Predicting Particulate Matter (PM2.5) in Malaysia using Multiple Linear Regression and Artificial Neural Network

Air pollution is a well-known issue for all countries, including Malaysia. It has been stated that particulate matter that less than 2.5mm known as PM2.5 has a greater effect on health as the smaller particulate size can penetrate deep into the respiratory system and affect the cardiovascular system significantly. Therefore, it is necessary to estimate the concentration of PM2.5 for haze precautions. This study characterizes the pattern of PM2.5 concentrations involving seven stations including Alor Setar, Shah Alam, Pasir Gudang, Ipoh, Kuantan, Kuala Terengganu and Miri with seven indicator parameters (Carbon Monoxide, Ozone, Sulphur Dioxide, Nitrogen Dioxide, Humidity, Temperature and Wind Speed). PM2.5 concentrations were predicted for each station using Multiple Linear Regression (MLR) and Artificial Neural Networks (ANN). Descriptive and trend analysis using Mann-Kandell Trend analysis was used to describe the haze characteristics and identify significant trends in the haze selected locations in Malaysia. MLR and ANN were fitted for the data. The performance of both prediction models was compared based on R2 and Mean Square Error (MSE). The results show ANN performed better than MLR with a high value of coefficient determination (R2) and low error measure. The ANN model was used to predict the occurrence of haze for the next day in the Air Quality Index (API).

The Planetary Vaporization Event Hypothesis: Supercharging Earth’s Geothermal Core, Identifying Side Effects Blast Patterns, and Inferring how to Find Earth-Like Planets or Identifying Super Charged Geothermal Cores and their Byproduct Blast Patterns

The supercharged nature of the Earth’s geothermal core can be demonstrated by three thought experiments exhibiting it is tremendously more powerful than any other terrestrial object in the solar system (planet or moon). Identifying a minimum of four byproduct asteroid blast patterns linked to the formation of Earth’s supercharged geothermal core is critical to properly identifying stars that also have these four byproduct asteroid blast patterns. These stars are the most likely to host an Earth-like planet qualified by having a supercharged geothermal core. The Planetary Vaporization-Event (PVE) Hypothesis provides a basis for correlation between the supercharged nature of Earth’s geothermal core and at least 14 listed side effects: (1) the asteroid-wide/planet-scale homogenization and lack thereof of 182W ε for Earth, the Moon, Mars and meteors, (2) the primary and secondary shifting of Earth’s tectonic plates, (3) the solar system wide displacement of Earth’s wayward moons (including Ceres, Pluto, Charon and Orcus) outgassing identical samples of ammoniated phyllosilicates, (4) the formation of asteroids at 100+ times the expected density of a nebular cloud vs. pre-solar grains formation density at the expected density of a nebular cloud, (5) three distinct formation timestamps for all known asteroids within a 5 million year window 4.55+ billion years ago, (6) the estimated formation temperature of CAI at 0.86 billion Kelvin and (7) the remaining chondritic meteorite matrix flash vaporizing at 1,200–1,900 °C, (8) followed by rapid freezing near 0 K, (9) the development of exactly 2 asteroid belts and a swarm of non-moon satellites, (10) particulate size distinction between the 2 asteroid belts of small/inner, large/outer, (11) the proximity of the Trojan Asteroid Groups to the Main Asteroid Belt, (12) observation of a past or present LHB, (13) the development of annual meteor showers for Earth proximal to apogee and/or perigee, (14) the Sun being the most-likely object struck by an asteroid in the inner solar system. Through better understanding of the relevant data at hand and reclassification of the byproducts of supercharging the core of a planet, at least 5 new insights can be inferred and are listed as: (1) the original mass, (2) distance and (3) speed of Earth Mark One, (4) the original order of Earth’s multi-moon formation and (5) the high probability of finding detectable signs of life on a planet orbiting the stars Epsilon Eridani and Eta Corvi. There are at least 6 popular hypothesis that the PVE Hypothesis is in conflict with, listed they are: (1) a giant impact forming the Moon, (2) asteroids being the building blocks of the solar system, (3) the Main Asteroid Belt being the result of a planet that never formed, (4) the LHB being a part of the accretion disk process, (5) the heat in Earth’s core coming primarily from the decay of radioactive elements, (6) the Oort Cloud being the source of ice comets.

GMMA-Based Vaccines: The Known and The Unknown

Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria engineered to provide an over-vesiculating phenotype, which represent an attractive platform for the design of affordable vaccines. GMMA can be further genetically manipulated to modulate the risk of systemic reactogenicity and to act as delivery system for heterologous polysaccharide or protein antigens. GMMA are able to induce strong immunogenicity and protection in animal challenge models, and to be well-tolerated and immunogenic in clinical studies. The high immunogenicity could be ascribed to their particulate size, to their ability to present to the immune system multiple antigens in a natural conformation which mimics the bacterial environment, as well as to their intrinsic self-adjuvanticity. However, GMMA mechanism of action and the role in adjuvanticity are still unclear and need further investigation. In this review, we discuss progresses in the development of the GMMA vaccine platform, highlighting successful applications and identifying knowledge gaps and potential challenges.

A New Approach of Dedusting for IGCC by a Two-Stage Moving Granular Bed Filter

We propose a dust removal technology in which a two-stage moving granular bed filter was employed using coarse and fine filtering granules. The pressure drop, collection efficiency, and dust particulate size distributions were investigated using various mass flow rates for coarse and fine granules at room temperature. In addition, the ratio of mass consumption was used to reveal the actual mass flow. The ratio of mass consumption influenced the pressure drop, collection efficiency, and dust particulate size distributions. Particulates larger than 1.775 μm were removed by the filter. Our results showed that a mass flow of 330 g/min for coarse granules and a mass flow of 1100 g/min for fine granules provided optimal collection efficiency and particulate size distribution. The proposed design can aid the development of high-temperature systems in power plants.

Recent advances in Nanocrystal

The biggest challenge in the discovery and fabrication of drugs nowadays is low solubility. Many new chemical entities have major therapeutic effects, increased performance, but due to poor water solubility their clinical applications are limited. This is why Nanocrystal technology to solve the issue of low aqueous solubility was established. Nanocrystal technology improves the rate of dissolution according to the surface area of the active medicinal substance by reducing its particulate size to the nano size level, maintaining the pharmaceutical crystal morphology and enhancing pharmacokinetic and pharmacodynamic properties of different types of pharmaceuticals. Nanocrystals are prepared using the method down, up and down, spray drying and thus new techniques. Nanocrystals loaded as tablet or capsule. The obtained nanocrystal can be managed in different ways. Using freeze-drying or spray-drying to produce powder, which then is used for tabletting or other oral product, may usually be dried with nanocrystal.

Effect of wood particulate size on the mechanical properties of PLA biocomposite

Purpose The purpose of this study is to carry out an investigation of the role of the wood particle size on the mechanical properties of poly lactic acid (PLA)-reinforced neem fiber biocomposite. Design/methodology/approach Composite test specimens were processed by reinforcing neem wood flour (NWF) in two different particle sizes, micro-sized NWF (MNWF) and nano-sized NWF (NNWF) separately into PLA. Composites were extruded at four different fiber loadings (10, 15, 20 and 25 Wt.%) into PLA matrix. The MNWF and NNWF had particle sizes varying from 5 to 15 µm and 10 to 15 nm, respectively. Findings Tensile strength, flexural strength and impact strength of PLA increased with fiber reinforcement for both the MNWF and NNWF cases. The NNWF-reinforced PLA composite at 20 Wt.% fiber loading proved to be the best composite that had outstanding mechanical properties in this research. Practical implications The developed composite can be used as a substitute for conventional plywood for furniture, building infrastructure and interior components for the automobile, aircraft and railway sectors. Originality/value A new biocomposite had been fabricated by using PLA and NWF and had been tested for its mechanical characteristics.