Cam Mechanisms Reverse Engineering Based on Evolutionary Algorithms

Cam follower mechanisms are widely used in automated manufacturing machinery to transform a rotary stationary motion into a more general required movement. Reverse engineering of cams has been studied, and some solutions based on different approaches have been identified in the literature. This article proposes an innovative method based on the use of an evolutionary algorithm for the identification of a law of motion that allows for approximating in the best way the motion or the sampled profile on the physical device. Starting from the acquired data, through a genetic algorithm, a representation of the movement (and therefore of the cam profile) is identified based on a type of motion law traditionally used for this purpose, i.e., the modified trapezoidal (better known as modified seven segments). With this method it is possible to estimate the coefficients of the parametric motion law, thus allowing the designer to further manipulate them according to the usual motion planning techniques. In a first phase, a study of the method based on simulations is carried out, considering sets of simulated experimental measures, obtained starting from different laws of motion, and verifying whether the developed genetic algorithm allows for identifying the original law or approximating one. For the computation of the objective function, the Euclidean norm and the Dynamic Time Warping (DTW) algorithm are compared. The performed analysis establishes in which situations each of them is more appropriate. Implementation of the method on experimental data validates its effectiveness.

Smart Monitoring of a Full-scale Composite Hydrofoil Manufactured using Automated Fibre Placement under High Cycle Fatigue

Fibre reinforced composites materials offer a pathway to produce passive shape adaptive smart marine propellers, which have improved performance characteristics over traditional metallic alloys. Automated Fibre Placement (AFP) technology can provide a leap forward in Cyber-Physical automated manufacturing, which is essential for the implementation and operation of smart factories in the marine propeller industry towards Industry 4.0 readiness. In this paper, a comprehensive structural health monitoring (SHM) routine was performed on an AFP full-scale composite hydrofoil to gain confidence in its dynamic and structural performances through a number of active and passive sensors. The hydrofoil was subjected to constant amplitude flexural fatigue loading in a purpose-built test rig for 105 cycles. The hydrofoil was embedded with distributed optical fibre sensors (DOFS), traditional electrical strain gauges and linear variable displacement transducers (LVDTs). Both microelectromechanical system (MEMS) and piezoelectric (PZT) accelerometers were used to conduct experimental modal analyses (EMA) to observe changes in the modal response of the hydrofoil at regular intervals throughout the fatigue program. The hydrofoils modal response, as well as the stiffness measured using both displacements and strains, remained unchanged over the fatigue loading regime demonstrating the structural integrity of the hydrofoil. The optical fibre sensors endured the fatigue test cycles showing their robustness under fatigue loads. Furthermore, the sensing systems demonstrated the potential of being utilised as a useful maintenance tool combining their adaptability with automated manufacturing during manufacturing through integration within the hydrofoil, a structural test framework for performance measurement, data acquisition and analytics for visualization, and the prospect of decision making for maintenance requirement during any onset in structural performance.

MODELLING COMPACTION BEHAVIOR OF TOUGHENED PREPREG DURING AUTOMATED FIBRE PLACEMENT

One of the most widely used automated manufacturing processes for composite parts is automated fibre placement (AFP). The deposition process involves the simultaneous warming, lay-up and consolidation of prepreg consisting of multitude of process parameters. Currently, AFP process parameters that ensure part conformance are derived by expensive and time-consuming trial-and-error approaches. The aim of this study is to demonstrate how physics-based finite element simulations that can predict the as manufactured geometry of a preform deposited by AFP can help reduce some of the empiricism associated with current industry practices. Here we particularly focus on the consolidation behaviour of toughened prepregs during the deposition process. An isothermal roller compaction model with thermal properties derived from an independent simplified thermo-mechanical model of the AFP head is used. Additionally, a fully characterised viscoelastic material definition is used for the prepreg tape along with a hyperelastic material for the compaction roller to accurately represent the physical parts. Various lay-up speeds, heater powers and compaction forces are simulated. To reduce the empiricism present in the manufacturing process, the viability of incorporating the numerical models into existing statistical relationships between process parameters and manufactured geometry is examined.

Metamorphosis of Contact Lenses

In 1971, soft contact lenses were a striking addition to the ophthalmic field that related functionally to the existing hard contact lenses by correctingrefractive error, but their properties and description were different so as to confound ophthalmic professionals in their introduction. Their inventor Otto Wichterle, a Czechoslovakian chemist and anticommunist dissident, developed the soft lens in the 1950-60s with little knowledge of the hard lens, but its potential was broad enough to break through the communist barriers and to spark international consumer interest and development.Challenges in manufacturing and developing soft contact lenses created a complex discipline around the cornea and lid physiology, and optics. This expanded greatly the scientific knowledge of the eye and adnexa to allow a soft, hydrophilic lens to remain symbiotic with the eye. Challenges were met over the past 50 years with a change in nomenclature and in automated manufacturing closer to hard lenses, optical advancements, new materials and surface treatments, and lens disinfection methods. The science developing from the diminutive soft lens led to the incorporation of related biomedical and polymer science within the broader ophthalmic field that inordinately influenced optical advancements, instrumentation,and ocular pathology.

Production and Application of CAR T Cells: Current and Future Role of Europe

Rapid developments in the field of CAR T cells offer important new opportunities while at the same time increasing numbers of patients pose major challenges. This review is summarizing on the one hand the state of the art in CAR T cell trials with a unique perspective on the role that Europe is playing. On the other hand, an overview of reproducible processing techniques is presented, from manual or semi-automated up to fully automated manufacturing of clinical-grade CAR T cells. Besides regulatory requirements, an outlook is given in the direction of digitally controlled automated manufacturing in order to lower cost and complexity and to address CAR T cell products for a greater number of patients and a variety of malignant diseases.