(RS)-bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis

2022 ◽  
Vol 103 ◽  
pp. 108501
Author(s):  
Liangjun Deng ◽  
Shanping Wang ◽  
Haihua Guo ◽  
Xiaoming Liu ◽  
Xinfeng Zou ◽  
...  
Keyword(s):  
Potential Improvement

The stabilization of B.C.C. Cu in Cu/Nb nanolayered composites

1996 ◽  
Vol 54 ◽  
pp. 228-229
Author(s):  
H. Kung ◽  
A.J. Griffin ◽  
Y.C. Lu ◽  
K.E. Sickafus ◽  
T.E. Mitchell ◽  
...  
Keyword(s):  
Electrical Resistivity ◽  
Layer Thickness ◽  
Volume Fraction ◽  
Ion Beam ◽  
High Strength ◽  
Cross Sectional ◽  
Metastable Structure ◽  
High Resolution Tem ◽  
Potential Improvement ◽  
Two Phases

Materials with compositionally modulated structures have gained much attention recently due to potential improvement in electrical, magnetic and mechanical properties. Specifically, Cu-Nb laminate systems have been extensively studied mainly due to the combination of high strength, and superior thermal and electrical conductivity that can be obtained and optimized for the different applications. The effect of layer thickness on the hardness, residual stress and electrical resistivity has been investigated. In general, increases in hardness and electrical resistivity have been observed with decreasing layer thickness. In addition, reduction in structural scale has caused the formation of a metastable structure which exhibits uniquely different properties. In this study, we report the formation of b.c.c. Cu in highly textured Cu/Nb nanolayers. A series of Cu/Nb nanolayered films, with alternating Cu and Nb layers, were prepared by dc magnetron sputtering onto Si {100} wafers. The nominal total thickness of each layered film was 1 μm. The layer thickness was varied between 1 nm and 500 nm with the volume fraction of the two phases kept constant at 50%. The deposition rates and film densities were determined through a combination of profilometry and ion beam analysis techniques. Cross-sectional transmission electron microscopy (XTEM) was used to examine the structure, phase and grain size distribution of the as-sputtered films. A JEOL 3000F high resolution TEM was used to characterize the microstructure.

“Getting High Resolution Out of A High Voltage Microscope”

1980 ◽  
Vol 38 ◽  
pp. 822-825
Author(s):  
David J. Smith
Keyword(s):  
Electron Microscope ◽  
High Resolution ◽  
High Voltage ◽  
Theoretical Limit ◽  
Voltage Electron ◽  
High Voltage Electron Microscope ◽  
High Voltage Electron ◽  
Technological Advances ◽  
Potential Improvement ◽  
Lower Voltage

The initial attractions of the high voltage electron microscope (HVEM) stemmed mainly from the possibility of considerable increases in electron penetration through thick specimens compared with conventional 100KV microscopes, although the potential improvement in resolution associated with the decrease in election wavelength had been fully appreciated for many years (eg. Cosslett, 1946)1, even if not realizable in practice. Subsequent technological advances enabled the performance of lower voltage machines to be brought closer to the theoretical limit, to be followed in turn by more recent projects which have been successful, eventually, in achieving even higher resolution with dedicated higher voltage instruments such as those at Kyoto (500KV)2, Munich (400KV)3, Ibaraki (1250KV)4 and Cambridge (600KV)5. It does not necessarily follow however that the performance of journal high voltage microscopes can be easily upgraded, retrospectively, to the same level, as will be discussed in detail below.

Sugar factory audits, debottlenecking and efficiency improvement

2020 ◽  
pp. 607-612
Author(s):  
Bernard Coûteaux
Keyword(s):  
Evaluation Method ◽  
Predictive Modelling ◽  
Cane Sugar ◽  
Sugar Factory ◽  
Low Energy Consumption ◽  
Process Simulations ◽  
Capital Efficiency ◽  
Potential Improvement ◽  
Primary Focus

This paper elaborates on the key solutions offered by De Smet Engineers & Contractors (DSEC) to optimize the efficiency of cane sugar producing and processing facilities. In order to meet customer needs, DSEC offers proprietary predictive models built using the latest versions of specialized software. These models allow factory managers to envision the whole picture of increased operational and capital efficiency before it becomes reality. An integrated energy model and the CAPEX/OPEX evaluation method are discussed as ways to estimate and optimize costs, both for new greenfield projects and revamping of existing factories. The models demonstrate that factory capacities can be successfully increased using equipment that is already available. Special attention is paid to crystallization and centrifugation process simulations and the potential improvement of the global energy balance. One case study shows the transformation of a beet sugar factory into a refinery to process raw cane sugar after beet crop season and the second case shows the integration of a refinery into a cane sugar factory. The primary focus of the article is optimization of the technological process through predictive modelling. DSEC’s suggested solutions, which lead to great improvements in a plant’s efficiency and its ability to obtain very low energy consumption, are discussed.

scholarly journals Towards a Methodology for Component Design of Metallic AM Parts Subjected to Cyclic Loading

Metals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 709
Author(s):  
Uwe Zerbst ◽  
Mauro Madia ◽  
Giovanni Bruno ◽  
Kai Hilgenberg
Keyword(s):  
Unsolved Problem ◽  
Fatigue Cracks ◽  
Special Focus ◽  
Laser Powder Bed Fusion ◽  
Powder Bed ◽  
Lack Of Fusion ◽  
Fatigue Design ◽  
Component Design ◽  
Similar Temperature ◽  
Potential Improvement

The safe fatigue design of metallic components fabricated by additive manufacturing (AM) is still a largely unsolved problem. This is primarily due to (a) a significant inhomogeneity of the material properties across the component; (b) defects such as porosity and lack of fusion as well as pronounced surface roughness of the as-built components; and (c) residual stresses, which are very often present in the as-built parts and need to be removed by post-fabrication treatments. Such morphological and microstructural features are very different than in conventionally manufactured parts and play a much bigger role in determining the fatigue life. The above problems require specific solutions with respect to the identification of the critical (failure) sites in AM fabricated components. Moreover, the generation of representative test specimens characterized by similar temperature cycles needs to be guaranteed if one wants to reproducibly identify the critical sites and establish fatigue assessment methods taking into account the effect of defects on crack initiation and early propagation. The latter requires fracture mechanics-based approaches which, unlike common methodologies, cover the specific characteristics of so-called short fatigue cracks. This paper provides a discussion of all these aspects with special focus on components manufactured by laser powder bed fusion (L-PBF). It shows how to adapt existing solutions, identifies fields where there are still gaps, and discusses proposals for potential improvement of the damage tolerance design of L-PBF components.

scholarly journals Review of Current Spinal Robotic Orthoses

Healthcare ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 70
Author(s):  
Siu Kei David Mak ◽  
Dino Accoto
Keyword(s):  
New Technologies ◽  
Current Knowledge ◽  
Axial Loading ◽  
Early Mobilization ◽  
Bed Rest ◽  
Field Application ◽  
Symptomatic Management ◽  
Spinal Brace ◽  
Potential Improvement ◽  
Spinal Orthosis

Osteoporotic spine fractures (OSF) are common sequelae of osteoporosis. OSF are directly correlated with increasing age and incidence of osteoporosis. OSF are treated conservatively or surgically. Associated acute pain, chronic disabilities, and progressive deformities are well documented. Conservative measures include a combination of initial bed rest, analgesia, early physiotherapy, and a spinal brace (orthosis), with the aim for early rehabilitation to prevent complications of immobile state. Spinal bracing is commonly used for symptomatic management of OSF. While traditional spinal braces aim to maintain the neutral spinal alignment and reduce the axial loading on the fractured vertebrae, they are well known for complications including discomfort with reduced compliance, atrophy of paraspinal muscles, and restriction of chest expansion leading to chest infections. Exoskeletons have been developed to passively assist and actively augment human movements with different types of actuators. Flexible, versatile spinal exoskeletons are designed to better support the spine. As new technologies enable the development of motorized wearable exoskeletons, several types have been introduced into the medical field application. We have provided a thorough review of the current spinal robotic technologies in this paper. The shortcomings in the current spinal exoskeletons were identified. Their limitations on the use for patients with OSF with potential improvement strategies were discussed. With our current knowledge of spinal orthosis for conservatively managed OSF, a semi-rigid backpack style thoracolumbar spinal robotic orthosis will reduce spinal bone stress and improve back muscle support. This will lead to back pain reduction, improved posture, and overall mobility. Early mobilization is an important part of management of patients with OSF as it reduces the chance of developing complications related to their immobile state for patients with OSF, which will be helpful for their recovery.

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice

2018 ◽  
Vol 53 (5) ◽  
pp. 459-469
Author(s):  
C Bauer ◽  
U Schillinger ◽  
J Brandl ◽  
A Meyer-Lindenberg ◽  
A Ott ◽  
...  
Keyword(s):  
Body Temperature ◽  
Pulse Oximetry ◽  
Respiratory Frequency ◽  
Painful Stimulus ◽  
Male Mice ◽  
Controlled Ventilation ◽  
Withdrawal Reaction ◽  
Potential Improvement ◽  
Frequency Pulse

In accordance with the ‘refinement’ component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide adequate surgical tolerance at a 50% dose relative to that of ketamine racemate and whether antagonism of medetomidine could be initiated 15 min earlier. The second aim was to investigate the potential improvement in analgesia for both anaesthetic protocols by adding butorphanol or metamizole. Analgesia was tested via the pedal withdrawal reaction (PWR) to a painful stimulus. During anaesthesia, respiratory frequency, pulse oximetry, body temperature and PWR were monitored. Among the 16 mice in each group, the PWR was lost in all the KM + metamizole (35:56 ± 6:07 min), KM + butorphanol (43:45 ± 2:14 min) and SKM + butorphanol (24:03 ± 5:50 min) mice, 15 of the non-premedicated KM (37:00 ± 8:11 min) mice, and 9 of the pure SKM (20:00 ± 4:19 min) mice; the latter group increased to 11 mice (17:16 ± 5:10 min) with premedication of metamizole. In contrast to the racemic combination, s-ketamine at the dose used here did not lead to sufficient loss of the PWR. However, earlier partial antagonism of SKM resulted in a slightly shorter and qualitatively better recovery than later partial antagonism of SKM. The addition of metamizole or butorphanol to KM or SKM anaesthesia positively influences the analgesic quality. However, when butorphanol is added, controlled ventilation may be necessary, especially for male mice.

scholarly journals The effects of leaf removal and artificial shading on the composition of Chardonnay and Pinot noir grapes

OENO One ◽  
2020 ◽  
Vol 54 (4) ◽  
pp. 761-777
Author(s):  
Isabella Ghiglieno ◽  
Fulvio Mattivi ◽  
Gabriele Cola ◽  
Davide Trionfini ◽  
Daniele Perenzoni ◽  
...  
Keyword(s):  
Phenolic Content ◽  
Pinot Noir ◽  
Vitis Vinifera L ◽  
Sparkling Wine ◽  
Leaf Removal ◽  
Early Ripening ◽  
Potential Improvement ◽  
Artificial Shading ◽  
Positive Effect

Aims: The aim of this study was to assess the effects of leaf removal and bunch shading on the analytical composition of Pinot noir and Chardonnay (Vitis vinifera L.) grapes suitable for making premium sparkling wine.Method and results: Total bunch defoliation (TD) and different treatments using shading nets (TD1L, TD2L and ND1L) were evaluated in comparison with a test with no defoliation and shading (ND) over three seasons in the southern part of Franciacorta, one of the most famous Italian sparkling wine regions. Micrometeorological variables, yield components, musts and grapes chemical composition were evaluated. Shading practices lead to a delay in ripening and they improve the acidic content of must, thus resulting in a potential improvement in the quality of juice suitable for producing sparkling wines. Furthermore, this particular type of vine canopy management leads to changes in the phenolic content of grapes.Conclusions: From the results obtained it was possible to underline the positive effect - delaying ripening, preserving acid concentration and reducing flavonol content - of shading on the composition of Pinot noir and Chardonnay grapes suitable for making premium sparkling wine.Significance of the study: This study shows the importance of shading, because it delays grape ripening and thereby preserves the acidic content of musts and, specifically, deals with the problem of early ripening related to the climate change now underway.

scholarly journals RETRACTED ARTICLE: Theoretical Limits of Energy Density in Silicon-Carbon Composite Anode Based Lithium Ion Batteries

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ranjan Dash ◽  
Sreekanth Pannala
Keyword(s):  
Energy Density ◽  
Volume Expansion ◽  
Lithium Ion ◽  
Threshold Value ◽  
Carbon Composite ◽  
Power Characteristics ◽  
Silicon Carbon ◽  
Retracted Article ◽  
Si Anode ◽  
Potential Improvement

Abstract Silicon (Si) is under consideration as a potential next-generation anode material for the lithium ion battery (LIB). Experimental reports of up to 40% increase in energy density of Si anode based LIBs (Si-LIBs) have been reported in literature. However, this increase in energy density is achieved when the Si-LIB is allowed to swell (volumetrically expand) more than graphite based LIB (graphite-LIB) and beyond practical limits. The volume expansion of LIB electrodes should be negligible for applications such as automotive or mobile devices. We determine the theoretical bounds of Si composition in a Si–carbon composite (SCC) based anode to maximize the volumetric energy density of a LIB by constraining the external dimensions of the anode during charging. The porosity of the SCC anode is adjusted to accommodate the volume expansion during lithiation. The calculated threshold value of Si was then used to determine the possible volumetric energy densities of LIBs with SCC anode (SCC-LIBs) and the potential improvement over graphite-LIBs. The level of improvement in volumetric and gravimetric energy density of SCC-LIBs with constrained volume is predicted to be less than 10% to ensure the battery has similar power characteristics of graphite-LIBs.

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