Correlation Between Anthropometric Parameters And Biochemical Markers Of Cardiovascular Risk In Chronic Renal Patients On Hemodialysis

Objective: To correlate anthropometric parameters and biochemical markers of cardiovascular risk in chronic renal patients undergoing hemodialysis. Methods: Cross-sectional observational study, carried out at the Instituto de Medicina Integral Professor Fernando Figueira – Imip (Recife-PE), from July to October 2018. Anthropometric parameters were analyzed: The anthropometric measurements used were waist circumference (WC) and waist-height ratio (WHT), sociodemographic data (sex and base disease) and biochemical parameters (HDL, LDL, Total Cholesterol, Triglycerides, Vitamin D, phosphorus, calcium, potassium and parathyroid hormone). Results: Fifty-nine patients with CKD were evaluated in a regular HD program. and males (54.2%). The majority of the population had an undetermined disease (44.1%). Regarding anthropometry, it was observed that there was a predominance in the change in waist circumference (57.6%) and waist/height ratio (59.3%). Regarding the biochemical profile, through pearson’s correlation, it was observed that there was a significant positive association of WC and WHT with phosphorus (ρ*=0.305 and 0.329). In the correlation of WC and WHT with vitamin D, it was seen that as these anthropometric indices increase, vitamin D decreases, making this correlation significant (ρ*=-0.435 and -0.368). Conclusion: It can be concluded that most patients presented inadequate nutritional status, as well as decreased serum vitamin D levels and changes in serum phosphorus levels. These changes may result in increased risk for cardiovascular events in this population.

Ultrafiltration (UF) Effectiveness on intradialytic hypertension (IDH) in chronic hemodialysed patients in a nephrology unit in Dakar: UF-IDH clinical trial

Introduction Progressive ultrafiltration (UF) could improve IDH. The aim of this work was to evaluate the effectiveness of progressive UF in the management of IDH. Methods This randomized clinical trial in two groups: interventional group A (UF, n = 12) and control group B (n = 12), was conducted in chronic hemodialysis patients with IDH. A first phase of cross-sectional collection of BP before and after dialysis, during 2 weeks, made it possible to obtain this cohort of 24 patients. A progressive decrease in basal weight of 0.25 kg per session as a function of hemodynamic tolerance was achieved in group A. The primary endpoint, the proportion of patients with disappearance of IDH, was assessed at baseline end of the 4th and 8th week. Results At the 4th week, the IDH disappeared in 83.3% and 41.7% of the patients of the group A and B respectively with a hazard ratio (HR) at 0.29; IC 95 = [0.14-0.59]; p = 0.035. At the 8th week, the IDH was missing in 72.7% and 66.7% of the patients of the group A and B respectively with a HR at 0.76; IC 95 = [0.58-1.00]; p = 0.75. In addition, the decrease in basal weight was associated with the occurrence of side effects (p = 0.0001) with a HR of 5 [1.45-7.27]. UF discontinuation was required in 4 patients in group A (36.4%). Conclusion Progressive UF was associated with a significant reduction in the prevalence of IDH in our patients at week 4.