scholarly journals Characterization of hydrodynamics and volumetric power input in microtiter plates for the scale‐up of downstream operations

2021 ◽  
Author(s):  
Ignacio Montes‐Serrano ◽  
Peter Satzer ◽  
Alois Jungbauer ◽  
Astrid Dürauer
Keyword(s):  
Scale Up ◽  
Power Input ◽  
Microtiter Plates

Scale-up of the necessary power input in stirred vessels with suspensions

1993 ◽  
Vol 51 (1) ◽  
pp. 29-39 ◽  
Author(s):  
R.K. Geisler ◽  
C. Buurman ◽  
A.B. Mersmann
Keyword(s):  
Scale Up ◽  
Power Input ◽  
Stirred Vessels

scholarly journals Novel Experimental Study of Fabric Drying Using Direct-Contact Ultrasonic Vibration

2018 ◽  
Vol 11 (2) ◽  
Author(s):  
Viral K. Patel ◽  
Frederick Kyle Reed ◽  
Roger Kisner ◽  
Chang Peng ◽  
Saeed Moghaddam ◽  
...  
Keyword(s):  
High Frequency ◽  
Direct Contact ◽  
First Generation ◽  
Scale Up ◽  
Enthalpy Of Vaporization ◽  
Piezoelectric Transducers ◽  
Scaling Analysis ◽  
Moisture Removal ◽  
Low Efficiency

Abstract Fabric drying is an energy-intensive process, which generally involves blowing hot dry air across tumbling wet fabric to facilitate evaporation and moisture removal. Most of the energy supplied is used to overcome the enthalpy of vaporization for water. Although this process tends to be inefficient, it is fairly simple and forms the basis for the majority of existing clothes dryer technology today. To address the relatively low efficiency, a new method of drying called “direct contact ultrasonic fabric drying” is proposed. The process involves using high-frequency vibration introduced by piezoelectric transducers, which are in contact with wet fabric. The vibration is used to extract water droplets from the fabric mechanically. In this study, a total of 24 individual transducers are used in a module to dry a 142 cm2 sized fabric. The performance characterization of this single module has enabled successful scale-up of the system to a midscale prototype dryer, which can be used to ultrasonically dry clothing-sized fabric (∼750 cm2). The first-generation ultrasonic fabric dryer fabricated uses as little as 17% of the energy needed by traditional evaporation-based drying techniques. In addition to experimental data, this paper presents the results of a kinetic and scaling analysis that provides some important insights into ultrasonic drying.

scholarly journals High-growth firms and scale-ups: a review and research agenda

2019 ◽  
Vol 54 (1) ◽  
pp. 96-111
Author(s):  
Guilherme Fowler A. Monteiro
Keyword(s):  
Research Agenda ◽  
Design Methodology ◽  
Scale Up ◽  
High Growth ◽  
Levels Of Analysis ◽  
Future Research ◽  
Content Type ◽  
Growth Firms ◽  
Different Levels

Purpose This paper aims to conduct an extensive review and advances a framework for the literature of high-growth firms (HGFs) and scale-ups. Design/methodology/approach This paper takes the form of a literature review. Findings The author makes three specific contributions. First, he presents a broad review of high growth in firms, shedding light on the different levels of analysis. Second, he advances a characterization of scale-up companies to enable a better basis for discussion. Finally, he identifies gaps in the existing literature and suggest paths for future research. Originality/value The interest in HGFs and those referred to as scale-ups has increased considerably in recent years. Despite this trend, existing studies still have conceptual divergences and a gap separating theoretical inputs from the actual experiences of entrepreneurs.

Application of the Continuous Rheoconversion Process (CRP) to Low Temperature HPDC-Part I: Microstructure

2006 ◽  
Vol 116-117 ◽  
pp. 402-405 ◽  
Author(s):  
Qin Yue Pan ◽  
Stuart Wiesner ◽  
Diran Apelian
Keyword(s):  
Low Temperature ◽  
Scale Up ◽  
Microstructural Characterization ◽  
Industrial Applications ◽  
Primary Phase ◽  
Heat Extraction ◽  
Initial Stage ◽  
Fraction Solid ◽  
Die Castings

The continuous rheoconversion process (CRP) is a novel slurry-on-demand process that was developed at MPI/WPI in 2002. The process is based on a passive liquid mixing technique in which the nucleation and growth of the primary phase are controlled using a specially designed “reactor”. The reactor provides heat extraction, copious nucleation, and forced convection during the initial stage of solidification, thus leading to the formation of globular structures. This paper presents our recent work on the scale-up of the CRP for industrial applications. Specifically, we demonstrate an important application of the CRP to low temperature (low fraction solid) HPDC. In Part I of this paper, we present salient results on microstructural characterization of CRP processed castings vs. conventional die castings.

scholarly journals Phase Behavior that Enables Solvent-Free Carbonate-Promoted Furoate Carboxylation

2020 ◽  
Author(s):  
Amy Frankhouser ◽  
Matthew Kanan
Keyword(s):  
Phase Behavior ◽  
Process Design ◽  
Heterogeneous Reaction ◽  
Scale Up ◽  
Solvent Free

<div><div><div><p>A solvent-free transformation that enables production of polyester precursors from inedible biomass proceeds from a heterogeneous reaction mixture containing both solid and molten components. Characterization of the evolution of these component phases over the course of the reaction provides insight relevant to process design and scale-up.</p></div></div></div>

Acidophilic biodesulphurization of calcined pet coke and coal samples in iron and iron-free leaching media

2020 ◽  
pp. 0958305X2093567
Author(s):  
Srabani Mishra ◽  
Sandeep Panda ◽  
Nilotpala Pradhan ◽  
SK Biswal ◽  
D Satapathy
Keyword(s):  
Scale Up ◽  
Xrd Analysis ◽  
Bacterial Consortium ◽  
Proximate Analysis ◽  
Indian Origin ◽  
Compositional Changes ◽  
Pet Coke ◽  
Assam Coal ◽  
Microbial Attack

Mineralogically distinct coal samples respond differently to microbial attack. In the present study, a mixed meso-acidophilic bacterial consortium predominantly comprising of Acidithiobacillus ferrooxidans strain was investigated for its biodesulphurization abilities for three distinct sulphur bearing samples (Goa CPC, Rajasthan Lignite, Assam Coal) of Indian origin in iron (9K+) and iron-free (9K−) media. A media devoid of Fe (II) iron was more effective for sulphur removal with maximum desulphurization of 45.19% for Assam coal followed by 36.8% for Rajasthan Lignite and 23.38% for CPC respectively. The proximate analysis, FTIR patterns and XRD analysis of the samples provided better insights into understanding the mineralogical and compositional changes in the coal matrix. Owing to the higher efficiency, Assam coal was additionally subjected to further optimization studies and characterization of the treated coal through TGA. The study indicated that the gross calorific values for all the samples increased following microbial treatment in 9K− media thereby providing a scope for further scale-up studies.

Volumetric mass transfer coefficient, power input and gas hold-up in viscous liquid in mechanically agitated fermenters. Measurements and scale-up

2018 ◽  
Vol 124 ◽  
pp. 1117-1135 ◽  
Author(s):  
Radim Petříček ◽  
Tomáš Moucha ◽  
František Jonáš Rejl ◽  
Lukáš Valenz ◽  
Jan Haidl ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Viscous Liquid ◽  
Scale Up ◽  
Power Input ◽  
Volumetric Mass Transfer Coefficient

scholarly journals Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Olushayo Oluseun Olu ◽  
Joy Luba Lomole Waya ◽  
Sylvester Maleghemi ◽  
John Rumunu ◽  
David Ameh ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Preventive Measures ◽  
Negative Impact ◽  
Control Strategies ◽  
Scientific Evidence ◽  
Scale Up ◽  
High Impact ◽  
The Social ◽  
And Control

Abstract The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak economy and health systems. In addition, inadequate access to the social determinants of health such as water and sanitation and socio-cultural attributes may constrain the implementation of critical preventive measures such as hand washing and social distancing on the continent. Given these facts, the continent needs to focus on targeted and high impact prevention and control strategies and interventions which could break the chain of transmission quickly. We conclude that the available body of scientific evidence on the coronavirus disease 2019 holds the key to the development of such strategies and interventions. Going forward, we recommend that the African research community should scale up research to provide scientific evidence for a better characterization of the epidemiology, transmission dynamics, prevention and control of the virus on the continent.

Object Categorization Using Biologically Inspired Nodemaps and the HITEC Categorization System

2009 ◽  
Vol 13 (5) ◽  
pp. 573-580
Author(s):  
Adam Csapo ◽  
◽  
Barna Resko ◽  
Domonkos Tikk ◽  
Peter Baranyi
Keyword(s):  
Visual Information ◽  
Scale Up ◽  
Research Field ◽  
Point Of View ◽  
Success Rates ◽  
Biologically Inspired ◽  
Text Documents ◽  
Independent Test ◽  
Categorization System

The computerized modeling of cognitive visual information has been a research field of great interest in the past several decades. The research field is interesting not only from a biological perspective, but also from an engineering point of view when systems are developed that aim to achieve similar goals as biological cognitive systems. This paper briefly describes a general framework for the extraction and systematic storage of low-level visual features, and demonstrates its applicability in image categorization using a linear categorization algorithm originally developed for the characterization of text documents. The performance of the algorithm together with the newly developed feature array was evaluated using the Caltech 101 database. Extremely high (95% and higher) success rates were achieved when distinguishing between pairs of categories using independent test images. Efforts were made to scale up the number of categories using a hierarchical, branch-and-bound decision tree, with limited success.

scholarly journals Characterization of the Sporulation Control Protein SsgA by Use of an Efficient Method To Create and Screen Random Mutant Libraries in Streptomycetes

2007 ◽  
Vol 73 (7) ◽  
pp. 2085-2092 ◽  
Author(s):  
Bjørn A. Traag ◽  
Nicolas Seghezzi ◽  
Erik Vijgenboom ◽  
Gilles P. van Wezel
Keyword(s):  
Efficient Method ◽  
Streptomyces Coelicolor ◽  
Product Formation ◽  
Single Amino Acid ◽  
Poor Growth ◽  
Microtiter Plates ◽  
Enhanced Expression ◽  
Major Bottleneck ◽  
Carboxy Terminal

ABSTRACT Filamentous actinomycetes are commercially widely used as producers of natural products. However, the mycelial lifestyle of actinomycetes has been a major bottleneck in their commercialization, and screening is difficult due to their poor growth on microtiter plates. We previously demonstrated that the enhanced expression of the cell division activator protein SsgA results in the fragmented growth of streptomycetes, with enhanced growth rates and improved product formation. We here describe a novel and efficient method to create, maintain, and screen mutant libraries in streptomycetes and the application of this method for the functional analysis of Streptomyces coelicolor ssgA. The variants were amplified directly from deep-frozen biomass suspensions. Around 800 ssgA variants, including single-amino-acid-substitution mutants corresponding to more than half of all SsgA residues, were analyzed for their abilities to restore sporulation to an ssgA mutant. The essential residues were clustered in three main sections, and hardly any were in the carboxy-terminal third of the protein. The majority of the crucial residues were conserved among all SsgA-like proteins (SALPs). However, the essential residues L29, D58, and S89 were conserved only in SsgA orthologues and not in other SALPs, suggesting an SsgA-specific function.

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