Stimuli-Responsive NO Release for On-Demand Gas-Sensitized Synergistic Cancer Therapy

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9-amino and 9-ammonium modified ortho-carboranes that bind to CB[7] with a Ka=1010 M-1. Upon treatment with base, the ortho-carboranes readily undergo deboronation to yield anionic nido-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified ortho-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.

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The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200924110418 ◽

2020 ◽

Vol 20 ◽

Author(s):

Feng Wu ◽

Fei Qiu ◽

Siew Anthony Wai-Keong ◽

Yong Diao

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Targeted Delivery ◽

Relevant Information ◽

Therapeutic Effects ◽

Stimuli Responsive ◽

Control Effect ◽

Chemotherapy Drugs ◽

Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

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Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽

10.3390/nano11051108 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1108

Author(s):

Manuela Curcio ◽

Alessandro Paolì ◽

Giuseppe Cirillo ◽

Sebastiano Di Pietro ◽

Martina Forestiero ◽

...

Keyword(s):

Cancer Therapy ◽

Drug Release ◽

Metastatic Cancer ◽

Stimuli Responsive ◽

Cancer Disease ◽

New Class ◽

Self Assembling ◽

Redox Responsive ◽

Potential Applicability ◽

Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

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Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽

10.3390/pharmaceutics13010071 ◽

2021 ◽

Vol 13 (1) ◽

pp. 71

Author(s):

Thashini Moodley ◽

Moganavelli Singh

Keyword(s):

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Therapeutic Agents ◽

Metal Species ◽

Stimuli Responsive ◽

Combination Drug ◽

Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

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A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents

Acta Biomaterialia ◽

10.1016/j.actbio.2016.10.001 ◽

2017 ◽

Vol 48 ◽

pp. 110-119 ◽

Cited By ~ 29

Author(s):

Hugh S. O’Neill ◽

Caroline C. Herron ◽

Conn L. Hastings ◽

Roel Deckers ◽

Adolfo Lopez Noriega ◽

...

Keyword(s):

Therapeutic Agents ◽

Stimuli Responsive ◽

On Demand

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Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽

10.1039/d0ra08602a ◽

2020 ◽

Vol 10 (66) ◽

pp. 40206-40214

Author(s):

Wararat Montha ◽

Weerakanya Maneeprakorn ◽

I-Ming Tang ◽

Weeraphat Pon-On

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Controlled Release ◽

Cancer Therapy ◽

Regenerative Medicine ◽

Alternating Magnetic Field ◽

Composite Particles ◽

Stimuli Responsive ◽

Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

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Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

Biomaterials Science ◽

10.1039/d0bm01406k ◽

2021 ◽

Vol 9 (1) ◽

pp. 38-50

Author(s):

Hien Phan ◽

Vincenzo Taresco ◽

Jacques Penelle ◽

Benoit Couturaud

Keyword(s):

Drug Delivery ◽

Block Copolymers ◽

Drug Release ◽

Self Assembly ◽

Drug Delivery Systems ◽

Amphiphilic Block Copolymers ◽

Stimuli Responsive ◽

Site Specific ◽

On Demand ◽

Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

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