scholarly journals Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2014
Author(s):  
Claudia Rebeca Rivera-Yañez ◽  
Porfirio Alonso Ruiz-Hurtado ◽  
María Isabel Mendoza-Ramos ◽  
Julia Reyes-Reali ◽  
Gina Stella García-Romo ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Physical Factors ◽  
Therapeutic Approaches ◽  
Biochemical Alterations ◽  
Different Types ◽  
Great Relevance ◽  
Different Origins ◽  
Scaly Skin

The skin is the main external organ. It protects against different types of potentially harmful agents, such as pathogens, or physical factors, such as radiation. Skin disorders are very diverse, and some of them lack adequate and accessible treatment. The photoaging of the skin is a problem of great relevance since it is related to the development of cancer, while psoriasis is a chronic inflammatory disease that causes scaly skin lesions and deterioration of the lifestyle of people affected. These diseases affect the patient’s health and quality of life, so alternatives have been sought that improve the treatment for these diseases. This review focuses on describing the properties and benefits of flavonoids from propolis against these diseases. The information collected shows that the antioxidant and anti-inflammatory properties of flavonoids play a crucial role in the control and regulation of the cellular and biochemical alterations caused by these diseases; moreover, flavones, flavonols, flavanones, flavan-3-ols, and isoflavones contained in different worldwide propolis samples are the types of flavonoids usually evaluated in both diseases. Therefore, the research carried out in the area of dermatology with bioactive compounds of different origins is of great relevance to developing preventive and therapeutic approaches.

scholarly journals Epidermolysis bullosa acquisita: an uncommon cause of esophageal stricture

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Carlos Figueredo ◽  
Konstantin Boroda ◽  
Hilary Hertan
Keyword(s):  
Epidermolysis Bullosa ◽  
Wide Spectrum ◽  
Skin Lesions ◽  
Epidermolysis Bullosa Acquisita ◽  
Therapeutic Modalities ◽  
Esophageal Strictures ◽  
Mucosal Involvement ◽  
Great Relevance ◽  
Low Prevalence

ABSTRACT Epidermolysis bullosa acquisita (EBA) encompasses a wide spectrum of rare diseases with a common genetic origin transmitted in an autosomal recessive fashion. Mild forms of non-inflammatory EBA are characterized by skin lesions and have gained great relevance in the literature. However, resistant inflammatory EBA with widespread mucosal involvement remains a rare entity given its low prevalence. It commonly represents a great burden for the patient’s quality of life with most cases being resistant to different therapeutic modalities. We present a case of resistant inflammatory EBA with esophageal strictures that improved after therapy with intravenous immunoglobulin and rituximab.

Conceptual Study on Prameha Pidakas w.s.r. to Skin Lesions In Diabetes

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Gujar Rakeshkumar ◽  
Prabhu Pavan ◽  
Masalekar Srinivas
Keyword(s):  
Adult Population ◽  
Skin Lesions ◽  
Treatment Modalities ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Ulcer ◽  
Different Types ◽  
Conceptual Study ◽  
Treatment Aspect

Diabetes is a disease known for its multifaceted complications. Diabetic ulcer is one of the major complications of diabetes. Diabetes affects more than 8% of Indian adult population. Up to 25% of diabetic patients develop foot ulcers. More than half of foot ulcers become infected and require hospitalisation and 20% of infections results in amputation. Early effective management can reduce the severity of complications such as preventable amputations and possible mortality and can also improve overall quality of life. Thousands of researches are being carried out on this in which Ayurveda has a major role. Different numbers of Prameha Pidakas are mentioned in Ayurvedic Classics. According to Sushruta there are 10 different types of Prameha Pidakas. Diagnostic pictures of these 10 are presented here w.s.r. to diabetic skin lesions with the brief treatment aspect. This article gives the obvious view for the diagnosis and treatment modalities of Prameha Pidakas.

Particularities of tinnitus in children and adolescents

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 40-42
Author(s):  
Alexandra Boloș ◽  
Sebastian Cozma ◽  
Andreea Silvana Szalontay
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Children And Adolescents ◽  
Psychological Factors ◽  
Ambient Noise ◽  
Psychological Consequences ◽  
Therapeutic Approaches

Tinnitus is a common otologic symptom and probably the most troublesome. Tinnitus causes a number of physical and psychological consequences, that interfere with the quality of life of the patient. Many authors believe that the presence of tinnitus in children is a matter of lesser importance than in adults because it is met less frequently and would be a fleeting symptom, inoffensive for them (Graham, 1981). In addition, the prevalence of tinnitus during adolescence and even in young adults is increasing, possibly as a consequence of the increased ambient noise (Bulbul SF, Shargorodsky J). Various therapeutic approaches have generated different results, which led us to consider the role of psychological factors, hence the need to underline the particularities of this symptom in childhood.  

ASPECTS OF THE ARCHITECTURAL AND URBAN HERITAGE: FROM REGISTERS TO CONSERVATION FOR ADAPTIVE AND MODERN USE AT THE HISTORIC CORES OF SALT AND IRBID, JORDAN

2017 ◽  
Vol 11 (2) ◽  
pp. 190
Author(s):  
Leen Adeeb Fakhoury ◽  
Naif Adel Haddad
Keyword(s):  
Local Community ◽  
Initial Assessment ◽  
Physical Factors ◽  
Cultural Significance ◽  
Community Quality Of Life ◽  
Urban Heritage ◽  
Two Cities ◽  
Conservation Actions ◽  
Historic Cities

This paper attempts to present and discuss the outcome of the results of the key different studies and projects carried out at Salt and at Irbid historic cores.  It focuses on the executed urban heritage projects undertaken mainly by the Ministry of Tourism and Antiquities (MoTA) of Jordan in the last two decades. It discusses their different aspects through initial assessment of the loss and degradation of the cultural heritage assets of the two cities; the fragmentation and lack of connectivity between the modern and historic cores; issues of sustainability of architectural and urban heritage projects i.e. tourism planning and conservation; and reuse projects at the historic cores in relation to cultural, physical factors and development needs. It also addresses the behaviour and characteristics of the urban regeneration process in those two historic cities, starting from their documentation to examination of the different aspects of the currently adopted urban practices and policies, and their impact on the existing urban heritage, depending on the specific identity of the respective historic cores. Finally, it aims to define the main constraints and challenges for the reuse of the existing heritage fabric including the local community quality of life, while building on sustainable heritage activities accommodating tourism opportunities. This will give, at least, some indications from which we can identify a use or combination of uses, and practical steps needed for successful heritage conservation actions in Jordan, in order to retain the cultural significance of the place.

Enumeration of Cryptosporidium oocysts from surface water concentrates by laser-scanning cytometry

2000 ◽  
Vol 41 (7) ◽  
pp. 197-202 ◽  
Author(s):  
F. Zanelli ◽  
B. Compagnon ◽  
J. C. Joret ◽  
M. R. de Roubin
Keyword(s):  
Surface Water ◽  
Water Samples ◽  
Laser Scanning ◽  
Immunomagnetic Separation ◽  
Entire Surface ◽  
Cryptosporidium Oocysts ◽  
Different Types ◽  
Laser Scanning Cytometry ◽  
Direct Microscopic Observation

The utilization of the ChemScan® RDI was tested for different types of water concentrates. Concentrates were prepared by cartridge filtration or flocculation, and analysed either without purification, or after Immunomagnetic separation (IMS) or flotation on percoll-sucrose gradients. Theenumeration of the oocysts was subsequently performed using the ChemScan® RDI Cryptosporidium application. Enumeration by direct microscopic observation of the entire surface of the membrane was carried out as a control, and recoveries were calculated as a ratio between the ChemScan® RDI result and the result obtained with direct microscopic enumeration. The Chemscan enumeration technique proved reliable, with recoveries yielding close to 100% in most cases (average 125%, range from 86 to 467%) for all the concentration/purification techniques tested. The quality of the antibodies was shown to be critical, with antibodies from some suppliers yielding recoveries a low as 10% in some cases. This difficulty could, however, be overcome by the utilization of the antibody provided by Chemunex. These data conclusively prove that laser scanning cytometry, which greatly facilitates the microscopic enumeration of Cryptosporidium oocysts from water samples and decreases the time of observation by four to six times, can be successfully applied to water concentrates prepared from a variety of concentration/purification techniques.

Emerging approaches for restoration of hearing and vision

2020 ◽  
Author(s):  
Sonja Kleinlogel ◽  
Christian Vogl ◽  
Marcus Jeschke ◽  
Jakob Neef ◽  
Tobias Moser
Keyword(s):  
Gene Therapy ◽  
Hearing Aids ◽  
Sensory Information ◽  
Gene Replacement ◽  
Therapeutic Approaches ◽  
Optogenetic Stimulation ◽  
Cellular Specificity ◽  
Socioeconomic Burden ◽  
Comprehensive Reference

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life and presenting a major socioeconomic burden. For long, retinal and cochlear disorders have remained intractable for causal therapies, with sensory rehabilitation limited to glasses, hearing aids, and electrical cochlear or retinal implants. Recently, the application of gene therapy and optogenetics to eye and ear has generated hope for a fundamental improvement of vision and hearing restoration. To date, one gene therapy for the restoration of vision has been approved and undergoing clinical trials will broaden its application including gene replacement, genome editing, and regenerative approaches. Moreover, optogenetics, i.e. controlling the activity of cells by light, offers a more general alternative strategy. Over little more than a decade, optogenetic approaches have been developed and applied to better understand the function of biological systems, while protein engineers have identified and designed new opsin variants with desired physiological features. Considering potential clinical applications of optogenetics, the spotlight is on the sensory systems. Multiple efforts have been undertaken to restore lost or hampered function in eye and ear. Optogenetic stimulation promises to overcome fundamental shortcomings of electrical stimulation, namely poor spatial resolution and cellular specificity, and accordingly to deliver more detailed sensory information. This review aims at providing a comprehensive reference on current gene therapeutic and optogenetic research relevant to the restoration of hearing and vision. We will introduce gene-therapeutic approaches and discuss the biotechnological and optoelectronic aspects of optogenetic hearing and vision restoration.

scholarly journals Comparison of Genetic Variants and Manifestations of OTUD6B-Related Disorder: The First Mexican Case

2020 ◽  
Vol 8 ◽  
pp. 232470962095777 ◽  
Author(s):  
Maria Elena Romero-Ibarguengoitia ◽  
Consuelo Cantú-Reyna ◽  
Dalia Gutierrez-González ◽  
Héctor Cruz-Camino ◽  
Arnulfo González-Cantú ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Genetic Variants ◽  
Therapeutic Approaches ◽  
Multisystem Disorder ◽  
Related Disorder ◽  
Dysmorphic Features ◽  
The Third ◽  
The Central Nervous System ◽  
Mexican Patient

The intellectual disability syndrome characterized by seizures and dysmorphic features was initially described in 2017 and was associated with genetic variants in the OTUD6B gene, identified by exome sequencing (ES) in a large cohort. This multisystem disorder primarily affects the central nervous system, the gastrointestinal, and the skeletal systems. In this article, we describe the first Mexican patient diagnosed by ES. The homozygous c.433C>T (p.Arg145*) variant of the OTUD6B gene confirmed this intellectual disability syndrome. In addition to seizures and other more frequently reported manifestations of this condition, this is the third patient with associated hypothyroidism and hypogammaglobulinemia, underscoring the value of screening for these conditions in other patients. The current challenge with this patient is to ensure medical management of his seizures and provide him with a better quality of life. The possibilities of additional therapeutic approaches may increase by understanding the physiopathology of the involved pathways.

scholarly journals Advances in Forest Robotics: A State-of-the-Art Survey

Robotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 53
Author(s):  
Luiz F. P. Oliveira ◽  
António P. Moreira ◽  
Manuel F. Silva
Keyword(s):  
Future Research ◽  
Navigation Systems ◽  
Public And Private ◽  
Environmental Preservation ◽  
The Public ◽  
Forest Exploitation ◽  
Different Types ◽  
Scientific Papers ◽  
Great Relevance ◽  
Robotic Applications

The development of robotic systems to operate in forest environments is of great relevance for the public and private sectors. In this sense, this article reviews several scientific papers, research projects and commercial products related to robotic applications for environmental preservation, monitoring, wildfire firefighting, inventory operations, planting, pruning and harvesting. After conducting critical analysis, the main characteristics observed were: (a) the locomotion system is directly affected by the type of environmental monitoring to be performed; (b) different reasons for pruning result in different locomotion and cutting systems; (c) each type of forest, in each season and each type of soil can directly interfere with the navigation technique used; and (d) the integration of the concept of swarm of robots with robots of different types of locomotion systems (land, air or sea) can compensate for the time of executing tasks in unstructured environments. Two major areas are proposed for future research works: Internet of Things (IoT)-based smart forest and navigation systems. It is expected that, with the various characteristics exposed in this paper, the current robotic forest systems will be improved, so that forest exploitation becomes more efficient and sustainable.

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