The patent landscape for developing scientometric library services (as exemplified by the discipline of Microbiology)

The author discusses the modern research tools in various domains of science and industry based on integrated assessment of scientometric indicators and patent analysis. Excerpts of microbiological research papers published in Russia and worldwide are included. The data on researchers’ inventive work and publication activities are cited. The possibility for using patent landscapes in assessing research and industrial domains is examined. The author argues that building patent landscapes is a quality tool to identify the most promising vectors of development. He demonstrates that the most research and development activities are concentrated in the countries with the largest numbers of patent applications. In Russia, the government-funded organizations make the key driving force in the scientific studies and technologies in the national microbiology. In analyzing vast data volumes, patent landscapes enable to improve the quality of analysis visualization and get reliable data on the subject of research owing to multidimensional analytical representations. The author insists that building patent landscape services might become one of science libraries’ key functions.

Analysis of International Patent Applications for Inventions Like Traditional Herbal Medicines

Numerous applications have been filed for patents based on bio-inventions in the Indian patent office. Although there is not any international patent, there is a system of international patent applications whereby the applicant may designate name of countries where they wish to file application for patents nationally. According to international patent classification, the concern class for such a patent applications is A61K36/00. More particularly, the international class (IC) A61K36/00 relates to medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof (e.g., traditional herbal medicines). International applications filings under patent cooperation treaty (PCT) for patent purposes can be accessed at the Patentscope (patent search tool of WIPO). All international patent applications for such TK-based inventions have been accessed online at Patentscope using the classification code A61K36 for this study.

PROMISING COMPOSITE MATERIALS BASED ON NANOSCALE APATITE WITH GELATIN AS A BINDING AGENT

Порошки наноразмерных гидроксиапатита и фторапатита синтезированы методом осаждения из растворов. В качестве связующего вещества использован пищевой желатин. Такая композиция имеет высокую адгезию на материалах различной природы и пористости. Получены также пористые пленки и гранулы с развитой удельной поверхностью. Рассмотрены их микроструктуры. Изучена возможность использования коллоидной суспензии и водной суспензии кристаллического апатита в сочетании с раствором желатина в качестве биоактивного материала, как для создания покрытий, так и получения гранул. Установлено, что использование порошка апатита совместно с желатином позволяет существенно сократить сроки формирования биоактивного покрытия и значительно повысить его адгезионную прочность. Сопоставлены получаемые гранулы апатита по размерам в зависимости от концентрации желатина в водном растворе. На разработанные биоактивные покрытия и гранулированный материал на основе наноразмерного апатита со связующим агентом поданы заявки на патент. Nanoscale hydroxyapatite and fluorapatite powders were synthesized by precipitation from solutions. Food gelatin is used as a binder. This composition has a high adhesion on materials of different nature and porosity. Porous films and granules with a developed specific surface area were also obtained. Their microstructures are considered. The possibility of using a colloidal suspension and an aqueous suspension of crystalline apatite in combination with a gelatin solution as a bioactive material, both for creating coatings and obtaining granules, has been studied. It is established that the use of apatite powder together with gelatin can significantly reduce the time of formation of a bioactive coating and significantly increase its adhesive strength. The obtained apatite granules are compared in size depending on the concentration of gelatin in an aqueous solution. Patent applications have been filed for the developed bioactive coatings and granular material based on nanoscale apatite with a binding agent.

Does Environmental Regulation Promote Environmental Innovation? An Empirical Study of Cities in China

Promoting environmental innovation through environmental regulation is a key measure for cities to reduce environmental pressure; however, the role of environmental regulation in environmental innovation is controversial. This study used the number of environmental patent applications to measure urban environmental innovation and analyzed the role of urban environmental regulation on urban environmental innovation with the help of the spatial Durbin model (SDM). The results showed that: (1) From 2007 to 2017, the number of environmental patent applications in China has grown rapidly, and technologies related to buildings dominated the development of China’s environmental innovation. (2) Although the number of cities participating in environmental innovation was increasing, China’s environmental innovation activities were highly concentrated in a few cities (Beijing, Shenzhen, and Shanghai), showing significant spatial correlation and spatial agglomeration characteristics. (3) Urban environmental regulation had a positive U-shaped relationship with urban environmental innovation capability, which was consistent with what the Porter hypothesis advocates.

Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions

The majority of lung cancers are non-small-cell lung cancer (NSCLC) having a low survival rate. Recent studies have indicated the involvement of epidermal growth factor receptor (EGFR) oncogene mutations like EGFR exon 20 insertions (EGFRex20ins) mutation among NSCLC patients. The response of patients of NSCLC with the EGFRex20ins mutation to the currently available EGFR inhibitor is negligible. Mobocertinib is the first oral treatment that has been approved by the USFDA, on 15 September 2021, to treat NSCLC with the EGFRex20ins mutation. This patent review discusses the inventions and patent literature of mobocertinib that will help the scientific community to develop additional and improved inventions related to mobocertinib. The structure of mobocertinib was first reported in 2015. Therefore, this article covered the patents/patent applications related to mobocertinib from 2015 to 25 October 2021. The patent search revealed 27 patents/patent applications related to compound, method of treatment, salt, polymorph, process, composition, and drug combinations of mobocertinib. The authors foresee an exciting prospect for developing a treatment for NSCLC with EGFRex20ins mutation, and other cancers employing a combination of mobocertinib with other approved anticancer agents. The inventions related to novel dosage forms, processes, and intermediates used in the synthesis of mobocertinib are also anticipated.

AN OVERVIEW OF BIG DATA IN COVID-19 AS A CONTRIBUTION TO THE MANAGEMENT OF SCIENTIFIC AND TECHNOLOGICAL KNOWLEDGE

In times of pandemic, rapid sharing of research data is urgently needed, as is the intensification of networking. The COVID-19 pandemic brought a new perspective in relation to knowledge management in various organizational means, whether through the search for innovation or the improvement of its processes. Thus, to calculate the state of the art and track scientific and technological knowledge in the COVID-19 spectrum, the keyword “Coronavir*” was used in the PubMed and Espacenet databases. Data were processed by Carrot Search Lingo4G® and PatentInspiration®. In the Pubmed database, 1,000 documents were retrieved, which were organized into 81 groups of sub-themes, with emphasis on the sub-theme “treatment during coronavirus disease”, with 188 articles (18.8% of the total). Regarding technological innovation, China and the United States were the countries that filed the most patent applications, especially in 2020 and 2021, corresponding to 68.5% of the total. The first 4 (four) applicants with the highest number of patents were Pfizer, Gilead Sciences Inc., Center Nat Rech, Crucell Holland. The results obtained over a period of time demonstrate a partnership between universities and companies towards the fight against the pandemic. The tools for identifying, extracting and processing data (or free), are needed efficiently in the management of scientific and technological knowledge in COVID -19, thus being able to contribute to more assertive decision-making at various organizational levels. Keywords: Big Data, COVID-19, Knowledge Management, coronavirus patents

The Impact of Foreign Venture Capital Intervention on Venture Capital Innovation of Startup Entrepreneurs Using Propensity Score Matching Model

The research expects to give full play to the role of venture capital in corporate innovation and enhance the development capability of enterprises. Based on Propensity Score Matching (PSM) model, the characteristics of venture capital and startup enterprises are analyzed, and the innovation of venture capital is discussed. Next, the PSM model is used to analyze the innovation of venture capital intervention in enterprises from risk probability intervention, probability evaluation, matching equilibrium validity test, matching results analysis, different venture capital, and different background risks. The results show that the difference of standardized mean is close to 0, which accords with the equilibrium test. The significant impact of venture capital intervention on the Number of Invention Patent Applications (NIPA) and Number of Utility Model Patent Applications (NUMPA) is 0.1 and 0.01, respectively. Venture capital intervention has a significantly positive impact on NIPA and NUMPA but has no significant positive impact on Number of Design Patent Applications (NDPA). The impact of joint venture capital intervention on the NIPA, NUMPA, and NDPA is 0.0874, 0.0635, and 0.1213, respectively. Hence, the intervention of joint venture capital can greatly promote the increase of Number of Patent Applications (NPA), especially, NIPA, and NUMPA. Compared with private venture capital, joint venture capital plays a greater role in promoting the growth of NPA and NIPA. Compared with private venture capital and foreign venture capital, national venture capital has a stronger innovation orientation and a longer investment cycle, which can greatly improve innovation performance, such as NIPA, while private venture capital and foreign venture capital have a less significant impact on enterprise innovation performance. The results demonstrate that the foreign capital sharing assessment based on the PSM model can be a good predictor of the performance of startups. It is hoped that the research results can provide a reference for the development of startups.