The effect of anti-microbial peptide on the performance, survival rate, and diarrhea ratio the pig: A meta-analysis

A meta-analysis conducted to determine effect of anti-microbial peptide (AMP) form on the per-formance of pig. A database was designed based on data published that reported used probiotic on pig. The method used in the selection of articles was based on the systematic review center for laboratory animal experimentation (SYRCLE's) method. The final database consisted of 41 in vivo studies with 241 treatments. The analysis statement in the system were R Version 3.6.30. In general, in the total phase, body weight and survival rate increased (p <0.05; quadratic) due to AMP administration. In continued of the phase 1, growth performance parameters [eg, body weight, average daily gain (ADG), and average daily intake (ADI), feed conversion ratio (FCR)] increased (p <0.05; quadratic) and FCR decreased (p <0.05; quadratic) due to SAP administration. In the total phase, parameters such as body weight, ADG, and survival rate increased (p <0.05; quadratic) while ADI tended to increase (p <0.1; linear) due to the increase in the CAP dose. Meanwhile, other parameters in the total phase, i.e. FCR decreased (p <0.05; quadratic). The optimal dose of CAP for the total phase was 21.406 mg/kg of feed with a predicted minimum FCR of 1.47. The AMP forms (SAP and CAP) improved (p <0.05) the pa-rameters of body weight, ADG, ADI, FCR, diarrhea ratios, and survival rate at each phase. In sum-mary, both form and dosage of the anti-microbial help to beneficial effect on the growth performance of pigs.

Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes

Aims Previous studies suggest that small intestinal bacterial overgrowth (SIBO) is associated with type 2 diabetes. However, few studies have evaluated the association between SIBO and beta-cell function in type 2 diabetes. The aim of this study was to evaluate whether beta-cell function was associated with SIBO. Materials and methods One hundred four patients with type 2 diabetes were included in this study. Based on the presence of SIBO, the patients were divided into SIBO-positive and SIBO-negative groups. Oral glucose tolerance tests were performed. Insulin sensitivity was measured using 1/homeostasis model assessment of insulin resistance (1/HOMA-IR) and the insulin sensitivity index (ISIM). Insulin release was calculated by HOMA-β, early-phase insulin secretion index InsAUC30/GluAUC30, and total-phase insulin secretion index InsAUC120/GluAUC120. Results Compared with the SIBO-negative group, patients in the SIBO-positive group showed a higher glucose level at 120 minutes, HbA1c, 1/HOMA-IR, and ISIM and a lower HOMA-β level, early-phase InsAUC30/GluAUC30, and total-phase InsAUC120/GluAUC120. Multiple linear regression analysis showed that body mass index, glucose at 0 minutes, and SIBO were independently associated with the early-phase and total-phase insulin secretion. Conclusion SIBO may be involved in lower levels of insulin release and worse glycemic control.

Optical spin-dependent beam separation in cyclic group symmetric metasurface

Cross-polarization scattering of a circularly polarized beam from nano-rod introduces a geometric phase to the outgoing beam with opposite circular polarization. By manipulating the spatial array of subwavelength nano-structure constituting metasurface, the geometric phase can be engineered to generate a variety of beam profiles, including vortex beam carrying orbital angular momentum via a process called spin-to-orbital angular momentum conversion. Here we introduce a cyclic group symmetric metasurface composed of tapered arc nano-rods and explore how azimuthal angular distribution of total phase determines the feature of spin-dependent beam separation. When scattered from a circular array of tapered arc nano-rods possessing varying width with a fixed length, a dynamical phase having non-constant azimuthal gradient is introduced to an incoming Gaussian beam. This leads to a spin-dependent beam separation in the outgoing vortex beam profile, which is attributed to an azimuthal angle dependent destructive interference between scatterings from two plasmonic excitations along the width and the length of tapered arc nano-rod. Relation of cyclic group symmetry property of metasurface and the generated vortex beam profile is examined in detail by experimental measurement and analysis in terms of partial-wave expansion and non-constant azimuthal gradient of total phase. Capability of spatial beam profiling by spin-dependent beam separation in vortex beam generation has an important implication for spatial demultiplexing in optical communication utilizing optical angular momentum mode division multiplexing as well as for optical vortex tweezers and optical signal processing employing vortex beams.

Lyapunov Exponents of Two Stochastic Lorenz 63 Systems

Two different types of perturbations of the Lorenz 63 dynamical system for Rayleigh–Bénard convection by multiplicative noise—called stochastic advection by Lie transport (SALT) noise and fluctuation–dissipation (FD) noise—are found to produce qualitatively different effects, possibly because the total phase-space volume contraction rates are different. In the process of making this comparison between effects of SALT and FD noise on the Lorenz 63 system, a stochastic version of a robust deterministic numerical algorithm for obtaining the individual numerical Lyapunov exponents was developed. With this stochastic version of the algorithm, the value of the sum of the Lyapunov exponents for the FD noise was found to differ significantly from the value of the deterministic Lorenz 63 system, whereas the SALT noise preserves the Lorenz 63 value with high accuracy. The Lagrangian averaged version of the SALT equations (LA SALT) is found to yield a closed deterministic subsystem for the expected solutions which is isomorphic to the original Lorenz 63 dynamical system. The solutions of the closed chaotic subsystem, in turn, drive a linear stochastic system for the fluctuations of the LA SALT solutions around their expected values.

Probing gas disc physics with LISA: simulations of an intermediate mass ratio inspiral in an accretion disc

The coalescence of a compact object with a $10^{4}\hbox{--}10^{7}\, {\rm M_\odot }$ supermassive black hole (SMBH) produces mHz gravitational waves (GWs) detectable by the future Laser Interferometer Space Antenna (LISA). If such an inspiral occurs in the accretion disc of an active galactic nucleus (AGN), the gas torques imprint a small deviation in the GW waveform. Here, we present two-dimensional hydrodynamical simulations with the moving-mesh code disco of a BH inspiraling at the GW rate in a binary system with a mass ratio q = M2/M1 = 10−3, embedded in an accretion disc. We assume a locally isothermal equation of state for the gas (with Mach number $\mathcal {M}=20$) and implement a standard α-prescription for its viscosity (with α = 0.03). We find disc torques on the binary that are weaker than in previous semi-analytic toy models, and are in the opposite direction: the gas disc slows down, rather than speeds up the inspiral. We compute the resulting deviations in the GW waveform, which scale linearly with the mass of the disc. The SNR of these deviations accumulates mostly at high frequencies, and becomes detectable in a 5 yr LISA observation if the total phase shift exceeds a few radians. We find that this occurs if the disc surface density exceeds $\Sigma _0 \gtrsim 10^{2-3}\rm g\, cm^{-2}$, as may be the case in thin discs with near-Eddington accretion rates. Since the characteristic imprint on the GW signal is strongly dependent on disc parameters, a LISA detection of an intermediate mass ratio inspiral would probe the physics of AGN discs and migration.