Women and the Islamic Republic

Based on extensive interviews and oral histories as well as archival sources, Women and the Islamic Republic challenges the dominant masculine theorizations of state-making in post-revolutionary Iran. Shirin Saeidi demonstrates that despite the Islamic Republic's non-democratic structures, multiple forms of citizenship have developed in post-revolutionary Iran. This finding destabilizes the binary formulation of democratization and authoritarianism which has not only dominated investigations of Iran, but also regime categorizations in political science more broadly. As non-elite Iranian women negotiate or engage with the state's gendered citizenry regime, the Islamic Republic is forced to remake, oftentimes haphazardly, its citizenry agenda. The book demonstrates how women remake their rights, responsibilities, and statuses during everyday life to condition the state-making process in Iran, showing women's everyday resistance to the state-making process.

GPS: Improvement in the Formulation of the TSP for Its Generalizations Type QUBO

We propose a new binary formulation of the Travelling Salesman Problem (TSP), with which we overcame the best formulation of the Vehicle Routing Problem (VRP) in terms of the minimum number of necessary variables. Furthermore, we present a detailed study of the constraints used and compare our model (GPS) with other frequent formulations (MTZ and native formulation). Finally, we have carried out a coherence and efficiency check of the proposed formulation by running it on a quantum annealing computer, D-Wave\_2000Q6.

Knights Exchange Puzzle—Teaching the Efficiency of Modeling

Puzzles and games enhance the quality of teaching by creating an enjoyable, interactive, and playful atmosphere. The knight exchange is a famous, very old, and amusing game on the chessboard. This puzzle was used by the author to teach modeling in a mathematical programming course designed for graduate students. The aim was to teach the students the efficiency of the models. Accordingly, first, a binary programming formulation was developed. This formulation was, however, found to be inefficient, and tremendous time (i.e., more than four hours) and a large amount of processing memory were needed to solve the puzzle. The puzzle was subsequently formulated as a minimum cost network flow problem. The latter formulation outperformed the general binary formulation by solving the puzzle in less than a minute. The network formulation could also save the required processing memory. The results could help students to learn the value of modeling combinatorial optimization problems as network flows.

Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

To prepare a binary formulation delivering miRNA-146 and evaluate a nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. The gel/NPs/miR-146a thermosensitive in situ chitosan hydrogel carrying a nucleic acid was prepared and evaluated for its characteristics, including temperature sensitivity, gel strength, mucosal adhesion and drug release profile. After nasal administration of the formulation to ovalbumin-sensitized rats, the treatment of allergic rhinitis was verified by assessing nasal symptoms, hematology, hematoxylin-eosin (HE) staining and immunohistochemistry. Western Blot(WB) was used to analyze nasal inflammatory factors as well as miRNA-146-related factors, and the miR146 expression level was measured by PCR. Subsequently, the effects of the gel/NPs/miR-146a binary formulation were evaluated for the nasal delivery of nucleic acids in rhinitis therapy. The prepared binary formulation quickly formed a gel in the nasal cavity at a temperature of 34 °C with good mucosal adhesion, which delivered nucleic acids into the nasal mucosa stably and continuously. Gel/NPs/miR-146a was able to sustain the delivery of miRNA into the mucosa after nasal administration. When compared with the monolithic formulations, the gel/NPs/miR-146a binary formulation performed better regarding its nucleic acid delivery ability and pharmacodynamic effects. The gel/NPs/miR-146a binary preparation has a suitable nasal mucosal drug delivery ability and has a positive pharmacodynamic effect for the treatment of ovalbumin-induced rhinitis in rats. It can serve as a potential nucleic acid delivery platform for the treatment of allergic rhinitis.

Learning Optimal Classification Trees Using a Binary Linear Program Formulation

We provide a new formulation for the problem of learning the optimal classification tree of a given depth as a binary linear program. A limitation of previously proposed Mathematical Optimization formulations is that they create constraints and variables for every row in the training data. As a result, the running time of the existing Integer Linear programming (ILP) formulations increases dramatically with the size of data. In our new binary formulation, we aim to circumvent this problem by making the formulation size largely independent from the training data size. We show experimentally that our formulation achieves better performance than existing formulations on both small and large problem instances within shorter running time.

Selective toxicityof acetamiprid and fipronil as a part of insecticidal baits

Monocomponent and combined insecticidal baits containing acetamiprid and fipronil are proposed to control the housefly Musca domestica at livestock facilities. The combination of active ingredients increases the insecticidal activity of formulations and simultaneously may lead to an increase in their toxicity to animals. The purpose of this work was to assess the selective toxicity of acetamiprid and fipronil as parts of mono- and bicomponent insecticides. The intestinal activity of insecticides against adult houseflies was assessed by no-choice feeding tests. The acute toxicity of insecticidal baits to animals was carried out by feeding to white mice. Probit analysis was used to calculate of median lethal doses of active ingredients and insecticidal baits. The selective toxicity was evaluated by the selective toxicity ratio, which was calculated by dividing the median lethal doses (LD50) of the active ingredients for white mice into LD50 for adult flies. The median lethal doses of acetamiprid and fipronil when applied alone for adult flies were 2.412 (2.023-2.862) and 0.087 (0.0285-0.2659) μg of active ingredient per g of insect weight, respectively. The insecticidal activity of active ingredients, applied in combination, against adult flies increased by 15 and 5 times, respectively. For the toxicity to mice, median lethal doses of acetamiprid and fipronil in formulations containing only one of the active substances were 94.9 (88.5 - 101.8) mg/kg and more than 22.5 mg/kg of animal weight, respectively. The selective toxicity ratio of fipronil in the monocomponent formulation was 6.8 times higher than that of acetamiprid. For the binary formulation, the selectivity of fipronil and acetamiprid activity was equal. The combination of acetamiprid and fipronil resulted in an increase in their toxicity for adults Musca domestica and for white mice and a change in the selectivity of their activity compared to monocomponent formulations.

Feasibility Study and Demonstration of an Aluminum and Ice Solid Propellant

Aluminum-water reactions have been proposed and studied for several decades for underwater propulsion systems and applications requiring hydrogen generation. Aluminum and water have also been proposed as a frozen propellant, and there have been proposals for other refrigerated propellants that could be mixed, frozen in situ, and used as solid propellants. However, little work has been done to determine the feasibility of these concepts. With the recent availability of nanoscale aluminum, a simple binary formulation with water is now feasible. Nanosized aluminum has a lower ignition temperature than micron-sized aluminum particles, partly due to its high surface area, and burning times are much faster than micron aluminum. Frozen nanoscale aluminum and water mixtures are stable, as well as insensitive to electrostatic discharge, impact, and shock. Here we report a study of the feasibility of an nAl-ice propellant in small-scale rocket experiments. The focus here is not to develop an optimized propellant; however improved formulations are possible. Several static motor experiments have been conducted, including using a flight-weight casing. The flight weight casing was used in the first sounding rocket test of an aluminum-ice propellant, establishing a proof of concept for simple propellant mixtures making use of nanoscale particles.