Introduction: Calcium-channel blockers are known for their buccal side effect as Gingival Overgrowth (GO). Although Amlodipine is considered a safe drug, it may induce gingival overgrowth for some individuals, inducing then, an aesthetic prejudice for the patient and causing serious managerial problems for clinicians. This case reports unusual defects of Amlodipine-induced gingival overgrowth, with a large gingival mass that almost completely disappeared only after improving the buccal environment. Case Study: A 51-year old Moroccan woman was complaining of gingival bleeding swelling. The examination revealed a general GO on the labial side, from the 22 to 15. It involved the entire height of the keratinized gingiva, including papillae on the buccal side. The oral hygiene was really defective with abundant plaque and calculus. The patient had hypertension and daily treated by Amlodipine 5mg for one year. But she developed the GO just few months before her first visit. The mass, associated with a chronic periodontitis, almost disappeared after scaling and root planning. Such a minimal surgical treatment showed improvement with no drug substitution or reduction. She was regularly followed up for 10 months. Conclusion: Improvement of oral hygiene, associated to periodontal non-surgical treatment alone, can afford clinical satisfaction. Changing the patient’s medication should be the last solution when local measures fail.