Homeostatic model of human thermoregulation with bi-stability

All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.

Filtration mechanisms and manufacturing methods of face masks: An overview

Face masks are loose-fitting masks that cover the nose and mouth and have ear ties at the back of the head whereas respirators are tight-fitting face covering devices which filter the air during inhalation and exhalation. Guidelines issued by the US Centers for Disease Control and Prevention (CDC) regarding proper design, filtration process and wearing should be followed. The mask equipment provides protection against the infections caused by particulate matters (PM), especially PM2.5, and biological pathogens such as bacteria and viruses. Although face masks offer benefits to a greater extent, it is not recommended to wear them for a long period of time. As N95 masks closely fit with the face, it may result in negative impact on respiratory and dermal mechanisms of human thermoregulation. In this article, currently available face masks including cloth masks, their filtration mechanisms, manufacturing methods and decontamination methods are reviewed for the purpose of helping with the coronavirus pandemic (COVID-19).

Validation of the Stolwijk and Tanabe Human Thermoregulation Models for Predicting Local Skin Temperatures of Older People under Thermal Transient Conditions

Human thermoregulation models can predict human thermal responses to evaluate thermal comfort and help create a healthy environment, while their applicability to older people has not been sufficiently validated. This study aimed to evaluate the performance of the Stolwijk model and the Tanabe model for predicting older people’s mean and local skin temperatures under thermal transient conditions. Eighteen healthy older people were recruited and exposed to transient environments including neutral (26 °C), low-temperature (23 and 21 °C), and high-temperature (29 and 32 °C) conditions. The local skin temperatures of the subjects were measured and compared to predictions of the Stolwijk model and the Tanabe model. The results revealed that the Stolwijk model and the Tanabe model could accurately predict the mean skin temperature of older people under neutral and high-temperature conditions, while their predictive accuracy declined under low-temperature conditions. Increased deviations were observed in the predictions of local skin temperatures for all conditions. This work attempted to provide an understanding of older people’s thermal response characteristics under transient conditions and to inspire the improvement of thermoregulation models for older people.

Fundamental Concepts of Human Thermoregulation and Adaptation to Heat: A Review in the Context of Global Warming

The international community has recognized global warming as an impending catastrophe that poses significant threat to life on earth. In response, the signatories of the Paris Agreement (2015) have committed to limit the increase in global mean temperature to <1.5 °C from pre-industry period, which is defined as 1850–1890. Considering that the protection of human life is a central focus in the Paris Agreement, the naturally endowed properties of the human body to protect itself from environmental extremes should form the core of an integrated and multifaceted solution against global warming. Scholars believe that heat and thermoregulation played important roles in the evolution of life and continue to be a central mechanism that allows humans to explore, labor and live in extreme conditions. However, the international effort against global warming has focused primarily on protecting the environment and on the reduction of greenhouse gases by changing human behavior, industrial practices and government policies, with limited consideration given to the nature and design of the human thermoregulatory system. Global warming is projected to challenge the limits of human thermoregulation, which can be enhanced by complementing innate human thermo-plasticity with the appropriate behavioral changes and technological innovations. Therefore, the primary aim of this review is to discuss the fundamental concepts and physiology of human thermoregulation as the underlying bases for human adaptation to global warming. Potential strategies to extend human tolerance against environmental heat through behavioral adaptations and technological innovations will also be discussed. An important behavioral adaptation postulated by this review is that sleep/wake cycles would gravitate towards a sub-nocturnal pattern, especially for outdoor activities, to avoid the heat in the day. Technologically, the current concept of air conditioning the space in the room would likely steer towards the concept of targeted body surface cooling. The current review was conducted using materials that were derived from PubMed search engine and the personal library of the author. The PubMed search was conducted using combinations of keywords that are related to the theme and topics in the respective sections of the review. The final set of articles selected were considered “state of the art,” based on their contributions to the strength of scientific evidence and novelty in the domain knowledge on human thermoregulation and global warming.