Increases in adipose and total body weight, but not in lean body mass, associated with subcutaneous administration of Sonic hedgehog-Ig fusion protein to mice

2002 ◽  
Vol 57 (3) ◽  
pp. 107-114 ◽  
Author(s):  
Pauline L. Martin ◽  
Joan Lane ◽  
Louise Pouliot ◽  
Malcolm Gains ◽  
Rudolph Stejskal ◽  
...  
Keyword(s):  
Body Weight ◽  
Fusion Protein ◽  
Lean Body Mass ◽  
Body Mass ◽  
Sonic Hedgehog ◽  
Subcutaneous Administration ◽  
Total Body Weight ◽  
Total Body

Loss of lean body mass within one week as a major determinant for total weight loss at one month after gastrectomy for gastric cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 219-219
Author(s):  
Toru Aoyama ◽  
Takaki Yoshikawa ◽  
Taiichi Kawabe ◽  
Hirohito Fujikawa ◽  
Tsutomu Hayashi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Lean Body Mass ◽  
Body Mass ◽  
Early Period ◽  
Body Weight Loss ◽  
Total Body Weight ◽  
Late Period ◽  
Total Body ◽  
Total Body Weight Loss

219 Background: Postoperative changes in body weight and composition during first 1 month after gastrectomy remained unclear. Methods: The patients who underwent gastrectomy for gastric cancer between May 2010 and October 2013 were examined. Body weight and composition were evaluated by bioelectrical impedance analyzer within 1 week before surgery (first measurement), at 1 week after surgery (second measurement), and at 1 month after surgery (third measurement). The changes of the early period were defined as the differences until the second measurement, while those of the late period as the differences from the second to the third measurement. Results: Two-hundred forty four patients were selected for this study. Total body weight loss (BWL) within 1 month was -3.4 kg and the rate of body weight at 1 month to the preoperative body weight was 94.1%. BWL was significantly greater in the early period rather than that of the late period (-2.1 kg vs -1.2 kg, p<0.001). In the early period, loss of lean body mass was significantly greater than loss of fat mass (-1.5 kg vs -0.6 kg, p<0.001). The same trend was observed regardless of type of gastrectomy and surgical approach. Conclusions: Loss of lean body mass within 1 week was a major determinant for total body weight loss at 1 month. To maintain lean body mass within 1 week and total body weight at 1 month, future trial should be focused on not the surgical approach but nutritional intervention within 1 week.

scholarly journals Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection

HIV Medicine ◽  
2002 ◽  
Vol 3 (4) ◽  
pp. 263-270 ◽  
Author(s):  
IB Wilson ◽  
DL Jacobson ◽  
R Roubenoff ◽  
D Spiegelman ◽  
TA Knox ◽  
...  
Keyword(s):  
Body Weight ◽  
Hiv Infection ◽  
Lean Body Mass ◽  
Body Mass ◽  
Physical Functioning ◽  
Total Body Weight ◽  
Total Body

Cross-sex hormone therapy in transgender persons affects total body weight, body fat and lean body mass: a meta-analysis

Andrologia ◽  
2016 ◽  
Vol 49 (5) ◽  
pp. e12660 ◽  
Author(s):  
M. Klaver ◽  
M. J. H. J. Dekker ◽  
R. de Mutsert ◽  
J. W. R. Twisk ◽  
M. den Heijer
Keyword(s):  
Body Weight ◽  
Hormone Therapy ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Meta Analysis ◽  
Total Body Weight ◽  
Sex Hormone ◽  
Transgender Persons ◽  
Total Body

scholarly journals Lean body mass and total body weight versus body surface area as determinant of docetaxel pharmacokinetics and toxicity

2022 ◽  
Author(s):  
Rien Hoge ◽  
Suzan Detert Oude Weme ◽  
Walter Vervenne ◽  
Inge van Berlo - van de Laar ◽  
Carla van Herpen ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Surface ◽  
Total Body Weight ◽  
Dose Individualisation ◽  
Total Body

Aim: In our study we examined whether anthropometric and body composition parameters, i.e. body surface area (BSA), lean body mass (LBM) and total body weight (TBW), are correlated with docetaxel clearance and exposure. In addition, LBM, TBW and a fixed dose were compared to BSA as dosing parameters for dose individualisation of docetaxel. Methods: Thirty-six patients affected by breast or castration-resistant prostate carcinoma receiving docetaxel chemotherapy entered the study. LBM was measured by a Dual Energy Xray Absorptiometry (DEXA) scanner before treatment. Blood samples were collected up to 180 minutes after dosing to analyse docetaxel concentrations and to determine individual pharmacokinetic (PK) parameters. Results: No significant correlations were found between the docetaxel pharmacokinetic parameters clearance and volume of distribution and the anthropometric and body composition variables BSA, LBM and TBW. AUC was significantly but poorly correlated with BSA (r=0.452 [p=0.016]) and with TBW (r=0.476 (p=0.011]). The Mean Absolute Percentage Error and Mean Error of simulated dosing based on LBM and fixed dosing ME were not significant different compared to BSA. For TBW, only the MAPE of dosing was significant higher compared to BSA (24.1 vs. 17.1, P=0.001). Conclusion: There is no correlations between docetaxel pharmacokinetics and the anthropometric and body composition variables BSA, LBM and TBW. Dose individualisation of docetaxel based on LBM or TBW or fixed dosing cannot be recommended over BSA based dosing.

scholarly journals Towards Personalised Contrast Injection: Artificial-Intelligence-Derived Body Composition and Liver Enhancement in Computed Tomography

2021 ◽  
Vol 11 (3) ◽  
pp. 159
Author(s):  
Daan J. de Jong ◽  
Wouter B. Veldhuis ◽  
Frank J. Wessels ◽  
Bob de Vos ◽  
Pim Moeskops ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Total Body Weight ◽  
Lean Body Weight ◽  
Contrast Enhanced ◽  
Total Body ◽  
Enhanced Computed Tomography

In contrast-enhanced computed tomography, total body weight adapted contrast injection protocols have proven successful in achieving a homogeneous enhancement of vascular structures and liver parenchyma. However, because solid organs have greater perfusion than adipose tissue, the lean body weight (fat-free mass) rather than the total body weight is theorised to cause even more homogeneous enhancement. We included 102 consecutive patients who underwent a multiphase abdominal computed tomography between March 2016 and October 2019. Patients received contrast media (300 mgI/mL) according to bodyweight categories. Using regions of interest, we measured the Hounsfield unit (HU) increase in liver attenuation from unenhanced to contrast-enhanced computed tomography. Furthermore, subjective image quality was graded using a four-point Likert scale. An artificial intelligence algorithm automatically segmented and determined the body compositions and calculated the percentages of lean body weight. The hepatic enhancements were adjusted for iodine dose and iodine dose per total body weight, as well as percentage lean body weight. The associations between enhancement and total body weight, body mass index, and lean body weight were analysed using linear regression. Patients had a median age of 68 years (IQR: 58–74), a total body weight of 81 kg (IQR: 73–90), a body mass index of 26 kg/m2 (SD: ±4.2), and a lean body weight percentage of 50% (IQR: 36–55). Mean liver enhancements in the portal venous phase were 61 ± 12 HU (≤70 kg), 53 ± 10 HU (70–90 kg), and 53 ± 7 HU (≥90 kg). The majority (93%) of scans were rated as good or excellent. Regression analysis showed significant correlations between liver enhancement corrected for injected total iodine and total body weight (r = 0.53; p < 0.001) and between liver enhancement corrected for lean body weight and the percentage of lean body weight (r = 0.73; p < 0.001). Most benefits from personalising iodine injection using %LBW additive to total body weight would be achieved in patients under 90 kg. Liver enhancement is more strongly associated with the percentage of lean body weight than with the total body weight or body mass index. The observed variation in liver enhancement might be reduced by a personalised injection based on the artificial-intelligence-determined percentage of lean body weight.

scholarly journals Evaluation of total body weight and body mass index cut-offs for increased cefazolin dose for surgical prophylaxis

2016 ◽  
Vol 48 (6) ◽  
pp. 633-640 ◽  
Author(s):  
Maya Hites ◽  
Guillaume Deprez ◽  
Fleur Wolff ◽  
Brigitte Ickx ◽  
Anita Verleije ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Total Body Weight ◽  
Surgical Prophylaxis ◽  
Total Body

scholarly journals Effect of neuroactive nutritional supplementation on body weight and composition in growing puppies

2017 ◽  
Vol 6 ◽  
Author(s):  
Wei Wang ◽  
Melissa Brooks ◽  
Cari Gardner ◽  
Norton Milgram
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Lean Body Mass ◽  
Body Mass ◽  
Growth And Development ◽  
Early Stage ◽  
Total Body Weight ◽  
The Body ◽  
Control Group ◽  
Significant Difference

AbstractNutritional factors can dramatically affect development of young animals during the early stage of life. The objective of the present study was to examine the effects of a neuroactive nutritional supplement (NNS) containing DHA, taurine, carotenoids and vitamins on the body weight and body composition of growing puppies. A total of twenty-four 2-month-old Beagles were fed a nutritionally complete and balanced base diet and a control supplement daily during an initial 1-month baseline assessment, after which they were divided into control and treatment groups. They were fed daily either control or treatment supplements in addition to the base diet from 3 to 12 months of age. Lean body mass and fat mass were assessed using quantitative magnetic resonance scans at 0 (baseline), 3, 6 and 9 months of treatment. Total body weight and lean body mass did not differ between groups over time. The puppies in the treatment group showed a trend of reduced fat gain compared with those in the control group, and with a marginally significant difference at 6 months (P = 0·05). At 3 months, insulin-like growth factor 1 was higher (P = 0·02) in the treatment group compared with the control group. At 9 months, fasting lipid levels were lower (P < 0·05) and fat-oxidation metabolite 3-hydroxybutyrate was higher (P < 0·05) in the treatment group compared with the control group. These results may indicate that NNS has an impact on puppy growth and development, possibly by promoting fat metabolism; further investigation would be necessary to determine the full impact of this supplement on growth and development.

Total body water-to-lean body mass ratio in baboons (Papio sp.) of varying adiposity

1986 ◽  
Vol 61 (3) ◽  
pp. 1234-1236 ◽  
Author(s):  
D. S. Lewis ◽  
H. A. Bertrand ◽  
E. J. Masoro
Keyword(s):  
Body Weight ◽  
Lean Body Mass ◽  
Body Mass ◽  
Total Body Water ◽  
Body Water ◽  
Unit Weight ◽  
Tissue Mass ◽  
Unit Body Weight ◽  
Triglyceride Content ◽  
Total Body

Total body water (TBW), lean body mass (LBM), and triglyceride mass were measured in 23 5-yr-old baboons (13 females and 10 males). Male baboons weighed more, had more LBM, more TBW, and contained less triglyceride mass per unit body weight than female baboons. Among all baboons, triglyceride mass per unit body weight ranged from 2.4 to 33.5%. The ratio TBW:LBM ranged from 0.70 to 0.92, increasing (r = 0.98) with increased body triglyceride content (both percent and absolute mass) in both male and female baboons. However, the water content per unit weight of tissues free of fat cells (liver, lungs, kidneys, central nervous system, eyes, tongue) was nearly constant at 0.73 +/- 0.02. The increase in TBW:LBM is more than can be expected from the water in the increased adipose tissue mass. We conclude that TBW:LBM is not constant but is influenced by body triglyceride content in baboons.

Application of Allometry to Zooarchaeology

1987 ◽  
Vol 52 (2) ◽  
pp. 304-317 ◽  
Author(s):  
Elizabeth J. Reitz ◽  
Irvy R. Quitmyer ◽  
H. Stephen Hale ◽  
Sylvia J. Scudder ◽  
Elizabeth S. Wing
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Linear Regression ◽  
Body Mass ◽  
Total Body Weight ◽  
Archaeological Sites ◽  
Average Weight ◽  
Total Body ◽  
The Relationship ◽  
Average Body

Zooarchaeologists have used several methods to assess the relative dietary contribution of species found at archaeological sites. The most common methods are either based upon the assumption that bone weight is a fixed percentage of total body weight, or require estimating an "average" body size for identified taxa. In fact, the relationship between parameters of bone and body mass is generally allometric and can be described by linear regression. Use of allometric models places original body mass predictions on a more sound biological basis and makes calculations of "average" weight unnecessary. The potential of allometry is discussed and objections addressed with the goal of encouraging others to develop allometric formulae and to use them in their research.

scholarly journals Lean body weight versus total body weight to calculate the iodinated contrast media volume in abdominal CT: a randomised controlled trial

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Moreno Zanardo ◽  
Fabio Martino Doniselli ◽  
Anastassia Esseridou ◽  
Massimiliano Agrò ◽  
Nicol Antonina Rita Panarisi ◽  
...  
Keyword(s):  
Body Weight ◽  
Contrast Media ◽  
Controlled Trial ◽  
Total Body Weight ◽  
Lean Body Weight ◽  
Iodinated Contrast Media ◽  
Abdominal Ct ◽  
Iodinated Contrast ◽  
Significant Difference ◽  
Total Body

Abstract Objectives Iodinated contrast media (ICM) could be more appropriately dosed on patient lean body weight (LBW) than on total body weight (TBW). Methods After Ethics Committee approval, trial registration NCT03384979, patients aged ≥ 18 years scheduled for multiphasic abdominal CT were randomised for ICM dose to LBW group (0.63 gI/kg of LBW) or TBW group (0.44 gI/kg of TBW). Abdominal 64-row CT was performed using 120 kVp, 100–200 mAs, rotation time 0.5 s, pitch 1, Iopamidol (370 mgI/mL), and flow rate 3 mL/s. Levene, Mann–Whitney U, and χ2 tests were used. The primary endpoint was liver contrast enhancement (LCE). Results Of 335 enrolled patients, 17 were screening failures; 44 dropped out after randomisation; 274 patients were analysed (133 LBW group, 141 TBW group). The median age of LBW group (66 years) was slightly lower than that of TBW group (70 years). Although the median ICM-injected volume was comparable between groups, its variability was larger in the former (interquartile range 27 mL versus 21 mL, p = 0.01). The same was for unenhanced liver density (IQR 10 versus 7 HU) (p = 0.02). Median LCE was 40 (35–46) HU in the LBW group and 40 (35–44) HU in the TBW group, without significant difference for median (p = 0.41) and variability (p = 0.23). Suboptimal LCE (< 40 HU) was found in 64/133 (48%) patients in the LBW group and 69/141 (49%) in the TBW group, but no examination needed repeating. Conclusions The calculation of the ICM volume to be administered for abdominal CT based on the LBW does not imply a more consistent LCE.

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