Investigation the Importance of Metabolism on Body Weight and Glucose for 8.5 Years using GH-Method:Math-Physical Medicine (No. 300)

The author uses GH-method: math-physical medicine (MPM) approach to investigate three sets of correlation between: (1) Weight vs. Metabolism Index (2) Glucose vs. Metabolism Index (3) Weight vs. Glucose - Weight is measured in early mornings and Glucose consists of daily average glucose, including both fasting plasma glucose (FPG) and three postprandial plasma glucose (PPG). He utilized time-series analysis on both his “daily data” and his “annual data” for comparison. His selected study period was 8.5 years (3,124 days) from 1/1/2012 through 7/23/2020. The reason for this specific time period was due to his weight (M1) and glucose (M2) data collection starting on 1/1/2012 along with the calculation of his metabolism index (MI) values. It is clear that, through his sophisticated math-physical medicine of metabolism and then statistical method of time-series analysis, all of these three biomarkers, weight, glucose, and metabolism index are proven to be highly correlated to each other. The following order ranking of correlation coefficients remained to be true between daily data and annual data: M1&MI > M2&MI > M1&M2 Daily: 84% > 72% > 61% Annual: 91% > 81% > 67% In other words, if you manage your metabolism (4 medical conditions and 6 lifestyle details) by controlling your disease conditions and monitoring your lifestyle details, your body weight and glucose will reduce accordingly. The author’s analyses is based on his personal biomarkers of two million data within 8.5 years (3,124 days) has further proven a simple and clean conclusion that has already been observed by many clinical physicians and healthcare professionals from their patients.

A Corrected H-Index for Academic Leadership Determination: A Bibliographic Research

Academic medical leadership is closely related to scientific research productivity and publication. A researcher’s h-index is based on his/her most cited papers and the number of citations that they have received in other’s publications. It is generally determined by knowing the number of articles written by the author indexed in citation databases. An H-index will be 10 if 10 articles have received at least 10 citations. Ignoring the order and authorship role of an individual researcher may lead to rather a misleading H-index that is totally not relevant to academic leadership determination. The publishing of research conducted by a large collaborative research group made many collaborators with minor role in research creation, development and leadership obtain a high misleading H-index and is not correlated with their academic and research prowess. The use of methods that increase the reliability of the H-index has been increasingly recommended. The aim of this paper is to describe the determination of a more accurate, non- misleading H-index that is more relevant to academic leadership determination.

COVID-19 and Intrauterine Fetal Death (IUFD): Possible Immunological Causes and Pathologies

COVID-19; The first recognized outbreak in Wuhan, China, December 2019 is considered a global threat (1,2) and its mortality rate according to WHO, ranges from 2-3% (3,4). The pregnant woman and her fetus are more susceptible to the poor outcomes of COVID-19, in which fatality rate may reach more than 35%(5,6). More than 90% of infected pregnant women suffering from pneumonia are susceptible to a miscarriage and other several adverse outcomes (4). A case report of intrauterine fetal death (IUFD) that occurred due to multiple organ dysfunction syndrome (MODS) accompanied by acute respiratory distress syndrome (ARDS) (7). A systemic review of seventeen published studies (8) reported several adverse fetal and neonatal outcomes, including stillbirth (1.2%) and fetal distress ( 10.7%). Moreover, one pregnant woman with Covid-19 had a stillbirth, delivered by the cesarean section (CS) according to Liu et al.(7). That occurred after she had a fever and a sore throat at the 34th week of needed to be transferred to the intensive care unit (ICU). The only available information about fetal and neonatal results is for women who were infected in their third trimester. It is still unknown whether the infection in the first or second trimester might increase the incidence of fetal and neonatal death(8). We will try to discuss the relation between COVID-19 and IUFD as possible complications via mentioning possible immunological mechanisms and pathologies for that via available data.

Food Cultures to Improve

I am writing this article inspired by three books i read: 1. Food and health, by Vandana Shiva et al 2. Diet myth, by Tim Spector 3. Zen and eating well art, by Seigaku All these books express food culture, that is basis to eat better, live better and perceive better eating habits, eating philosophy, relationship with food and the link between food and environment, between food and us or our wellbeing.

Antioxidant Effects of Vitamins C, E and Provitamin A Compounds as Monitored by Use of Biochemical Oxidative Indicators Linked to Atherosclerosis and Carcinogenesis

Reactive oxygen species as initiators of oxidative stress account for LDL and DNA oxidative changes that are respectively associated with the development of pathological conditions such as atherosclerosis and carcinogenesis. This review paper first focuses on specific bio-indicators used to monitor these harmful oxidative stress conditions and develop health strategies against the associated human diseases. Subsequently, it provides an overview of the most recent available literature on the protective role that certain antioxidant vitamins (vitamin C, vitamin E and provitamin A compounds) have been reported to exert against the biochemical oxidative processes that govern the initiation of these specific human diseases.

The System View of the Origin of Cellular Life

The commonly accepted view in the system biology of the minimal cell is a bottom-up approach which assumes that one can reach the properties of modern cells by stepwise increasing the complexity of biopolymers-containing vesicles. It is argued here that the great gap between the paucity of the results achievable in such a way, vis a vis the complexity of modern minimal cells, opens the question of the validity of this bottom up, stepwise approach as a matter of principle. We present here arguments in favor of an alternative view point, a systemic approach starting from the top, namely with the whole system of a very large population of mutually interacting vesicles initially randomly overfilled with DNA, RNA, proteins. This view is based on published literature data reporting the spontaneous overcrowding of vesicles formed in situ in a diluted solution of biopolymers, once that there is the simultaneous occurrence of vesicle-forming surfactants in the same macromolecular solution [28-32]. The assumption is then made, that if such an enormous number (109-1011) of overfilled vesicles would be formed, then there would be a finite probability that one of them, or even a few, could have the right combination and concentration to start life – or at least the first dynamic steps towards a selection process, which, through mutual interaction, fusion and eventually vesicles proliferation, could arrive at a homeostatic equilibrium, conductive to the first forms of cellular life – possibly already at a level of a quasi-colony.

Glimpses On White Spot Disease in Shrimps and its Significance in e-Resource Development

The worldwide distribution of White Spot Disease (WSD) instigated by White Spot Syndrome Virus (WSSV) is one of the most pathogenic and devastating viruses in shrimps and crustaceans. WSSV categorized into a new family named Nimaviridae causes the disease that has been considered as havoc as it severely affects the shrimp population and in its most fatal form due to its high virulence, it has the ability to wipe out all the shrimp population within a week. Surprisingly till date, no effective drugs are available to prevent the disease because of incomplete understanding on the disbandment of the disease mechanism and further protein of this virus has not shown any homology with already existing viral proteins. Earlier, many attempts were made to understand the mechanism of entry, propagation and spread of this virus within the host, but till now, the information and knowledge generated from these studies have not been compiled with an aim to construct systematic and comprehensive e-resource covering information relating to genes, proteins and protein interactions of the disease. To accomplish this, it is imperative to have the understanding about the available resources that contains information and knowledge about this disease so as to provide the complete understanding about the disease and the related phenomena. Such publically available resources can be of extreme importance in developing an e-resource in the form of an online database that might be of much useful to the shrimp and allied researchers and in future of tremendous benefit as the shrimp researchers might perform many operations from the 'omics' data stored in the database. The present paper discusses about WSD, its resources and utility in accomplishing database in a nutshell.

Citrus Limonoid Glucosyltransferase: AKey Player For Natural Debittering And Anticancerous Potential

Citrus fruits and juices are rich source of health benefitting phytochemicals which play a vital role in balanced diet and disease prevention. Citrus limonoids and flavonoids are the major phytochemicals which are of great interest in pharmaceutical industries because of their demonstrated anticancerous, antioxidant, anti-inflammatory, hormonal stimulation, antibacterial and antiviral actions. Citrus limonoid biosynthetic pathway contains an important regulatory limonoid glucosyltransferase enzyme (LGT). LGT is the natural debittering enzyme encoded by a single copy gene which has been isolated from different Citrus spp. This enzyme is mainly responsible for conversion of all limonoid aglycones (mostly bitter) to their corresponding glucosides (mostly nonbitter) but only during late fruit developmental stage of citrus. Citrus LGT belongs to glycosyltransferase super family whose members are the wide managers to catalyze the transfer of sugar molecules to their acceptor molecules to play several key modifications in plant secondary metabolites. These reveal great significance value in plant cell metabolism especially in detoxification of xenobiotics, production and storage of natural products. Despite to the fact that over expression of LGT in citrus will lead to reduce the delayed bitterness caused by limonin (an aglycone) but in addition will enhance the accumulation of limonoid glucosides in fruits. Further, recent studies suggest that citrus limonoids especially glucosides have shown importance against brain, pancreas, colon, and breast cancers. Thus, future studies should be focused on utilizing the potential of LGT present in citrus plants in terms of anticancerous properties as well as reducing the delayed bitterness problem important for citrus juice industry