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2021 ◽  
pp. 1-6
Author(s):  
H.S. Randhawa ◽  
R.J. Graf

AAC Whitehead, an awned hard white spring wheat (Triticum aestivum L.) cultivar, combines high grain yield and good agronomic characteristics with excellent disease resistance. Based on 34 station-years of registration trial data from 2017 to 2019, AAC Whitehead had grain yield significantly higher than all of the check cultivars. AAC Whitehead had maturity similar to the checks, low lodging scores, and significantly shorter plant height than Snowstar and Whitehawk. AAC Whitehead had significantly lower test weight and higher kernel mass than than all the check cultivars. AAC Whitehead expressed resistance to the prevalent races of leaf, stripe and stem rust, and common bunt; and moderate resistance to Fusarium head blight (FHB). It also expressed tolerance to the orange wheat blossom midge. AAC Whitehead expresses quality attributes within the range of the check cultivars and is eligible for grades of Canada Western Hard White Spring wheat.


Author(s):  
Tasneem Dambha ◽  
De Wet Swanepoel ◽  
Faheema Mahomed-Asmail ◽  
Karina C. De Sousa ◽  
Marien A. Graham ◽  
...  

Purpose: This study compared the test characteristics, test–retest reliability, and test efficiency of three novel digits-in-noise (DIN) test procedures to a conventional antiphasic 23-trial adaptive DIN (D23). Method: One hundred twenty participants with an average age of 42 years ( SD  = 19) were included. Participants were tested and retested with four different DIN procedures. Three new DIN procedures were compared to the reference D23 version: (a) a self-selected DIN (DSS) to allow participants to indicate a subjective speech recognition threshold (SRT), (b) a combination of self-selected and adaptive eight-trial DIN (DC8) that utilized a self-selected signal-to-noise ratio (SNR) followed by an eight-trial adaptive DIN procedure, and (c) a fixed SNR DIN (DF) approach using a fixed SNR value for all presentations to produce a pass/fail test result. Results: Test–retest reliability of the D23 procedure was better than that of the DSS and DC8 procedures. SRTs from DSS and DC8 were significantly higher than SRTs from D23. DSS was not accurate to discriminate between normal-hearing and hard of hearing listeners. The DF and DC8 procedures with an adapted cutoff showed good hearing screening test characteristics. All three novel DIN procedure durations were significantly shorter (< 70 s) than that of D23. DF showed a reduction of 46% in the number of presentations compared to D23 (from 23 presentations to an average of 12.5). Conclusions: The DF and DC8 procedures had significantly lower test durations than the reference D23 and show potential to be more time-efficient screening tools to determine normal hearing or potential hearing loss. Further studies are needed to optimize the DC8 procedure. The reference D23 remains the most reliable and accurate DIN hearing screening test, but studies in which the potentially efficient new DIN procedures are compared to pure-tone thresholds are needed to validate these procedures.


BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e056077
Author(s):  
Scott A McDonald ◽  
Lucia C Soetens ◽  
C Maarten A Schipper ◽  
Ingrid Friesema ◽  
Cees C van den Wijngaard ◽  
...  

ObjectivesWe aimed to identify populations at a high risk for SARS-CoV-2 infection but who are less likely to present for testing, by determining which sociodemographic and household factors are associated with a lower propensity to be tested and, if tested, with a higher risk of a positive test result.Design and settingInternet-based participatory surveillance data from the general population of the Netherlands.ParticipantsWeekly survey data collected over a 5-month period (17 November 2020 to 18 April 2021) from a total of 12 026 participants who had contributed at least 2 weekly surveys was analysed.MethodsMultivariable analyses using generalised estimating equations for binomial outcomes were conducted to estimate the adjusted ORs of testing and of test positivity associated with participant and household characteristics.ResultsMale sex (adjusted OR for testing (ORt): 0.92; adjusted OR for positivity (ORp): 1.30, age groups<20 (ORt: 0.89; ORp: 1.27), 50–64 years (ORt: 0.94; ORp: 1.06) and 65+ years (ORt: 0.78; ORp: 1.24), diabetics (ORt: 0.97; ORp: 1.06) and sales/administrative employees (ORt: 0.93; ORp: 1.90) were distinguished as lower test propensity/higher test positivity factors.ConclusionsThe factors identified using this approach can help identify potential target groups for improving communication and encouraging testing among those with symptoms, and thus increase the effectiveness of testing, which is essential for the response to the COVID-19 pandemic and for public health strategies in the longer term.


2021 ◽  
Author(s):  
◽  
John G Dickie

<p>An investigation of sites, uses and practices for literacy in the lives of Pasifika students Lower test scores on school measures of literacy for Pasifika students than for the majority of students in New Zealand are a cause for concern. As part of a wider attempt to address this problem the Ministry of Education has argued that teachers need to be better informed of out-of-school literacy practices. This thesis considers what can be learned when this guidance is followed and it investigates students' social and cultural uses of literacy in family and community settings. It explores the argument that knowledge of these out-of-school literacies will inform teachers and through incorporation (McNaughton, 2002) teachers may be able to make effective connections for students to school literacy. A sociocultural perspective is used to investigate the social and cultural practices of the students while the study also uses Cremin's (1976) concept of configurations of sites to consider how learning is mediated for students in different settings. Rogoff's (1995) three planes of analysis provide a tool to examine students' practices at the community, interpersonal, and personal levels. The investigation sought the students' own perspective of how they appropriate knowledge about literacy as they collected information with cameras and journals on their own practices. The participants were 14 Pasifika students aged 11 and 12 years (mostly Samoan) as well as three adult Samoan church representatives and teachers from the students' school. Students' photos were used to elicit rich description in semi-structured interviews and interview schedules were also used with students and adult participants. The findings illustrate how the students were socialised into particular practices that are contextualised in the sites of family, church and neighbourhood. They reveal that for the students there was both overlapping of values and conflict between their sites of literacy practice. The complementarities occurred most strongly between family and church and a valued feature of the students' practice was the use of Samoan language. The most common conflicts were those related to popular culture and they occurred between the sites of family, church and school on the one hand and neighbourhood sites on the other as well as within family sites. The thesis argues that awareness of the complementary and conflicting features is essential for teachers in understanding the complexity the students face in choosing their paths among two cultures. This knowledge enables teachers to incorporate aspects of out-of-school literacy into school practice and to draw on those in the students' backgrounds who may facilitate students' literacy acquisition.</p>


2021 ◽  
Author(s):  
◽  
John G Dickie

<p>An investigation of sites, uses and practices for literacy in the lives of Pasifika students Lower test scores on school measures of literacy for Pasifika students than for the majority of students in New Zealand are a cause for concern. As part of a wider attempt to address this problem the Ministry of Education has argued that teachers need to be better informed of out-of-school literacy practices. This thesis considers what can be learned when this guidance is followed and it investigates students' social and cultural uses of literacy in family and community settings. It explores the argument that knowledge of these out-of-school literacies will inform teachers and through incorporation (McNaughton, 2002) teachers may be able to make effective connections for students to school literacy. A sociocultural perspective is used to investigate the social and cultural practices of the students while the study also uses Cremin's (1976) concept of configurations of sites to consider how learning is mediated for students in different settings. Rogoff's (1995) three planes of analysis provide a tool to examine students' practices at the community, interpersonal, and personal levels. The investigation sought the students' own perspective of how they appropriate knowledge about literacy as they collected information with cameras and journals on their own practices. The participants were 14 Pasifika students aged 11 and 12 years (mostly Samoan) as well as three adult Samoan church representatives and teachers from the students' school. Students' photos were used to elicit rich description in semi-structured interviews and interview schedules were also used with students and adult participants. The findings illustrate how the students were socialised into particular practices that are contextualised in the sites of family, church and neighbourhood. They reveal that for the students there was both overlapping of values and conflict between their sites of literacy practice. The complementarities occurred most strongly between family and church and a valued feature of the students' practice was the use of Samoan language. The most common conflicts were those related to popular culture and they occurred between the sites of family, church and school on the one hand and neighbourhood sites on the other as well as within family sites. The thesis argues that awareness of the complementary and conflicting features is essential for teachers in understanding the complexity the students face in choosing their paths among two cultures. This knowledge enables teachers to incorporate aspects of out-of-school literacy into school practice and to draw on those in the students' backgrounds who may facilitate students' literacy acquisition.</p>


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Patrik Waldmann

Abstract Background The genetic basis of phenotypic traits is highly variable and usually divided into mono-, oligo- and polygenic inheritance classes. Relatively few traits are known to be monogenic or oligogeneic. The majority of traits are considered to have a polygenic background. To what extent there are mixtures between these classes is unknown. The rapid advancement of genomic techniques makes it possible to directly map large amounts of genomic markers (GWAS) and predict unknown phenotypes (GWP). Most of the multi-marker methods for GWAS and GWP falls into one of two regularization frameworks. The first framework is based on $$\ell _1$$ ℓ 1 -norm regularization (e.g. the LASSO) and is suitable for mono- and oligogenic traits, whereas the second framework regularize with the $$\ell _2$$ ℓ 2 -norm (e.g. ridge regression; RR) and thereby is favourable for polygenic traits. A general framework for mixed inheritance is lacking. Results We have developed a proximal operator algorithm based on the recent LAVA regularization method that jointly performs $$\ell _1$$ ℓ 1 - and $$\ell _2$$ ℓ 2 -norm regularization. The algorithm is built on the alternating direction method of multipliers and proximal translation mapping (LAVA ADMM). When evaluated on the simulated QTLMAS2010 data, it is shown that the LAVA ADMM together with Bayesian optimization of the regularization parameters provides an efficient approach with lower test prediction mean-squared-error (65.89) than the LASSO (66.11), Ridge regression (83.41) and Elastic net (66.11). For the real pig data the test MSE of the LAVA ADMM is 0.850 compared to the LASSO, RR and EN with 0.875, 0.853 and 0.853, respectively. Conclusions This study presents the LAVA ADMM that is capable of joint modelling of monogenic major genetic effects and polygenic minor genetic effects which can be used for both genome-wide assoiciation and prediction purposes. The statistical evaluations based on both simulated and real pig data set shows that the LAVA ADMM has better prediction properies than the LASSO, RR and EN. Julia code for the LAVA ADMM is available at: https://github.com/patwa67/LAVAADMM.


Author(s):  
Vishnupriya Shivakumar ◽  
◽  
C. Senthilpari ◽  
Zubaida Yusoff ◽  
◽  
...  

A linear feedback shift register (LFSR) has been frequently used in the Built-in Self-Test (BIST) designs for the pseudo-random test pattern generation. The higher volume of the test patterns and the lower test power consumption are the key features in the large complex designs. The motivation of this study is to generate efficient pseudo-random test patterns by the proposed LFSR and to be applied in the BIST designs. For the BIST designs, the proposed LFSR satisfied with the main strategies such as re-seeding and lesser test power consumption. However, the reseeding approach was utilized by the maximum-length pseudo-random test patterns. The objective of this paper is to propose a new LFSR circuit based on the proposed Reed-Solomon (RS) algorithm. The RS algorithm is created by considering the factors of the maximum length test patterns with a minimum distance over the time t. Also, it has been achieved an effective generation of test patterns over a stage of complexity order O (m log2 m), where m denotes the total number of message bits. We analysed our RS LFSR mathematically using the feedback polynomial function to decrease the area overhead occupied in the designs. The simulation works of the proposed RS LFSR bit-wise stages are simulated using the TSMC 130 nm on the Mentor Graphics IC design platform. Experimental results showed that the proposed LFSR achieved the effective pseudo-random test patterns with a lower test power consumption of 25.13 µW and 49.9 µs. In addition, proposed LFSR along with existing authors’ LFSR are applied in the BIST design to examine their power consumption. Ultimately, overall simulations operated with the highest operating frequency environment as 1.9 GHz.


Author(s):  
Peter Rockett

AbstractThis paper extends the numerical tuning of tree constants in genetic programming (GP) to the multiobjective domain. Using ten real-world benchmark regression datasets and employing Bayesian comparison procedures, we first consider the effects of feature standardization (without constant tuning) and conclude that standardization generally produces lower test errors, but, contrary to other recently published work, we find much less clear trend for tree sizes. In addition, we consider the effects of constant tuning – with and without feature standardization – and observe that (1) constant tuning invariably improves test error, and (2) usually decreases tree size. Combined with standardization, constant tuning produces the best test error results; tree sizes, however, are increased. We also examine the effects of applying constant tuning only once at the end a conventional GP run which turns out to be surprisingly promising. Finally, we consider the merits of using numerical procedures to tune tree constants and observe that for around half the datasets evolutionary search alone is superior whereas for the remaining half, parameter tuning is superior. We identify a number of open research questions that arise from this work.


Processes ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 1216
Author(s):  
Kai-Shing Yang ◽  
Khalid Hamid ◽  
Shih-Kuo Wu ◽  
Uzair Sajjad ◽  
Chi-Chuan Wang

This study examines the performance of three heat pump dryers: the original reference design, a modified drying chamber, and an external desiccant wheel design. Unlike most existing studies that normally adopt organic products as the drying materials, in this study we used moist sodium polyacrylate (Orbeez) as the drying material for consistent characterization of the heat pump performance. R-134a was adopted as the refrigerant for the heat pump system. The experiments were performed subject to different weights of Orbeez (drying material) at a constant volumetric flow rate of 100 m3/h. During experimentation, different parameters like the coefficient of performance (COPHP), drying rate, heat transfer rate by the condenser, moisture extraction rate, and specific moisture extraction rate were calculated. The average COPHP, mass transfer rate, heat transfer rate, MER, and SMER of the system were calculated as 3.9, 0.30 kg/s, 0.56 kW, 0.495 kg/h, and 1.614 kg/kWh, respectively. The maximum COP for the refrigeration system was achieved at lower test loads with the desiccant wheel. The moisture extraction rate for a lower test loading was higher than that for a higher test load due to the higher penetration of drying air at the lower test load, although the maximum test load showed the maximum relative humidity at the dryer outlet. The desiccant wheel showed good performance in terms of moisture extraction rate and COPHP, but it showed poor performance in terms of the specific moisture extraction rate due to the high power consumption (around 2.6 kW) of the desiccant dehumidifier. The moisture extraction rate (MER) for all designs increased to a maximum value, followed by consistent decline. However, the maximum MER for the desiccant design exceeded those for the other designs.


2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 5539-5539
Author(s):  
Stephanie Cham ◽  
Alexi A. Wright

5539 Background: Germline BRCA (gBRCA) testing has prognostic, therapeutic, and familial implications for patients with ovarian cancer. Since 2010, national guidelines have recommended universal genetic testing, but few data are available about rates and timeliness of testing or factors associated with testing. Methods: We examined rates of gBRCA testing and the time from index procedure to testing among commercially-insured women aged 18 to 64 with claims for ovarian, fallopian tube, or primary peritoneal cancers cancer who received cytoreductive surgery and chemotherapy between 2008-2018. We used logistic regression to assess patient-, clinician-, and practice-level characteristics associated with testing. Results: Overall, the rate of g BRCA testing was 33.9%, increasing from 14.7% in 2008 to 46.4% in 2018; the median time to testing decreased from 280.0 to 72.5 days. Patients who were tested were younger than those who were not (mean [SD] 54.7 [9.9] years vs. 58.1 [11.8] years, P<.001) and had fewer comorbidities (Charlson score ≥2: 3.7% vs. 9.5%, P=0.01). There were no differences in testing rates by US region, rurality of practice location, or medical vs. gynecologic oncology providers. However, testing rates were higher in academic and NCI-designated cancer centers (36.2% and 32.5%, respectively), compared with community practices (25.5%; P<0.001) (Table). In adjusted analyses, lower test rates were associated with older age (aOR=0.97, 95%CI=0.96-0.98), more medical comorbidities (Charlson score ≥2: aOR=0.77, 95%CI=0.61-0.97), and community practices vs. NCI cancer centers (aOR=0.64, 95%CI=0.46-0.88). Conclusions: While the rates and time to testing for gBRCA in patients with new diagnoses of ovarian cancer have improved over time, testing remains underutilized, even among well-insured populations. Future studies should examine barriers to timely genetic testing and identify scalable strategies for increasing testing in women with ovarian cancer, particularly for women treated in community practices.[Table: see text]


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