Defensive activity of Hesperidin against Ciprofloxacin induced hepatic injury in rabbits.

2019 ◽  
Vol 10 (03) ◽  
Author(s):  
Hawraa M. Murad ◽  
Tamadhur Hani Hussein ◽  
Audai Sulaiman Khudhair ◽  
Manal Muhi Murad ◽  
Jawad Kadhim Faris
Keyword(s):  
Body Weight ◽  
Bacterial Infections ◽  
Hepatoprotective Activity ◽  
The Body ◽  
Local Breed ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Defensive Activity ◽  
Antioxidant Effects

This study was conducted to find out hepatoprotective activity of hesperidin (HES) 100mg/kg body weight (b.w.) against ciprofloxacin (CPX) 100 mg/kg induced hepatotoxicity in local breed rabbits .CPX is a broad spectrum antibiotic used for treatment of many bacterial infections. Twenty four male rabbits were divided into four groups ,group1: control, (1 ml/kg Saline orally) group 2: CPX (100 mg/kg orally) for (14) consecutive days , group 3: HES (100 mg//kg) orally for (14) consecutive days group 4: CPX (100 mg/kg orally) plus HES (100 mg//kg orally ) for (14) consecutive days. All the rabbits were killed on the (15) day of the experiment, and then the blood, and livers samples were taken. CPX induced hepatotoxicity was proved by a significant (p less than 0.01) reduction in the body weight ,and a significant (p less than 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT) , Malonaldehyde enzyme (MAD) and histopathological changes. Protective hepatic toxicity effect and oxidative damage caused by CPX significantly (p less than 0.01) increasing in body weight and significantly (p less than 0.01) decreasing AST , ALT, MAD and improving tissue morphology in HES (100 mg//kg) . These results assure that HES (100 mg//kg) antioxidant effects can protect CPX-induced hepatotoxicity in rabbits.

scholarly journals Effectiveness of medical treatment in overcoming the ureteral double-J stent related symptoms

2012 ◽  
Vol 6 (6) ◽  
pp. 234 ◽  
Author(s):  
Ugur Kuyumcuoglu ◽  
Bilal Eryildirim ◽  
Murat Tuncer ◽  
Gokhan Faydaci ◽  
Fatih Tarhan ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Stone Treatment ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background: We investigated whether the frequency of lower urinary tract symptoms (LUTS) increased in patients in whom double-J stents were applied. We also evaluated several medical therapy protocols to treat symptoms related with ureteral stents.Materials and Methods: A total of 108 patients, in whom unilateral double-j stent was applied during ureteral stone treatment, were included. Before the double-J stent was applied, all patients completed storage components of the “International Prostate Symptom Score” (IPSSs), quality of life components of the IPSS (IPSS-QOL) and “Overactive Bladder Questionnaire” (OABq) forms and scores were calculated. After the procedure, cases were randomized into 5 groups, an antiinflammatory was given to Group 1, spasmolytic to Group 2, anticholinergic to Group 3 and α-blocker to Group 4. No additional drug was given to Group 5 as this control group. During the fourth week of the procedure, IPSSs, IPSS-QOL and OABq forms were again completed and scores were compared with the previous ones.Results: When all the cases were evaluated, the IPSSs, IPSS-QOLand OABq scores of patients in whom the double-J stent was applied were statistically significantly higher the procedure. Compared to the control group, the cases where the double-J stent was applied showed a higher IPSSs, IPSS-QOL and OABq scores and none of the medical therapies could prevent this increase.Interpretation: The frequency of LUTS increased in cases where the ureteral stent was applied and discomfort continued as long as the stent stayed in the body.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

The importance of laboratory tests and Body Mass Index in the diagnosis of acute appendicitis

2020 ◽  
Vol 92 (5) ◽  
pp. 1-5
Author(s):  
Atakan Ozkan ◽  
Aylin Hande Gokce ◽  
Feridun Suat Gokce
Keyword(s):  
Body Mass Index ◽  
Acute Appendicitis ◽  
Body Mass ◽  
The Body ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

<b>Background:</b> Acute appendicitis is the most common cause of acute abdomen. Delay in diagnosis increases the mortality and morbidity. <br><b>Aim: </b>In this study, we aimed to investigate whether the body mass index is useful in diagnosis and whether the neutrophil /lymphocyte and platelet/lymphocyte ratios can help in determining the inflammation level of acute appendicitis. <br><b>Meterial and Methods:</b> Cases of appendectomy performed between June 2012 and December 2018 in our clinic were analyzed retrospectively. Based on the pathology results of the cases included in the study, 4 groups were formed, i.e.: Group 1 (initial stage), Group 2 (catarrhal stage), Group 3 (phlegmonous-gangrenous stage) and Group 4 (perforation). The study compared age, body mass index, leukocyte values, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), platelet /lymphocyte ratio (PLR), and mean platelet volume (MPV) between groups. <br><b> Results:</b> 828 cases were included in the study. When compared between groups, the values of Group 3 and Group 4 were higher than those of Group 1 and Group 2 for PLR and NLR. There was no difference in RDW and MPV values in the blood. When Body Mass Index (BMI) was compared between groups, it was found to be significantly higher with increasing histopathological stage. <br><b>Conclusion:</b> In acute appendicitis, the blood leukocyte value, elevated PLR and NLR are helpful in diagnosis. We aimed to emphasize that the diagnosis of acute appendicitis is delayed in patients with a BMI above 30 and/or at age of over 40 years, with the perforation rate being determined more frequently.

scholarly journals Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice

2020 ◽  
Vol 80 (3) ◽  
pp. 484-496 ◽  
Author(s):  
S. Ali ◽  
M. Ejaz ◽  
K. K. Dar ◽  
S. Nasreen ◽  
N. Ashraf ◽  
...  
Keyword(s):  
Body Weight ◽  
Plant Extract ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Artemisia Vulgaris ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract The main objective of current study was to investigate the chemopreventive and chemotherapeutic activity of Artemisia vulgaris extract on diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice. Diethylnitrosoamine (DEN: 0.9%) was prepared to induce hepatocarcinoma in Balb C mice. The extract Artemisia vulgaris (AV) was prepared by maceration technique. Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). After eight weeks of DEN administration, mice of group 2 were divided into two subgroups containing seven mice each; subgroup 1 was sacrificed while subgroup 2 was treated with plant extract only (150 mg/kg (body weight)) once in a week for eight consecutive weeks. The DEN injected mice significant decline in levels of albumin with concomitant significant elevations such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alpha feto protein, gamma glutamyl transferase, 5 nucleotidase, glucose-6-phosphate dehydrogenase and bilirubin. The administration of A. vulgaris significantly decreased the DEN induced hepatotoxicity. Present study revealed the potential anti-cancerous nature of Artemisia vulgaris, both in case of chemopreventive and post-treatment of A. vulgaris. Further studies are needed to explore the mechanism of prevention and therapy.

scholarly journals Influence of cadmium sulfate at different doses on the functional state of the liver of laying chicken

2019 ◽  
Vol 21 (94) ◽  
pp. 103-108 ◽  
Author(s):  
A. Y. Ostapyuk ◽  
B. V. Gutyj
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Functional State ◽  
The Body ◽  
Control Group ◽  
Cadmium Sulfate ◽  
Group 4 ◽  
Group 2 ◽  
Destructive Processes ◽  
Different Doses

The article presents the results of studies on the influence of cadmium sulfate in different doses on the organism of poultry. Absorbed cadmium accumulates in the liver as a complex with metallothionein. The purpose of the work was to find out the effect of cadmium sulfate in doses of 2 and 4 mg / kg of body weight on the functional state of the liver of chicken. For research, three groups of birds were formed: control and two experimental. The control group of chickens were in the usual diet, they were fed with forage and were given water without introducing cadmium sulfate. To the drinking water of chickens of experimental groups for 30 days, added cadmium sulfate in doses: the first group – 2 mg/kg, the second group – 4 mg/kg body weight. The conditions for keeping chickens and the microclimate parameters in the room for all bird groups were similar. Blood from the chickens was taken from the subclavian vein in periods: before the dasg was given and on the first, seventh, fourteenth, twenty-first and thirtieth day of the experiment. It was determined that the presentation of cadmium sulfate in doses of 2 and 4 mg/kg of body weight of cows, which contributed to a violation of the functional state of the liver, as evidenced by the increased activity of aminotransferases in their blood serum. The activity of alanine and aspartate aminotransferase was higher in serum of blood of chickens in the second experimental group at 21st and 30th days of the experiment. The high activity of aminotransferases in the blood serum of chickens for cadmium loading indicates destructive processes in the liver that cause an increase in the release of aminotransaminases from cellular organelles in the blood of experimental poultry. Thus, the obtained results indicate an increase in destructive processes in the body of chickens for cadmium loading.

scholarly journals Preliminary Study on the Effect of Methanolic Extract of Watermelon (Citrullus lanatus) Rind on Prednisolone Suppressed Immunity in Male Wistar Rats

2021 ◽  
pp. 1-6
Author(s):  
Nyejirime Young Wike ◽  
Mobisson Samuel Kelechi ◽  
Godspower Onyeso ◽  
Okekem Amadi ◽  
Elizabeth Eepho Krukru
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Control Group ◽  
Group 4 ◽  
Watermelon Rind ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 2

Citrullus lanatus thumb (Cucurbitaceae) commonly called watermelon is widely consumed in this part of the world as food and medicine. This study was carried out to examine the effect of methanolic extract of watermelon (Citrullus lanatus) rind on prednisolone suppressed immunity in male wistar rats. A total of 20 male wistar rats weighing 150-294g were used in 4 groups with five rats each. Group 1, the control group was given distilled water and feed, Group 2 was given 200 mg/kg body weight of methanolic extract of watermelon rind, Group 3 rats were given 2.5 mg/kg body weight of prednisolone and Group 4 rats were given 2.5 mg/kg body weight of prednisolone and 200 mg/kg body weight of methanolic extract of watermelon rind. Prednisolone and the methanolic extract of watermelon rind were administered orally for a period of 30 days. Blood samples were collected by cardio puncture from the rats for white blood cell (WBC), lymphocyte, and granulocyte and monocyte counts at the end of the experiment.  The data were statistically analysed using one-way ANOVA (Analysis of variance). Data were considered significant at p<0.05. The results obtained showed that methanolic extract of watermelon rind caused a significant increasen in immune function of rats when compared with the control and immune suppressed rats.

scholarly journals PRODUCTIVE AND BIOLOGICAL TRAITS OF YOUNGS DIFFERENT GENOTYPES OF KAZAKH WHITE-HEADED BREED

2019 ◽  
Vol 4 (2) ◽  
pp. 94-101
Author(s):  
Асемгул Бактыгалиева ◽  
Asemgul Baktygalieva ◽  
Киниспай Джуламанов ◽  
Kinispai Dzhulamanov ◽  
Андрей Ухтверов ◽  
...  
Keyword(s):  
Body Weight ◽  
Positive Impact ◽  
Biological Traits ◽  
Group 4 ◽  
Group 3 ◽  
White Cattle ◽  
Group 5 ◽  
Group 2 ◽  
West Kazakhstan ◽  
Meat Productivity

The research aim is increasing the potential of meat productivity of young Shagatay Zavodska type of livestock based on a heterogeneous selection of Shagatay cows with bulls – Ural type of hereford. The experience carried out on the breeding farm «Sabit» in West Kazakhstan region according to the scheme: group 1 – bull, group 2 – castrated males, group 3 – heifers of Shagatay breed of Kazakh white cattle and hybrids from crossing Shagatay cows with bulls of Ural Hereford, group 4 – bulls, 5 group – castrated males, 6 group – heifers. Groups were formed on the principle of analogues of 12 animals. Bulls by the age of 15 months of the Ural hereford reached the highest body weight and surpassed shagatai peers taking into account this selection feature in regard to sex by 20.4 kg. In castrates at the age of 18 months, this difference was in favor of the youngsters of group 5 and was 23.0 kg. Heter-ogeneous selection had a positive impact on the important productive qualities by heifers. Youngsters of group 6, born due to servicing bulls of the Ural Hereford, dominated in weight in regard to all analyzed periods. The contents of lizo the meyerhold centre in both winter and summer was greater at animal – hybrids of the Ural hereford and Shagatay animals, winter amount was 0,45-0,94 µg/ml in the summer – from 0.06 to 1.97 µg/ml. Significantly lower bactericidal activity of blood serum and slightly increased amount of lysozyme was shown by hybrids from the Ural hereford in the winter. Regardless of gender, the greatest consumption of both protein (8-41 g) and energy (0.48-2.54 MJ) per unit of body weight gained was characterized by descendants from parents of the Shagatai type of Ka-zakh white-headed breed. Hybrids the offspring of the Ural hereford – used crude protein in feeding more often for the synthesis of dietary protein.

scholarly journals Centella Asiatica Extracts Regulates Aluminium Chloride-Induced Neurotoxicity in Rats: Impact on Inflammation, Apoptosis and Biogenic Amine Levels

2018 ◽  
Vol 2 (1) ◽  
pp. 1-8
Author(s):  
Shaik Amjad ◽  
Keyword(s):  
Body Weight ◽  
Therapeutic Potential ◽  
Centella Asiatica ◽  
Aluminium Chloride ◽  
Albino Rats ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Group 1

investigate the therapeutic potential of CA against chronic Aluminium Chloride (AlCl3) exposure induced rats. Wistar albino rats were segregated into four groups: group 1-control rats, group 2-rats received AlCl3 (300 mg/kg body weight, every day orally) for 60 days, rats in group 3-received CA (500 mg/kg body weight, orally) and group 4 rats were initiated with both AlCl3 and CA treatment.

Partial Liquid Ventilation Reduces Fluid Filtration of Isolated Rabbit Lungs with Acute Hydrochloric Acid-induced Edema

2001 ◽  
Vol 94 (6) ◽  
pp. 1045-1049 ◽  
Author(s):  
Stephan A. Loer ◽  
Jörg Tarnow
Keyword(s):  
Body Weight ◽  
Hydrochloric Acid ◽  
Intratracheal Instillation ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Lung Weight ◽  
Fluid Filtration ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

Background Hydrochloric acid aspiration increases pulmonary microvascular permeability. The authors tested the hypothesis that partial liquid ventilation has a beneficial effect on filtration coefficients in acute acid-induced lung injury. Methods Isolated blood-perfused rabbit lungs were assigned randomly to one of four groups. Group 1 (n = 6) served as a control group without edema. In group 2 (n = 6), group 3 (n = 6), and group 4 (n = 6), pulmonary edema was induced by intratracheal instillation of hydrochloric acid (0.1 N, 2 ml/kg body weight). Filtration coefficients were determined 30 min after this injury (by measuring loss of perfusate after increase of left atrial pressure). Group 2 lungs were gas ventilated, and group 3 lungs received partial liquid ventilation (15 ml perfluorocarbon/kg body weight). In group 4 lungs, the authors studied the immediate effects of bronchial perfluorocarbon instillation on ongoing filtration. Results Intratracheal instillation of hydrochloric acid markedly increased filtration coefficients when compared with non-injured control lungs (2.3 +/- 0.7 vs. 0.31 +/- 0.08 ml.min(-1). mmHg(-1).100 g(-1) wet lung weight, P &lt; 0.01). Partial liquid ventilation reduced filtration coefficients of the injured lungs (to 0.9 +/- 0.3 ml.min(-1).mmHg(-1).100 g(-1) wet lung weight, P = 0.022). Neither pulmonary artery nor capillary pressures (determined by simultaneous occlusion of inflow and outflow of the pulmonary circulation) were changed by hydrochloric acid instillation or by partial liquid ventilation. During ongoing filtration, bronchial perfluorocarbon instillation (5 ml/kg body weight) immediately reduced the amount of filtered fluid by approximately 50% (P = 0.027). Conclusions In the acute phase after acid injury, partial liquid ventilation reduced pathologic fluid filtration. This effect started immediately after bronchial perfluorocarbon instillation and was not associated with changes in mean pulmonary artery, capillary, or airway pressures. The authors suggest that in the early phase of acid injury, reduction of fluid filtration contributes to the beneficial effects of partial liquid ventilation on gas exchange and lung mechanics.

scholarly journals AB1022 PANNICULITIS IN RHEUMATOLOGICAL PRACTICE: THE RESULTS OF LONG-TERM FOLLOW-UP

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1803.1-1804
Author(s):  
O. Egorova ◽  
B. Belov
Keyword(s):  
Bacterial Infections ◽  
Inflammatory Diseases ◽  
Subcutaneous Fat ◽  
Weight Lifting ◽  
Group 4 ◽  
Group 3 ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Group 1

Background:Panniculitis is a group of heterogeneous inflammatory diseases that occur with damage to the subcutaneous fat (SCF), musculoskeletal system, and often internal organsObjectives:to evaluate the course and outcome in patients with panniculitisMethods:the course of the disease was monitored in 193 patients treated at the V.A. Nasonova Research Institute of Rheumatology for 3-5 years (142 women, 51 men) aged 19 to 77 with the referral diagnosis of erythema nodosum (EN) and undifferentiated panniculitis and with the disease duration of 1 week to 13 years. In addition to general clinical study, serum concentrations of α-1 antitrypsin, amylase, lipase, ferritin, creatinephosphokinase were determined, computed tomography of the chest organs, immunological, ultrasound scanning of the skin and SCF of the node area, tuberculosis tests and pathomorphological study of skin biopsy from the node area were performed.Results:: as a result of laboratory and instrumental examination, the following diagnoses were made: EN associated with infection (72 people – group 1), lipodermatosclerosis (LDS) (40 –group 2), idiopathic lobular panniculitis (ILP) (32 – group 3), Löfgren’s syndrome (SL) (49 –group 4). During the follow-up period, 6 deaths occurred (3.1%): in a patient with LDS due to acute heart failure and in 5 patients with ILP due to the activity of the disease which led to the development of cardiopulmonary pathology and disseminated intravascular coagulation (DIC) syndrome. In group 1, during the observation period, UE recurred in 18 people (25%), the probable causes were: hypothermia (6), exacerbation of chronic tonsillitis (6), acute respiratory viral infections (ARVI) (4), stress (1), a rapid decrease in the dose of glucocorticoids (GC) (1), the cause is unknown (2). In group 2, recurrence occurred in 19 patients (47.5%) due to the lack of anti-inflammatory therapy (plaquenil) (10), trauma (4), stress (3), and weight lifting (2). There was no recurrence in 7 patients in this group, however, nodes would not disappear completely, which is obviously due to the absence of plaquenil. In group 3, recurrence was registered in 24 cases (75%) and it was associated with insufficient effect of the ongoing anti-inflammatory therapy (9), a decrease in blood glucose to minimal doses (6), hypothermia (6) and the absence/cancellation of anti-inflammatory therapy (3). In group 4, recurrence of nodes was registered in 14 cases (28.5%), possible causes: cancellation of GC (9) and cooling/ARVI(5).Conclusion:in the observed group of patients with panniculitis mortality was 3.1%. The main causes of recurrence in EN were viral-bacterial infections, and in case of ILP, LDS and SL it was insufficient effect/absence of anti-inflammatory therapy.Disclosure of Interests:None declared

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