IMMEDIATE APPLY COST-EFFECTIVE EASILY PREPARABLE-AVAILABLE 21STCENTURY POTENTIAL-AYURVEDIC-HERBAL-INTEGRATIVE-MEDICINAL-VACCINE OF COVID-19: ACHIEVED AGRICULTURE HEALTHCARE-SOCIO-ECONOMY SCIENCE TECHNOLOGY COMMUNICATION MECHANISM!

The 5th epidemic-COVID-19 spreads all around the world forming total change of the world health, education, research, travel, socioeconomic, and human civilization, and the proper potential vaccine still unknown for the future efficacy of reinfection outbreaks of the vaccinated peoples with manufacturing capacity for the whole world population including new variant also. The poor marginalized society, aged people, street -children, and -animals, are not able to manage and purchase vaccines. And the pandemic must be controlled or managed by every nation; otherwise, a globe is at risk of further outbreaks, and India with the whole world develop a policy to overcome the pandemic-COVID-19. India emphasis on consumption of vegetable as the preventive traditional-ayurvedic-medicines against many naturally-infected-diseases of man, animals and plants caused by various-pathogens, remarkably reducing agricultural productions. The various-pesticides reduce the plant-diseases, but it is not cost-effective and environment-friendly. The present treatment confirms the flowering-meristems of wormwoods-Artemisia nilagirica (Clarke) Pamp, prepared or developed the ayurvedic-medicine, dissolved in germfree-tap-water applying foliar-spray against plant-diseases, and the molecular-weight of soluble-root-proteins were determined. The recent treatment confirms once again that the ayurvedic-medicines-prepared from the flowering-meristems of Artemisia nilagirica (Clarke) Pamp are very much effective in controlling different-plant-pathogens caused many-diseases, synthesizing many new PR-proteins (pathogenesis-related-protein), boosting their response of defense naturally against pathogens, and increased growth of plants and protein-content, by confirming the “Immediate Apply Cost-Effective Easily Preparable-Available 21stCentury Potential-Ayurvedic-Herbal-Integrative-Medicinal-Vaccine of COVID-19: Achieved Agriculture Healthcare-Socio-Economy Science Technology Communication Mechanism with Clinical, Physical, Chemical, Biological, Physiological, and Molecular Weight”, by boosting-immunity. And it will be best side-effect-free potential-ayurvedic-COVID-19-Vaccine due to an ultra-diluted-low-dose, and globally develop all aspects in the scientific-basis of the ayurvedic-biomedicines, and it is thought that the present problems of the civilization of human will soon be overcome as early as possible retaining whole world in the new-normal or old-forms against the COVID-19.

BIOMEDICINES-CINA AGAINST COVID-19: CONTROLLED PLANT DISEASES ENRICHED SCIENCE AND TECHNOLOGY COMMUNICATION GREEN ECONOMY

The economic-plant-mulberry is infected by different pathogens causing diseases and significantly reduces silk production. Though pesticides are the most effective means of control, but they are expensive and not environment friendly. On the other hand, the ongoing spread of the novel coronavirus, forming epidemic, affecting human civilizations, because recently, no appropriate antiviral drugs for effective treatments or vaccines against COVID-19. To meet the challenge, it is reported that the therapeutic value of traditional-, complementary- and alternative-biomedicines-Artemisia nilagirica, has been used for centuries, to overcome various medical disorders. So, to concur with the situation, it will require new and more efficient solutions, technologies, and products. Present pretreatment with ultra-high-diluted biomedicines-Cina, prepared from the flowering meristems of Artemisia nilagirica (Clarke) pamp, mixed with water at an extremely low dose, were applied by foliar spray once daily for 15 days @ 10 ml/plant, against naturally occurring, root-knot-, leaf spot-, powdery mildew-, mosaic- and tukra- mulberry diseases, in field trials and silkworms rearing. Pretreatment-investigations have revealed that ultra-high-diluted-Cina, highly effective in ameliorating different mulberry-diseases by inducing their natural defense-response against pathogens-infection and leaving no residual-toxicity in the leaves to affect the growth of silkworms also. It can be concluded that the ultra-high-diluted, eco-friendly easily-available, easily applicable-Cina, at an extremely low dose, not only used as a potential-biomedical-drug against various plant-diseases, by inducing natural-defense- response, but also, it may be effective against COVID-19 for vaccinations and clinical trials by boosting the natural immune system for the improvement of Science and Technology communication cost-effectiveness green-economy and biodiversity conservations as well as bio-applications issues. And the future clinical-scientists develop all aspects of clinical-case-reports by publishing in the appropriate medical research archives, with the sincere hope that this crisis will soon be over and the whole world, may fight against the COVID-19 war, retaining normal forms of human civilizations globally.

Acaricidal Activity of Artemisia nilagirica Leaves Against Rhipicephalus (Boophilus) annulatus Ticks

Since time immemorial, human beings have used various parts of plants in either prevention or treatment of ailments. Plants are rich sources of secondary metabolites such as alkaloids, steroids, terpenoids, flavonoids, and phenolic compounds with a high structural diversity. Many plants/herbs with specific biological activities such as antitumor, antioxidant, anti-inflammatory, antifungal, sedative, and acaricidal activity have been reported. Artemisia nilagirica (C. B. Clarke) Pamp. (Compositae) is a plant traditionally used for insect control in the southern part of India. Previous studies have demonstrated the activity of Artemisia species against pests. The present study thus evaluates the acaricidal activity of crude ethanolic extract of A. nilagirica leaves and its fractions against Rhipicephalus (Boophilus) annulatus. Ticks are ectoparasites that transmit several protozoal, viral, and rickettsial diseases. In south India, R. (B.) annulatus is the commonly observed tick species. Control of these acarine parasites that adversely affect milk and meat production is a tough task. Chemical acaricides such as organophosphates, synthetic pyrethroids, amitraz, and ivermectin are commonly used in tick control. The high cost, environmental hazards, and development of acaricidal resistance are some of the drawbacks of these chemical acaricides. Plant-based formulations are one of the promising approaches for the control of ectoparasites. Previously, extracts from various medicinal/aromatic plants were reported for acaricidal activity from our laboratory, such as Tetrastigma leucostaphylum (Dennst.) Alston, Chassalia curviflora (Wall.) Thwaites, Jatropha curcas L., and Ageratum conyzoides Hieron. Biochemical quantification, fluorescence analysis, and primary phytochemical analysis are already reported for the ethanolic extract and its fractions of areal parts of A. nilagirica. Phytochemical characterization of ethanolic extract of A. nilagirica from Kerala, India was shown to have the presence of terpenoids, flavonoids, steroids, saponins, fixed oils and fats, tannins, and glycosides.