Role of Sex on the Genetic Susceptibility to Childhood Asthma in Latinos and African Americans

Asthma is a respiratory disease whose prevalence changes throughout the lifespan and differs by sex, being more prevalent in males during childhood and in females after puberty. In this study, we assessed the influence of sex on the genetic susceptibility to childhood asthma in admixed populations. Sex-interaction and sex-stratified genome-wide association studies (GWAS) were performed in 4291 Latinos and 1730 African Americans separately, and results were meta-analyzed. Genome-wide (p ≤ 9.35 × 10−8) and suggestive (p ≤ 1.87 × 10−6) population-specific significance thresholds were calculated based on 1000 Genomes Project data. Additionally, protein quantitative trait locus (pQTL) information was gathered for the suggestively associated variants, and enrichment analyses of the proteins identified were carried out. Four independent loci showed interaction with sex at a suggestive level. The stratified GWAS highlighted the 17q12-21 asthma locus as a contributor to asthma susceptibility in both sexes but reached genome-wide significance only in females (p-females < 9.2 × 10−8; p-males < 1.25 × 10−2). Conversely, genetic variants upstream of ligand-dependent nuclear receptor corepressor-like gene (LCORL), previously involved in height determination and spermatogenesis, were associated with asthma only in males (minimum p = 5.31 × 10−8 for rs4593128). Enrichment analyses revealed an overrepresentation of processes related to the immune system and highlighted differences between sexes. In conclusion, we identified sex-specific polymorphisms that could contribute to the differences in the prevalence of childhood asthma between males and females.

Airborne Validation of ICESat-2 ATLAS Data Over Crevassed Surfaces and Other Complex Glacial Environments: Results From Experiments of Laser Altimeter and Kinematic GPS Data Collection From a Helicopter Over a Surging Arctic Glacier (Negribreen, Svalbard)

The topic of this paper is the airborne evaluation of ICESat-2 Advanced Topographic Laser Altimeter System (ATLAS) measurement capabilities and surface-height-determination over crevassed glacial terrain, with a focus on the geodetical accuracy of geophysical data collected from a helicopter. To obtain surface heights over crevassed and otherwise complex ice surface, ICESat-2 data are analyzed using the density-dimension algorithm for ice surfaces (DDA-ice), which yields surface heights at the nominal 0.7~m along-track spacing of ATLAS data. As the result of an ongoing surge, Negribreen, Svalbard, provided an ideal situation for the validation objectives in 2018 and 2019, because many different crevasse types and morphologically complex ice surfaces existed in close proximity. Airborne geophysical data, including laser altimeter data (profilometer data at 905~nm frequency), differential Global Positioning System (GPS), Inertial Measurement Unit (IMU) data, on-board-time-lapse imagery and photographs, were collected during two campaigns in summers of 2018 and 2019. Airborne experiment setup, geodetical correction and data processing steps are described here. To date, there is relatively little knowledge of the geodetical accuracy that can be obtained from kinematic data collection from a helicopter. Our study finds that (1)~Kinematic GPS data collection with correction in post-processing yields higher accuracies than Real-Time-Kinematic (RTK) data collection. (2)~Processing of only the rover data using the Natural Resources Canada Spatial Reference System Precise Point Positioning (CSRS-PPP) software is sufficiently accurate for the sub-satellite validation purpose. (3)~Distances between ICESat-2 ground tracks and airborne ground tracks were generally better than 25~m, while distance between predicted and actual ICESat-2 ground track was on the order of 9~m, which allows direct comparison of ice-surface heights and spatial statistical characteristics of crevasses from the satellite and airborne measurements. (4)~The Lasertech Universal Laser System (ULS), operated at up to 300~m above ground level, yields full return frequency (400~Hz) and 0.06-0.08~m on-ice along-track spacing of height measurements. (5)~Cross-over differences of airborne laser altimeter data are 0.1918 $\pm$ 2.385~m along straight paths over generally crevassed terrain, which implies a precision of approximately 2.4~m for ICESat-2 validation experiments. (6)~In summary, the comparatively light-weight experiment setup of a suite of small survey equipment mounted on a Eurocopter (Helicopter AS-350) and kinematic GPS data analyzed in post-processing using CSRS-PPP leads to high accuracy repeats of the ICESat-2 tracks. The technical results (1)-(6) indicate that direct comparison of ice-surface heights and crevasse depths from the ICESat-2 and airborne laser altimeter data is warranted. The final result of the validation is that ICESat-2 ATLAS data, analyzed with the DDA-ice, facilitate surface-height determination over crevassed terrain, in good agreement with airborne data, including spatial characteristics, such as surface roughness, crevasse spacing and depth, which are key informants on the deformation and dynamics of a glacier during surge.

Airborne Validation of ICESat-2 ATLAS Data Over Crevassed Surfaces and Other Complex Glacial Environments: Results From Experiments of Laser Altimeter and Kinematic GPS Data Collection From a Helicopter Over a Surging Arctic Glacier (Negribreen, Svalbard)

The topic of this paper is the airborne evaluation of ICESat-2 Advanced Topographic Laser Altimeter System (ATLAS) measurement capabilities and surface-height-determination over crevassed glacial terrain, with a focus on the geodetical accuracy of geophysical data collected from a helicopter. To obtain surface heights over crevassed and otherwise complex ice surface, ICESat-2 data are analyzed using the density-dimension algorithm for ice surfaces (DDA-ice), which yields surface heights at the nominal 0.7~m along-track spacing of ATLAS data. As the result of an ongoing surge, Negribreen, Svalbard, provided an ideal situation for the validation objectives in 2018 and 2019, because many different crevasse types and morphologically complex ice surfaces existed in close proximity. Airborne geophysical data, including laser altimeter data (profilometer data at 905~nm frequency), differential Global Positioning System (GPS), Inertial Measurement Unit (IMU) data, on-board-time-lapse imagery and photographs, were collected during two campaigns in summers of 2018 and 2019. Airborne experiment setup, geodetical correction and data processing steps are described here. To date, there is relatively little knowledge of the geodetical accuracy that can be obtained from kinematic data collection from a helicopter. Our study finds that (1)~Kinematic GPS data collection with correction in post-processing yields higher accuracies than Real-Time-Kinematic (RTK) data collection. (2)~Processing of only the rover data using the Natural Resources Canada Spatial Reference System Precise Point Positioning (CSRS-PPP) software is sufficiently accurate for the sub-satellite validation purpose. (3)~Distances between ICESat-2 ground tracks and airborne ground tracks were generally better than 25~m, while distance between predicted and actual ICESat-2 ground track was on the order of 9~m, which allows direct comparison of ice-surface heights and spatial statistical characteristics of crevasses from the satellite and airborne measurements. (4)~The Lasertech Universal Laser System (ULS), operated at up to 300~m above ground level, yields full return frequency (400~Hz) and 0.06-0.08~m on-ice along-track spacing of height measurements. (5)~Cross-over differences of airborne laser altimeter data are 0.1918 $\pm$ 2.385~m along straight paths over generally crevassed terrain, which implies a precision of approximately 2.4~m for ICESat-2 validation experiments. (6)~In summary, the comparatively light-weight experiment setup of a suite of small survey equipment mounted on a Eurocopter (Helicopter AS-350) and kinematic GPS data analyzed in post-processing using CSRS-PPP leads to high accuracy repeats of the ICESat-2 tracks. The technical results (1)-(6) indicate that direct comparison of ice-surface heights and crevasse depths from the ICESat-2 and airborne laser altimeter data is warranted. The final result of the validation is that ICESat-2 ATLAS data, analyzed with the DDA-ice, facilitate surface-height determination over crevassed terrain, in good agreement with airborne data, including spatial characteristics, such as surface roughness, crevasse spacing and depth, which are key informants on the deformation and dynamics of a glacier during surge.

Monocular Pedestrian 3D Localization for Social Distance Monitoring

Social distancing protocols have been highly recommended by the World Health Organization (WHO) to curb the spread of COVID-19. However, one major challenge to enforcing social distancing in public areas is how to perceive people in three dimensions. This paper proposes an innovative pedestrian 3D localization method using monocular images combined with terrestrial point clouds. In the proposed approach, camera calibration is achieved based on the correspondences between 2D image points and 3D world points. The vertical coordinates of the ground plane where pedestrians stand are extracted from the point clouds. Then, using the assumption that the pedestrian is always perpendicular to the ground, the 3D coordinates of the pedestrian’s feet and head are calculated iteratively using collinear equations. This allows the three-dimensional localization and height determination of pedestrians using monocular cameras, which are widely distributed in many major cities. The performance of the proposed method was evaluated using two different datasets. Experimental results show that the pedestrian localization error of the proposed approach was less than one meter within tens of meters and performed better than other localization techniques. The proposed approach uses simple and efficient calculations, obtains accurate location, and can be used to implement social distancing rules. Moreover, since the proposed approach also generates accurate height values, exclusionary schemes to social distancing protocols, particularly the parent-child exemption, can be introduced in the framework.

Improved Height Estimation Using Extended Kalman Filter on UWB-Barometer 3D Indoor Positioning System

Indoor 3D positioning system requires precise information from all three dimensions in space, but measurements in the vertical direction are usually interfered by sensors properties, unexpected obstructions, and other factors. Thus, accuracy and robustness are not guaranteed. Aiming at this problem, we propose a novel sensor fusion algorithm to improve the height estimation for a UWB-barometer integrated positioning system by introducing a pseudo reference update mechanism and the extended Kalman filter (EKF). The proposed fusion approach effectively helps with sensing noise reduction and outlier restraint. The results from numerical experiment investigations demonstrate that the accuracy and robustness of the proposed method achieved better improvement in height determination.

IWV retrieval from ship-borne GNSS receiver in the framework of the MAP-IO project

&lt;p&gt;In the framework of the research project &amp;#8220;Marion Dufresne Atmospheric Program &amp;#8211; Indian Ocean&amp;#8221; (MAP-IO), which is aiming at collecting long-term atmospheric and marine biology observations in the under-instrumented Indian and Austral Oceans, a Global Navigation Satellite System (GNSS) receiver was installed on the research vessel (RV) Marion Dufresne in October 2020 to describe, and monitor, global moisture changes in these areas. GNSS raw data are recorded continuously and used to retrieve integrated water vapor contents (IWV) along the RV route.&lt;/p&gt;&lt;p&gt;After a data quality check that confirmed that a wise choice of location of the GNSS antenna on the RV is crucial to avoid mask, signal reflection and interference from other instruments that may degrade IWV retrieval, a first assessment of the GNSS analysis performances was carried out by comparing the vertical component of the estimated positions to sea surface height model. The differences are on the order of 20 to 30 cm; they are consistent with both the error budget for sea surface height determination using GNSS and the sea surface height model formal errors.&lt;/p&gt;&lt;p&gt;An evaluation of GNSS-derived IWV was conducted using IWV estimates from the ECMWF fifth ReAnalysis (ERA5) and ground-based GNSS reference stations located nearby the tracks of RV Marion Dufresne. Preliminary analyses show encouraging results with a mean root mean square error of ~2-3&amp;#160;kg&amp;#160;m&lt;sup&gt;-&lt;/sup&gt;&lt;sup&gt;2&lt;/sup&gt; between ERA5 and GNSS-derived IWV. The use of ultra-rapid GNSS orbit and clock product was also investigated to assess the performance of near real-time GNSS-derived IWV estimation for numerical weather prediction purposes.&lt;/p&gt;

Analyzing Precision and Efficiency of Global Navigation Satellite System-Derived Height Determination for Coastal and Island Areas

The global navigation satellite system (GNSS)-derived height determination technique is applied in the field of surveying owing to the broad use of GNSS and the development of precise local geoid models. In Korea, this technique was officially adopted in 2020 for public surveying, such as urban facility mapping; it is also treated as an efficient way to unify the vertical datum of the inland and island areas of Korea. Here, GNSS surveying was conducted on 19 stations located in Korea’s coastal regions and islands, and GNSS-derived elevations were determined. When each GNSS-derived elevation was compared with elevations from spirit leveling, all stations showed differences of less than 3 cm when GNSS surveying was conducted for 4 h/day over two days; they were smaller than 5 cm with 2 h of surveying. These differences meet the standards of GNSS-derived elevations in Korea. In addition, GNSS-derived elevations were compared with those obtained via sea-crossing leveling in two regions, showing differences smaller than 1 cm. Sea-crossing leveling takes longer than GNSS-derived height determination, and its accuracy can be significantly affected by various environments, such as sea fog. Thus, GNSS-derived height determination represents a practical and useful technique.

Report of the D-A-CH geoid and height unification project and prospects for the extension to the European Alps and beyond

&lt;p&gt;The D-A-CH geoid project was initiated in 2017 between the national mapping agencies of Germany (BKG), Austria (BEV) and Switzerland (swisstopo), as well as the regional authorities of the German federal states of Bavaria (LDBV) and Baden-W&amp;#252;rttemberg (LGL), with the motivation to better harmonize the basis for height determination.&lt;/p&gt;&lt;p&gt;In these countries, the official national height reference systems that are still in use apply different definitions of the height and the zero levels refer to different tide gauges and epochs. Additionally, the treatment of the permanent tide is not fully consistent. This causes differences at the decimeter scale which also vary along the national borders. At the same time, Austria and Switzerland do compute and store also EVRS-compatible geopotential numbers that are valuable for height system unification.&lt;/p&gt;&lt;p&gt;The ambitions of the initiative therefore mirror the situation as described above &amp;#8210; to foster and to intensify the cooperation between the partners regarding regional gravity field modeling and to provide better information about the transformations between the national height systems.&lt;/p&gt;&lt;p&gt;It was agreed that the cooperation should first focus on a case study area around Lake Constance, with envisaged extension to the complete territories of the &amp;#8220;D-A-CH countries&amp;#8221; and/or, ideally, to the most of the European Alps. The following achievements have been reached for the focus area:&lt;/p&gt;&lt;p&gt;In view of these developments, and taking into account that these challenges are not unique for this specific area, it is planned to extend this initiative to the computation of the entire European Alps (and surrounding lowland areas) and rename the project to &amp;#8220;European Alps Geoid (EAlpG)&amp;#8221;.&lt;/p&gt;&lt;p&gt;We believe that this project can contribute to a better understanding of height differences across borders. Such height differences are for instance of great interest for ground water level investigations or flood protection. Other crucial applications for cross-border height unification are engineering projects such as tunnels, bridges, supply lines, etc.&lt;/p&gt;&lt;p&gt;What is more, these activities shall be embedded in a pan-European geoid initiative within EUREF. Contributing to the upcoming EUREF Working Group &amp;#8220;European Height Reference Surface&amp;#8221;, the European Alps Geoid will be one of many cornerstones to build an official EVRS height reference surface.&lt;/p&gt;&lt;p&gt;Potential cooperation partners have been contacted. Nevertheless, the initiative shall be open to interested parties. A virtual meeting is planned to be held shortly after the vEGU2021.&lt;/p&gt;

Characterization of Cirrus Clouds in the Mid-Latitude Tropopause Region

&lt;p&gt;Cirrus clouds contribute to the general radiation budget of the Earth, playing an important role in climate projections. Of special interest are optically thin cirrus clouds close to the tropopause due to the fact that they are difficult to capture and thus their impact is not yet well understood. This study presents a characterization of cirrus clouds observed by the limb sounder GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) aboard the German research aircraft HALO during the WISE (Wave-driven ISentropic Exchange) campaign in September/October 2017. This campaign took place in Shannon, Ireland (52.70&amp;#176;N, 8.86&amp;#176;W).&amp;#160; We developed an optimized cloud detection method and derived macro-physical characteristics of the detected cirrus clouds: cloud top height, cloud bottom height, vertical extent and cloud top position with respect to the tropopause. The fraction of cirrus clouds detected above the tropopause (&gt; 0 km) is in the order of 13% to 27%, depending on the detection method and the definition of the tropopause. In general, good agreement with the clouds predicted by the ERA5 reanalysis dataset is obtained. However, cloud occurrence is &amp;#8776;50% higher in the observations for the region close to and above the tropopause. Cloud bottom heights are also detected above the tropopause. Considering the uncertainties for the tropopause height, cloud top height and cloud bottom height determination we could not find unambiguous evidence for the formation of cirrus layers above the tropopause. In addition, for a better understanding of the tropopause cirrus properties and life conditions, two cirrus cases observed during two scientific flights were selected from&amp;#160; the observations and compared with cirrus simulations performed with the 3D Lagrangian microphysical model&amp;#160; CLaMS-Ice, which is based on the two-moment bulk &amp;#160;cirrus model by Spichtinger and Gierens (2009) (doi: 10.5194/acp-9-685-2009). The model is fed by backward trajectories computed from high resolution ERA5 data (hourly, spatial grid 30 km). This contribution summarizes and extends on work described by Bartolome Garcia et al. (2020) (doi:10.5194/amt-2020-394).&lt;/p&gt;