Evaluation of Phenolic Compound Toxicity Using a Bioluminescent Assay with the Fungus Gerronema viridilucens

2020 ◽  
Vol 39 (8) ◽  
pp. 1558-1565
Author(s):  
Fernanda F. Ventura ◽  
Luiz F. Mendes ◽  
Anderson G. Oliveira ◽  
Reinaldo C. Bazito ◽  
Etelvino J.H. Bechara ◽  
...  
Keyword(s):  
Phenolic Compound ◽  
Bioluminescent Assay

Study of the phenolic compound profile and antioxidant activity of human milk from Spanish women at different stages of lactation: A comparison with infant formulas

2021 ◽  
Vol 141 ◽  
pp. 110149
Author(s):  
Silvia Sánchez-Hernández ◽  
Adelaida Esteban-Muñoz ◽  
Cristina Samaniego-Sánchez ◽  
Rafael Giménez-Martínez ◽  
Beatriz Miralles ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Human Milk ◽  
Phenolic Compound ◽  
Infant Formulas ◽  
Spanish Women

scholarly journals Cytotoxic and antigenotoxic properties of phenolic compound isolated from the fruit of Terminalia chebula on HeLa cell

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
K. Soumya ◽  
Jesna James ◽  
T. M. Archana ◽  
A. T. Dhanya ◽  
A. P. Shahid ◽  
...  
Keyword(s):  
Dna Damage ◽  
Gallic Acid ◽  
Phenolic Compound ◽  
Diethyl Ether ◽  
Hela Cells ◽  
Protective Role ◽  
Terminalia Chebula ◽  
Diethyl Ether Extract ◽  
Toxic Concentration ◽  
Isolated Compound

Abstract Background DNA in a human cell is subjected to constant assault from both environmental factors and normal metabolic processes. Accumulation of DNA damage drives the progression of many health disorders like aging, cancer, diabetes, and neurodegenerative disorders. Results The present study focuses on the isolation of phenolic compound from the fruit of Terminalia chebula and its protective role on induced DNA damage. Diethyl ether and ethyl acetate extract of Terminalia chebula fruit were subjected to column chromatographic purification, and the fractions obtained were tested for the presence of phenolics. Fraction-12 isolated from diethyl ether extract was identified as gallic acid, which is used for cytotoxic and DNA damage protection activity assays. To select a non-toxic concentration of isolated compound, cytotoxicity was assessed by MTT assay. Gallic acid showed moderate toxicity at the highest concentration tested (i.e., percentage cell viability at 100 μg/ml is 40.51 ± 1.31). Antigenotoxic effect of gallic acid on HeLa cells was carried by alkaline comet assay. The compound showed significant protective abilities against hydrogen peroxide-induced DNA damage in HeLa cells. Conclusion These results show the importance of gallic acid isolated from Terminalia chebula fruit, as protector of oxidative stress-induced DNA damage.

Tyrosol, a phenolic compound from Phomopsis sp., is a potential biostimulant in soybean seed treatment

2021 ◽  
Vol 43 ◽  
pp. 40-44
Author(s):  
Geraldo Humberto Silva ◽  
Josiane Abadia Resende de Souza ◽  
Willian Rodrigues Macedo ◽  
Frederico Garcia Pinto
Keyword(s):  
Phenolic Compound ◽  
Seed Treatment ◽  
Soybean Seed

Tyrosol, a phenolic compound, ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

2015 ◽  
Vol 229 ◽  
pp. 44-54 ◽  
Author(s):  
Ramasamy Chandramohan ◽  
Leelavinothan Pari ◽  
Ayyasamy Rathinam ◽  
Bashir Ahmad Sheikh
Keyword(s):  
Carbohydrate Metabolism ◽  
Phenolic Compound ◽  
Diabetic Rats ◽  
Key Enzymes ◽  
Enzymes Of Carbohydrate Metabolism

scholarly journals Hydroxytyrosol alleviates oxidative stress, neuroinflammation and enhances hippocampal neurotropic signaling to improve stress-induced depressive behaviors in mice

2021 ◽  
Author(s):  
Yun- Tao Zhao ◽  
lu lu zhang ◽  
Haowen Yin ◽  
Ling Shen ◽  
Wenjing Zheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phenolic Compound ◽  
Physiological Functions ◽  
Anti Inflammatory

Hydroxytyrosol (HT), the main phenolic compound in olives and olive products, has antioxidative, anti-inflammatory, neuroprotective, and other physiological functions. The effects of HT on depression are unclear. The aim of...

scholarly journals Optimization of Phenolic Compound Production By Local Aspergillus Niger B1b Isolate

2021 ◽  
Vol 761 (1) ◽  
pp. 012119
Author(s):  
N. Sh. Ahmed ◽  
E. I. Al- Shamary
Keyword(s):  
Aspergillus Niger ◽  
Phenolic Compound

scholarly journals Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential In Vivo Projection

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 92 ◽  
Author(s):  
Alexis Matute ◽  
Jessica Tabart ◽  
Jean-Paul Cheramy-Bien ◽  
Bernard Pirotte ◽  
Claire Kevers ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Compound ◽  
Vascular Reactivity ◽  
Ex Vivo ◽  
Clinical Investigation ◽  
Epigallocatechin Gallate ◽  
Fruit Juices ◽  
Organ Bath ◽  
Total Polyphenol ◽  
Total Anthocyanin

The real impact of polyphenol-rich vegetable and fruit juice intake on cardiovascular health remains a matter of controversy. In the present study, rat aorta segments immersed in an organ bath (OB) were used to explore whether the total polyphenol content and/or individual phenolic compound contents of 22 commercial vegetable (n = 3) and fruit juices [(citrus (n = 5), berries (n = 10), apple (n = 2), pineapple (n = 2)] might be associated with vascular tone. Red juices (particularly blackcurrant) and lemon juice caused the most marked vasorelaxation, its amplitude being endothelium dependent or not according to the volume ratio of juice to initial OB solution Vjuice/VOBS). At volume ratios 5% and 10%, both the juice and OB total polyphenol for all juices and total anthocyanin contents for berry juices significantly correlated with aorta vasorelaxation intensity. This was not the case for total or individual flavonols (except kaempferol) or for total or individual flavanols (except epigallocatechin gallate). If one relates our measured concentrations of individual phenolic compounds in OB to what is known about their physiological concentrations, and given our evidenced correlations between compound concentrations and vasorelaxation intensity, kaempferol, epigallocatechin gallate and peonidin-3-O-glucoside seem to emerge as the interesting phenolic compounds likely to be responsible for the potent vasorelaxation observed with fruit juices, and more particularly blackcurrant ones. Clinical investigation is required, however, to confirm our observations.

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