The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2, corona virus) pandemic has introduced a sudden and overwhelming change into our everyday lives, which had a significant impact on various vital aspects of our society. The first officially registered case of infection was reported on December 31st, 2019. in Wuhan, China. Since then, its worldwide spread has led to a global pandemic of the respiratory disease COVID-19 (Coronavirus Disease 19). Up to May 31st, 2021, there have been over 169 million officially reported cases of infection in the world, with over 3.5 million deaths. Since the first day of the pandemic, huge efforts have been employed by the health and scientific community to enable most efficient diagnostics, treatment and prevention by development of efficient vaccines. In Serbia, the first official SARS-CoV-2 case was registered on March 6th, 2020. Until May 31st, 2021, the total number of infected people was 712 472, total number of deaths 6 865 and the mortality rate 0.96%. The first antiSARS-CoV-2 vaccine was administered on December 24th, 2020, and by May 31st 2021 over 2 million people were successfully vaccinated in Serbia. If any positive effects of the pandemic can be highlighted, the health institutions of our country have prepared protocols and recommendations which can be modified according to specific needs in the case of future pandemics. Further dynamic of this pandemic will depend in great part on our responsibility for personal and collective health, as well as on global measures undertaken to reach a new eagerly awaited normality.