This chapter talks about three major intertwined themes that emerge in the new cultural economics: causal effects of culture on economic outcomes and institutions, the origins of culture, and the issues of cultural transmission, persistence, and change. It emphasizes the studies related to the field of long-run economic growth and development which explores culture as one of the key “deep determinants” of economic performance. The chapter reviews some of the recent empirical studies attempting to identify the causal effects of culture, and examines the research on the origins of culture, its social benefits, and costs. It also considers the evidence on cultural persistence and discusses the mechanisms of cultural transmission and change.