Deep Brain Stimulation Treating Dystonia: A Systematic Review of Targets, Body Distributions and Etiology Classifications

Background: Deep brain stimulation (DBS) is a typical intervention treating drug-refractory dystonia. Currently, the selection of the better target, the GPi or STN, is debatable. The outcomes of DBS treating dystonia classified by body distribution and etiology is also a popular question.Objective: To comprehensively compare the efficacy, quality of life, mood, and adverse effects (AEs) of GPi-DBS vs. STN-DBS in dystonia as well as in specific types of dystonia classified by body distribution and etiology.Methods: PubMed, Embase, the Cochrane Library, and Google Scholar were searched to identify studies of GPi-DBS and STN-DBS in populations with dystonia. The efficacy, quality of life, mood, and adverse effects were quantitatively compared. Meta-regression analyses were also performed. This analysis has been registered in PROSPERO under the number CRD42020146145.Results: Thirty five studies were included in the main analysis, in which 319 patients underwent GPI-DBS and 113 patients underwent STN-DBS. The average follow-up duration was 12.48 months (range, 3–49 months). The GPI and STN groups were equivalent in terms of efficacy, quality of life, mood, and occurrence of AEs. The focal group demonstrated significantly better disability symptom improvement (P = 0.012) than the segmental and generalized groups but showed less SF-36 enhancement than the segmental group (P < 0.001). The primary groups exhibited significantly better movement and disability symptom improvements than the secondary non-hereditary group (P < 0.005), which demonstrated only disability symptom improvement compared with the secondary hereditary group (P < 0.005). The primary hereditary and idiopathic groups had a significantly lower frequency of AEs than the secondary non-hereditary group (P < 0.005). The correlation between disability symptom improvement and movement symptom improvement was also significant (P < 0.05).Conclusion: GPi-DBS and STN-DBS were both safe and resulted in excellent improvement in efficacy and quality of life in patients with dystonia. Compared with patients with segmental dystonia, patients with focal dystonia demonstrated better improvement in dystonia symptoms but less enhancement of quality of life. Those with primary dystonia had a better response to DBS in terms of efficacy than those with secondary dystonia. Patients who exhibit a significant improvement in movement symptoms might also exhibit excellent improvement in disability symptoms.

Investigation of anti-aging of SBS modified bitumen containing surface organic layered double hydroxide

OLDH exhibits excellent improvement on the thermo-oxidative aging and ultraviolet aging resistance of SBS modified bitumen.

EVALUATE THE PHYSICALACTIVITY (MOBILITY-INDOOR,OUTDOOR) AND VAS SCORE OF TRANSPEDICULAR DECOMPRESSION AND INSTRUMENTED FUSION IN PATIENTS WITH THORACIC AND THORACOLUMBAR FRACTURE

AIMS & OBJECTIVES Evaluate the Physical activity (mobility-indoor,outdoor) and VAS score of Transpedicular decompression and instrumented fusion in patients with thoracic and thoracolumbar fracture . Method We include 30 patients and score was recorded from admission, preoperatively, immediate post operatively at the time of discharge and follow up period ( 1 month, 6 month, 1 year ) and evaluate the patients Physical activity (mobility-indoor,outdoor) and VAS score. Result In this study we found that there is gradual and excellent improvement in functional outcome in patients daily life . with the help of walking aids , wheelchair/ physiotherapy patients improve their routine lifestyle after undergo transpedicul decompression and instrumented fusion. In this study we found that there is gradual and excellent improvement in functional outcome in patients daily life .Mean mobility-indoor,outdoor is 1.4 in post op, 8.9 in 3 month, 14.23 at 6 month , 19.36 at 1 year and VAS score at pre op , post op , 3 month 6 month and 1 year is respectively 8 , 7.75 , 4.06 ,1.9 , and 1.23 .

Mechanical Properties of Geopolymer Concrete Reinforced with the Natural and Waste Plastic Fibers

The flexural and splitting tensile strength were investigated on the specimens prepared with the geopolymer concrete (GPC) reinforced by the combined usage of coir and metalized plastic fibers. The combined addition of natural and artificial fibers has not been explored extensively into the GPC. The objective was to obtain the optimum combined dosage of the artificial and natural fibers to prepare a sustainable construction composite. The results showed excellent improvement of the properties of the GPC at the combined addition of 1% of the fibers for all test conditions.

The use of histafen in the complex treat-ment of patients with senile itching

The purpose of the work is to evaluate the efficacy and tolerability of the drug Histafen (sechifenadine) in com­parison with the drug Loratodin in patients with senile itching. Materials and research methods. Under our supervision there were 60 patients over the age of 50 years. Clinical and laboratory examination and dynamic observation consisted of conducting a general clinical ex­amination and treatment of thematic patients with a sub­sequent analysis of the results. 30 patients of the main group who were prescribed with Histafen (sechifenadine) and 30 patients of the comparison group treated with Lor- atodine have been included in the complex treatment with the use as a blocker of histamine H1-receptors and sero­tonin 5-HT1-receptors. Histafen was prescribed 1 tablet twice a day, Loratadine - 1 tablet once a day. The ob­served patients took both drugs for 14 days. Results and its discussion. When assessing the therapeutic effect in patients of the main group as a result of the therapy with the Histafen drug, “excellent improvement” was regis­tered in 10 (33.33 %) cases, “good improvement” - in 18 (60.0 %), and “moderate improvement” - in 2 (6.67 %); “no improvement” and “deterioration” were not marked. Conclusions. The use of the drug Histafen in the treat­ment of patients with senile itching made it possible to achieve pronounced positive dynamics with rapid relief of subjective symptoms.

Impact of FDI in Insurance Sector

One of the most hanging traits during the last many years is the amazing increase of FDI in the international economic system panorama. This excellent improvement of FDI in 1990 around the globe make FDI a important and critical phase of development technique in each created and creating nations and preparations are configuration with a selected cease intention to animate internal streams. FDI offers a win-win situation to the host and the nations of origin. The international locations are straightforwardly inspired by way of welcoming FDI, in mild of the fact that they advantage a great deal from such kind of task. As a rule FDI alludes to capital inflows from abroad that put sources into the era limit of the economic system and are normally favoured over other sort of outer fund due to the fact they're non-obligation making non-risky and their earnings rely upon the execution of the undertakings financed by the economic professionals. FDIinflow encourages the creating countries to created sincere, expansive and compelling association situation for task troubles and, assembles human and institutional abilties to execute the identical. The safety phase is of massive importance to each developing economic system; in includes the sparing propensity, which thusly produces lengthy haul investible assets for basis constructing. This present day Paper's locations are to explore the Indian Insurance part, to realize blessings of expanded outdoor direct undertaking restrain in protection section, to recognize the Government arrangement with respect to protection department in India, to understand Issues in FDI in Insurance Sector.

PENINGKATAN HASIL BELAJAR SMASH BOLAVOLI MELALUI PEMBELAJARAN BERBASIS MEDIA

This study aims to improve student learning outcomes in learning volleyball smash through media-based learning. The method used is action research design Kemmis and Taggart. The subjects in this study were students of SMA Santo Tomas X totaling 38 people.Research in cycle 1 meeting performed 3 times, starting from initial tests to measure students' abilities before the given action. After the act of learning undertaken, researchers gave a final test on the students and the result is a complete student as many as 16 students with a percentage of completeness 42.11%, when compared to the success criteria specified actions, namely 80% of the study conducted in cycle 1 could not be said to be successful , The study was continued to cycle 2 with slight changes and additions to the previous learning of each action and the second cycle will be implemented as much as 3 meeting. The final test in cycle 2 showed excellent improvement as many as 32 students get finished with a percentage of 84.21%. In other words, this study also no longer need to be continued because it is in accordance with the criteria of success of 80%.Based on these results we can conclude that: 1) through media-based learning can improve student learning outcomes in learning smash volleyball, 2) the application of media-based learning gives students the convenience and can motivate students in implementing the learning.

Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients

AIM: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009. METHODS: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm2 of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm2 of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996). RESULTS: In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 ± 0.53 mm in the studied group and 0.81 ± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group. CONCLUSION: Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm2 scar is the best dose for treatment of keloid.