Smoking status before and after colorectal cancer diagnosis and mortality in Korean men: A population‐based cohort study

Background and study aims: Post-colonoscopy colorectal cancers (PCCRCs) may account for up to 50% of all colorectal cancers (CRCs) diagnosed in patients with inflammatory bowel disease (IBD). This may reflect a high colonoscopy frequency; however evidence remains limited. Patient and methods: We conducted a cohort study of IBD and non-IBD patients undergoing colonoscopy. We calculated 6-36 months CIPs of PCCRC after first-time and subsequent colonoscopies. We also computed crude and adjusted HRs of PCCRC, comparing IBD with non-IBD patients undergoing first-time and subsequent colonoscopies. Separate analyses were conducted for consecutive colonoscopies. We calculated PCCRC-3 year rates to estimate the proportion of IBD and non-IBD CRC patients experiencing PCCRC. Results: We observed 138 and 1,909 PCCRCs among 34,688 IBD and 358,217 non-IBD patients who underwent colonoscopy. The CIP of PCCRC after first-time colonoscopy was 0.21%, 95% confidence interval (CI): [0.17-0.27] for IBD patients and 0.37%, 95% CI: [0.35-0.39] for non-IBD patients. The adjusted HR of PCCRC after a first-time colonoscopy was 0.96, 95% CI: [0.75-1.22] and the adjusted HRs after subsequent colonoscopies had point estimates around 1.0. The PCCRC-3 year rate was 24.3%, 95% CI: [20.4-28.7] for IBD and 7.5%, 95% CI [7.2-7.8] for non-IBD patients. Conclusions: Although PCCRCs accounted for a substantial proportion of all IBD-related CRCs, IBD patients had a low CIP of PCCRC after colonoscopy. The elevated PCCRC-3 year rates may among other factors stem from increased colonoscopy frequency in IBD patients.

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Trajectories of sickness absence and disability pension before and after colorectal cancer: A Swedish longitudinal population-based matched cohort study

PLoS ONE ◽

10.1371/journal.pone.0245246 ◽

2021 ◽

Vol 16 (1) ◽

pp. e0245246

Author(s):

Lingjing Chen ◽

Kristina A. E. Alexanderson

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cohort Study ◽

Mental Disorders ◽

Educational Level ◽

Disability Pension ◽

Population Based ◽

Matched Cohort ◽

Before And After ◽

Very High

Objectives Working-aged colorectal cancer (CRC) patients have a much better survival, indicating the importance of their future work situation. We investigated trajectories of sickness absence and disability pension (SADP) days before and after CRC diagnosis, and risk factors associated with different trajectories. Methods A longitudinal, population-based matched cohort study of 4735 CRC survivors in Sweden aged 19–62 when first diagnosed with CRC in 2008–2011, and 18,230 matched references was conducted, using microdata linked from several nationwide registers. The annual SADP net days for 2 years before through 5 years after diagnosis date were computed. A group-based trajectory model was used to depict SADP trajectories. Associations between trajectory membership, and sociodemographic and clinical variables were tested by chi2 test and multinomial logistic regression. Results Four trajectories of SADP days/year for CRC survivors were identified: “only increase around diagnosis” (52% of all), “slight increase after diagnosis” (27%), “high then decrease moderately after diagnosis” (13%), and “constantly very high” (8%). Educational level, Charlson’s Comorbidity Index, and prediagnostic mental disorders were the strongest factors determining the SADP trajectory groups. In references, three trajectories (“constantly low” (80% of all), “constantly moderate and decrease gradually” (12%), and “very high then decrease overtime” (8%)) were identified. Conclusion Approximately 80% of CRC survivors return to a low level of SADP at 5 years postdiagnosis. Prediagnostic status of mental disorders, somatic comorbidity, and low educational level are good indicators of future high SADP levels for them. CRC survivors will benefit from early rehabilitation programs with identified risk factors.

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Su1228 Increased Risk of Colorectal Cancer in Patients With Prior Ovarian Cancer Diagnosis: A Population Based US Study

Gastroenterology ◽

10.1016/s0016-5085(14)61474-8 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-408

Author(s):

Yezaz A. Ghouri ◽

Sachin Batra ◽

Nirav C. Thosani ◽

Sushovan Guha

Keyword(s):

Colorectal Cancer ◽

Ovarian Cancer ◽

Cancer Diagnosis ◽

Population Based ◽

Increased Risk

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Trajectories of sickness absence and disability pension in colorectal cancer: a Swedish cohort study

European Journal of Public Health ◽

10.1093/eurpub/ckaa165.697 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

L Chen ◽

K Alexanderson

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

Sickness Absence ◽

Educational Level ◽

Disability Pension ◽

Population Based ◽

Work Situation ◽

Working Age ◽

Future Work ◽

Very High

Abstract Background Working-aged colorectal cancer (CRC) patients have a much better survival nowadays, indicating the importance of their future work situation. We aimed to investigate trajectories of sickness absence and disability pension (SADP) days before and after CRC diagnosis and in references, and risk factors associated with different trajectories. Methods A longitudinal, population-based matched cohort study of 4735 CRC survivors in Sweden aged 19-62 when first diagnosed with CRC in 2008-2011, and 18,230 matched references was conducted, using microdata linked from several nationwide registers. The annual SADP net days for 2 years before through 5 years after diagnosis date were computed. A group-based trajectory model was used to depict SADP trajectories. Associations between trajectory membership, and sociodemographic and clinical variables were tested by chi2 test and multinomial logistic regression. Results Four trajectories of SADP days/year for CRC survivors were identified: “only increase around diagnosis” (52% of all, n = 2481), “slight increase after diagnosis” (27%), “high then decrease moderately after diagnosis” (13%), and “constantly very high” (8%). Educational level (R2=0.022), Charlson's Comorbidity Index (R2=0.029), and prediagnostic mental disorders (R2=0.066) were the strongest factors determining the SADP trajectory groups. In references, three trajectories (”constantly low” (80% of all), “constantly moderate and decrease gradually” (12%), and “very high then decrease overtime” (8%)) were identified. Conclusions Approximately 80% of CRC survivors return to a low level of SADP (0-60 days/year) at 5 years postdiagnosis. Prediagnostic status of mental disorders, somatic comorbidity, and low educational level are good indicators of future high SADP levels for CRC survivors. Key messages Most of working-age colorectal cancer survivors have low levels of sickness absence and disability pension days five years after their diagnosis. Trajectory analyses based on population-based register data can be used as a good approach in understanding future work situation regarding sick leave among working-age cancer survivors.

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115 RISK OF POST-COLONOSCOPY COLORECTAL CANCER IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A DANISH POPULATION-BASED COHORT STUDY

Gastroenterology ◽

10.1016/s0016-5085(21)00818-0 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-30

Author(s):

Frederikke Sch⊘nfeldt Troelsen ◽

Henrik Toft S⊘rensen ◽

Lars Pedersen ◽

Rune Erichsen

Keyword(s):

Diabetes Mellitus ◽

Colorectal Cancer ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cohort Study ◽

Population Based ◽

Danish Population

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Unemployment risk at 2 and 4 years following colorectal cancer diagnosis: a population based study

European Journal of Cancer ◽

10.1016/j.ejca.2016.09.025 ◽

2016 ◽

Vol 69 ◽

pp. 70-76 ◽

Cited By ~ 5

Author(s):

Yakir Rottenberg ◽

Navah Z. Ratzon ◽

Miri Cohen ◽

Ayala Hubert ◽

Beatrice Uziely ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Diagnosis ◽

Population Based ◽

Population Based Study ◽

Unemployment Risk

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Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s138435 ◽

2017 ◽

Vol Volume 12 ◽

pp. 2425-2432 ◽

Cited By ~ 9

Author(s):

Dionne CW Braeken ◽

Gernot GU Rohde ◽

Frits ME Franssen ◽

Johanna HM Driessen ◽

Tjeerd P van Staa ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Cohort Study ◽

United Kingdom ◽

Pulmonary Disease ◽

Smoking Status ◽

Population Based ◽

Community Acquired Pneumonia ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

The United Kingdom

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Divergent patterns of anti-fracture medication use following fracture on therapy: A population-based cohort study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab696 ◽

2021 ◽

Author(s):

Gregory A Kline ◽

Suzanne N Morin ◽

Lisa M Lix ◽

William D Leslie

Keyword(s):

Cohort Study ◽

Medication Adherence ◽

Vertebral Fracture ◽

Drug Efficacy ◽

Population Based ◽

Duration Of Treatment ◽

Traumatic Fracture ◽

Before And After ◽

One Year

Abstract Context Fracture-on-therapy should motivate better anti-fracture medication adherence. Objective Describe osteoporosis medication adherence in women before and following a fracture. Design Retrospective cohort study. Setting Manitoba BMD Registry (1996-2013). Patients Women who started anti-fracture drug therapy after a DXA-BMD with follow-up for 5 years during which a non-traumatic fracture occurred at least one year after starting treatment. Main Outcome Linked prescription records determined medication adherence (estimated by medication possession ratios, MPR) in one-year intervals. The variable of interest was MPR in the year before and after the year in which the fracture occurred with subgroup analyses according to duration of treatment pre-fracture. We chose an MPR of ≥0.50 to indicate minimum adherence needed for drug efficacy. Results There were 585 women with fracture-on-therapy, 193(33%) had hip or vertebral fracture. Bisphosphonates accounted for 82.2% of therapies. Median MPR the year prior to fracture was 0.89(IQR 0.49-1.0) and 0.69(IQR 0.07-0.96) the year following the year of fracture(p< 0.0001). The percentage of women with MPR ≥ 0.5 pre-fracture was 73.8%, dropping to 57.3% post-fracture(p<0.0001); restricted to hip/vertebral fracture results were similar (58.2% to 33.3%, p <0.002). Among those with pre-fracture MPR <0.5, only 21.7% achieved a post-fracture MPR ≥ 0.5. Conclusions Although fracture-on-therapy may motivate sustained/improved adherence, MPR remains low or even declines after fracture in many. This could reflect natural decline in MPR with time but is paradoxical to expectations. Fracture-on-therapy represents an important opportunity for clinicians to re-emphasize treatment adherence.

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