Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes

Background: The prevention and treatment of obesity and its cardio-metabolic complications are relevant issues worldwide. Among lifestyle approaches, very low-calorie ketogenic diets (VLCKD) have been shown to lead to rapid initial weight loss, resulting in better long-term weight loss maintenance. As no information on VLCKD studies carried on in a real-world setting are available, we conducted this multi-centre study in a real-world setting, aiming at assessing the efficacy and the safety of a specific multiphasic VLCKD program in women with overweight or obesity. Methods: A multi-center, prospective, uncontrolled trial was conducted in 33 outpatient women (age range 27–60 y) with overweight or obesity (BMI: 30.9 ± 2.7 kg/m2; waist circumference: 96.0 ± 9.4 cm) who started a VLCKD dietary program (duration: 24 weeks), divided into four phases. The efficacy of VLCKD was assessed by evaluating anthropometric measures and cardiometabolic markers; liver and kidney function biomarkers were assessed as safety parameters. Results: The VLCKD program resulted in a significant decrease of body weight and BMI (−14.6%) and waist circumference (−12.4%). At the end of the protocol, 33.3% of the participants reached a normal weight and the subjects in the obesity range were reduced from 70% to 16.7%. HOMA-IR was markedly reduced from 3.17 ± 2.67 to 1.73 ± 1.23 already after phase 2 and was unchanged thereafter. Systolic blood pressure decreased after phase 1 (−3.5 mmHg) and remained unchanged until the end of the program. Total and LDL cholesterol and triglycerides were significantly reduced by VLCKD along with a significant HDL cholesterol increase. Liver, kidney and thyroid function markers did not change and remained within the reference range. Conclusions: The findings of a multi-center VLCKD program conducted in a real-world setting in a cohort of overweight/obese women indicate that it is safe and effective, as it results in a major improvement of cardiometabolic parameters, thus leading to benefits that span well beyond the mere body weight/adiposity reduction.

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Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy and Body Weight in Adults With Overweight or Obesity

JAMA ◽

10.1001/jama.2021.13021 ◽

2021 ◽

Vol 326 (12) ◽

pp. 1213

Author(s):

Christopher K. Rayner ◽

Karen L. Jones ◽

Michael Horowitz

Keyword(s):

Body Weight ◽

Behavioral Therapy ◽

Overweight Or Obesity

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Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy and Body Weight in Adults With Overweight or Obesity—Reply

JAMA ◽

10.1001/jama.2021.13024 ◽

2021 ◽

Vol 326 (12) ◽

pp. 1214

Author(s):

Ildiko Lingvay ◽

W. Timothy Garvey ◽

Thomas A. Wadden

Keyword(s):

Body Weight ◽

Behavioral Therapy ◽

Overweight Or Obesity

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Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial

Lipids in Health and Disease ◽

10.1186/s12944-020-01399-0 ◽

2020 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Mahsa Maroofi ◽

Javad Nasrollahzadeh

Keyword(s):

Body Weight ◽

Calorie Restriction ◽

Density Lipoprotein ◽

The Body ◽

Trial Registration ◽

Lipoprotein Cholesterol ◽

Short Term ◽

Significant Difference ◽

The Impact ◽

Overweight Or Obesity

Abstract Background Intermittent calorie restriction (ICR) is a novel method of dietary restriction for body weight control with the potential to improve obesity-related cardiometabolic markers, but the impact of this diet on subjects with hypertriglyceridemia (HTG) remains unknown. Methods Eighty-eight subjects with overweight or obesity and mild-to-moderate HTG were randomized to the continuous calorie restriction (CCR) group, or ICR group (a very low-calorie diet during 3 days of the week) for 8 weeks (44 patients in each group). Body composition, plasma lipids, glucose, insulin, adiponectin, and liver enzymes were measured at baseline and after 8 weeks. An intention-to-treat analysis was performed. Results The body weight decreased in both groups (4.07 ± 1.83 kg in the CCR group and 4.57 ± 2.21 kg in the ICR group) with no significant difference between the groups. There was no significant difference between the two groups in the reduced amount of fat mass, fat-free mass, and waist circumference. Both groups achieved a significant reduction in plasma triglycerides after 8 weeks (by 15.6 and 6.3% in ICR and CCR groups, respectively) with no difference between treatment groups. HOMA-IR improved significantly in ICR compared to the CCR group (P = 0.03). Plasma glucose, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, liver enzyme, and adiponectin were not different between the two groups. Conclusions The results of this short-term study suggest that three-days a week of the ICR is comparable to a CCR diet for the reduction of triglycerides level in patients with HTG and in the short-term it appears to be more effective than continuous dieting in improving insulin resistance. However, longer-term studies are needed to confirm these findings. Trial registration Trial registration number:NCT04143971.

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Licogliflozin, a Novel SGLT1 and 2 Inhibitor: Body Weight Effects in a Randomized Trial in Adults with Overweight or Obesity

Obesity ◽

10.1002/oby.22764 ◽

2020 ◽

Vol 28 (5) ◽

pp. 870-881 ◽

Cited By ~ 3

Author(s):

Harold E. Bays ◽

Plamen Kozlovski ◽

Qing Shao ◽

Pieter Proot ◽

Deborah Keefe

Keyword(s):

Body Weight ◽

Randomized Trial ◽

Overweight Or Obesity

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PARENTS BODY SHAPE PROFILE AND OVERWEIGHT AMONG STUDENTS AT SINGKAWANG ADVENTIST SCHOOL

Abstract Proceedings International Scholars Conference ◽

10.35974/isc.v7i1.806 ◽

2019 ◽

Vol 7 (1) ◽

pp. 17-32

Author(s):

Sultan Fredyansyah Bagaskara Djula ◽

Sapti Widyarti Djula

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Significant Relationship ◽

Body Shape ◽

Body Height ◽

The Body ◽

School Students ◽

Cross Sectional ◽

Overweight Or Obesity

Introduction: When both parents are obesity, thus the children are 80% potentially become overweight or obesity. If one of the parent is overweight or obesity, thus the children are 40% potentially to become overweight or obesity. The purpose of the study is to analyze is there any significant relationship between parents’ body shape with overweight among students at Singkawang Adventist School. Method: The method of the study is descriptive with quantitative method and the cross sectional design. Sampling technique is total sampling among the overweight students. Number of respondens are 35 persons which have been measure body height, body weight and determined Body Mass Index (BMI). Data processing using SPSS Program. Result: The results of the study show that the status of overweight students is obesity and parents’ body shape are overweight (there is no significant relationship between obesity in adolescents with the body shape of the father with a significance of (0.086) with a ρ value> 0.05 as well as no significant relationship between obesity in adolescents with the body shape of their mothers, with a significance of (0.411) with ρ value> 0.005). There is no significant relationship between overweight students with parents’ body shape. There is not enough evidence to refuse null hypothesis. Disscussion: Recommendation are given to Singkawang Adventist School Students in order to maintain a healthy lifestyle and give effort to reduce body weight. To the next researcher to do research with bigger sample size. Keywords : overweight, obesity, Body Mass Index(BMI), body shape

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Melatonin Supplementation and Anthropometric Indices: A Randomized Double-Blind Controlled Clinical Trial

BioMed Research International ◽

10.1155/2021/3502325 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Salman Mohammadi ◽

Reza Rastmanesh ◽

Farzaneh Jahangir ◽

Zohreh Amiri ◽

Kurosh Djafarian ◽

...

Keyword(s):

Body Weight ◽

Body Fat ◽

Repeated Measure ◽

Controlled Clinical Trial ◽

Mass Percentage ◽

Anthropometric Indices ◽

Double Blind ◽

Significance Level ◽

Measure Anova ◽

Overweight Or Obesity

Obesity, as the most common metabolic disorder in the world, is characterized by excess body fat. This study is aimed at determining the effects of melatonin supplementation on body weight, nody mass index (BMI), waist circumference (WC), and body fat mass percentage (BFMP) in people with overweight or obesity. Thirty eight overweight or class-I obese adult individuals were recruited in the study (8 men and 30 women). Participants prescribed a weight-loss diet and then randomly were allocated to melatonin or placebo groups. Participants received either a 3-milligram melatonin or placebo tablet per day for 12 weeks. In order to assess differences at the significance level of 0.05, repeated measure ANOVA and paired t -test were used. According to the results, a significant reduction was found in participants’ body weight, WC, and BMI in both groups ( p = 0.001 ). However, for the last six weeks, significant reductions of these parameters were observed only in the melatonin group ( p = 0.01 ). The BFMP of participants in the melatonin group showed a significant reduction at the end of the study compared to the initial measurements ( p = 0.008 ). Nevertheless, the results of the present study alone are not sufficient to conclude on the effects of melatonin consumption on anthropometric indices, and it seems that further studies are required in this regard.

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Pilates for Overweight or Obesity: A Meta-Analysis

Frontiers in Physiology ◽

10.3389/fphys.2021.643455 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yi Wang ◽

Zehua Chen ◽

Zugui Wu ◽

Xiangling Ye ◽

Xuemeng Xu

Keyword(s):

Body Weight ◽

Body Mass ◽

Body Fat ◽

Data Extraction ◽

Meta Analysis ◽

Controlled Trials ◽

Body Fat Percentage ◽

Fat Percentage ◽

Randomized Controlled ◽

Overweight Or Obesity

Background: Evidence for the efficacy of Pilates for the modulation of body weight and body composition is unclear.Objective: This meta-analysis aimed to evaluate the effects of Pilates on body weight and body composition in adults with overweight or obesity.Data Sources: The PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and EMBASE databases were systematically searched from the inception dates to 12 November 2020 for relevant randomized controlled trials (RCTs).Study Selection: Randomized controlled trials comparing Pilates with other physical exercises or without any intervention were included.Data Extraction and Synthesis: Three reviewers independently performed the data extraction and assessed study quality. The mean differences (MDs) and 95% confidence intervals (CIs) for pooled data were calculated.Main Outcomes and Measures: Outcome measures were body weight, body mass index (BMI), body fat percentage, lean body mass, and waist circumference.Results: Eleven RCTs with 393 subjects were included. This study revealed that Pilates dramatically reduces body weight (MD = −2.40, 95% CI: [−4.04, −0.77], P = 0.004, I2 = 51%), BMI (MD = −1.17, 95% CI: [−1.85, −0.50], P = 0.0006, I2 = 61%), and body fat percentage (MD = −4.22, 95% CI: [−6.44, −2.01], P = 0.0002, I2 = 88%) in adults with overweight or obesity. The reduction in body weight and body fat percentage appears to be more pronounced in studies including participants with obesity only, and the efficacy of Pilates for the improvement of body weight and BMI appears to be more evident in longer intervention duration. However, Pilates has no significant effect on waist circumference (MD = −2.65, 95% CI: [−6.84, 1.55], P = 0.22, I2 = 0%) and lean body mass (MD = −0.00, 95% CI: [−1.40, 1.40], P = 1.00, I2 = 23%).Conclusions: Pilates dramatically reduces body weight, BMI, and body fat percentage in adults with overweight or obesity. Large-scale and well-designed RCTs with improved methodology and reporting are urgently needed to further confirm these results.

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