Comparison of CNN Algorithms for Feature Extraction on Fundus Images to Detect Glaucoma

Glaucoma is a disease where the optic nerve of the eyes is smashed up due to the building up of pressure inside the vision point. This has no symptoms at the initial stages, and hence, patients with this disease cannot identify them at the beginning stage. It is explained as if the pressure in the eye increases, then it will hurt the optic nerve which sends images to the brain. This will lead to permanent vision loss or total blindness. The existing method used for the detection of glaucoma includes k-nearest neighbour and support vector machine algorithms. The k-nearest neighbour algorithm and support vector machine algorithm are the machine learning methods for both categorization and degeneration problems. The drawback in using these algorithms is that we can get accuracy level only up to 80%. The proposed methods in this study focus on the convolution neural network for the recognition of glaucoma. In this study, 2 architectures of VGG, Inception method, AlexNet, GoogLeNet, and ResNet architectures which provide accuracy levels up to 100% are presented.

Autism and Visual impairment: A First Approach to a Complex Relationship

Since the first half of the 20th century there has been an interest in the study of the relationship between autism and autistic-like clinical features and with visual impairments. Autism Spectrum disorders are one of the more worldwide-studied neurodevelopmental disorder with an increasing prevalence in the last ten years. Visual impairment is a condition which derives from several causes (genetic, constitutional, injuries, nutritional and environmental ones). Again, it is a kind of spectrum and an overarching category, because visual impairments range from refractive errors (myopia, hyperopia, astigmatism), to amblyopia, strabismus, and to partial and total blindness. Since the first study of Keeler (1956) which described autistic-like patterns in five preschool children who were totally blind due to retinopathy of prematurity (ROP), a growing number of researchers addressed the relationship between autism and visual impairment. In this paper we focused on it, aiming to discuss on some lessons learned in this field and to discuss some open questions since the first research in this field.

Efficacy and Safety of Various Treatments for Proliferative Diabetic Retinopathy: A Systematic Review and Network Meta-Analysis

Diabetic retinopathy is the main cause of visual impairment and blindness. The proliferative diabetic retinopathy at the severe stage of diabetic retinopathy is more harmful to vision and even leads to total blindness. To evaluate the visual acuity, central retinal thickness, and adverse reactions of various treatments for proliferative diabetic retinopathy through a systematic network meta-analysis. The relevant research published in English or Chinese from January 1, 2011, to February 1, 2021, was systematically searched by using PubMed, science network, EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and other electronic databases. A total of 15 studies were selected, including 3,222 eyes of PDR patients. Our results show that in terms of visual score improvement, ranibizumab alone (69.90%) and laser + ranibizumab (67.90%) are the best. However, if the groups were grouped again according to the dose and times of ranibizumab injection, the results showed that 0.5 mg ranibizumab injection per month (58.0%) had the best effect on vision improvement. For the change of central retinal thickness, the thickness decreased the most after the laser combined with ranibizumab (96.5%). After the same subgroup analysis, the results were further refined into the best effect of laser combined with 0.3 mg ranibizumab per quarter (72.7%). In addition, our analysis of complications also showed that the overall incidence of adverse reactions of PRP (11.1 ± 12.4, %) was greater than that of ranibizumab (10.6 ± 13.0, %). However, more high-quality randomized controlled trials with longer follow-up using standard methods are still needed to verify the correlation.

Retrospective Analysis of Firecracker Injuries and Review of Literature at a Tertiary Eye Care Hospital in South India

Purpose: To analyze demographics, risk factors, clinical features, functional, anatomical outcomes, and prevalence of blindness in firecracker injury patients presenting to a major tertiary eye care centre.Methodology: A retrospective analysis of firecracker injury patients who presented to our tertiary eye care hospital was performed from April 2018 to March 2019. A total of 114 patients with a minimum follow-up of 3 months were included. The parameters recorded were demographics, mode of injury, type of cracker, baseline best-corrected visual acuity (BCVA) and on last follow up, detailed anterior and posterior segment evaluation, seidel's test, intraocular pressure, gonioscopy, complications, treatment, functional and anatomical outcomes. Investigations in the form of B Scan, X-ray, or CT scan were undertaken whenever indicated. Results: A total of 132 eyes of 114 patients were analysed. The mean (SD) age of patients was 18.96 +/- 15.4 years (range 3-71 years). Seventy-four (64.91%) patients were less than or equal to 18 years of age. The male-to-female ratio was 4:1. The ratio of right: left eye involvement was 1:1. Eighteen patients (15.79%) had bilateral involvement. A total of 125 eyes had closed globe injury, 7 eyes had open globe injury and 17 patients needed hospital admission for management. The mean (SD) baseline BCVA was 0.54(+/- 0.75). The mean (SD) final BCVA improved to 0.23(+/- 0.62) till the last follow-up. The final outcome was good in most patients, except 5 eyes (3.78%) which resulted in near/total blindness. Conclusion: Firecracker injuries are a major cause of irreversible blindness, and these are more common in the younger age group (64.91%). Prompt diagnosis with meticulous management can prevent devastating sequelae.

Hypothermic Shock Applied After Perinatal Asphyxia Prevents Retinal Damage in Rats

Perinatal asphyxia (PA) can cause retinopathy and different degrees of visual loss, including total blindness. In a rat model of PA, we have previously shown a protective effect of hypothermia on the retina when applied simultaneously with the hypoxic insult. In the present work, we evaluated the possible protective effect of hypothermia on the retina of PA rats when applied immediately after delivery. Four experimental groups were studied: Rats born naturally as controls (CTL), animals that were exposed to PA for 20 min at 37°C (PA), animals exposed to PA for 20 min at 15°C (HYP), and animals that were exposed to PA for 20 min at 37°C and, immediately after birth, kept for 15 min at 8°C (HYP-PA). To evaluate the integrity of the visual pathway, animals were subjected to electroretinography at 45 days of age. Molecular (real time PCR) and histological (immunohistochemistry, immunofluorescence, TUNEL assay) techniques were applied to the eyes of all experimental groups collected at 6, 12, 24, and 48 h, and 6 days after birth. PA resulted in a significant reduction in the amplitude of the a- and b-wave and oscillatory potentials (OP) of the electroretinogram. All animals treated with hypothermia had a significant correction of the a-wave and OP, but the b-wave was fully corrected in the HYP group but only partially in the HYP-PA group. The number of TUNEL-positive cells increased sharply in the ganglion cell layer of the PA animals and this increase was significantly prevented by both hypothermia treatments. Expression of the cold-shock proteins, cold-inducible RNA binding protein (CIRP) and RNA binding motif protein 3 (RBM3), was undetectable in retinas of the CTL and PA groups, but they were highly expressed in ganglion neurons and cells of the inner nuclear layer of the HYP and HYP-PA groups. In conclusion, our results suggest that a post-partum hypothermic shock could represent a useful and affordable method to prevent asphyxia-related vision disabling sequelae.

relationship between emotional intelligence and hardiness on stress resistance in athletes with disabilities in Indonesian national Paralympic committee

The purpose was to determine the relationship between emotional intelligence and hardiness on stress resistance in athletes with disabilities. This research is a quantitative approach. The data analysis technique using SPSS 22 16.0. The results can be concluded: (1) Emotional Intelligence and Stress Resistance, in athletes with disabilities with a total blindness correlation value of 0.450 with p. value or a significance of 0.062. (2) Emotional Intelligence and Stress Resistance, in athletes with disabilities with a low vision correlation value of 0.568 with p. value or a significance of 0.001. (3) Hardiness and Stress Resistance, in Athletes with Disabilities with a Blind correlation value of 0.638 with p. value or a significance of 0.002. (4) Hardiness and Stress Resistance in Athletes with Disabilities with Low Vision correlation value of 0.573 with p. value or a significance of 0.001. (5) Emotional Intelligence and Hardiness with Stress Resistance, in athletes with disabilities to Totally Blind r square of 0.495 with a significance value 0.002 which is less than 0.05. (6) Emotional Intelligence and Hardiness with Stress Resistance, in athletes with disabilities with low vision r square of 0.420 with a significance value. 0.001 which is less than 0.05.