: Lateral Epicondylitis has been found to be the second most frequently diagnosed musculoskeletal disorder. A wide range of symptomatic treatments are available such as use of anti-inflammatory analgesic drugs, steroids, physiotherapy. This study aims to know about the diagnosis, prescription pattern and current practice on management of tennis elbow in Nepal. Methods: This is a hospital based observational study carried out at Bir Hospital, Kathmandu, Nepal. Patients diagnosed with tennis elbow were purposively selected through prospective sampling technique from Orthopedic Department. Questionnaire and patient medication files were used as tools for data collection. Results: A total of 97 patients were found to be suffering from tennis elbow affecting mostly 41-50 years of age group and seen mostly in female (62%). Further, it was found that housewives (31%) were mostly affected. Diagnosis of tennis elbow was done commonly by clinical evaluation (61%) and X-ray (39%). Both Pharmacological and Non-Pharmacological approaches were in practice. Pharmacological treatment include NSAIDS (59% Aceclofenac, 19% Naproxen, 18% Indomethacin, 16% Diclofenac, 6% Piroxicam) and Steroids (23% methylprednisolone acetate and 21% oral prednisolone). Non-Pharmacological treatment was done by lifestyle modification (100%), 78% application of heat, 63% use of tennis elbow band, 29% exercise and 28% physiotherapy. Surgical intervention (3%) was also done when the conservative management failed. Conclusions: There is professional risk of tennis elbow for housewives, farmers and shopkeepers in context of Nepal. Only one treatment approach is not effective in management of tennis elbow for long term effect. Keywords: lateral epicondylitis; NSAIDs; physiotherapy; steroid; tennis elbow.