scholarly journals Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 ( Ae Kir) Channel and Larvicides

ChemMedChem ◽  
2020 ◽  
Author(s):  
Christopher D. Aretz ◽  
Sujay V. Kharade ◽  
Keagan Chronister ◽  
Renata Rusconi Trigueros ◽  
Erick J. Martinez Rodriguez ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Kir Channel

scholarly journals Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

2020 ◽  
Author(s):  
Christopher D. Aretz ◽  
Sujay V. Kharade ◽  
Keagan S. Chronister ◽  
Erick J. Martinez Rodriguez ◽  
Peter M. Piermarini ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Chemical Compounds ◽  
Mechanisms Of Action ◽  
Kir Channel ◽  
Primary Vector ◽  
Resistant Strains ◽  
New Compounds

We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.

scholarly journals Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever Mosquito Aedes aegypti

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100700 ◽  
Author(s):  
Matthew F. Rouhier ◽  
Rene Raphemot ◽  
Jerod S. Denton ◽  
Peter M. Piermarini
Keyword(s):  
Aedes Aegypti ◽  
Yellow Fever ◽  
Inward Rectifier ◽  
Yellow Fever Mosquito ◽  
Kir Channel

scholarly journals Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

2020 ◽  
Author(s):  
Christopher D. Aretz ◽  
Sujay V. Kharade ◽  
Keagan S. Chronister ◽  
Erick J. Martinez Rodriguez ◽  
Peter M. Piermarini ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Chemical Compounds ◽  
Mechanisms Of Action ◽  
Kir Channel ◽  
Primary Vector ◽  
Resistant Strains ◽  
New Compounds

We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.

scholarly journals Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti

Insects ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 163 ◽  
Author(s):  
Renata Rusconi Trigueros ◽  
Corey Hopkins ◽  
Jerod Denton ◽  
Peter Piermarini
Keyword(s):  
Aedes Aegypti ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Inward Rectifier ◽  
Kir Channels ◽  
Pharmacological Inhibition ◽  
Inward Rectifier Potassium Channels ◽  
Kir Channel ◽  
Potential Applications ◽  
Control Adult

The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for developing new insecticides to control adult female mosquitoes. However, the potential use of Kir channel inhibitors as larvicidal agents is unknown. Here we tested the hypothesis that pharmacological inhibition of Kir channels in the larvae of Aedes aegypti, the vector of several medically important arboviruses, induces lethality. We demonstrated that adding barium, a non-specific blocker of Kir channels, or VU041, a specific small-molecule inhibitor of mosquito Kir1 channels, to the rearing water (deionized H2O) of first instar larvae killed them within 48 h. We further showed that the toxic efficacy of VU041 within 24 h was significantly enhanced by increasing the osmolality of the rearing water to 100 mOsm/kg H2O with NaCl, KCl or mannitol; KCl provided the strongest enhancement compared to NaCl and mannitol. These data suggest: (1) the important role of Kir channels in the acclimation of larvae to elevated ambient osmolality and KCl concentrations; and (2) the disruption of osmoregulation as a potential mechanism of the toxic action of VU041. The present study provides the first evidence that inhibition of Kir channels is lethal to larval mosquitoes and broadens the potential applications of our existing arsenal of small molecule inhibitors of Kir channels, which have previously only been considered for developing adulticides.

Composition of Prangos pabularia Essential Oil: Identification of an Unknown Compound from the Oil and its Insecticidal Activity against Yellow Fever Mosquito, Aedes aegypti

Planta Medica ◽  
2013 ◽  
Vol 79 (05) ◽  
Author(s):  
N Tabanca ◽  
A Ali ◽  
M Tsikolia ◽  
UR Bernier ◽  
G Ozek ◽  
...  
Keyword(s):  
Essential Oil ◽  
Aedes Aegypti ◽  
Yellow Fever ◽  
Insecticidal Activity ◽  
Yellow Fever Mosquito ◽  
Unknown Compound

GAMBARAN INDEKS LARVA AEDES AEGYPTI DI BUFFER WILAYAH KERJA BANDARA SEPINGGAN BALIKPAPAN

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Abdurrakhman abdurrakhman Abdurrakhman
Keyword(s):  
Aedes Aegypti ◽  
Buffer Zone ◽  
Chi Square ◽  
Cross Sectional ◽  
Breeding Sites ◽  
Dengue Disease ◽  
Vector Borne Diseases ◽  
Transportation Equipment ◽  
Chi Square Test ◽  
Larvae Density

ABSTRACT : The House index and Container Index in the buffer area of ​​the working area of ​​Balikpapan Sepinggan Airport is still above 1%, so the potential for the spread of dengue disease. Mobilization of people, goods and transportation equipment will increasingly affect the transmission of disease in ports and airports, especially for vector-borne diseases. This study aims to analyze the risk factors associated with larvae density of Aedes aegypti and describe the larvae index in the buffer zone of the Sepinggan Balikpapan Airport This study was a descriptive study with a cross sectional design. The sample in this study was 121 houses with a proportionate stratified random sampling, the research location was in the buffer zone of Sepinggan Balikpapan Airport in November 2018. The variables studied were houses with positive larvae containers, breeding sites and PSN behavior and larvasidation. The data was analyzed using the chi square test. There was a relationship between houses with larvae positive Aedes aegypti, behavior of Mosquito Nest Eradication (PSN) and larvasidation with larvae density of Aedes aegypti but not for breeding sites (p = 0.00 and 95% CI = 0.64), and   (p = 0.00 and 95% CI = 0.34). The description of several Aedes aegypti larvae index, namely House Index (HI) = 57.02%, Container Index (CI) = 24.36%, Bruteau Index (BI) = 148.76, and Flick Free Numbers (ABJ) = 42.98 %. Houses with larvae of Aedes aegypti larvae and PSN and larvasidation behavior were associated with larvae density of Aedes aegypti. The index of HI, CI and BI larvae is of high value so there is a risk of DBD transmission

Detection of dengue virus in Aedes mosquitoes in Delhi, India

ENTOMON ◽  
2019 ◽  
Vol 44 (3) ◽  
pp. 213-218
Author(s):  
Suresh Chand Kaushik ◽  
Sukhvir Singh ◽  
Purnima Srivastava ◽  
R. Rajendran
Keyword(s):  
Early Intervention ◽  
Early Detection ◽  
Aedes Aegypti ◽  
Dengue Virus ◽  
Infection Rate ◽  
Transmission Season ◽  
Aedes Mosquitoes ◽  
Alternative Approach ◽  
Human Sera ◽  
Minimum Infection Rate

Detection of viruses in human sera particularly in endemic areas is cumbersome and laborious. Therefore, an alternative approach, Immuno-fluorescence assay (IFA) was performed to determine dengue virus (DENV) positivity in mosquitoes. A total of 1055 adult Aedes aegypti female mosquitoes were tested for IFA test against DENV. Minimum infection rate (MIR) for DENV was found higher during August to November 2016 ranging from 10.75 to 20.83. The average yearly MIR was about 6.64. Higher MIR for Ae. aegypti was found in Sarfabad, Noida (12.71) and Khoda Colony, Ghaziabad (11.90). Minimum MIR (4.67) was observed in Sanjay colony (Faridabad). The main contribution of this study resides in the development of a more suitable monitoring system for early detection of viral circulation and to prioritize early intervention in the non-transmission season.

Distribution of Aedes aegypti and Aedes albopictus in different eco zones of Thiruvananthapuram city with special reference to dengue viremia in humans

ENTOMON ◽  
2018 ◽  
Vol 43 (4) ◽  
pp. 223-230
Author(s):  
S. Sunil Kumar ◽  
D.A. Evans ◽  
K. Muthulakshmi ◽  
T. DilipKumar ◽  
R. Heera Pillai ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
Dengue Shock Syndrome ◽  
Single Step ◽  
Equal Distribution ◽  
Distribution Study ◽  
Urban Zone ◽  
High Prevalence ◽  
Vector Management ◽  
Efficient Vector

Mosquito index study of three ecologically different ecozones of the Thiruvananthapuram district, Kerala showed sharp difference on the proportionate distribution of Aedes aegypti and Aedes albopictus. Human dengue viremia (HDV) was very high in those ecozones where A.aegypti density was high and HDV was low where A.albopictus was high. In a coastal zone of Thiruvananthapuram city, A. aegypti was the most abundant vector and in a hilly, arid suburban zone, A.albopictus was the abundant vector. In the urban zone both species of mosquitoes showed equal distribution. Study on the circulating serotypes in the serum of HDV by Single step single tube Multiplex PCR showed all the four serotypes viz DENV1, DENV2, DENV3 and DENV4 in patients of Thiruvananthapuram city, which indicated the possibility of Dengue Shock Syndrome, unless there is efficient vector management. Among the four dengue serotypes, Type 1 was the most abundant virus. Abundance of microhabitats in Thiruvananthapuram city, which support A. aegypti may be the reason for high prevalence of dengue fever in the urban zone.

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