The Understanding of Intertwined Physics: Discovering Capillary Pressure and Permeability Co-Determination

<p>Although capillary and permeability are the two most important physical properties controlling fluid distribution and flow in nature, the interconnectivity function between them was a pressing challenge. Because knowing permeability leads to determining capillary pressure. Geodynamics (e.g., subsurface water, CO2 sequestration) and organs (e.g., plants, blood vessels) depend on capillary pressure and permeability. The first determines how far the fluid can reach, while the second determines how fast the fluid can flow in porous media. They are also vital to designing synthetic materials and micro-objects like membranes and micro-robotics. Here, we reveal the capillary and permeability intertwined behavior function. And demonstrate the unique physical connectors: pore throat size and network, linking capillary pressure and permeability. Our discovery quantifies the inverse relationship between capillary pressure and permeability for the first time, which we analytically derived and experimentally proved.</p>

The Understanding of Intertwined Physics: Discovering Capillary Pressure and Permeability Co-Determination

<p>Although capillary and permeability are the two most important physical properties controlling fluid distribution and flow in nature, the interconnectivity function between them was a pressing challenge. Because knowing permeability leads to determining capillary pressure. Geodynamics (e.g., subsurface water, CO2 sequestration) and organs (e.g., plants, blood vessels) depend on capillary pressure and permeability. The first determines how far the fluid can reach, while the second determines how fast the fluid can flow in porous media. They are also vital to designing synthetic materials and micro-objects like membranes and micro-robotics. Here, we reveal the capillary and permeability intertwined behavior function. And demonstrate the unique physical connectors: pore throat size and network, linking capillary pressure and permeability. Our discovery quantifies the inverse relationship between capillary pressure and permeability for the first time, which we analytically derived and experimentally proved.</p>

Estimation of Cole Parameters in ex-vivo tissues as a function of degradation time

Bioimpedance spectroscopy has been used to evaluate and characterize the integrity of different tissues and organs, as well as to detect tissue structural alterations. The tissue electrical model alterations as an influence of the anisotropy of the tissue structure and its intrinsic metabolism on the degradation dynamic have not been completely understood. In this work, the dynamic of Cole parameters was estimated as a function of degradation time in ex vivo skeletal muscle, skin, and white adipose tissues. The results indicate a non-linear behavior function of the Cole parameters through degradation progress in the three evaluated tissues, and such non-linearities might be associated with different capacities of adaptation to anaerobic metabolism, energy production, and water content under stress conditions.

Research on the influencing factors of the switching behavior of Chinese social media users: QQ transfer to WeChat

PurposeThis research takes the transfer behavior of users from Tencent QQ to WeChat as an example to discuss the wider transfer behavior of social media users on the Internet.Design/methodology/approachThis paper collects data through a combination of offline interviews and online questionnaire surveys, and utilizes data analysis tools to construct structural equation modeling (SEM). Using Statistical Product and Service Solutions (SPSS) Statistics 22.0 and Analysis of Moment Structures (AMOS) 22.0 software with SEM, this study was carried out to provide reasonable statistical support for relevant proposed hypotheses based on 368 effective samples acquired through the questionnaire.FindingsThe findings of this study show that subjective norm, transfer experience, social communication, and knowledge acquisition all have significant associations with transfer intention and switching behavior. To be specific, transfer intention exerts a positive association on switching behavior; function setting, privacy protection and personal innovation have a favorable association with transfer intention; transfer cost has a significantly negative relationship with transfer intention and switching behavior; function setting has no important relationship on switching behavior.Originality/valueThe research results provide a reference for improving the viscosity and loyalty of social media users in the new era and resolving the problem of user churn.

Muscle forces and the demands of human walking

ABSTRACT Reconstructing the locomotor behavior of extinct animals depends on elucidating the principles that link behavior, function, and morphology, which can only be done using extant animals. Within the human lineage, the evolution of bipedalism represents a critical transition, and evaluating fossil hominins depends on understanding the relationship between lower limb forces and skeletal morphology in living humans. As a step toward that goal, here we use a musculoskeletal model to estimate forces in the lower limb muscles of ten individuals during walking. The purpose is to quantify the consistency, timing, and magnitude of these muscle forces during the stance phase of walking. We find that muscles which act to support or propel the body during walking demonstrate the greatest force magnitudes as well as the highest consistency in the shape of force curves among individuals. Muscles that generate moments in the same direction as, or orthogonal to, the ground reaction force show lower forces of greater variability. These data can be used to define the envelope of load cases that need to be examined in order to understand human lower limb skeletal load bearing.

MBRS-73. AN EXPLORATORY ANALYSIS LOOKING AT THE ASSOCIATION OF GERMLINE CODING MUTATIONS WITH IMPAIRED DEVELOPMENT AND ADAPTIVE BEHAVIOR FUNCTION IN PEDIATRIC MEDULLOBLASTOMA PATIENTS TREATED ON HEAD START 4

Children with brain tumors often carry germline mutations known to contribute to tumorigenesis and treatment response; however, little is known about how these mutations impact developmental and behavioral outcomes. As the molecular mechanisms governing cancerous and normal tissues expand, we hypothesize that specific germline variants may impact baseline neurocognitive function and/or treatment-induced toxicities. In this pilot study, ten children on the Head Start 4 (HS4) clinical trial diagnosed with medulloblastoma were assessed for baseline adaptive functioning using the Adaptive Behavior Assessment System Third Edition (ABAS-III) and germline whole-exome sequencing was performed. After filtering for high impact variants, Welch’s T-tests were used to identify mutations associated with lower ABAS-III General Adaptive Composite (GAC) scores, reflecting developmental and adaptive behavior delays compared with peers their age. We found twenty genes with alterations associated with lower scores with p-values less than 0.05. Genes found to be significant included LAMC1 (p=0.04) and KRTAP1-1 (p=0.045), which encode members of the laminin and keratin family respectively and are involved in extracellular matrix adhesion. Mutations in PITX1, a known suppressor of RAS, were also associated with lower ABAS-III GAC scores (p=0.007). We hypothesize that additional analyses of HS4 patients will reveal alterations in cell-to-cell communication and signal transduction pathways, common molecular perturbations in tumors that would likely impact central nervous system function. Validation studies are essential to improve our understanding of the functional impact of germline variants on both tumor and regular tissue biology, allowing for novel strategies to circumvent these delays.

A Diachronic Analysis of the Translation of English Sound Symbolism in Italian Comics

Phonosymbolic elements such as ideophones and interjections test the translator’s ability in various ways. These forms would, in theory, require a complete change of form and substance of the source text but this has not always been possible because of graphical, cultural and linguistic reasons, and this led, in certain cases, to a foreignized target-text environment. Recent research has started to consider the relationship between verbal and visual modes as beneficial and not just as a mere constraint for the translator. This research aims to align itself with this approach in order to analyze how verbal and visual modes in Disney comic books have come together to welcome sound symbolic forms and how translators have dealt with them in Italian Disney comics, in particular. In order to clarify the behavior, function, translation and use of expressive sound symbolic devices in Italian Disney comics, this article will offer a diachronic analysis of these strategies as found in a diachronic bidirectional corpus compiled through extensive archival research.