scholarly journals SOME MEDICINAL PLANTS WITH ANTI-DIABETIC ACTIVITY IN EXPERIMENTAL ANIMALS

2021 ◽  
Vol 11 (6) ◽  
pp. 31-36
Author(s):  
Komal K Nikumbh
Keyword(s):  
Diabetes Management ◽  
Health Concern ◽  
Antidiabetic Activity ◽  
Endocrine Disease ◽  
Major Health ◽  
Experimental Animals ◽  
Swertia Chirata ◽  
Multisystem Involvement ◽  
Life Threatening

Diabetes is a long-term endocrine disease that affects people all over the world and is getting increasingly common. Because of its multisystem involvement and life-threatening effects, diabetes has become a major health concern for people of all ages in recent years. In 2019, diabetes was directly responsible for around 1.5 million fatalities. It's the primary cause of blindness, kidney failure, heart attack, stroke, and lower-limb amputations. Despite advances in pharmacological research and therapy, effective diabetes management remains a problem. Many therapeutic plants have demonstrated promising outcomes in animals in studies, and these findings can be applied to humans. This review examines the antidiabetic activity of common medicinal herbs such as Gymnema sylvestre, Swertia chirata, Momordica charantia, and others in experimental animals

scholarly journals ANTI-DIABETIC EFFECTS OF SOME MEDICINAL PLANTS IN EXPERIMENTAL ANIMALS: A REVIEW

2019 ◽  
Vol 7 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Mudasir Maqbool ◽  
Imran Gani ◽  
Mohmad Amin Dar
Keyword(s):  
Medicinal Plants ◽  
Age Groups ◽  
Therapeutic Interventions ◽  
Endocrine Disease ◽  
Major Health ◽  
Experimental Animals ◽  
Traditional Medicines ◽  
Multisystem Involvement ◽  
Analytical Work ◽  
Treatment Of Diabetes

Diabetes is a chronic endocrine disease with global prevalence and increasing incidence. Diabetes presents with a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. In spite of drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on finding alternative modalities. By conducting sizable amount of analytical work, numerous traditional medicines have been found for diabetes. Substances and extracts isolated from completely different natural resources particularly plants have perpetually been a fashionable arsenal for dominant and treating polygenic disorders downside and complication arising because of it. Many medicinal plants have shown promising effects in experimental animals which can be extrapolated to humans also. In this paper, we will review various medicinal plants showing anti-diabetic activity in experimental animals.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Hyperandrogenism after menopause

2015 ◽  
Vol 172 (2) ◽  
pp. R79-R91 ◽  
Author(s):  
Marios C Markopoulos ◽  
Evanthia Kassi ◽  
Krystallenia I Alexandraki ◽  
George Mastorakos ◽  
Gregory Kaltsas
Keyword(s):  
Postmenopausal Women ◽  
Imaging Modalities ◽  
Adrenal Androgen ◽  
Androgen Excess ◽  
Endocrine Disease ◽  
Diagnostic Certainty ◽  
Cardiovascular Morbidity And Mortality ◽  
Need To Evaluate ◽  
Life Threatening

Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evaluate such patients and exclude the presence of the relatively rare but potentially life-threatening underlying tumorous causes, particularly adrenal androgen-secreting tumors. It has been suggested that the rapidity of onset along with severity of symptom and the degree of androgen excess followed by relevant imaging studies may suffice to identify the source of excessive androgen secretion. However, up to date, there is no consensus regarding specific clinical and hormonal indices and/or imaging modalities required for diagnostic certainty. This is particularly relevant as the aging population is increasing and more cases of postmenopausal women with clinical/biochemical evidence of hyperandrogenism may become apparent. Furthermore, the long-term sequels of nontumorous hyperandrogenism in postmenopausal women in respect to cardiovascular morbidity and mortality still remain unsettled. This review delineates the etiology and pathophysiology of relative and absolute androgen excess in postmenopausal women. Also, it attempts to unravel distinctive clinical features along with specific hormonal cut-off levels and/or appropriate imaging modalities for the facilitation of the differential diagnosis and the identification of potential long-term sequels.

scholarly journals Case Report: Recent Case Reports of Levant Blunt-Nosed Viper Macrovipera lebetina obtusa Snakebites in Iran

2021 ◽  
Author(s):  
Seyed Mahdi Kazemi ◽  
Ahmed Al-Sabi ◽  
Chengbo Long ◽  
Mahmoud I. Shoulkamy ◽  
Tarek Mohamed Abd El-Aziz
Keyword(s):  
Case Reports ◽  
Public Health Problem ◽  
Health Concern ◽  
Systemic Hemodynamic ◽  
Significant Public Health Problem ◽  
Low Blood Pressure ◽  
Significant Public Health ◽  
Life Threatening ◽  
Macrovipera Lebetina Obtusa

Envenomation and death resulting from snakebites represent a significant public health problem worldwide, particularly in tropical and subtropical regions. The WHO has defined snakebite as a neglected tropical health concern. Bites from Macrovipera lebetina obtusa usually cause life-threatening systemic hemodynamic disturbances, reduced functionality of the kidneys, and other serious symptoms, including hypotension shock, edema, and tissue necrosis, at the bite site. Herein, we highlight five cases of M. l. obtusa envenomation that presented with wide-ranging manifestations. Many recovered cases were left with long-term musculoskeletal disabilities. In a particular case, a 15-year-old male patient was envenomed in his palm by an 80-cm M. l. obtusa. Within 12 hours, swelling extended to near the shoulder. Fasciotomy was performed on the forearm and part of the upper arm of this patient. Symptoms of severe localized pain and swelling, dizziness, weakness, low blood pressure, and itching around the bite area were documented. The patient remained in the hospital for 13 days.

Dietary Phytonutrients in the Prevention of Diabetes-related Complications

2020 ◽  
Vol 16 (7) ◽  
pp. 657-673 ◽  
Author(s):  
Pamela Jha ◽  
Sonit Kumari ◽  
Renitta Jobby ◽  
Nitin Desai ◽  
Ahmad Ali
Keyword(s):  
Clinical Evidence ◽  
Diabetes Management ◽  
Health Concern ◽  
Global Public Health ◽  
Insulin Production ◽  
Cellular Mechanisms ◽  
Biochemical Processes ◽  
Depth Study ◽  
Prevention Of Diabetes

Background: The increasing prevalence of reported cases of diabetes has evidently become a major global public health concern. Although diabetes management is possible by the administration of synthetic anti-diabetic agents, there are profound side-effects associated with their long-term usage. Hence there is a demand for safer alternatives which could be possibly formulated using specific yet common phytonutrients. Objectives: The main objective of this review is to describe the cellular mechanisms of phytonutrients as an alternative to commercially available synthetic anti-diabetic agents in the management of diabetes and related complications. Furthermore, the clinical evidence that supports this view is also highlighted. Methodology: An in-depth review of published literature was carried out to identify the most promising phytonutrients in the management of diabetes and related complications. Results: A number of phytonutrients are reported to be potential anti-diabetic agents. Few examples include biguanides, resveratrol, lycopene, thymoquinone and quercetin. However, suitable formulations using these phytonutrients and their clinical trials are still underway. Most of the reported findings focus on one aspect of several biochemical processes e.g. enhancement of glucose utilization, antioxidation, induction of insulin production, antiglycation, etc. An in-depth study of phytonutrients with respect to functional, immunological as well as biochemical factors suggesting their efficacy, as well as safety in the management of diabetes, is rarely reported. Conclusion: Our study thus highlights the abundance of clinical evidence of the efficiency of phytonutrients, and at the same time, the scarcity of clinically approved and marketed phytonutrients, as drugs, for the management of diabetes and related complications.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

335-OR: A Successful Diabetes Management Model of Care in Long-Term Care Facilities

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 335-OR
Author(s):  
SARAH L. SY ◽  
MEDHA MUNSHI
Keyword(s):  
Long Term Care ◽  
Diabetes Management ◽  
Management Model ◽  
Model Of Care ◽  
Term Care ◽  
Care Facilities

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Influence of the Intestinal Microbiota on Diabetes Management

2020 ◽  
Vol 21 (15) ◽  
pp. 1603-1615
Author(s):  
Eva Alvarez-Vieites ◽  
Arora López-Santamarina ◽  
José M. Miranda ◽  
Alicia del Carmen Mondragón ◽  
Alexandre Lamas ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microbiota ◽  
Diabetes Management ◽  
Scientific Evidence ◽  
Focused Attention ◽  
Economic Implications ◽  
Experimental Animals ◽  
Low Intensity ◽  
New Treatments ◽  
The Relationship

In recent decades, there has been a very rapid increase in the prevalence of diabetes globally, with serious health and economic implications. Although today there are several therapeutic treatments for this disease, these do not address the causes of the disease and have serious side effects, so it is necessary to seek new treatments to replace or complement the existing ones. Among these complementary treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated, which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of the latest scientific evidence on diabetes, gathering information about new trends in its management, and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible to conclude that the relationship between the intestinal microbiota and diabetes is carried out through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using probiotics for diabetes management, has been done on experimental animals, the results obtained are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the symptoms and severity of diabetes through various mechanisms related to these alterations.

scholarly journals Profile of Organophosphorus Poisoning

KYAMC Journal ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 133-135
Author(s):  
Joya Debnath ◽  
Arpan Kumar Basak ◽  
Md Zubaidur Rahman ◽  
Anujit Saha
Keyword(s):  
Organophosphorus Compound ◽  
Economic Status ◽  
Frequency Pattern ◽  
Major Health Problem ◽  
Major Health ◽  
The Public ◽  
Medical College ◽  
Phosphorus Poisoning ◽  
Life Threatening ◽  
The Government

Background : Self poisoning with organophosphate pesticides is a major health problem in world wide. Organophosphorus compound poisoning is a very common toxicological emergency encountered at Mirzapur in Tangail. It is particularly common among the rural agricultural worker's which comprise a substantial group of the population of this region.Objective: The objective of this study was to find out the incidence, frequency, pattern of poisoning, outcome and aetiological aspect of Organo phosphorus poisoning patient admitted in Kumudini Women's Medical college Hospital.Methods: A total 366 cases of OPC poisoning were analysed during 1 year from January 2015 to December 2015. The emphasis was given on age, sex, socio-economic status, occupation, motive of poisoning, types of compound consumed its quality, place, distance from referral place and the ultimate outcome.Results: Young population of rural background, particularly agricultural workers were the commonest patients (51.91%). The most common motive of poisoning was with a suicidal intent, both in males (27.59%) and females (66.39%). Financial crisis was one of the most common reasons analysed as the motive behind the poisoning (54.20%). Three hundred forty four Patients recovered and 22 were expired. The major cause of death in these cases was respiratory failure followed by multi-organ failure.Conclusion : Strict of the pesticide act and involving a new policy by the government to educate the public and youth in large about the dangerous, life threatening effects of Organophosphorus compound could help amelerioating the harmful effects of such poisoning.KYAMC Journal Vol. 9, No.-3, October 2018, Page 133-135

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